1GMOA

Crystal structures of nk1-heparin complexes reveal the basis for nk1 activity and enable engineering of potent agonists of the met receptor
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
172
structure length
172
Chain Sequence
NTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCADRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Nk1-Heparin Complexes Reveal the Basis for Nk1 Activity and Enable Engineering of Potent Agonists of the met Receptor
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 37
structure length 172
sequence length 172
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2001-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gmoA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gmoA01
2KJ4A 2QJ4A 2I9BA 1PMLA 1PKRA 1BHTA 3ZLEA 4A5TS 3HMTA 3MKPA 2HPQP 3BT2A 3KIVA 4BVCA 2KNFA 2YILA 2X2ZA 1I5KA 1KIVA 4Z0EA 4BV7A 2LL4M 5COEA 2L0SA 5I25A 3K65A 1A0HA 2FEBA 2HPPP 3U73A 3LAQA 4UV6A 5CS5A 4Z0FA 4IUAA 4NZQA 2K51A 2PF2A 2J8JA 3ZWZA 1W8KA 1NK1A 4APMA 1I8NA 5CT1A 5CS3A 2I9AA 4R1CA 4APLA 4BVWA 5CT2A 4BV5A 1W81A 5EOKA 3HMRA 1YXEA 4BVVA 5CT3A 1KDUA 2PK4A 1GP9A 1NL1A 2DOHX 2F83A 1GMOA 2SPTA 2Z8VA 4R1BA 1CEAA 2LL3A 1JFNA 2QJ2A 1HPKA 4D3CA 1HPJA 4Z0DA 3NXPA 3BT1A 1URKA 5CP9A 4DURA 4CIKA 4R19A 1CEBA 2YIPA 2FD6A 2Y8RA 3HMSA 1Z40A 2HGFA 2Q8BA 4BVDA 2K13X 4Z09A 2YIOA 2Q8AA 2DOIA 1I71A 1PK4A 5CSQA 4UAOA 1HKYA 4O03A 5CS1A 2Z8WA 2K4RA 1PMKA 3SRJA 1PK2A 1KI0A 5CS9A 1NL2A 2PF1A 4KIVA 5EODA 1GMNA 3SP8A 1TPKA 3SRIA 3E6PL 2J8LA 4R1AA 1KRNA 3HN4A 4HZHA 1B2IA 5HPGA
chains in the Genus database with same CATH superfamily
2KJ4A 2QJ4A 2I9BA 1PMLA 1PKRA 1BHTA 3ZLEA 4A5TS 3HMTA 3MKPA 2HPQP 3BT2A 3KIVA 4BVCA 2KNFA 2YILA 2X2ZA 1I5KA 1KIVA 4Z0EA 4BV7A 2LL4M 5COEA 2L0SA 5I25A 3K65A 1A0HA 2FEBA 2HPPP 3U73A 3LAQA 4UV6A 5CS5A 4Z0FA 4IUAA 4NZQA 2K51A 2PF2A 2J8JA 3ZWZA 1W8KA 1NK1A 4APMA 1I8NA 5CT1A 5CS3A 2I9AA 4R1CA 4APLA 4BVWA 5CT2A 4BV5A 1W81A 5EOKA 3HMRA 1YXEA 4BVVA 5CT3A 1KDUA 2PK4A 1GP9A 1NL1A 2DOHX 2F83A 1GMOA 2SPTA 2Z8VA 4YIZA 4R1BA 1CEAA 2LL3A 1JFNA 2QJ2A 1HPKA 4D3CA 1HPJA 4Z0DA 3NXPA 4YIVA 3BT1A 1URKA 5CP9A 4DURA 4CIKA 4R19A 1CEBA 2YIPA 2FD6A 2Y8RA 3HMSA 1Z40A 2HGFA 2Q8BA 4BVDA 2K13X 4Z09A 2YIOA 2Q8AA 2DOIA 1I71A 1PK4A 5CSQA 4UAOA 1HKYA 4O03A 5CS1A 2Z8WA 2K4RA 1PMKA 3SRJA 1PK2A 1KI0A 5CS9A 1NL2A 2PF1A 4KIVA 5EODA 2KL5A 1GMNA 3SP8A 1TPKA 3SRIA 3E6PL 2J8LA 4R1AA 1KRNA 3HN4A 4HZHA 1B2IA 5HPGA
chains in the Genus database with same CATH topology
2KJ4A 2QJ4A 2I9BA 1PMLA 1PKRA 1BHTA 3ZLEA 4A5TS 3HMTA 3MKPA 2HPQP 3BT2A 3KIVA 4BVCA 2KNFA 2YILA 2X2ZA 1I5KA 1KIVA 4Z0EA 4BV7A 2LL4M 5COEA 2L0SA 5I25A 3K65A 1A0HA 2FEBA 2HPPP 3U73A 3LAQA 4UV6A 5CS5A 4Z0FA 4IUAA 4NZQA 2K51A 2PF2A 2J8JA 3ZWZA 1W8KA 1NK1A 4APMA 1I8NA 5CT1A 5CS3A 2I9AA 4R1CA 4APLA 4BVWA 5CT2A 4BV5A 1W81A 5EOKA 3HMRA 1YXEA 4BVVA 5CT3A 1KDUA 2PK4A 1GP9A 1NL1A 2DOHX 2F83A 1GMOA 2SPTA 2Z8VA 4YIZA 4R1BA 1CEAA 2LL3A 1JFNA 2QJ2A 1HPKA 4D3CA 1HPJA 4Z0DA 3NXPA 4YIVA 3BT1A 1URKA 5CP9A 4DURA 4CIKA 4R19A 1CEBA 2YIPA 2FD6A 2Y8RA 3HMSA 1Z40A 2HGFA 2Q8BA 4BVDA 2K13X 4Z09A 2YIOA 2Q8AA 2DOIA 1I71A 1PK4A 5CSQA 4UAOA 1HKYA 4O03A 5CS1A 2Z8WA 2K4RA 1PMKA 3SRJA 1PK2A 1KI0A 5CS9A 1NL2A 2PF1A 4KIVA 5EODA 2KL5A 1GMNA 3SP8A 1TPKA 3SRIA 3E6PL 2J8LA 4R1AA 1KRNA 3HN4A 4HZHA 1B2IA 5HPGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KJ4 A;  2QJ4 A;  2I9B A;  1PML A;  1PKR A;  1BHT A;  3ZLE A;  4A5T S;  3HMT A;  3MKP A;  2HPQ P;  3BT2 A;  3KIV A;  4BVC A;  2KNF A;  2YIL A;  2X2Z A;  1I5K A;  1KIV A;  4Z0E A;  4BV7 A;  2LL4 M;  5COE A;  2L0S A;  5I25 A;  3K65 A;  1A0H A;  2FEB A;  2HPP P;  3U73 A;  3LAQ A;  4UV6 A;  5CS5 A;  4Z0F A;  4IUA A;  4NZQ A;  2K51 A;  2PF2 A;  2J8J A;  3ZWZ A;  1W8K A;  1NK1 A;  4APM A;  1I8N A;  5CT1 A;  5CS3 A;  2I9A A;  4R1C A;  4APL A;  4BVW A;  5CT2 A;  4BV5 A;  1W81 A;  5EOK A;  3HMR A;  1YXE A;  4BVV A;  5CT3 A;  1KDU A;  2PK4 A;  1GP9 A;  1NL1 A;  2DOH X;  2F83 A;  1GMO A;  2SPT A;  2Z8V A;  4R1B A;  1CEA A;  2LL3 A;  1JFN A;  2QJ2 A;  1HPK A;  4D3C A;  1HPJ A;  4Z0D A;  3NXP A;  3BT1 A;  1URK A;  5CP9 A;  4DUR A;  4CIK A;  4R19 A;  1CEB A;  2YIP A;  2FD6 A;  2Y8R A;  3HMS A;  1Z40 A;  2HGF A;  2Q8B A;  4BVD A;  2K13 X;  4Z09 A;  2YIO A;  2Q8A A;  2DOI A;  1I71 A;  1PK4 A;  5CSQ A;  4UAO A;  1HKY A;  4O03 A;  5CS1 A;  2Z8W A;  2K4R A;  1PMK A;  3SRJ A;  1PK2 A;  1KI0 A;  5CS9 A;  1NL2 A;  2PF1 A;  4KIV A;  5EOD A;  1GMN A;  3SP8 A;  1TPK A;  3SRI A;  3E6P L;  2J8L A;  4R1A A;  1KRN A;  3HN4 A;  4HZH A;  1B2I A;  5HPG A; 
#chains in the Genus database with same CATH topology
 2KJ4 A;  2QJ4 A;  2I9B A;  1PML A;  1PKR A;  1BHT A;  3ZLE A;  4A5T S;  3HMT A;  3MKP A;  2HPQ P;  3BT2 A;  3KIV A;  4BVC A;  2KNF A;  2YIL A;  2X2Z A;  1I5K A;  1KIV A;  4Z0E A;  4BV7 A;  2LL4 M;  5COE A;  2L0S A;  5I25 A;  3K65 A;  1A0H A;  2FEB A;  2HPP P;  3U73 A;  3LAQ A;  4UV6 A;  5CS5 A;  4Z0F A;  4IUA A;  4NZQ A;  2K51 A;  2PF2 A;  2J8J A;  3ZWZ A;  1W8K A;  1NK1 A;  4APM A;  1I8N A;  5CT1 A;  5CS3 A;  2I9A A;  4R1C A;  4APL A;  4BVW A;  5CT2 A;  4BV5 A;  1W81 A;  5EOK A;  3HMR A;  1YXE A;  4BVV A;  5CT3 A;  1KDU A;  2PK4 A;  1GP9 A;  1NL1 A;  2DOH X;  2F83 A;  1GMO A;  2SPT A;  2Z8V A;  4YIZ A;  4R1B A;  1CEA A;  2LL3 A;  1JFN A;  2QJ2 A;  1HPK A;  4D3C A;  1HPJ A;  4Z0D A;  3NXP A;  4YIV A;  3BT1 A;  1URK A;  5CP9 A;  4DUR A;  4CIK A;  4R19 A;  1CEB A;  2YIP A;  2FD6 A;  2Y8R A;  3HMS A;  1Z40 A;  2HGF A;  2Q8B A;  4BVD A;  2K13 X;  4Z09 A;  2YIO A;  2Q8A A;  2DOI A;  1I71 A;  1PK4 A;  5CSQ A;  4UAO A;  1HKY A;  4O03 A;  5CS1 A;  2Z8W A;  2K4R A;  1PMK A;  3SRJ A;  1PK2 A;  1KI0 A;  5CS9 A;  1NL2 A;  2PF1 A;  4KIV A;  5EOD A;  2KL5 A;  1GMN A;  3SP8 A;  1TPK A;  3SRI A;  3E6P L;  2J8L A;  4R1A A;  1KRN A;  3HN4 A;  4HZH A;  1B2I A;  5HPG A; 
#chains in the Genus database with same CATH homology
 2KJ4 A;  2QJ4 A;  2I9B A;  1PML A;  1PKR A;  1BHT A;  3ZLE A;  4A5T S;  3HMT A;  3MKP A;  2HPQ P;  3BT2 A;  3KIV A;  4BVC A;  2KNF A;  2YIL A;  2X2Z A;  1I5K A;  1KIV A;  4Z0E A;  4BV7 A;  2LL4 M;  5COE A;  2L0S A;  5I25 A;  3K65 A;  1A0H A;  2FEB A;  2HPP P;  3U73 A;  3LAQ A;  4UV6 A;  5CS5 A;  4Z0F A;  4IUA A;  4NZQ A;  2K51 A;  2PF2 A;  2J8J A;  3ZWZ A;  1W8K A;  1NK1 A;  4APM A;  1I8N A;  5CT1 A;  5CS3 A;  2I9A A;  4R1C A;  4APL A;  4BVW A;  5CT2 A;  4BV5 A;  1W81 A;  5EOK A;  3HMR A;  1YXE A;  4BVV A;  5CT3 A;  1KDU A;  2PK4 A;  1GP9 A;  1NL1 A;  2DOH X;  2F83 A;  1GMO A;  2SPT A;  2Z8V A;  4YIZ A;  4R1B A;  1CEA A;  2LL3 A;  1JFN A;  2QJ2 A;  1HPK A;  4D3C A;  1HPJ A;  4Z0D A;  3NXP A;  4YIV A;  3BT1 A;  1URK A;  5CP9 A;  4DUR A;  4CIK A;  4R19 A;  1CEB A;  2YIP A;  2FD6 A;  2Y8R A;  3HMS A;  1Z40 A;  2HGF A;  2Q8B A;  4BVD A;  2K13 X;  4Z09 A;  2YIO A;  2Q8A A;  2DOI A;  1I71 A;  1PK4 A;  5CSQ A;  4UAO A;  1HKY A;  4O03 A;  5CS1 A;  2Z8W A;  2K4R A;  1PMK A;  3SRJ A;  1PK2 A;  1KI0 A;  5CS9 A;  1NL2 A;  2PF1 A;  4KIV A;  5EOD A;  2KL5 A;  1GMN A;  3SP8 A;  1TPK A;  3SRI A;  3E6P L;  2J8L A;  4R1A A;  1KRN A;  3HN4 A;  4HZH A;  1B2I A;  5HPG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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