3G4SE

Co-crystal structure of tiamulin bound to the large ribosomal subunit
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 32
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2009-02-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g4sE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g4sE01
5GAEG 5AN9B 3OW2E 3CCRE 3CMEE 5MLCH 3DLLE 1Q86G 1KC8G 5GAGG 4IO9E 3CC4E 1M1KG 3CCVE 1YI2E 1S72E 1VQOE 3CCSE 1VQPE 5JVHE 2CQLA 3CC7E 1VQ9E 1YJWE 1Q82G 3CCLE 3PIOE 1VQ8E 3G4SE 5DM7E 1YJNE 1K9MG 3CPWE 3CCEE 1Q7YG 1K73G 4IOCE 2ZJPE 3CXCE 1M90G 4IOAE 1RL6A 4WF9E 1VQLE 5H1SI 3G6EE 4UY8G 4WFAE 1YJ9E 1VQ6E 1JJ2E 5GAHG 3CD6E 2QEXE 1K8AG 1Q81G 2ZJQE 5JVGE 3I55E 1NJIG 3I56E 1VQKE 1YIJE 1N8RG 1QVGE 3CF5E 1KD1G 4WFBE 1YITE 3CMAE 1KQSE 1VQME 3J7ZG 3CCUE 1VQNE 3G71E 5HL7E 1YHQE 2QA4E 4U67E 1VQ5E 1QVFE 2ZJRE 4WFNE 1W2BE 5DM6E 2OTJE 3CC2E 1VQ7E 4WCEE 3CCJE 3CCME 5GADG 3CCQE 2OTLE 3PIPE 1VQ4E
chains in the Genus database with same CATH superfamily
2OY8A 5GAEG 1P4PA 5AN9B 3IGEA 3OW2E 3CCRE 5B2AO 3CMEE 5MLCH 3DLLE 1Q86G 1KC8G 5GAGG 4IO9E 2OY1O 5B11O 3CC4E 2OY5O 1M1KG 3EC5A 3CCVE 1YI2E 1VQOE 1S72E 3CCSE 1VQPE 1RJLC 5JVHE 2CQLA 3CC7E 1VQ9E 2HKDA 1YJWE 1Q82G 3CCLE 2OL7A 3PIOE 1VQ8E 3G4SE 5B3MO 2OYBO 5DM7E 1YJNE 1K9MG 3AUMO 3CPWE 3CCEE 1Q7YG 5B10O 2OL8O 1K73G 4IOCE 2ZJPE 3CXCE 1M90G 4IOAE 1RL6A 4WF9E 3CKGA 1VQLE 5H1SI 2FKJA 1OSPO 2OY7A 3G6EE 4UY8G 4WFAE 2I5VO 1YJ9E 1VQ6E 1JJ2E 5GAHG 3CD6E 2QEXE 1K8AG 1Q81G 2I5ZO 2ZJQE 5JVGE 3I55E 1NJIG 3I56E 1VQKE 1YIJE 2PI3O 1N8RG 1QVGE 3CF5E 1KD1G 2G8CO 4WFBE 1YITE 2AF5A 1FJ1E 3CMAE 2FKGA 1KQSE 1VQME 3J7ZG 3CCUE 1VQNE 3G71E 5HL7E 1YHQE 2QA4E 4U67E 1VQ5E 1QVFE 2ZJRE 3CKFA 4WFNE 1W2BE 5DM6E 2OTJE 3CC2E 1VQ7E 4WCEE 3CCJE 3CCME 5GADG 3CCQE 2OTLE 2OL6O 3IG9A 3PIPE 1VQ4E
chains in the Genus database with same CATH topology
5GAEG 5AN9B 3OW2E 3CCRE 3CMEE 5MLCH 3DLLE 1Q86G 1KC8G 5GAGG 4IO9E 3CC4E 1M1KG 3CCVE 1YI2E 1S72E 1VQOE 3CCSE 1VQPE 5JVHE 2CQLA 3CC7E 1VQ9E 1YJWE 1Q82G 3CCLE 3PIOE 1VQ8E 3G4SE 5DM7E 1YJNE 1K9MG 3CPWE 3CCEE 1Q7YG 1K73G 4IOCE 2ZJPE 3CXCE 1M90G 4IOAE 1RL6A 4WF9E 1VQLE 5H1SI 3G6EE 4UY8G 4WFAE 1YJ9E 1VQ6E 1JJ2E 5GAHG 3CD6E 2QEXE 1K8AG 1Q81G 2ZJQE 5JVGE 3I55E 1NJIG 3I56E 1VQKE 1YIJE 1N8RG 1QVGE 3CF5E 1KD1G 4WFBE 1YITE 3CMAE 1KQSE 1VQME 3J7ZG 3CCUE 1VQNE 3G71E 5HL7E 1YHQE 2QA4E 4U67E 1VQ5E 1QVFE 2ZJRE 4WFNE 1W2BE 5DM6E 2OTJE 3CC2E 1VQ7E 4WCEE 3CCJE 3CCME 5GADG 3CCQE 2OTLE 3PIPE 1VQ4E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5GAE G;  5AN9 B;  3OW2 E;  3CCR E;  3CME E;  5MLC H;  3DLL E;  1Q86 G;  1KC8 G;  5GAG G;  4IO9 E;  3CC4 E;  1M1K G;  3CCV E;  1YI2 E;  1S72 E;  1VQO E;  3CCS E;  1VQP E;  5JVH E;  2CQL A;  3CC7 E;  1VQ9 E;  1YJW E;  1Q82 G;  3CCL E;  3PIO E;  1VQ8 E;  3G4S E;  5DM7 E;  1YJN E;  1K9M G;  3CPW E;  3CCE E;  1Q7Y G;  1K73 G;  4IOC E;  2ZJP E;  3CXC E;  1M90 G;  4IOA E;  1RL6 A;  4WF9 E;  1VQL E;  5H1S I;  3G6E E;  4UY8 G;  4WFA E;  1YJ9 E;  1VQ6 E;  1JJ2 E;  5GAH G;  3CD6 E;  2QEX E;  1K8A G;  1Q81 G;  2ZJQ E;  5JVG E;  3I55 E;  1NJI G;  3I56 E;  1VQK E;  1YIJ E;  1N8R G;  1QVG E;  3CF5 E;  1KD1 G;  4WFB E;  1YIT E;  3CMA E;  1KQS E;  1VQM E;  3J7Z G;  3CCU E;  1VQN E;  3G71 E;  5HL7 E;  1YHQ E;  2QA4 E;  4U67 E;  1VQ5 E;  1QVF E;  2ZJR E;  4WFN E;  1W2B E;  5DM6 E;  2OTJ E;  3CC2 E;  1VQ7 E;  4WCE E;  3CCJ E;  3CCM E;  5GAD G;  3CCQ E;  2OTL E;  3PIP E;  1VQ4 E; 
#chains in the Genus database with same CATH topology
 2OY8 A;  5GAE G;  1P4P A;  5AN9 B;  3IGE A;  3OW2 E;  3CCR E;  5B2A O;  3CME E;  5MLC H;  3DLL E;  1Q86 G;  1KC8 G;  5GAG G;  4IO9 E;  2OY1 O;  5B11 O;  3CC4 E;  2OY5 O;  1M1K G;  3EC5 A;  3CCV E;  1YI2 E;  1VQO E;  1S72 E;  3CCS E;  1VQP E;  1RJL C;  5JVH E;  2CQL A;  3CC7 E;  1VQ9 E;  2HKD A;  1YJW E;  1Q82 G;  3CCL E;  2OL7 A;  3PIO E;  1VQ8 E;  3G4S E;  5B3M O;  2OYB O;  5DM7 E;  1YJN E;  1K9M G;  3AUM O;  3CPW E;  3CCE E;  1Q7Y G;  5B10 O;  2OL8 O;  1K73 G;  4IOC E;  2ZJP E;  3CXC E;  1M90 G;  4IOA E;  1RL6 A;  4WF9 E;  3CKG A;  1VQL E;  5H1S I;  2FKJ A;  1OSP O;  2OY7 A;  3G6E E;  4UY8 G;  4WFA E;  2I5V O;  1YJ9 E;  1VQ6 E;  1JJ2 E;  5GAH G;  3CD6 E;  2QEX E;  1K8A G;  1Q81 G;  2I5Z O;  2ZJQ E;  5JVG E;  3I55 E;  1NJI G;  3I56 E;  1VQK E;  1YIJ E;  2PI3 O;  1N8R G;  1QVG E;  3CF5 E;  1KD1 G;  2G8C O;  4WFB E;  1YIT E;  2AF5 A;  1FJ1 E;  3CMA E;  2FKG A;  1KQS E;  1VQM E;  3J7Z G;  3CCU E;  1VQN E;  3G71 E;  5HL7 E;  1YHQ E;  2QA4 E;  4U67 E;  1VQ5 E;  1QVF E;  2ZJR E;  3CKF A;  4WFN E;  1W2B E;  5DM6 E;  2OTJ E;  3CC2 E;  1VQ7 E;  4WCE E;  3CCJ E;  3CCM E;  5GAD G;  3CCQ E;  2OTL E;  2OL6 O;  3IG9 A;  3PIP E;  1VQ4 E; 
#chains in the Genus database with same CATH homology
 5GAE G;  5AN9 B;  3OW2 E;  3CCR E;  3CME E;  5MLC H;  3DLL E;  1Q86 G;  1KC8 G;  5GAG G;  4IO9 E;  3CC4 E;  1M1K G;  3CCV E;  1YI2 E;  1S72 E;  1VQO E;  3CCS E;  1VQP E;  5JVH E;  2CQL A;  3CC7 E;  1VQ9 E;  1YJW E;  1Q82 G;  3CCL E;  3PIO E;  1VQ8 E;  3G4S E;  5DM7 E;  1YJN E;  1K9M G;  3CPW E;  3CCE E;  1Q7Y G;  1K73 G;  4IOC E;  2ZJP E;  3CXC E;  1M90 G;  4IOA E;  1RL6 A;  4WF9 E;  1VQL E;  5H1S I;  3G6E E;  4UY8 G;  4WFA E;  1YJ9 E;  1VQ6 E;  1JJ2 E;  5GAH G;  3CD6 E;  2QEX E;  1K8A G;  1Q81 G;  2ZJQ E;  5JVG E;  3I55 E;  1NJI G;  3I56 E;  1VQK E;  1YIJ E;  1N8R G;  1QVG E;  3CF5 E;  1KD1 G;  4WFB E;  1YIT E;  3CMA E;  1KQS E;  1VQM E;  3J7Z G;  3CCU E;  1VQN E;  3G71 E;  5HL7 E;  1YHQ E;  2QA4 E;  4U67 E;  1VQ5 E;  1QVF E;  2ZJR E;  4WFN E;  1W2B E;  5DM6 E;  2OTJ E;  3CC2 E;  1VQ7 E;  4WCE E;  3CCJ E;  3CCM E;  5GAD G;  3CCQ E;  2OTL E;  3PIP E;  1VQ4 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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