1NK1 | Genus

Total Genus 32

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	32
sequence length	172
structure length	172
Chain Sequence	TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hormone/growth factor
source organism	Homo sapiens
publication title	Crystal structure of the NK1 fragment of HGF/SF suggests a novel mode for growth factor dimerization and receptor binding. pubmed doi rcsb
molecule keywords	PROTEIN (HEPATOCYTE GROWTH FACTOR PRECURSOR)
total genus	32
structure length	172
sequence length	172
chains with identical sequence	B
ec nomenclature
pdb deposition date	1998-08-20

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00024	PAN_1	PAN domain
A	PF00051	Kringle	Kringle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.40.20.10	Mainly Beta	Beta Barrel	Plasminogen Kringle 4	Plasminogen Kringle 4	1nk1A02
3.50.4.10	Alpha Beta	3-Layer(bba) Sandwich	Hepatocyte Growth Factor	Hepatocyte Growth Factor	1nk1A01

1I5KA 4BV5A 4A5TS 2KJ4A 1PKRA 3E6PL 4D3CA 2Z8WA 1W81A 2HPQP 1NL1A 2K13X 4R1AA 2F83A 2K4RA 2LL4M 3HMTA 4CIKA 3U73A 2PF1A 2J8LA 2HPPP 4BVDA 3BT1A 3HN4A 2FD6A 3LAQA 5CS3A 1KDUA 2Q8BA 4APLA 1JFNA 3K65A 5CS1A 1I8NA 1PK4A 5COEA 2HGFA 2DOIA 1URKA 5I25A 3NXPA 4UV6A 1PK2A 5CT2A 4DURA 5CT1A 2QJ2A 5CS9A 3MKPA 1PMLA 2I9AA 3BT2A 3SRJA 2FEBA 1KI0A 5CP9A 4KIVA 4BVVA 1YXEA 3ZWZA 4UAOA 1NL2A 1Z40A 3HMRA 2Z8VA 3SRIA 4BVCA 4R1CA 2YIPA 4BVWA 2PF2A 2DOHX 3KIVA 5HPGA 4IUAA 4HZHA 1B2IA 5EODA 4NZQA 1TPKA 5CS5A 5CSQA 2Y8RA 1A0HA 4Z0EA 4Z09A 1W8KA 1NK1A 2KNFA 2YILA 1CEBA 1GP9A 1HPJA 4BV7A 4R1BA 3ZLEA 1CEAA 1GMOA 3HMSA 2I9BA 4R19A 4Z0FA 2L0SA 1KIVA 2PK4A 4Z0DA 5EOKA 2Q8AA 2X2ZA 2SPTA 3SP8A 1BHTA 2K51A 2YIOA 1PMKA 1HKYA 5CT3A 1I71A 2QJ4A 1HPKA 1GMNA 2J8JA 1KRNA 4APMA 2LL3A 4O03A
chains in the Genus database with same CATH superfamily

1I5KA 4BV5A 4A5TS 2KJ4A 1PKRA 3E6PL 4D3CA 2Z8WA 1W81A 2HPQP 1NL1A 4YIVA 2K13X 4R1AA 2F83A 2K4RA 2LL4M 3HMTA 4CIKA 3U73A 2PF1A 2J8LA 2HPPP 4BVDA 3BT1A 3HN4A 2FD6A 3LAQA 5CS3A 1KDUA 2Q8BA 4APLA 1JFNA 3K65A 5CS1A 1I8NA 1PK4A 5COEA 2HGFA 2DOIA 1URKA 5I25A 3NXPA 4UV6A 1PK2A 5CT2A 4DURA 5CT1A 2QJ2A 5CS9A 3MKPA 1PMLA 4YIZA 2I9AA 3BT2A 3SRJA 2FEBA 1KI0A 5CP9A 4KIVA 4BVVA 1YXEA 3ZWZA 4UAOA 1NL2A 1Z40A 3HMRA 2Z8VA 3SRIA 4BVCA 4R1CA 2YIPA 4BVWA 2PF2A 2DOHX 3KIVA 5HPGA 2KL5A 4IUAA 4HZHA 1B2IA 5EODA 4NZQA 1TPKA 5CS5A 5CSQA 2Y8RA 1A0HA 4Z0EA 4Z09A 1W8KA 1NK1A 2KNFA 2YILA 1CEBA 1GP9A 1HPJA 4BV7A 4R1BA 3ZLEA 1CEAA 1GMOA 3HMSA 2I9BA 4R19A 4Z0FA 2L0SA 1KIVA 2PK4A 4Z0DA 5EOKA 2Q8AA 2X2ZA 2SPTA 3SP8A 1BHTA 2K51A 2YIOA 1PMKA 1HKYA 5CT3A 1I71A 2QJ4A 1HPKA 1GMNA 2J8JA 1KRNA 4APMA 2LL3A 4O03A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 1I5K A;  4BV5 A;  4A5T S;  2KJ4 A;  1PKR A;  3E6P L;  4D3C A;  2Z8W A;  1W81 A;  2HPQ P;  1NL1 A;  2K13 X;  4R1A A;  2F83 A;  2K4R A;  2LL4 M;  3HMT A;  4CIK A;  3U73 A;  2PF1 A;  2J8L A;  2HPP P;  4BVD A;  3BT1 A;  3HN4 A;  2FD6 A;  3LAQ A;  5CS3 A;  1KDU A;  2Q8B A;  4APL A;  1JFN A;  3K65 A;  5CS1 A;  1I8N A;  1PK4 A;  5COE A;  2HGF A;  2DOI A;  1URK A;  5I25 A;  3NXP A;  4UV6 A;  1PK2 A;  5CT2 A;  4DUR A;  5CT1 A;  2QJ2 A;  5CS9 A;  3MKP A;  1PML A;  2I9A A;  3BT2 A;  3SRJ A;  2FEB A;  1KI0 A;  5CP9 A;  4KIV A;  4BVV A;  1YXE A;  3ZWZ A;  4UAO A;  1NL2 A;  1Z40 A;  3HMR A;  2Z8V A;  3SRI A;  4BVC A;  4R1C A;  2YIP A;  4BVW A;  2PF2 A;  2DOH X;  3KIV A;  5HPG A;  4IUA A;  4HZH A;  1B2I A;  5EOD A;  4NZQ A;  1TPK A;  5CS5 A;  5CSQ A;  2Y8R A;  1A0H A;  4Z0E A;  4Z09 A;  1W8K A;  1NK1 A;  2KNF A;  2YIL A;  1CEB A;  1GP9 A;  1HPJ A;  4BV7 A;  4R1B A;  3ZLE A;  1CEA A;  1GMO A;  3HMS A;  2I9B A;  4R19 A;  4Z0F A;  2L0S A;  1KIV A;  2PK4 A;  4Z0D A;  5EOK A;  2Q8A A;  2X2Z A;  2SPT A;  3SP8 A;  1BHT A;  2K51 A;  2YIO A;  1PMK A;  1HKY A;  5CT3 A;  1I71 A;  2QJ4 A;  1HPK A;  1GMN A;  2J8J A;  1KRN A;  4APM A;  2LL3 A;  4O03 A; 
#chains in the Genus database with same CATH topology
 1I5K A;  4BV5 A;  4A5T S;  2KJ4 A;  1PKR A;  3E6P L;  4D3C A;  2Z8W A;  1W81 A;  2HPQ P;  1NL1 A;  4YIV A;  2K13 X;  4R1A A;  2F83 A;  2K4R A;  2LL4 M;  3HMT A;  4CIK A;  3U73 A;  2PF1 A;  2J8L A;  2HPP P;  4BVD A;  3BT1 A;  3HN4 A;  2FD6 A;  3LAQ A;  5CS3 A;  1KDU A;  2Q8B A;  4APL A;  1JFN A;  3K65 A;  5CS1 A;  1I8N A;  1PK4 A;  5COE A;  2HGF A;  2DOI A;  1URK A;  5I25 A;  3NXP A;  4UV6 A;  1PK2 A;  5CT2 A;  4DUR A;  5CT1 A;  2QJ2 A;  5CS9 A;  3MKP A;  1PML A;  4YIZ A;  2I9A A;  3BT2 A;  3SRJ A;  2FEB A;  1KI0 A;  5CP9 A;  4KIV A;  4BVV A;  1YXE A;  3ZWZ A;  4UAO A;  1NL2 A;  1Z40 A;  3HMR A;  2Z8V A;  3SRI A;  4BVC A;  4R1C A;  2YIP A;  4BVW A;  2PF2 A;  2DOH X;  3KIV A;  5HPG A;  2KL5 A;  4IUA A;  4HZH A;  1B2I A;  5EOD A;  4NZQ A;  1TPK A;  5CS5 A;  5CSQ A;  2Y8R A;  1A0H A;  4Z0E A;  4Z09 A;  1W8K A;  1NK1 A;  2KNF A;  2YIL A;  1CEB A;  1GP9 A;  1HPJ A;  4BV7 A;  4R1B A;  3ZLE A;  1CEA A;  1GMO A;  3HMS A;  2I9B A;  4R19 A;  4Z0F A;  2L0S A;  1KIV A;  2PK4 A;  4Z0D A;  5EOK A;  2Q8A A;  2X2Z A;  2SPT A;  3SP8 A;  1BHT A;  2K51 A;  2YIO A;  1PMK A;  1HKY A;  5CT3 A;  1I71 A;  2QJ4 A;  1HPK A;  1GMN A;  2J8J A;  1KRN A;  4APM A;  2LL3 A;  4O03 A; 
#chains in the Genus database with same CATH homology
 1I5K A;  4BV5 A;  4A5T S;  2KJ4 A;  1PKR A;  3E6P L;  4D3C A;  2Z8W A;  1W81 A;  2HPQ P;  1NL1 A;  4YIV A;  2K13 X;  4R1A A;  2F83 A;  2K4R A;  2LL4 M;  3HMT A;  4CIK A;  3U73 A;  2PF1 A;  2J8L A;  2HPP P;  4BVD A;  3BT1 A;  3HN4 A;  2FD6 A;  3LAQ A;  5CS3 A;  1KDU A;  2Q8B A;  4APL A;  1JFN A;  3K65 A;  5CS1 A;  1I8N A;  1PK4 A;  5COE A;  2HGF A;  2DOI A;  1URK A;  5I25 A;  3NXP A;  4UV6 A;  1PK2 A;  5CT2 A;  4DUR A;  5CT1 A;  2QJ2 A;  5CS9 A;  3MKP A;  1PML A;  4YIZ A;  2I9A A;  3BT2 A;  3SRJ A;  2FEB A;  1KI0 A;  5CP9 A;  4KIV A;  4BVV A;  1YXE A;  3ZWZ A;  4UAO A;  1NL2 A;  1Z40 A;  3HMR A;  2Z8V A;  3SRI A;  4BVC A;  4R1C A;  2YIP A;  4BVW A;  2PF2 A;  2DOH X;  3KIV A;  5HPG A;  2KL5 A;  4IUA A;  4HZH A;  1B2I A;  5EOD A;  4NZQ A;  1TPK A;  5CS5 A;  5CSQ A;  2Y8R A;  1A0H A;  4Z0E A;  4Z09 A;  1W8K A;  1NK1 A;  2KNF A;  2YIL A;  1CEB A;  1GP9 A;  1HPJ A;  4BV7 A;  4R1B A;  3ZLE A;  1CEA A;  1GMO A;  3HMS A;  2I9B A;  4R19 A;  4Z0F A;  2L0S A;  1KIV A;  2PK4 A;  4Z0D A;  5EOK A;  2Q8A A;  2X2Z A;  2SPT A;  3SP8 A;  1BHT A;  2K51 A;  2YIO A;  1PMK A;  1HKY A;  5CT3 A;  1I71 A;  2QJ4 A;  1HPK A;  1GMN A;  2J8J A;  1KRN A;  4APM A;  2LL3 A;  4O03 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1NK1A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations