1YHQE

Crystal structure of azithromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 37
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2005-01-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yhqE01
3CC4E 1VQ9E 3G6EE 1VQKE 1KD1G 5DM6E 1YJNE 5JVHE 1Q81G 5GAGG 1QVFE 3OW2E 4UY8G 5HL7E 4IO9E 1Q82G 1VQLE 1Q7YG 1VQOE 1K8AG 1QVGE 3CD6E 4IOAE 1VQ6E 4WFBE 5DM7E 3CCQE 5AN9B 5GAHG 3DLLE 3I56E 4IOCE 1YHQE 5GAEG 1VQ5E 1YITE 1VQNE 3I55E 3G71E 3CCLE 4WF9E 1YIJE 3CCRE 2CQLA 5GADG 1K73G 2QEXE 4WFAE 5JVGE 3CXCE 1VQME 3CCEE 3CMEE 1NJIG 2OTJE 1KC8G 1KQSE 2OTLE 2ZJQE 3G4SE 2ZJRE 1M1KG 3PIPE 1JJ2E 1VQ8E 3CPWE 3CC2E 1YJWE 3PIOE 1M90G 1S72E 5MLCH 2QA4E 4WCEE 5H1SI 1W2BE 1VQ7E 3CCUE 3CCSE 1RL6A 1Q86G 1N8RG 3CMAE 2ZJPE 3CC7E 4WFNE 1K9MG 3CCVE 3CCME 4U67E 3CF5E 1YJ9E 3J7ZG 1VQ4E 1VQPE 1YI2E 3CCJE
chains in the Genus database with same CATH superfamily
2I5VO 3CC4E 1VQ9E 3G6EE 1VQKE 1OSPO 1KD1G 5DM6E 1YJNE 5JVHE 1Q81G 3AUMO 3CKFA 5GAGG 2PI3O 1QVFE 3OW2E 4UY8G 5HL7E 4IO9E 5B10O 1Q82G 1VQLE 1Q7YG 2OYBO 2OL8O 1VQOE 1K8AG 3EC5A 1QVGE 3CD6E 4IOAE 1VQ6E 4WFBE 5DM7E 3CCQE 2OY8A 5AN9B 5GAHG 3DLLE 3IG9A 5B11O 3I56E 4IOCE 1YHQE 5GAEG 1VQ5E 1YITE 1VQNE 2OL6O 2FKJA 3I55E 3IGEA 3G71E 3CCLE 4WF9E 1YIJE 3CCRE 2CQLA 5GADG 2OY5O 1K73G 2QEXE 2G8CO 4WFAE 1P4PA 5B2AO 5JVGE 3CXCE 1VQME 3CCEE 3CMEE 1NJIG 2OTJE 1KC8G 1KQSE 2OTLE 2ZJQE 3G4SE 2ZJRE 1M1KG 2I5ZO 3PIPE 2HKDA 2OY1O 1JJ2E 1VQ8E 3CPWE 3CC2E 1YJWE 3PIOE 1M90G 1S72E 5MLCH 2QA4E 4WCEE 5H1SI 1W2BE 1VQ7E 3CCUE 3CCSE 1RL6A 1Q86G 1FJ1E 1N8RG 3CMAE 2ZJPE 2OY7A 2AF5A 1RJLC 3CC7E 4WFNE 2OL7A 1K9MG 3CCVE 3CCME 4U67E 3CF5E 1YJ9E 2FKGA 3CKGA 5B3MO 3J7ZG 1VQ4E 1VQPE 1YI2E 3CCJE
chains in the Genus database with same CATH topology
3CC4E 1VQ9E 3G6EE 1VQKE 1KD1G 5DM6E 1YJNE 5JVHE 1Q81G 5GAGG 1QVFE 3OW2E 4UY8G 5HL7E 4IO9E 1Q82G 1VQLE 1Q7YG 1VQOE 1K8AG 1QVGE 3CD6E 4IOAE 1VQ6E 4WFBE 5DM7E 3CCQE 5AN9B 5GAHG 3DLLE 3I56E 4IOCE 1YHQE 5GAEG 1VQ5E 1YITE 1VQNE 3I55E 3G71E 3CCLE 4WF9E 1YIJE 3CCRE 2CQLA 5GADG 1K73G 2QEXE 4WFAE 5JVGE 3CXCE 1VQME 3CCEE 3CMEE 1NJIG 2OTJE 1KC8G 1KQSE 2OTLE 2ZJQE 3G4SE 2ZJRE 1M1KG 3PIPE 1JJ2E 1VQ8E 3CPWE 3CC2E 1YJWE 3PIOE 1M90G 1S72E 5MLCH 2QA4E 4WCEE 5H1SI 1W2BE 1VQ7E 3CCUE 3CCSE 1RL6A 1Q86G 1N8RG 3CMAE 2ZJPE 3CC7E 4WFNE 1K9MG 3CCVE 3CCME 4U67E 3CF5E 1YJ9E 3J7ZG 1VQ4E 1VQPE 1YI2E 3CCJE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CC4 E;  1VQ9 E;  3G6E E;  1VQK E;  1KD1 G;  5DM6 E;  1YJN E;  5JVH E;  1Q81 G;  5GAG G;  1QVF E;  3OW2 E;  4UY8 G;  5HL7 E;  4IO9 E;  1Q82 G;  1VQL E;  1Q7Y G;  1VQO E;  1K8A G;  1QVG E;  3CD6 E;  4IOA E;  1VQ6 E;  4WFB E;  5DM7 E;  3CCQ E;  5AN9 B;  5GAH G;  3DLL E;  3I56 E;  4IOC E;  1YHQ E;  5GAE G;  1VQ5 E;  1YIT E;  1VQN E;  3I55 E;  3G71 E;  3CCL E;  4WF9 E;  1YIJ E;  3CCR E;  2CQL A;  5GAD G;  1K73 G;  2QEX E;  4WFA E;  5JVG E;  3CXC E;  1VQM E;  3CCE E;  3CME E;  1NJI G;  2OTJ E;  1KC8 G;  1KQS E;  2OTL E;  2ZJQ E;  3G4S E;  2ZJR E;  1M1K G;  3PIP E;  1JJ2 E;  1VQ8 E;  3CPW E;  3CC2 E;  1YJW E;  3PIO E;  1M90 G;  1S72 E;  5MLC H;  2QA4 E;  4WCE E;  5H1S I;  1W2B E;  1VQ7 E;  3CCU E;  3CCS E;  1RL6 A;  1Q86 G;  1N8R G;  3CMA E;  2ZJP E;  3CC7 E;  4WFN E;  1K9M G;  3CCV E;  3CCM E;  4U67 E;  3CF5 E;  1YJ9 E;  3J7Z G;  1VQ4 E;  1VQP E;  1YI2 E;  3CCJ E; 
#chains in the Genus database with same CATH topology
 2I5V O;  3CC4 E;  1VQ9 E;  3G6E E;  1VQK E;  1OSP O;  1KD1 G;  5DM6 E;  1YJN E;  5JVH E;  1Q81 G;  3AUM O;  3CKF A;  5GAG G;  2PI3 O;  1QVF E;  3OW2 E;  4UY8 G;  5HL7 E;  4IO9 E;  5B10 O;  1Q82 G;  1VQL E;  1Q7Y G;  2OYB O;  2OL8 O;  1VQO E;  1K8A G;  3EC5 A;  1QVG E;  3CD6 E;  4IOA E;  1VQ6 E;  4WFB E;  5DM7 E;  3CCQ E;  2OY8 A;  5AN9 B;  5GAH G;  3DLL E;  3IG9 A;  5B11 O;  3I56 E;  4IOC E;  1YHQ E;  5GAE G;  1VQ5 E;  1YIT E;  1VQN E;  2OL6 O;  2FKJ A;  3I55 E;  3IGE A;  3G71 E;  3CCL E;  4WF9 E;  1YIJ E;  3CCR E;  2CQL A;  5GAD G;  2OY5 O;  1K73 G;  2QEX E;  2G8C O;  4WFA E;  1P4P A;  5B2A O;  5JVG E;  3CXC E;  1VQM E;  3CCE E;  3CME E;  1NJI G;  2OTJ E;  1KC8 G;  1KQS E;  2OTL E;  2ZJQ E;  3G4S E;  2ZJR E;  1M1K G;  2I5Z O;  3PIP E;  2HKD A;  2OY1 O;  1JJ2 E;  1VQ8 E;  3CPW E;  3CC2 E;  1YJW E;  3PIO E;  1M90 G;  1S72 E;  5MLC H;  2QA4 E;  4WCE E;  5H1S I;  1W2B E;  1VQ7 E;  3CCU E;  3CCS E;  1RL6 A;  1Q86 G;  1FJ1 E;  1N8R G;  3CMA E;  2ZJP E;  2OY7 A;  2AF5 A;  1RJL C;  3CC7 E;  4WFN E;  2OL7 A;  1K9M G;  3CCV E;  3CCM E;  4U67 E;  3CF5 E;  1YJ9 E;  2FKG A;  3CKG A;  5B3M O;  3J7Z G;  1VQ4 E;  1VQP E;  1YI2 E;  3CCJ E; 
#chains in the Genus database with same CATH homology
 3CC4 E;  1VQ9 E;  3G6E E;  1VQK E;  1KD1 G;  5DM6 E;  1YJN E;  5JVH E;  1Q81 G;  5GAG G;  1QVF E;  3OW2 E;  4UY8 G;  5HL7 E;  4IO9 E;  1Q82 G;  1VQL E;  1Q7Y G;  1VQO E;  1K8A G;  1QVG E;  3CD6 E;  4IOA E;  1VQ6 E;  4WFB E;  5DM7 E;  3CCQ E;  5AN9 B;  5GAH G;  3DLL E;  3I56 E;  4IOC E;  1YHQ E;  5GAE G;  1VQ5 E;  1YIT E;  1VQN E;  3I55 E;  3G71 E;  3CCL E;  4WF9 E;  1YIJ E;  3CCR E;  2CQL A;  5GAD G;  1K73 G;  2QEX E;  4WFA E;  5JVG E;  3CXC E;  1VQM E;  3CCE E;  3CME E;  1NJI G;  2OTJ E;  1KC8 G;  1KQS E;  2OTL E;  2ZJQ E;  3G4S E;  2ZJR E;  1M1K G;  3PIP E;  1JJ2 E;  1VQ8 E;  3CPW E;  3CC2 E;  1YJW E;  3PIO E;  1M90 G;  1S72 E;  5MLC H;  2QA4 E;  4WCE E;  5H1S I;  1W2B E;  1VQ7 E;  3CCU E;  3CCS E;  1RL6 A;  1Q86 G;  1N8R G;  3CMA E;  2ZJP E;  3CC7 E;  4WFN E;  1K9M G;  3CCV E;  3CCM E;  4U67 E;  3CF5 E;  1YJ9 E;  3J7Z G;  1VQ4 E;  1VQP E;  1YI2 E;  3CCJ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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