1GMOA

Crystal structures of nk1-heparin complexes reveal the basis for nk1 activity and enable engineering of potent agonists of the met receptor
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
172
structure length
172
Chain Sequence
NTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCADRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 37
structure length 172
sequence length 172
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2001-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gmoA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gmoA01
1PKRA 1GMNA 1Z40A 3HMTA 1HKYA 4NZQA 2HGFA 1CEBA 5CS3A 2DOIA 2J8JA 3LAQA 4BVVA 3NXPA 1PK2A 1CEAA 1KRNA 4Z0EA 4D3CA 1BHTA 4BV7A 2SPTA 4Z0FA 2Z8WA 2LL4M 3HMRA 2QJ4A 1I71A 2KNFA 5HPGA 4KIVA 2FEBA 1GMOA 5CS9A 1URKA 4Z09A 1A0HA 5EOKA 2YIOA 4UAOA 4APLA 1HPKA 2PK4A 4O03A 3BT2A 2YILA 2K4RA 5CT2A 5CT3A 2F83A 1HPJA 4R1BA 2X2ZA 2QJ2A 5CS5A 4BVCA 1PMKA 2DOHX 5CT1A 4A5TS 5CP9A 4R1CA 1KDUA 2HPPP 1KI0A 2Z8VA 5COEA 4IUAA 4HZHA 1I5KA 5CSQA 3MKPA 2PF2A 3U73A 3HMSA 2I9BA 2PF1A 2I9AA 2K51A 1W8KA 3KIVA 4Z0DA 1NL1A 2LL3A 3ZWZA 4UV6A 3SP8A 2HPQP 4R19A 3ZLEA 2K13X 4BVWA 4BV5A 5EODA 1B2IA 4DURA 2YIPA 2Q8AA 4CIKA 3E6PL 5CS1A 1PMLA 2J8LA 1I8NA 2FD6A 3K65A 3SRIA 1W81A 3HN4A 1TPKA 4BVDA 1GP9A 1NK1A 3BT1A 1NL2A 1JFNA 1KIVA 4APMA 2L0SA 2KJ4A 1PK4A 2Q8BA 4R1AA 2Y8RA 1YXEA 5I25A 3SRJA
chains in the Genus database with same CATH superfamily
4YIZA 1PKRA 1GMNA 1Z40A 3HMTA 1HKYA 4NZQA 2HGFA 1CEBA 5CS3A 2DOIA 2J8JA 3LAQA 4BVVA 3NXPA 1PK2A 1CEAA 1KRNA 2KL5A 4D3CA 4Z0EA 1BHTA 4BV7A 2SPTA 4Z0FA 2Z8WA 2LL4M 3HMRA 2QJ4A 1I71A 2KNFA 5HPGA 4KIVA 2FEBA 1GMOA 5CS9A 1URKA 4Z09A 1A0HA 5EOKA 2YIOA 4UAOA 4APLA 1HPKA 2PK4A 4O03A 3BT2A 2YILA 2K4RA 5CT2A 5CT3A 2F83A 1HPJA 4R1BA 2X2ZA 2QJ2A 5CS5A 4BVCA 1PMKA 2DOHX 5CT1A 4A5TS 5CP9A 4R1CA 1KDUA 2HPPP 1KI0A 2Z8VA 5COEA 4IUAA 4HZHA 1I5KA 5CSQA 3MKPA 2PF2A 3U73A 3HMSA 2I9BA 2PF1A 2I9AA 2K51A 1W8KA 3KIVA 4Z0DA 1NL1A 2LL3A 3ZWZA 4UV6A 3SP8A 2HPQP 4R19A 3ZLEA 2K13X 4BVWA 4BV5A 5EODA 1B2IA 4DURA 2YIPA 2Q8AA 4CIKA 3E6PL 5CS1A 1PMLA 2J8LA 1I8NA 2FD6A 3K65A 3SRIA 1W81A 3HN4A 1TPKA 4BVDA 1GP9A 1NK1A 3BT1A 1NL2A 4YIVA 1JFNA 1KIVA 4APMA 2L0SA 2KJ4A 1PK4A 2Q8BA 4R1AA 2Y8RA 1YXEA 5I25A 3SRJA
chains in the Genus database with same CATH topology
4YIZA 1PKRA 1GMNA 1Z40A 3HMTA 1HKYA 4NZQA 2HGFA 1CEBA 5CS3A 2DOIA 2J8JA 3LAQA 4BVVA 3NXPA 1PK2A 1CEAA 1KRNA 2KL5A 4D3CA 4Z0EA 1BHTA 4BV7A 2SPTA 4Z0FA 2Z8WA 2LL4M 3HMRA 2QJ4A 1I71A 2KNFA 5HPGA 4KIVA 2FEBA 1GMOA 5CS9A 1URKA 4Z09A 1A0HA 5EOKA 2YIOA 4UAOA 4APLA 1HPKA 2PK4A 4O03A 3BT2A 2YILA 2K4RA 5CT2A 5CT3A 2F83A 1HPJA 4R1BA 2X2ZA 2QJ2A 5CS5A 4BVCA 1PMKA 2DOHX 5CT1A 4A5TS 5CP9A 4R1CA 1KDUA 2HPPP 1KI0A 2Z8VA 5COEA 4IUAA 4HZHA 1I5KA 5CSQA 3MKPA 2PF2A 3U73A 3HMSA 2I9BA 2PF1A 2I9AA 2K51A 1W8KA 3KIVA 4Z0DA 1NL1A 2LL3A 3ZWZA 4UV6A 3SP8A 2HPQP 4R19A 3ZLEA 2K13X 4BVWA 4BV5A 5EODA 1B2IA 4DURA 2YIPA 2Q8AA 4CIKA 3E6PL 5CS1A 1PMLA 2J8LA 1I8NA 2FD6A 3K65A 3SRIA 1W81A 3HN4A 1TPKA 4BVDA 1GP9A 1NK1A 3BT1A 1NL2A 4YIVA 1JFNA 1KIVA 4APMA 2L0SA 2KJ4A 1PK4A 2Q8BA 4R1AA 2Y8RA 1YXEA 5I25A 3SRJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1PKR A;  1GMN A;  1Z40 A;  3HMT A;  1HKY A;  4NZQ A;  2HGF A;  1CEB A;  5CS3 A;  2DOI A;  2J8J A;  3LAQ A;  4BVV A;  3NXP A;  1PK2 A;  1CEA A;  1KRN A;  4Z0E A;  4D3C A;  1BHT A;  4BV7 A;  2SPT A;  4Z0F A;  2Z8W A;  2LL4 M;  3HMR A;  2QJ4 A;  1I71 A;  2KNF A;  5HPG A;  4KIV A;  2FEB A;  1GMO A;  5CS9 A;  1URK A;  4Z09 A;  1A0H A;  5EOK A;  2YIO A;  4UAO A;  4APL A;  1HPK A;  2PK4 A;  4O03 A;  3BT2 A;  2YIL A;  2K4R A;  5CT2 A;  5CT3 A;  2F83 A;  1HPJ A;  4R1B A;  2X2Z A;  2QJ2 A;  5CS5 A;  4BVC A;  1PMK A;  2DOH X;  5CT1 A;  4A5T S;  5CP9 A;  4R1C A;  1KDU A;  2HPP P;  1KI0 A;  2Z8V A;  5COE A;  4IUA A;  4HZH A;  1I5K A;  5CSQ A;  3MKP A;  2PF2 A;  3U73 A;  3HMS A;  2I9B A;  2PF1 A;  2I9A A;  2K51 A;  1W8K A;  3KIV A;  4Z0D A;  1NL1 A;  2LL3 A;  3ZWZ A;  4UV6 A;  3SP8 A;  2HPQ P;  4R19 A;  3ZLE A;  2K13 X;  4BVW A;  4BV5 A;  5EOD A;  1B2I A;  4DUR A;  2YIP A;  2Q8A A;  4CIK A;  3E6P L;  5CS1 A;  1PML A;  2J8L A;  1I8N A;  2FD6 A;  3K65 A;  3SRI A;  1W81 A;  3HN4 A;  1TPK A;  4BVD A;  1GP9 A;  1NK1 A;  3BT1 A;  1NL2 A;  1JFN A;  1KIV A;  4APM A;  2L0S A;  2KJ4 A;  1PK4 A;  2Q8B A;  4R1A A;  2Y8R A;  1YXE A;  5I25 A;  3SRJ A; 
#chains in the Genus database with same CATH topology
 4YIZ A;  1PKR A;  1GMN A;  1Z40 A;  3HMT A;  1HKY A;  4NZQ A;  2HGF A;  1CEB A;  5CS3 A;  2DOI A;  2J8J A;  3LAQ A;  4BVV A;  3NXP A;  1PK2 A;  1CEA A;  1KRN A;  2KL5 A;  4D3C A;  4Z0E A;  1BHT A;  4BV7 A;  2SPT A;  4Z0F A;  2Z8W A;  2LL4 M;  3HMR A;  2QJ4 A;  1I71 A;  2KNF A;  5HPG A;  4KIV A;  2FEB A;  1GMO A;  5CS9 A;  1URK A;  4Z09 A;  1A0H A;  5EOK A;  2YIO A;  4UAO A;  4APL A;  1HPK A;  2PK4 A;  4O03 A;  3BT2 A;  2YIL A;  2K4R A;  5CT2 A;  5CT3 A;  2F83 A;  1HPJ A;  4R1B A;  2X2Z A;  2QJ2 A;  5CS5 A;  4BVC A;  1PMK A;  2DOH X;  5CT1 A;  4A5T S;  5CP9 A;  4R1C A;  1KDU A;  2HPP P;  1KI0 A;  2Z8V A;  5COE A;  4IUA A;  4HZH A;  1I5K A;  5CSQ A;  3MKP A;  2PF2 A;  3U73 A;  3HMS A;  2I9B A;  2PF1 A;  2I9A A;  2K51 A;  1W8K A;  3KIV A;  4Z0D A;  1NL1 A;  2LL3 A;  3ZWZ A;  4UV6 A;  3SP8 A;  2HPQ P;  4R19 A;  3ZLE A;  2K13 X;  4BVW A;  4BV5 A;  5EOD A;  1B2I A;  4DUR A;  2YIP A;  2Q8A A;  4CIK A;  3E6P L;  5CS1 A;  1PML A;  2J8L A;  1I8N A;  2FD6 A;  3K65 A;  3SRI A;  1W81 A;  3HN4 A;  1TPK A;  4BVD A;  1GP9 A;  1NK1 A;  3BT1 A;  1NL2 A;  4YIV A;  1JFN A;  1KIV A;  4APM A;  2L0S A;  2KJ4 A;  1PK4 A;  2Q8B A;  4R1A A;  2Y8R A;  1YXE A;  5I25 A;  3SRJ A; 
#chains in the Genus database with same CATH homology
 4YIZ A;  1PKR A;  1GMN A;  1Z40 A;  3HMT A;  1HKY A;  4NZQ A;  2HGF A;  1CEB A;  5CS3 A;  2DOI A;  2J8J A;  3LAQ A;  4BVV A;  3NXP A;  1PK2 A;  1CEA A;  1KRN A;  2KL5 A;  4D3C A;  4Z0E A;  1BHT A;  4BV7 A;  2SPT A;  4Z0F A;  2Z8W A;  2LL4 M;  3HMR A;  2QJ4 A;  1I71 A;  2KNF A;  5HPG A;  4KIV A;  2FEB A;  1GMO A;  5CS9 A;  1URK A;  4Z09 A;  1A0H A;  5EOK A;  2YIO A;  4UAO A;  4APL A;  1HPK A;  2PK4 A;  4O03 A;  3BT2 A;  2YIL A;  2K4R A;  5CT2 A;  5CT3 A;  2F83 A;  1HPJ A;  4R1B A;  2X2Z A;  2QJ2 A;  5CS5 A;  4BVC A;  1PMK A;  2DOH X;  5CT1 A;  4A5T S;  5CP9 A;  4R1C A;  1KDU A;  2HPP P;  1KI0 A;  2Z8V A;  5COE A;  4IUA A;  4HZH A;  1I5K A;  5CSQ A;  3MKP A;  2PF2 A;  3U73 A;  3HMS A;  2I9B A;  2PF1 A;  2I9A A;  2K51 A;  1W8K A;  3KIV A;  4Z0D A;  1NL1 A;  2LL3 A;  3ZWZ A;  4UV6 A;  3SP8 A;  2HPQ P;  4R19 A;  3ZLE A;  2K13 X;  4BVW A;  4BV5 A;  5EOD A;  1B2I A;  4DUR A;  2YIP A;  2Q8A A;  4CIK A;  3E6P L;  5CS1 A;  1PML A;  2J8L A;  1I8N A;  2FD6 A;  3K65 A;  3SRI A;  1W81 A;  3HN4 A;  1TPK A;  4BVD A;  1GP9 A;  1NK1 A;  3BT1 A;  1NL2 A;  4YIV A;  1JFN A;  1KIV A;  4APM A;  2L0S A;  2KJ4 A;  1PK4 A;  2Q8B A;  4R1A A;  2Y8R A;  1YXE A;  5I25 A;  3SRJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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