3G6EE

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 35
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
35
sequence length
172
structure length
172
Chain Sequence
PRVELEIPEDVDAEQDHLDITVEGDNGSVTRRLWYPDIDVSVDGDTVVIESDEDNAKTMSTIGTFQSHIENMFHGVTEGWEYGMEVFYSHFPMQVNVEGDEVVIENFLGEKAPRRTTIHGDTDVEIDGEELTVSGPDIEAVGQTAADIEQLTRINDKDVRVFQDGVYITRKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule tags Ribosome
molecule keywords 23S ribosomal RNA
total genus 35
structure length 172
sequence length 172
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00347 Ribosomal_L6 Ribosomal protein L6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g6eE02
3.90.930.12 Alpha Beta Alpha-Beta Complex Outer Surface Protein A; domain 3 Ribosomal protein L6, alpha-beta domain 3g6eE01
5DM7E 3OW2E 3I55E 1VQ4E 5JVGE 2OTLE 3CCLE 4WCEE 4IO9E 1VQOE 1YHQE 3CC2E 1VQKE 2QA4E 1VQ5E 4IOCE 1YJ9E 1VQ9E 3I56E 1VQ7E 1W2BE 3PIPE 3CCVE 5GADG 1KQSE 1VQ6E 1N8RG 4WFBE 1K8AG 5H1SI 3CCME 1YI2E 1QVGE 3DLLE 5GAEG 3CMAE 5MLCH 1KC8G 3CF5E 3CXCE 5HL7E 2ZJPE 3G71E 1Q86G 1JJ2E 5JVHE 1YITE 3CCEE 3CPWE 2CQLA 1YIJE 1VQLE 3CMEE 5DM6E 1NJIG 1K73G 1K9MG 3J7ZG 3CCQE 1YJNE 1VQNE 1YJWE 2ZJQE 3CC4E 2OTJE 1Q81G 3CCJE 3CCSE 3CCRE 4IOAE 4UY8G 3PIOE 1VQME 1Q82G 1Q7YG 4WFNE 4WFAE 1M1KG 4U67E 1VQPE 1RL6A 5GAHG 3CD6E 4WF9E 3CCUE 1QVFE 3CC7E 3G4SE 1S72E 1KD1G 1M90G 3G6EE 2ZJRE 5AN9B 2QEXE 1VQ8E 5GAGG
chains in the Genus database with same CATH superfamily
2OY8A 5DM7E 3OW2E 1RJLC 3I55E 1VQ4E 5JVGE 2OTLE 3CCLE 4WCEE 4IO9E 1VQOE 3CKGA 2FKGA 1YHQE 3CC2E 1VQKE 2QA4E 1VQ5E 1OSPO 2OY1O 5B3MO 3CKFA 4IOCE 1YJ9E 2OL8O 1FJ1E 1VQ9E 3I56E 1VQ7E 1W2BE 3PIPE 3CCVE 5GADG 1KQSE 1VQ6E 1N8RG 4WFBE 1K8AG 5H1SI 3CCME 1YI2E 1QVGE 2PI3O 5GAEG 3DLLE 3CMAE 5B10O 5MLCH 1KC8G 2FKJA 1P4PA 3CF5E 3CXCE 5HL7E 3IG9A 2ZJPE 3G71E 1Q86G 1JJ2E 5JVHE 1YITE 3CCEE 3CPWE 2CQLA 1YIJE 2OY7A 2OL7A 1VQLE 2OY5O 3CMEE 5DM6E 1NJIG 2OL6O 1K73G 1K9MG 3J7ZG 3CCQE 1YJNE 1VQNE 1YJWE 2ZJQE 3CC4E 2I5ZO 2OTJE 1Q81G 3CCJE 2HKDA 3EC5A 3CCSE 3CCRE 4IOAE 4UY8G 5B11O 3PIOE 1VQME 1Q82G 1Q7YG 4WFNE 5B2AO 4WFAE 1M1KG 4U67E 1VQPE 3IGEA 1RL6A 5GAHG 3CD6E 4WF9E 3CCUE 1QVFE 3CC7E 2OYBO 3G4SE 1S72E 1KD1G 1M90G 3AUMO 3G6EE 2AF5A 2ZJRE 5AN9B 2QEXE 2G8CO 1VQ8E 2I5VO 5GAGG
chains in the Genus database with same CATH topology
5DM7E 3OW2E 3I55E 1VQ4E 5JVGE 2OTLE 3CCLE 4WCEE 4IO9E 1VQOE 1YHQE 3CC2E 1VQKE 2QA4E 1VQ5E 4IOCE 1YJ9E 1VQ9E 3I56E 1VQ7E 1W2BE 3PIPE 3CCVE 5GADG 1KQSE 1VQ6E 1N8RG 4WFBE 1K8AG 5H1SI 3CCME 1YI2E 1QVGE 3DLLE 5GAEG 3CMAE 5MLCH 1KC8G 3CF5E 3CXCE 5HL7E 2ZJPE 3G71E 1Q86G 1JJ2E 5JVHE 1YITE 3CCEE 3CPWE 2CQLA 1YIJE 1VQLE 3CMEE 5DM6E 1NJIG 1K73G 1K9MG 3J7ZG 3CCQE 1YJNE 1VQNE 1YJWE 2ZJQE 3CC4E 2OTJE 1Q81G 3CCJE 3CCSE 3CCRE 4IOAE 4UY8G 3PIOE 1VQME 1Q82G 1Q7YG 4WFNE 4WFAE 1M1KG 4U67E 1VQPE 1RL6A 5GAHG 3CD6E 4WF9E 3CCUE 1QVFE 3CC7E 3G4SE 1S72E 1KD1G 1M90G 3G6EE 2ZJRE 5AN9B 2QEXE 1VQ8E 5GAGG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5DM7 E;  3OW2 E;  3I55 E;  1VQ4 E;  5JVG E;  2OTL E;  3CCL E;  4WCE E;  4IO9 E;  1VQO E;  1YHQ E;  3CC2 E;  1VQK E;  2QA4 E;  1VQ5 E;  4IOC E;  1YJ9 E;  1VQ9 E;  3I56 E;  1VQ7 E;  1W2B E;  3PIP E;  3CCV E;  5GAD G;  1KQS E;  1VQ6 E;  1N8R G;  4WFB E;  1K8A G;  5H1S I;  3CCM E;  1YI2 E;  1QVG E;  3DLL E;  5GAE G;  3CMA E;  5MLC H;  1KC8 G;  3CF5 E;  3CXC E;  5HL7 E;  2ZJP E;  3G71 E;  1Q86 G;  1JJ2 E;  5JVH E;  1YIT E;  3CCE E;  3CPW E;  2CQL A;  1YIJ E;  1VQL E;  3CME E;  5DM6 E;  1NJI G;  1K73 G;  1K9M G;  3J7Z G;  3CCQ E;  1YJN E;  1VQN E;  1YJW E;  2ZJQ E;  3CC4 E;  2OTJ E;  1Q81 G;  3CCJ E;  3CCS E;  3CCR E;  4IOA E;  4UY8 G;  3PIO E;  1VQM E;  1Q82 G;  1Q7Y G;  4WFN E;  4WFA E;  1M1K G;  4U67 E;  1VQP E;  1RL6 A;  5GAH G;  3CD6 E;  4WF9 E;  3CCU E;  1QVF E;  3CC7 E;  3G4S E;  1S72 E;  1KD1 G;  1M90 G;  3G6E E;  2ZJR E;  5AN9 B;  2QEX E;  1VQ8 E;  5GAG G; 
#chains in the Genus database with same CATH topology
 2OY8 A;  5DM7 E;  3OW2 E;  1RJL C;  3I55 E;  1VQ4 E;  5JVG E;  2OTL E;  3CCL E;  4WCE E;  4IO9 E;  1VQO E;  3CKG A;  2FKG A;  1YHQ E;  3CC2 E;  1VQK E;  2QA4 E;  1VQ5 E;  1OSP O;  2OY1 O;  5B3M O;  3CKF A;  4IOC E;  1YJ9 E;  2OL8 O;  1FJ1 E;  1VQ9 E;  3I56 E;  1VQ7 E;  1W2B E;  3PIP E;  3CCV E;  5GAD G;  1KQS E;  1VQ6 E;  1N8R G;  4WFB E;  1K8A G;  5H1S I;  3CCM E;  1YI2 E;  1QVG E;  2PI3 O;  5GAE G;  3DLL E;  3CMA E;  5B10 O;  5MLC H;  1KC8 G;  2FKJ A;  1P4P A;  3CF5 E;  3CXC E;  5HL7 E;  3IG9 A;  2ZJP E;  3G71 E;  1Q86 G;  1JJ2 E;  5JVH E;  1YIT E;  3CCE E;  3CPW E;  2CQL A;  1YIJ E;  2OY7 A;  2OL7 A;  1VQL E;  2OY5 O;  3CME E;  5DM6 E;  1NJI G;  2OL6 O;  1K73 G;  1K9M G;  3J7Z G;  3CCQ E;  1YJN E;  1VQN E;  1YJW E;  2ZJQ E;  3CC4 E;  2I5Z O;  2OTJ E;  1Q81 G;  3CCJ E;  2HKD A;  3EC5 A;  3CCS E;  3CCR E;  4IOA E;  4UY8 G;  5B11 O;  3PIO E;  1VQM E;  1Q82 G;  1Q7Y G;  4WFN E;  5B2A O;  4WFA E;  1M1K G;  4U67 E;  1VQP E;  3IGE A;  1RL6 A;  5GAH G;  3CD6 E;  4WF9 E;  3CCU E;  1QVF E;  3CC7 E;  2OYB O;  3G4S E;  1S72 E;  1KD1 G;  1M90 G;  3AUM O;  3G6E E;  2AF5 A;  2ZJR E;  5AN9 B;  2QEX E;  2G8C O;  1VQ8 E;  2I5V O;  5GAG G; 
#chains in the Genus database with same CATH homology
 5DM7 E;  3OW2 E;  3I55 E;  1VQ4 E;  5JVG E;  2OTL E;  3CCL E;  4WCE E;  4IO9 E;  1VQO E;  1YHQ E;  3CC2 E;  1VQK E;  2QA4 E;  1VQ5 E;  4IOC E;  1YJ9 E;  1VQ9 E;  3I56 E;  1VQ7 E;  1W2B E;  3PIP E;  3CCV E;  5GAD G;  1KQS E;  1VQ6 E;  1N8R G;  4WFB E;  1K8A G;  5H1S I;  3CCM E;  1YI2 E;  1QVG E;  3DLL E;  5GAE G;  3CMA E;  5MLC H;  1KC8 G;  3CF5 E;  3CXC E;  5HL7 E;  2ZJP E;  3G71 E;  1Q86 G;  1JJ2 E;  5JVH E;  1YIT E;  3CCE E;  3CPW E;  2CQL A;  1YIJ E;  1VQL E;  3CME E;  5DM6 E;  1NJI G;  1K73 G;  1K9M G;  3J7Z G;  3CCQ E;  1YJN E;  1VQN E;  1YJW E;  2ZJQ E;  3CC4 E;  2OTJ E;  1Q81 G;  3CCJ E;  3CCS E;  3CCR E;  4IOA E;  4UY8 G;  3PIO E;  1VQM E;  1Q82 G;  1Q7Y G;  4WFN E;  4WFA E;  1M1K G;  4U67 E;  1VQP E;  1RL6 A;  5GAH G;  3CD6 E;  4WF9 E;  3CCU E;  1QVF E;  3CC7 E;  3G4S E;  1S72 E;  1KD1 G;  1M90 G;  3G6E E;  2ZJR E;  5AN9 B;  2QEX E;  1VQ8 E;  5GAG G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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