1GP9A

A new crystal form of the nk1 splice variant of hgf/sf demonstrates extensive hinge movement and suggests that the nk1 dimer originates by domain swapping
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
170
structure length
170
Chain Sequence
VHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 37
structure length 170
sequence length 170
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2001-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gp9A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gp9A01
3ZLEA 1CEAA 1KI0A 2HPQP 2Y8RA 5CT3A 5I25A 1NL2A 5CP9A 2I9BA 3BT1A 5COEA 2PF2A 2Q8BA 1I5KA 2I9AA 2PK4A 3K65A 4Z0FA 4R19A 3NXPA 1I8NA 3MKPA 1TPKA 1PKRA 1Z40A 1GP9A 1YXEA 4APLA 1NL1A 1BHTA 4BV7A 4D3CA 3KIVA 1B2IA 2SPTA 4Z0EA 3HMTA 1HPKA 4UAOA 1PK2A 5CS1A 1KIVA 3BT2A 1I71A 2X2ZA 2YIPA 2L0SA 2DOHX 2DOIA 4BVVA 3U73A 2HPPP 4DURA 5CS9A 4CIKA 3LAQA 4R1AA 4BVWA 2J8LA 3HN4A 2LL4M 1HPJA 4O03A 1JFNA 1KRNA 2J8JA 2Q8AA 1GMNA 3SRIA 4KIVA 2K13X 2PF1A 2K51A 2FD6A 4BV5A 3ZWZA 1PMKA 1KDUA 5HPGA 2Z8WA 3HMRA 5CS3A 3SP8A 5EODA 4IUAA 1PMLA 1NK1A 1W8KA 4BVDA 4R1CA 2KJ4A 2Z8VA 4APMA 4A5TS 5CT2A 5CT1A 4NZQA 1W81A 2HGFA 4UV6A 2FEBA 1A0HA 4Z09A 5EOKA 2QJ4A 1URKA 3E6PL 2YILA 1HKYA 2YIOA 1CEBA 3SRJA 2K4RA 2QJ2A 2KNFA 4BVCA 4Z0DA 2F83A 4HZHA 5CS5A 1GMOA 4R1BA 5CSQA 3HMSA 2LL3A 1PK4A
chains in the Genus database with same CATH superfamily
3ZLEA 1CEAA 1KI0A 2HPQP 2Y8RA 5CT3A 5I25A 1NL2A 5CP9A 2I9BA 3BT1A 5COEA 2PF2A 2Q8BA 1I5KA 2I9AA 2PK4A 3K65A 4Z0FA 4R19A 3NXPA 1I8NA 3MKPA 1TPKA 1PKRA 1Z40A 1GP9A 1YXEA 4APLA 1NL1A 1BHTA 4BV7A 4D3CA 3KIVA 1B2IA 2SPTA 4Z0EA 3HMTA 1HPKA 4UAOA 1PK2A 5CS1A 1KIVA 3BT2A 1I71A 2X2ZA 2YIPA 2L0SA 2DOHX 2DOIA 4BVVA 3U73A 2HPPP 4DURA 5CS9A 4CIKA 3LAQA 4R1AA 4BVWA 2J8LA 3HN4A 2LL4M 1HPJA 4O03A 1JFNA 1KRNA 2J8JA 2Q8AA 4YIZA 1GMNA 3SRIA 4KIVA 2K13X 2PF1A 2K51A 2FD6A 4BV5A 3ZWZA 1PMKA 1KDUA 5HPGA 2Z8WA 3HMRA 5CS3A 3SP8A 5EODA 4IUAA 1PMLA 1NK1A 1W8KA 4BVDA 4R1CA 2KJ4A 2Z8VA 4APMA 4A5TS 5CT2A 5CT1A 2KL5A 4NZQA 1W81A 2HGFA 4UV6A 2FEBA 1A0HA 4Z09A 5EOKA 2QJ4A 1URKA 3E6PL 2YILA 1HKYA 2YIOA 1CEBA 3SRJA 2K4RA 2QJ2A 2KNFA 4BVCA 4YIVA 4Z0DA 2F83A 4HZHA 5CS5A 1GMOA 4R1BA 5CSQA 3HMSA 2LL3A 1PK4A
chains in the Genus database with same CATH topology
3ZLEA 1CEAA 1KI0A 2HPQP 2Y8RA 5CT3A 5I25A 1NL2A 5CP9A 2I9BA 3BT1A 5COEA 2PF2A 2Q8BA 1I5KA 2I9AA 2PK4A 3K65A 4Z0FA 4R19A 3NXPA 1I8NA 3MKPA 1TPKA 1PKRA 1Z40A 1GP9A 1YXEA 4APLA 1NL1A 1BHTA 4BV7A 4D3CA 3KIVA 1B2IA 2SPTA 4Z0EA 3HMTA 1HPKA 4UAOA 1PK2A 5CS1A 1KIVA 3BT2A 1I71A 2X2ZA 2YIPA 2L0SA 2DOHX 2DOIA 4BVVA 3U73A 2HPPP 4DURA 5CS9A 4CIKA 3LAQA 4R1AA 4BVWA 2J8LA 3HN4A 2LL4M 1HPJA 4O03A 1JFNA 1KRNA 2J8JA 2Q8AA 4YIZA 1GMNA 3SRIA 4KIVA 2K13X 2PF1A 2K51A 2FD6A 4BV5A 3ZWZA 1PMKA 1KDUA 5HPGA 2Z8WA 3HMRA 5CS3A 3SP8A 5EODA 4IUAA 1PMLA 1NK1A 1W8KA 4BVDA 4R1CA 2KJ4A 2Z8VA 4APMA 4A5TS 5CT2A 5CT1A 2KL5A 4NZQA 1W81A 2HGFA 4UV6A 2FEBA 1A0HA 4Z09A 5EOKA 2QJ4A 1URKA 3E6PL 2YILA 1HKYA 2YIOA 1CEBA 3SRJA 2K4RA 2QJ2A 2KNFA 4BVCA 4YIVA 4Z0DA 2F83A 4HZHA 5CS5A 1GMOA 4R1BA 5CSQA 3HMSA 2LL3A 1PK4A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3ZLE A;  1CEA A;  1KI0 A;  2HPQ P;  2Y8R A;  5CT3 A;  5I25 A;  1NL2 A;  5CP9 A;  2I9B A;  3BT1 A;  5COE A;  2PF2 A;  2Q8B A;  1I5K A;  2I9A A;  2PK4 A;  3K65 A;  4Z0F A;  4R19 A;  3NXP A;  1I8N A;  3MKP A;  1TPK A;  1PKR A;  1Z40 A;  1GP9 A;  1YXE A;  4APL A;  1NL1 A;  1BHT A;  4BV7 A;  4D3C A;  3KIV A;  1B2I A;  2SPT A;  4Z0E A;  3HMT A;  1HPK A;  4UAO A;  1PK2 A;  5CS1 A;  1KIV A;  3BT2 A;  1I71 A;  2X2Z A;  2YIP A;  2L0S A;  2DOH X;  2DOI A;  4BVV A;  3U73 A;  2HPP P;  4DUR A;  5CS9 A;  4CIK A;  3LAQ A;  4R1A A;  4BVW A;  2J8L A;  3HN4 A;  2LL4 M;  1HPJ A;  4O03 A;  1JFN A;  1KRN A;  2J8J A;  2Q8A A;  1GMN A;  3SRI A;  4KIV A;  2K13 X;  2PF1 A;  2K51 A;  2FD6 A;  4BV5 A;  3ZWZ A;  1PMK A;  1KDU A;  5HPG A;  2Z8W A;  3HMR A;  5CS3 A;  3SP8 A;  5EOD A;  4IUA A;  1PML A;  1NK1 A;  1W8K A;  4BVD A;  4R1C A;  2KJ4 A;  2Z8V A;  4APM A;  4A5T S;  5CT2 A;  5CT1 A;  4NZQ A;  1W81 A;  2HGF A;  4UV6 A;  2FEB A;  1A0H A;  4Z09 A;  5EOK A;  2QJ4 A;  1URK A;  3E6P L;  2YIL A;  1HKY A;  2YIO A;  1CEB A;  3SRJ A;  2K4R A;  2QJ2 A;  2KNF A;  4BVC A;  4Z0D A;  2F83 A;  4HZH A;  5CS5 A;  1GMO A;  4R1B A;  5CSQ A;  3HMS A;  2LL3 A;  1PK4 A; 
#chains in the Genus database with same CATH topology
 3ZLE A;  1CEA A;  1KI0 A;  2HPQ P;  2Y8R A;  5CT3 A;  5I25 A;  1NL2 A;  5CP9 A;  2I9B A;  3BT1 A;  5COE A;  2PF2 A;  2Q8B A;  1I5K A;  2I9A A;  2PK4 A;  3K65 A;  4Z0F A;  4R19 A;  3NXP A;  1I8N A;  3MKP A;  1TPK A;  1PKR A;  1Z40 A;  1GP9 A;  1YXE A;  4APL A;  1NL1 A;  1BHT A;  4BV7 A;  4D3C A;  3KIV A;  1B2I A;  2SPT A;  4Z0E A;  3HMT A;  1HPK A;  4UAO A;  1PK2 A;  5CS1 A;  1KIV A;  3BT2 A;  1I71 A;  2X2Z A;  2YIP A;  2L0S A;  2DOH X;  2DOI A;  4BVV A;  3U73 A;  2HPP P;  4DUR A;  5CS9 A;  4CIK A;  3LAQ A;  4R1A A;  4BVW A;  2J8L A;  3HN4 A;  2LL4 M;  1HPJ A;  4O03 A;  1JFN A;  1KRN A;  2J8J A;  2Q8A A;  4YIZ A;  1GMN A;  3SRI A;  4KIV A;  2K13 X;  2PF1 A;  2K51 A;  2FD6 A;  4BV5 A;  3ZWZ A;  1PMK A;  1KDU A;  5HPG A;  2Z8W A;  3HMR A;  5CS3 A;  3SP8 A;  5EOD A;  4IUA A;  1PML A;  1NK1 A;  1W8K A;  4BVD A;  4R1C A;  2KJ4 A;  2Z8V A;  4APM A;  4A5T S;  5CT2 A;  5CT1 A;  2KL5 A;  4NZQ A;  1W81 A;  2HGF A;  4UV6 A;  2FEB A;  1A0H A;  4Z09 A;  5EOK A;  2QJ4 A;  1URK A;  3E6P L;  2YIL A;  1HKY A;  2YIO A;  1CEB A;  3SRJ A;  2K4R A;  2QJ2 A;  2KNF A;  4BVC A;  4YIV A;  4Z0D A;  2F83 A;  4HZH A;  5CS5 A;  1GMO A;  4R1B A;  5CSQ A;  3HMS A;  2LL3 A;  1PK4 A; 
#chains in the Genus database with same CATH homology
 3ZLE A;  1CEA A;  1KI0 A;  2HPQ P;  2Y8R A;  5CT3 A;  5I25 A;  1NL2 A;  5CP9 A;  2I9B A;  3BT1 A;  5COE A;  2PF2 A;  2Q8B A;  1I5K A;  2I9A A;  2PK4 A;  3K65 A;  4Z0F A;  4R19 A;  3NXP A;  1I8N A;  3MKP A;  1TPK A;  1PKR A;  1Z40 A;  1GP9 A;  1YXE A;  4APL A;  1NL1 A;  1BHT A;  4BV7 A;  4D3C A;  3KIV A;  1B2I A;  2SPT A;  4Z0E A;  3HMT A;  1HPK A;  4UAO A;  1PK2 A;  5CS1 A;  1KIV A;  3BT2 A;  1I71 A;  2X2Z A;  2YIP A;  2L0S A;  2DOH X;  2DOI A;  4BVV A;  3U73 A;  2HPP P;  4DUR A;  5CS9 A;  4CIK A;  3LAQ A;  4R1A A;  4BVW A;  2J8L A;  3HN4 A;  2LL4 M;  1HPJ A;  4O03 A;  1JFN A;  1KRN A;  2J8J A;  2Q8A A;  4YIZ A;  1GMN A;  3SRI A;  4KIV A;  2K13 X;  2PF1 A;  2K51 A;  2FD6 A;  4BV5 A;  3ZWZ A;  1PMK A;  1KDU A;  5HPG A;  2Z8W A;  3HMR A;  5CS3 A;  3SP8 A;  5EOD A;  4IUA A;  1PML A;  1NK1 A;  1W8K A;  4BVD A;  4R1C A;  2KJ4 A;  2Z8V A;  4APM A;  4A5T S;  5CT2 A;  5CT1 A;  2KL5 A;  4NZQ A;  1W81 A;  2HGF A;  4UV6 A;  2FEB A;  1A0H A;  4Z09 A;  5EOK A;  2QJ4 A;  1URK A;  3E6P L;  2YIL A;  1HKY A;  2YIO A;  1CEB A;  3SRJ A;  2K4R A;  2QJ2 A;  2KNF A;  4BVC A;  4YIV A;  4Z0D A;  2F83 A;  4HZH A;  5CS5 A;  1GMO A;  4R1B A;  5CSQ A;  3HMS A;  2LL3 A;  1PK4 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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