1YI2E

Crystal structure of erythromycin bound to the g2099a mutant 50s ribosomal subunit of haloarcula marismortui
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S Ribosomal RNA
total genus 38
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2005-01-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yi2E02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 1yi2E01
1RL6A 5H1SI 1QVGE 1KD1G 3CMAE 5GAEG 3CCJE 1QVFE 3CCEE 5GAHG 1YI2E 4WFNE 1VQLE 3PIPE 2QA4E 1S72E 5DM6E 4WCEE 3DLLE 3CC7E 3CCRE 3G6EE 2QEXE 3I56E 4U67E 5GAGG 4IOCE 3CXCE 1VQKE 1KQSE 3I55E 2ZJRE 4IOAE 1M90G 4WF9E 4WFAE 3CC4E 4UY8G 2CQLA 4WFBE 1Q86G 2OTLE 4IO9E 3CCUE 3CCVE 1VQ8E 1YITE 3CPWE 1VQ9E 1VQME 5GADG 5HL7E 5JVHE 3CMEE 2ZJPE 2ZJQE 3CCME 1N8RG 1VQ4E 1VQNE 1W2BE 5MLCH 3G71E 2OTJE 1VQ6E 1KC8G 3CCLE 1JJ2E 1K8AG 3J7ZG 3CC2E 1K9MG 1VQOE 1VQ5E 1Q82G 3CD6E 1K73G 5DM7E 3CF5E 3G4SE 1YJNE 1M1KG 5JVGE 3PIOE 1YJWE 3CCQE 1YJ9E 1YHQE 1Q81G 1NJIG 5AN9B 1VQ7E 1VQPE 3CCSE 1Q7YG 1YIJE 3OW2E
chains in the Genus database with same CATH superfamily
1RL6A 5H1SI 1QVGE 1KD1G 3IGEA 3CMAE 2I5VO 5GAEG 2OY5O 3CCJE 1QVFE 3CCEE 5GAHG 1YI2E 4WFNE 1VQLE 2PI3O 3PIPE 1FJ1E 2OY8A 1S72E 5DM6E 4WCEE 2G8CO 3DLLE 3CC7E 3CKGA 3CCRE 3G6EE 2QEXE 3I56E 2OL7A 4U67E 5GAGG 2FKJA 1RJLC 3CXCE 4IOCE 1VQKE 2HKDA 1KQSE 2I5ZO 3I55E 2ZJRE 1M90G 4IOAE 4WF9E 4WFAE 3CC4E 4UY8G 2CQLA 4WFBE 1Q86G 2OTLE 4IO9E 3CCUE 3CCVE 1VQ8E 1YITE 3CPWE 1VQ9E 1VQME 5B11O 5GADG 5HL7E 2OY7A 5JVHE 2OY1O 3CMEE 2ZJPE 2ZJQE 3CCME 1N8RG 1VQ4E 1VQNE 1W2BE 5MLCH 3AUMO 3G71E 2OTJE 1P4PA 1Q7YG 1VQ6E 1KC8G 3CCLE 1JJ2E 1K8AG 2AF5A 3J7ZG 2FKGA 3CC2E 1OSPO 1K9MG 1VQOE 1VQ5E 2OYBO 2OL8O 2OL6O 5B10O 5B3MO 1Q82G 3CD6E 1K73G 5DM7E 3CF5E 3G4SE 1YJNE 1M1KG 3EC5A 5JVGE 3PIOE 5B2AO 3CCQE 1YJWE 1YJ9E 1YHQE 1Q81G 1NJIG 5AN9B 1VQ7E 1VQPE 3IG9A 3CCSE 2QA4E 3CKFA 1YIJE 3OW2E
chains in the Genus database with same CATH topology
1RL6A 5H1SI 1QVGE 1KD1G 3CMAE 5GAEG 3CCJE 1QVFE 3CCEE 5GAHG 1YI2E 4WFNE 1VQLE 3PIPE 2QA4E 1S72E 5DM6E 4WCEE 3DLLE 3CC7E 3CCRE 3G6EE 2QEXE 3I56E 4U67E 5GAGG 4IOCE 3CXCE 1VQKE 1KQSE 3I55E 2ZJRE 4IOAE 1M90G 4WF9E 4WFAE 3CC4E 4UY8G 2CQLA 4WFBE 1Q86G 2OTLE 4IO9E 3CCUE 3CCVE 1VQ8E 1YITE 3CPWE 1VQ9E 1VQME 5GADG 5HL7E 5JVHE 3CMEE 2ZJPE 2ZJQE 3CCME 1N8RG 1VQ4E 1VQNE 1W2BE 5MLCH 3G71E 2OTJE 1VQ6E 1KC8G 3CCLE 1JJ2E 1K8AG 3J7ZG 3CC2E 1K9MG 1VQOE 1VQ5E 1Q82G 3CD6E 1K73G 5DM7E 3CF5E 3G4SE 1YJNE 1M1KG 5JVGE 3PIOE 1YJWE 3CCQE 1YJ9E 1YHQE 1Q81G 1NJIG 5AN9B 1VQ7E 1VQPE 3CCSE 1Q7YG 1YIJE 3OW2E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1RL6 A;  5H1S I;  1QVG E;  1KD1 G;  3CMA E;  5GAE G;  3CCJ E;  1QVF E;  3CCE E;  5GAH G;  1YI2 E;  4WFN E;  1VQL E;  3PIP E;  2QA4 E;  1S72 E;  5DM6 E;  4WCE E;  3DLL E;  3CC7 E;  3CCR E;  3G6E E;  2QEX E;  3I56 E;  4U67 E;  5GAG G;  4IOC E;  3CXC E;  1VQK E;  1KQS E;  3I55 E;  2ZJR E;  4IOA E;  1M90 G;  4WF9 E;  4WFA E;  3CC4 E;  4UY8 G;  2CQL A;  4WFB E;  1Q86 G;  2OTL E;  4IO9 E;  3CCU E;  3CCV E;  1VQ8 E;  1YIT E;  3CPW E;  1VQ9 E;  1VQM E;  5GAD G;  5HL7 E;  5JVH E;  3CME E;  2ZJP E;  2ZJQ E;  3CCM E;  1N8R G;  1VQ4 E;  1VQN E;  1W2B E;  5MLC H;  3G71 E;  2OTJ E;  1VQ6 E;  1KC8 G;  3CCL E;  1JJ2 E;  1K8A G;  3J7Z G;  3CC2 E;  1K9M G;  1VQO E;  1VQ5 E;  1Q82 G;  3CD6 E;  1K73 G;  5DM7 E;  3CF5 E;  3G4S E;  1YJN E;  1M1K G;  5JVG E;  3PIO E;  1YJW E;  3CCQ E;  1YJ9 E;  1YHQ E;  1Q81 G;  1NJI G;  5AN9 B;  1VQ7 E;  1VQP E;  3CCS E;  1Q7Y G;  1YIJ E;  3OW2 E; 
#chains in the Genus database with same CATH topology
 1RL6 A;  5H1S I;  1QVG E;  1KD1 G;  3IGE A;  3CMA E;  2I5V O;  5GAE G;  2OY5 O;  3CCJ E;  1QVF E;  3CCE E;  5GAH G;  1YI2 E;  4WFN E;  1VQL E;  2PI3 O;  3PIP E;  1FJ1 E;  2OY8 A;  1S72 E;  5DM6 E;  4WCE E;  2G8C O;  3DLL E;  3CC7 E;  3CKG A;  3CCR E;  3G6E E;  2QEX E;  3I56 E;  2OL7 A;  4U67 E;  5GAG G;  2FKJ A;  1RJL C;  3CXC E;  4IOC E;  1VQK E;  2HKD A;  1KQS E;  2I5Z O;  3I55 E;  2ZJR E;  1M90 G;  4IOA E;  4WF9 E;  4WFA E;  3CC4 E;  4UY8 G;  2CQL A;  4WFB E;  1Q86 G;  2OTL E;  4IO9 E;  3CCU E;  3CCV E;  1VQ8 E;  1YIT E;  3CPW E;  1VQ9 E;  1VQM E;  5B11 O;  5GAD G;  5HL7 E;  2OY7 A;  5JVH E;  2OY1 O;  3CME E;  2ZJP E;  2ZJQ E;  3CCM E;  1N8R G;  1VQ4 E;  1VQN E;  1W2B E;  5MLC H;  3AUM O;  3G71 E;  2OTJ E;  1P4P A;  1Q7Y G;  1VQ6 E;  1KC8 G;  3CCL E;  1JJ2 E;  1K8A G;  2AF5 A;  3J7Z G;  2FKG A;  3CC2 E;  1OSP O;  1K9M G;  1VQO E;  1VQ5 E;  2OYB O;  2OL8 O;  2OL6 O;  5B10 O;  5B3M O;  1Q82 G;  3CD6 E;  1K73 G;  5DM7 E;  3CF5 E;  3G4S E;  1YJN E;  1M1K G;  3EC5 A;  5JVG E;  3PIO E;  5B2A O;  3CCQ E;  1YJW E;  1YJ9 E;  1YHQ E;  1Q81 G;  1NJI G;  5AN9 B;  1VQ7 E;  1VQP E;  3IG9 A;  3CCS E;  2QA4 E;  3CKF A;  1YIJ E;  3OW2 E; 
#chains in the Genus database with same CATH homology
 1RL6 A;  5H1S I;  1QVG E;  1KD1 G;  3CMA E;  5GAE G;  3CCJ E;  1QVF E;  3CCE E;  5GAH G;  1YI2 E;  4WFN E;  1VQL E;  3PIP E;  2QA4 E;  1S72 E;  5DM6 E;  4WCE E;  3DLL E;  3CC7 E;  3CCR E;  3G6E E;  2QEX E;  3I56 E;  4U67 E;  5GAG G;  4IOC E;  3CXC E;  1VQK E;  1KQS E;  3I55 E;  2ZJR E;  4IOA E;  1M90 G;  4WF9 E;  4WFA E;  3CC4 E;  4UY8 G;  2CQL A;  4WFB E;  1Q86 G;  2OTL E;  4IO9 E;  3CCU E;  3CCV E;  1VQ8 E;  1YIT E;  3CPW E;  1VQ9 E;  1VQM E;  5GAD G;  5HL7 E;  5JVH E;  3CME E;  2ZJP E;  2ZJQ E;  3CCM E;  1N8R G;  1VQ4 E;  1VQN E;  1W2B E;  5MLC H;  3G71 E;  2OTJ E;  1VQ6 E;  1KC8 G;  3CCL E;  1JJ2 E;  1K8A G;  3J7Z G;  3CC2 E;  1K9M G;  1VQO E;  1VQ5 E;  1Q82 G;  3CD6 E;  1K73 G;  5DM7 E;  3CF5 E;  3G4S E;  1YJN E;  1M1K G;  5JVG E;  3PIO E;  1YJW E;  3CCQ E;  1YJ9 E;  1YHQ E;  1Q81 G;  1NJI G;  5AN9 B;  1VQ7 E;  1VQP E;  3CCS E;  1Q7Y G;  1YIJ E;  3OW2 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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