1O7DD

The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
272
structure length
269
Chain Sequence
RDLVIQNEYLRARFDPNTGLLMELENLLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Lysosomal alpha-mannosidase
total genus 59
structure length 269
sequence length 272
ec nomenclature ec 3.2.1.24: Alpha-mannosidase.
pdb deposition date 2002-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF07748 Glyco_hydro_38C Glycosyl hydrolases family 38 C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.98.30 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Golgi alpha-mannosidase II; domain 4 1o7dD01
1O7DD 1TQVA 3BUPA 3DX2A 3BVUA 3BUDA 2F1BA 1HTYA 3BUBA 1QWNA 2F7PA 3DX1A 3EJTA 3EJPA 3CZNA 2ALWA 3CZSA 4K3AA 3LVTA 3BVVA 3D52A 3D4YA 3DDGA 1HXKA 2F18A 3EJQA 3DX3A 1TQWA 2WYHA 2FYVA 1R33A 1HWWA 3CV5A 2F7OA 1TQSA 3EJUA 3EJSA 1TQUA 2F7QA 1PS3A 2F7RA 3D50A 3DDFA 3DX4A 2OW6A 1TQTA 3D51A 4K35A 1QWUA 3BVWA 5KBPA 2WYIA 2OW7A 3BLBA 2F1AA 3DX0A 3D4ZA 3BVXA 3EJRA 3BUQA 3BUIA 1QX1A 1R34A 3BVTA
chains in the Genus database with same CATH superfamily
1SNZA 2CG0A 3TY1A 3D4YA 2Y73A 1LF6A 1RWCA 2OOVA 3VD9A 1A2VA 3VDCA 1RWFA 3PGBA 1IVXA 1K1YA 1V7XA 1JZ7A 4KFFA 3SEPA 2CFLA 3DYOA 4BTXA 1TU5A 2ZQ0A 1TQVA 3QDEA 3ECQA 3J7HA 3CZSA 3DDGA 1F1SA 2CQSA 3CV5A 1SO0A 3T2PA 2WGQA 1W6GA 1MN0A 2CFWA 2WO0A 2F1AA 2D1WA 1OJNA 1I8QA 2JKPA 3VD5A 5JMDA 3RSYA 2Y74A 1HM2A 4NEIA 1IU7A 3BUDA 2ZXQA 2Q1FA 3S4AA 2WW3A 1US1A 3S4CA 1F4HA 3T08A 3T0DA 3QG0A 3SXXA 2CQTA 1IVWA 1UG9A 1N9EA 2F7PA 2YX9A 5JMFA 1SIHA 2WVXA 1HXKA 3WIQA 3W7UA 1TQWA 1NSXA 2WZSA 1NS8A 2D73A 4EV2A 3T0BA 1OJPA 3VD3A 3DX0A 2OOVC 3VD7A 1J0MA 1R34A 1V7VA 3IAQA 4OJZA 3MI6A 4AQ0A 1QWNA 2RDYA 1H54A 1NSSA 1F9GA 4K3AA 3VSNA 3X3YA 3D52A 1JZ6A 3EJUA 3Q1NA 3WVFA 2OW6A 2CIRA 4OK2A 5KBPA 2WW2A 3QFYA 3VD4A 3T0UA 1JYXA 3T0AA 1O7DD 1AV4A 2BRPA 4MMHA 1LVNA 3DX1A 1JYVA 1C82A 1RJOA 4BZGA 3W7WA 1N7OA 1RKYA 4DUWA 2E2UA 3AFLA 3W7SA 3A24A 1SPUA 3W7XA 2XHNA 5A1AA 3VDBA 1JZ5A 3S4BA 3OB8A 1RWGA 1L7KA 2CIQA 3CZJA 1NSVA 1UI7A 4MMIA 4BTWA 4BTYA 4BZHA 3BVUA 1N7QA 3EJTA 2C10A 1LXMA 1J0NA 1DP0A 1TXKA 1PX3A 3T2OA 1SIIA 3WA3A 4FNPA 2CFDA 3IMHA 3HI7A 2CG1A 2E2VA 3MWXA 1AVKA 3MUZ1 2WCOA 3D3IA 1OJMA 4DUXA 3S4DA 1EGUA 3BVVA 1NSMA 3KIIA 3I3BA 1NS2A 3T09A 2X03A 3ACTA 1MMUA 2XN0A 1TQTA 2CWUA 2JKAA 4K35A 3AMOB 2EAEA 3QFZA 1RWHA 3BUQA 1JZ3A 1LXKA 3X41A 1UI8A 1QAFA 1QAKA 3T2QA 1HTYA 1N7RA 2E2TA 2XN1A 1JZ8A 1N7PA 3K5TA 2ZL8A 3VSMA 1NS4A 2WW0A 1LURA 3VDAA 3OS7A 2CFGA 3X42A 4FNUA 4TTGA 4KFDA 1JYWA 1IVVA 3BVTA 1OJOA 1NKGA 1DYUA 3DX2A 2BT3A 1W3YA 1NS7A 2JKEA 2WYHA 2OQEA 3E1F1 2CFKA 3E7JA 3K25A 1JOVA 1WMPA 1QALA 1RWAA 4RNLA 1NSUA 3DYPA 2WDAA 1W6CA 1JZ4A 1CB8A 1MMZA 3BUPA 1EKMA 2WVZA 3I3DA 3DCDA 3NJXA 3RRSA 3HIGA 4KTRA 1D6YA 3EJQA 4FNVA 3MUY1 1OACA 3WFAA 1W2ZA 1Z45A 2WYIA 3A0OA 3D4ZA 1X1IA 3X40A 4FNQA 1HN1A 1AVLA 1LOHA 1MMYA 3CZNA 1D6ZA 2E24A 3LVTA 1NSZA 2HTAA 1WMOA 2FYVA 1HWWA 2YFOA 3NJVA 5CA3A 3IAPA 1PS3A 3DDFA 1HM3A 3BVWA 3BLBA 1W5ZA 3BGAA 3DYMA 3LOYA 3EJRA 2EABA 5E1QA 3DECA 1K1WA 1L7JA 1YQ2A 3EJPA 2F1BA 2PNCA 3BUBA 1ULVA 1N7NA 3I3EA 3MV11 2FUQA 1W4NA 1NS0A 1W7CA 1X1JA 2XSGA 2F7RA 1JYNA 3AMOA 2EACA 1NSRA 3WIRA 3W7TA 4FNRA 3BVXA 2OQEC 3NREA 1KSIA 5GW7A 3X3ZA 1WMNA 1YGAA 2BRWA 2WOFA 3OBAA 1IQXA 2WOHA 1D6UA 3X3XA 2F18A 3ACSA 4FNSA 2WW1A 4FNTA 2YFNA 1IQYA 1TQSA 3NBBA 3BS6A 4BZEA 3E80A 2W0QA 2FUTA 2OW7A 3AFJA 1PX4A 4EV5A 4KFEA 3BUIA 2C11A 4DUVA 1HMWA 1LF9A 4J5TA 1X1HA 3N9HA 2HTBA 2WVXB 1HMUA 2CWVA 1R33A 1K1XA 2BRVX 2E22A 2F7OA 4OK4A 2F7QA 2CWTA 3HIIA 1QWUA 3MV01 3SX1A 1QX1A 3MPHA 2XN2A 4KTPA 2ALWA 1RW9A 1V7WA 4UFCA 3DX3A 3NBJA 2EADA 3WA2X 3EJSA 1TQUA 3D50A 3DX4A 3KN4A 3D51A 1F4AA 1IVUA 1MMXA 2WVYA 1JZ2A 2CISA 3BLCA 1JRQA 3ALAA 4BZFA 1HN0A 1PU4A
chains in the Genus database with same CATH topology
1O7DD 1TQVA 3BUPA 3DX2A 3BVUA 3BUDA 2F1BA 1HTYA 3BUBA 1QWNA 2F7PA 3DX1A 3EJTA 3EJPA 3CZNA 2ALWA 3CZSA 4K3AA 3LVTA 3BVVA 3D52A 3D4YA 3DDGA 1HXKA 2F18A 3EJQA 3DX3A 1TQWA 2WYHA 2FYVA 1R33A 1HWWA 3CV5A 2F7OA 1TQSA 3EJUA 3EJSA 1TQUA 2F7QA 1PS3A 2F7RA 3D50A 3DDFA 3DX4A 2OW6A 1TQTA 3D51A 4K35A 1QWUA 3BVWA 5KBPA 2WYIA 2OW7A 3BLBA 2F1AA 3DX0A 3D4ZA 3BVXA 3EJRA 3BUQA 3BUIA 1QX1A 1R34A 3BVTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1O7D D;  1TQV A;  3BUP A;  3DX2 A;  3BVU A;  3BUD A;  2F1B A;  1HTY A;  3BUB A;  1QWN A;  2F7P A;  3DX1 A;  3EJT A;  3EJP A;  3CZN A;  2ALW A;  3CZS A;  4K3A A;  3LVT A;  3BVV A;  3D52 A;  3D4Y A;  3DDG A;  1HXK A;  2F18 A;  3EJQ A;  3DX3 A;  1TQW A;  2WYH A;  2FYV A;  1R33 A;  1HWW A;  3CV5 A;  2F7O A;  1TQS A;  3EJU A;  3EJS A;  1TQU A;  2F7Q A;  1PS3 A;  2F7R A;  3D50 A;  3DDF A;  3DX4 A;  2OW6 A;  1TQT A;  3D51 A;  4K35 A;  1QWU A;  3BVW A;  5KBP A;  2WYI A;  2OW7 A;  3BLB A;  2F1A A;  3DX0 A;  3D4Z A;  3BVX A;  3EJR A;  3BUQ A;  3BUI A;  1QX1 A;  1R34 A;  3BVT A; 
#chains in the Genus database with same CATH topology
 1SNZ A;  2CG0 A;  3TY1 A;  3D4Y A;  2Y73 A;  1LF6 A;  1RWC A;  2OOV A;  3VD9 A;  1A2V A;  3VDC A;  1RWF A;  3PGB A;  1IVX A;  1K1Y A;  1V7X A;  1JZ7 A;  4KFF A;  3SEP A;  2CFL A;  3DYO A;  4BTX A;  1TU5 A;  2ZQ0 A;  1TQV A;  3QDE A;  3ECQ A;  3J7H A;  3CZS A;  3DDG A;  1F1S A;  2CQS A;  3CV5 A;  1SO0 A;  3T2P A;  2WGQ A;  1W6G A;  1MN0 A;  2CFW A;  2WO0 A;  2F1A A;  2D1W A;  1OJN A;  1I8Q A;  2JKP A;  3VD5 A;  5JMD A;  3RSY A;  2Y74 A;  1HM2 A;  4NEI A;  1IU7 A;  3BUD A;  2ZXQ A;  2Q1F A;  3S4A A;  2WW3 A;  1US1 A;  3S4C A;  1F4H A;  3T08 A;  3T0D A;  3QG0 A;  3SXX A;  2CQT A;  1IVW A;  1UG9 A;  1N9E A;  2F7P A;  2YX9 A;  5JMF A;  1SIH A;  2WVX A;  1HXK A;  3WIQ A;  3W7U A;  1TQW A;  1NSX A;  2WZS A;  1NS8 A;  2D73 A;  4EV2 A;  3T0B A;  1OJP A;  3VD3 A;  3DX0 A;  2OOV C;  3VD7 A;  1J0M A;  1R34 A;  1V7V A;  3IAQ A;  4OJZ A;  3MI6 A;  4AQ0 A;  1QWN A;  2RDY A;  1H54 A;  1NSS A;  1F9G A;  4K3A A;  3VSN A;  3X3Y A;  3D52 A;  1JZ6 A;  3EJU A;  3Q1N A;  3WVF A;  2OW6 A;  2CIR A;  4OK2 A;  5KBP A;  2WW2 A;  3QFY A;  3VD4 A;  3T0U A;  1JYX A;  3T0A A;  1O7D D;  1AV4 A;  2BRP A;  4MMH A;  1LVN A;  3DX1 A;  1JYV A;  1C82 A;  1RJO A;  4BZG A;  3W7W A;  1N7O A;  1RKY A;  4DUW A;  2E2U A;  3AFL A;  3W7S A;  3A24 A;  1SPU A;  3W7X A;  2XHN A;  5A1A A;  3VDB A;  1JZ5 A;  3S4B A;  3OB8 A;  1RWG A;  1L7K A;  2CIQ A;  3CZJ A;  1NSV A;  1UI7 A;  4MMI A;  4BTW A;  4BTY A;  4BZH A;  3BVU A;  1N7Q A;  3EJT A;  2C10 A;  1LXM A;  1J0N A;  1DP0 A;  1TXK A;  1PX3 A;  3T2O A;  1SII A;  3WA3 A;  4FNP A;  2CFD A;  3IMH A;  3HI7 A;  2CG1 A;  2E2V A;  3MWX A;  1AVK A;  3MUZ 1;  2WCO A;  3D3I A;  1OJM A;  4DUX A;  3S4D A;  1EGU A;  3BVV A;  1NSM A;  3KII A;  3I3B A;  1NS2 A;  3T09 A;  2X03 A;  3ACT A;  1MMU A;  2XN0 A;  1TQT A;  2CWU A;  2JKA A;  4K35 A;  3AMO B;  2EAE A;  3QFZ A;  1RWH A;  3BUQ A;  1JZ3 A;  1LXK A;  3X41 A;  1UI8 A;  1QAF A;  1QAK A;  3T2Q A;  1HTY A;  1N7R A;  2E2T A;  2XN1 A;  1JZ8 A;  1N7P A;  3K5T A;  2ZL8 A;  3VSM A;  1NS4 A;  2WW0 A;  1LUR A;  3VDA A;  3OS7 A;  2CFG A;  3X42 A;  4FNU A;  4TTG A;  4KFD A;  1JYW A;  1IVV A;  3BVT A;  1OJO A;  1NKG A;  1DYU A;  3DX2 A;  2BT3 A;  1W3Y A;  1NS7 A;  2JKE A;  2WYH A;  2OQE A;  3E1F 1;  2CFK A;  3E7J A;  3K25 A;  1JOV A;  1WMP A;  1QAL A;  1RWA A;  4RNL A;  1NSU A;  3DYP A;  2WDA A;  1W6C A;  1JZ4 A;  1CB8 A;  1MMZ A;  3BUP A;  1EKM A;  2WVZ A;  3I3D A;  3DCD A;  3NJX A;  3RRS A;  3HIG A;  4KTR A;  1D6Y A;  3EJQ A;  4FNV A;  3MUY 1;  1OAC A;  3WFA A;  1W2Z A;  1Z45 A;  2WYI A;  3A0O A;  3D4Z A;  1X1I A;  3X40 A;  4FNQ A;  1HN1 A;  1AVL A;  1LOH A;  1MMY A;  3CZN A;  1D6Z A;  2E24 A;  3LVT A;  1NSZ A;  2HTA A;  1WMO A;  2FYV A;  1HWW A;  2YFO A;  3NJV A;  5CA3 A;  3IAP A;  1PS3 A;  3DDF A;  1HM3 A;  3BVW A;  3BLB A;  1W5Z A;  3BGA A;  3DYM A;  3LOY A;  3EJR A;  2EAB A;  5E1Q A;  3DEC A;  1K1W A;  1L7J A;  1YQ2 A;  3EJP A;  2F1B A;  2PNC A;  3BUB A;  1ULV A;  1N7N A;  3I3E A;  3MV1 1;  2FUQ A;  1W4N A;  1NS0 A;  1W7C A;  1X1J A;  2XSG A;  2F7R A;  1JYN A;  3AMO A;  2EAC A;  1NSR A;  3WIR A;  3W7T A;  4FNR A;  3BVX A;  2OQE C;  3NRE A;  1KSI A;  5GW7 A;  3X3Z A;  1WMN A;  1YGA A;  2BRW A;  2WOF A;  3OBA A;  1IQX A;  2WOH A;  1D6U A;  3X3X A;  2F18 A;  3ACS A;  4FNS A;  2WW1 A;  4FNT A;  2YFN A;  1IQY A;  1TQS A;  3NBB A;  3BS6 A;  4BZE A;  3E80 A;  2W0Q A;  2FUT A;  2OW7 A;  3AFJ A;  1PX4 A;  4EV5 A;  4KFE A;  3BUI A;  2C11 A;  4DUV A;  1HMW A;  1LF9 A;  4J5T A;  1X1H A;  3N9H A;  2HTB A;  2WVX B;  1HMU A;  2CWV A;  1R33 A;  1K1X A;  2BRV X;  2E22 A;  2F7O A;  4OK4 A;  2F7Q A;  2CWT A;  3HII A;  1QWU A;  3MV0 1;  3SX1 A;  1QX1 A;  3MPH A;  2XN2 A;  4KTP A;  2ALW A;  1RW9 A;  1V7W A;  4UFC A;  3DX3 A;  3NBJ A;  2EAD A;  3WA2 X;  3EJS A;  1TQU A;  3D50 A;  3DX4 A;  3KN4 A;  3D51 A;  1F4A A;  1IVU A;  1MMX A;  2WVY A;  1JZ2 A;  2CIS A;  3BLC A;  1JRQ A;  3ALA A;  4BZF A;  1HN0 A;  1PU4 A; 
#chains in the Genus database with same CATH homology
 1O7D D;  1TQV A;  3BUP A;  3DX2 A;  3BVU A;  3BUD A;  2F1B A;  1HTY A;  3BUB A;  1QWN A;  2F7P A;  3DX1 A;  3EJT A;  3EJP A;  3CZN A;  2ALW A;  3CZS A;  4K3A A;  3LVT A;  3BVV A;  3D52 A;  3D4Y A;  3DDG A;  1HXK A;  2F18 A;  3EJQ A;  3DX3 A;  1TQW A;  2WYH A;  2FYV A;  1R33 A;  1HWW A;  3CV5 A;  2F7O A;  1TQS A;  3EJU A;  3EJS A;  1TQU A;  2F7Q A;  1PS3 A;  2F7R A;  3D50 A;  3DDF A;  3DX4 A;  2OW6 A;  1TQT A;  3D51 A;  4K35 A;  1QWU A;  3BVW A;  5KBP A;  2WYI A;  2OW7 A;  3BLB A;  2F1A A;  3DX0 A;  3D4Z A;  3BVX A;  3EJR A;  3BUQ A;  3BUI A;  1QX1 A;  1R34 A;  3BVT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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