1GP9A

A new crystal form of the nk1 splice variant of hgf/sf demonstrates extensive hinge movement and suggests that the nk1 dimer originates by domain swapping
Total Genus 37
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
37
sequence length
170
structure length
170
Chain Sequence
VHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A New Crystal Form of the Nk1 Splice Variant of Hgf/Sf Demonstrates Extensive Hinge Movement and Suggests that the Nk1 Dimer Originates by Domain Swapping
pubmed doi rcsb
molecule tags Hormone/growth factor
source organism Homo sapiens
molecule keywords HEPATOCYTE GROWTH FACTOR
total genus 37
structure length 170
sequence length 170
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2001-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 1gp9A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 1gp9A01
4HZHA 2FD6A 3HN4A 2QJ2A 3LAQA 1KDUA 5CS9A 4APMA 2L0SA 5CT2A 3ZLEA 1TPKA 4BVWA 4IUAA 1PMLA 5HPGA 4APLA 5CS1A 1A0HA 2I9BA 2K4RA 4KIVA 3K65A 2KNFA 2Q8BA 5CS3A 4R1BA 2HPQP 1KIVA 1I5KA 5EODA 2HGFA 4Z0EA 4Z09A 1YXEA 5CS5A 4Z0DA 2J8JA 3SRIA 1URKA 1CEAA 2SPTA 3ZWZA 4BVDA 2DOIA 4CIKA 2YILA 5CT1A 4O03A 1JFNA 1GMNA 2Y8RA 1NK1A 2LL4M 2K51A 2YIOA 3U73A 4BV5A 2Q8AA 4BVCA 1CEBA 1I8NA 3BT1A 2PF1A 3KIVA 3E6PL 1W8KA 2K13X 5EOKA 2YIPA 3HMRA 1GP9A 2QJ4A 3HMSA 1HPKA 1NL2A 1KRNA 5CT3A 2X2ZA 3SRJA 2KJ4A 1PKRA 2I9AA 1BHTA 4R19A 2PF2A 3HMTA 3MKPA 5COEA 5I25A 4Z0FA 3BT2A 4R1AA 4NZQA 2Z8WA 1PK4A 4BVVA 4A5TS 3SP8A 1PK2A 2LL3A 5CSQA 4R1CA 2PK4A 2J8LA 1I71A 4D3CA 3NXPA 1HPJA 1Z40A 1GMOA 1NL1A 4DURA 2DOHX 2F83A 5CP9A 1HKYA 2FEBA 1B2IA 1W81A 4BV7A 2HPPP 4UAOA 1PMKA 4UV6A 2Z8VA 1KI0A
chains in the Genus database with same CATH superfamily
4HZHA 2FD6A 3HN4A 2QJ2A 3LAQA 1KDUA 5CS9A 4APMA 2L0SA 5CT2A 3ZLEA 1TPKA 4BVWA 4IUAA 1PMLA 5HPGA 4APLA 5CS1A 1A0HA 2I9BA 2K4RA 4KIVA 3K65A 2KNFA 2Q8BA 5CS3A 4R1BA 2HPQP 1KIVA 1I5KA 5EODA 2HGFA 4Z0EA 4Z09A 1YXEA 5CS5A 4Z0DA 2J8JA 3SRIA 1URKA 1CEAA 2SPTA 3ZWZA 4BVDA 2DOIA 4CIKA 2YILA 5CT1A 4O03A 1JFNA 1GMNA 2Y8RA 1NK1A 2LL4M 2K51A 2YIOA 3U73A 4BV5A 2Q8AA 4BVCA 1CEBA 1I8NA 3BT1A 4YIVA 2PF1A 3KIVA 3E6PL 1W8KA 2K13X 5EOKA 2YIPA 3HMRA 1GP9A 2QJ4A 3HMSA 1HPKA 1NL2A 1KRNA 5CT3A 2X2ZA 3SRJA 2KJ4A 1PKRA 2I9AA 1BHTA 4R19A 2PF2A 3HMTA 3MKPA 5COEA 4YIZA 5I25A 4Z0FA 3BT2A 4R1AA 4NZQA 2Z8WA 1PK4A 4BVVA 4A5TS 3SP8A 1PK2A 2LL3A 5CSQA 4R1CA 2PK4A 2J8LA 1I71A 4D3CA 3NXPA 1HPJA 1Z40A 1GMOA 1NL1A 4DURA 2DOHX 2F83A 5CP9A 2KL5A 1HKYA 2FEBA 1B2IA 1W81A 4BV7A 2HPPP 4UAOA 1PMKA 4UV6A 2Z8VA 1KI0A
chains in the Genus database with same CATH topology
4HZHA 2FD6A 3HN4A 2QJ2A 3LAQA 1KDUA 5CS9A 4APMA 2L0SA 5CT2A 3ZLEA 1TPKA 4BVWA 4IUAA 1PMLA 5HPGA 4APLA 5CS1A 1A0HA 2I9BA 2K4RA 4KIVA 3K65A 2KNFA 2Q8BA 5CS3A 4R1BA 2HPQP 1KIVA 1I5KA 5EODA 2HGFA 4Z0EA 4Z09A 1YXEA 5CS5A 4Z0DA 2J8JA 3SRIA 1URKA 1CEAA 2SPTA 3ZWZA 4BVDA 2DOIA 4CIKA 2YILA 5CT1A 4O03A 1JFNA 1GMNA 2Y8RA 1NK1A 2LL4M 2K51A 2YIOA 3U73A 4BV5A 2Q8AA 4BVCA 1CEBA 1I8NA 3BT1A 4YIVA 2PF1A 3KIVA 3E6PL 1W8KA 2K13X 5EOKA 2YIPA 3HMRA 1GP9A 2QJ4A 3HMSA 1HPKA 1NL2A 1KRNA 5CT3A 2X2ZA 3SRJA 2KJ4A 1PKRA 2I9AA 1BHTA 4R19A 2PF2A 3HMTA 3MKPA 5COEA 4YIZA 5I25A 4Z0FA 3BT2A 4R1AA 4NZQA 2Z8WA 1PK4A 4BVVA 4A5TS 3SP8A 1PK2A 2LL3A 5CSQA 4R1CA 2PK4A 2J8LA 1I71A 4D3CA 3NXPA 1HPJA 1Z40A 1GMOA 1NL1A 4DURA 2DOHX 2F83A 5CP9A 2KL5A 1HKYA 2FEBA 1B2IA 1W81A 4BV7A 2HPPP 4UAOA 1PMKA 4UV6A 2Z8VA 1KI0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HZH A;  2FD6 A;  3HN4 A;  2QJ2 A;  3LAQ A;  1KDU A;  5CS9 A;  4APM A;  2L0S A;  5CT2 A;  3ZLE A;  1TPK A;  4BVW A;  4IUA A;  1PML A;  5HPG A;  4APL A;  5CS1 A;  1A0H A;  2I9B A;  2K4R A;  4KIV A;  3K65 A;  2KNF A;  2Q8B A;  5CS3 A;  4R1B A;  2HPQ P;  1KIV A;  1I5K A;  5EOD A;  2HGF A;  4Z0E A;  4Z09 A;  1YXE A;  5CS5 A;  4Z0D A;  2J8J A;  3SRI A;  1URK A;  1CEA A;  2SPT A;  3ZWZ A;  4BVD A;  2DOI A;  4CIK A;  2YIL A;  5CT1 A;  4O03 A;  1JFN A;  1GMN A;  2Y8R A;  1NK1 A;  2LL4 M;  2K51 A;  2YIO A;  3U73 A;  4BV5 A;  2Q8A A;  4BVC A;  1CEB A;  1I8N A;  3BT1 A;  2PF1 A;  3KIV A;  3E6P L;  1W8K A;  2K13 X;  5EOK A;  2YIP A;  3HMR A;  1GP9 A;  2QJ4 A;  3HMS A;  1HPK A;  1NL2 A;  1KRN A;  5CT3 A;  2X2Z A;  3SRJ A;  2KJ4 A;  1PKR A;  2I9A A;  1BHT A;  4R19 A;  2PF2 A;  3HMT A;  3MKP A;  5COE A;  5I25 A;  4Z0F A;  3BT2 A;  4R1A A;  4NZQ A;  2Z8W A;  1PK4 A;  4BVV A;  4A5T S;  3SP8 A;  1PK2 A;  2LL3 A;  5CSQ A;  4R1C A;  2PK4 A;  2J8L A;  1I71 A;  4D3C A;  3NXP A;  1HPJ A;  1Z40 A;  1GMO A;  1NL1 A;  4DUR A;  2DOH X;  2F83 A;  5CP9 A;  1HKY A;  2FEB A;  1B2I A;  1W81 A;  4BV7 A;  2HPP P;  4UAO A;  1PMK A;  4UV6 A;  2Z8V A;  1KI0 A; 
#chains in the Genus database with same CATH topology
 4HZH A;  2FD6 A;  3HN4 A;  2QJ2 A;  3LAQ A;  1KDU A;  5CS9 A;  4APM A;  2L0S A;  5CT2 A;  3ZLE A;  1TPK A;  4BVW A;  4IUA A;  1PML A;  5HPG A;  4APL A;  5CS1 A;  1A0H A;  2I9B A;  2K4R A;  4KIV A;  3K65 A;  2KNF A;  2Q8B A;  5CS3 A;  4R1B A;  2HPQ P;  1KIV A;  1I5K A;  5EOD A;  2HGF A;  4Z0E A;  4Z09 A;  1YXE A;  5CS5 A;  4Z0D A;  2J8J A;  3SRI A;  1URK A;  1CEA A;  2SPT A;  3ZWZ A;  4BVD A;  2DOI A;  4CIK A;  2YIL A;  5CT1 A;  4O03 A;  1JFN A;  1GMN A;  2Y8R A;  1NK1 A;  2LL4 M;  2K51 A;  2YIO A;  3U73 A;  4BV5 A;  2Q8A A;  4BVC A;  1CEB A;  1I8N A;  3BT1 A;  4YIV A;  2PF1 A;  3KIV A;  3E6P L;  1W8K A;  2K13 X;  5EOK A;  2YIP A;  3HMR A;  1GP9 A;  2QJ4 A;  3HMS A;  1HPK A;  1NL2 A;  1KRN A;  5CT3 A;  2X2Z A;  3SRJ A;  2KJ4 A;  1PKR A;  2I9A A;  1BHT A;  4R19 A;  2PF2 A;  3HMT A;  3MKP A;  5COE A;  4YIZ A;  5I25 A;  4Z0F A;  3BT2 A;  4R1A A;  4NZQ A;  2Z8W A;  1PK4 A;  4BVV A;  4A5T S;  3SP8 A;  1PK2 A;  2LL3 A;  5CSQ A;  4R1C A;  2PK4 A;  2J8L A;  1I71 A;  4D3C A;  3NXP A;  1HPJ A;  1Z40 A;  1GMO A;  1NL1 A;  4DUR A;  2DOH X;  2F83 A;  5CP9 A;  2KL5 A;  1HKY A;  2FEB A;  1B2I A;  1W81 A;  4BV7 A;  2HPP P;  4UAO A;  1PMK A;  4UV6 A;  2Z8V A;  1KI0 A; 
#chains in the Genus database with same CATH homology
 4HZH A;  2FD6 A;  3HN4 A;  2QJ2 A;  3LAQ A;  1KDU A;  5CS9 A;  4APM A;  2L0S A;  5CT2 A;  3ZLE A;  1TPK A;  4BVW A;  4IUA A;  1PML A;  5HPG A;  4APL A;  5CS1 A;  1A0H A;  2I9B A;  2K4R A;  4KIV A;  3K65 A;  2KNF A;  2Q8B A;  5CS3 A;  4R1B A;  2HPQ P;  1KIV A;  1I5K A;  5EOD A;  2HGF A;  4Z0E A;  4Z09 A;  1YXE A;  5CS5 A;  4Z0D A;  2J8J A;  3SRI A;  1URK A;  1CEA A;  2SPT A;  3ZWZ A;  4BVD A;  2DOI A;  4CIK A;  2YIL A;  5CT1 A;  4O03 A;  1JFN A;  1GMN A;  2Y8R A;  1NK1 A;  2LL4 M;  2K51 A;  2YIO A;  3U73 A;  4BV5 A;  2Q8A A;  4BVC A;  1CEB A;  1I8N A;  3BT1 A;  4YIV A;  2PF1 A;  3KIV A;  3E6P L;  1W8K A;  2K13 X;  5EOK A;  2YIP A;  3HMR A;  1GP9 A;  2QJ4 A;  3HMS A;  1HPK A;  1NL2 A;  1KRN A;  5CT3 A;  2X2Z A;  3SRJ A;  2KJ4 A;  1PKR A;  2I9A A;  1BHT A;  4R19 A;  2PF2 A;  3HMT A;  3MKP A;  5COE A;  4YIZ A;  5I25 A;  4Z0F A;  3BT2 A;  4R1A A;  4NZQ A;  2Z8W A;  1PK4 A;  4BVV A;  4A5T S;  3SP8 A;  1PK2 A;  2LL3 A;  5CSQ A;  4R1C A;  2PK4 A;  2J8L A;  1I71 A;  4D3C A;  3NXP A;  1HPJ A;  1Z40 A;  1GMO A;  1NL1 A;  4DUR A;  2DOH X;  2F83 A;  5CP9 A;  2KL5 A;  1HKY A;  2FEB A;  1B2I A;  1W81 A;  4BV7 A;  2HPP P;  4UAO A;  1PMK A;  4UV6 A;  2Z8V A;  1KI0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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