1O7DD

The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low ph activation
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
272
structure length
269
Chain Sequence
RDLVIQNEYLRARFDPNTGLLMELENLLLLPVRQAFYWYNASTGNNLSSQASGAYIFRPNQNKPLFVSHWAQTHLVKASLVQEVHQNFSAWCSQVVRLYPRQRHLELEWTVGPIPVGDGWGKEVISRFDTALATRGLFYTDSNGREILERRRNYRPTWKLNQTEPVAGNYYPVNSRIYITDGNMQLTVLTDRSQGGSSLRDGSLELMVHRRLLKDDARGVGEPLNKEGSGLWVRGRHLVLLDKKETAAARHRLQAEMEVLAPQVVLAQG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
pubmed doi rcsb
molecule keywords Lysosomal alpha-mannosidase
molecule tags Hydrolase
total genus 59
structure length 269
sequence length 272
ec nomenclature ec 3.2.1.24: Alpha-mannosidase.
pdb deposition date 2002-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF07748 Glyco_hydro_38C Glycosyl hydrolases family 38 C-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.98.30 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Golgi alpha-mannosidase II; domain 4 1o7dD01
1R33A 3D4YA 3DX1A 2WYHA 2WYIA 3BVVA 2F1BA 3BUQA 3LVTA 3DX4A 2F7PA 2OW6A 3BUPA 1HXKA 3BVUA 3D50A 3BUDA 3D51A 3CZNA 3DDGA 1QX1A 1QWNA 3DX0A 3CZSA 3BUBA 1TQWA 3D4ZA 1O7DD 1TQTA 3DDFA 3EJRA 3BVXA 1HWWA 2F18A 1QWUA 2FYVA 3EJUA 2F7OA 1PS3A 1TQVA 3BUIA 2F7RA 2F1AA 3DX3A 3EJQA 4K3AA 5KBPA 1TQSA 1R34A 4K35A 3EJPA 3BVWA 3EJSA 2ALWA 3DX2A 1TQUA 3BVTA 2OW7A 3EJTA 1HTYA 3BLBA 3CV5A 3D52A 2F7QA
chains in the Genus database with same CATH superfamily
1V7XA 2WYIA 1D6YA 1SO0A 1NKGA 1A2VA 5GW7A 1IVUA 1L7KA 1IVWA 1HM3A 1OJMA 1Z45A 3S4AA 1W6CA 3VD5A 3AFJA 2Y74A 1RWHA 3HI7A 1LF9A 2CWUA 3EJPA 1F4HA 1HN1A 3S4DA 3T2OA 3CV5A 1W4NA 1WMNA 4KFDA 2CIRA 3T2QA 2ZXQA 3WFAA 3VD7A 1JZ6A 3BVVA 2WOFA 2Y73A 3DX0A 1HMWA 3W7TA 2WVYA 2RDYA 3RRSA 1UI7A 3VSNA 1N7NA 2BT3A 1SIIA 3DECA 1TQUA 4KFFA 2CFDA 3LVTA 4OJZA 2OW6A 3DYPA 3D50A 3BUDA 2WOHA 1QX1A 1EGUA 3D4ZA 1RWAA 3DYOA 3S4CA 1NSMA 2WVXA 1W6GA 1W7CA 1TQSA 1RWGA 5JMFA 3BVTA 2C11A 3X41A 1JYXA 3T0AA 1HN0A 2WW2A 2ZL8A 1D6ZA 1MMXA 1IVVA 1PS3A 1J0MA 3IAQA 1JZ5A 2EAEA 1NS4A 1OACA 3SXXA 2F1BA 1D6UA 3MWXA 3DDFA 2F18A 2F7OA 1MMYA 3BUIA 3DX3A 3T0BA 2E2VA 4NEIA 3N9HA 3ECQA 3DX2A 3T09A 1ULVA 2HTBA 1J0NA 2WCOA 3OS7A 3D3IA 2YFOA 2CFLA 2WGQA 3AMOB 4FNQA 3BUBA 2WVZA 1LXMA 1AVLA 2X03A 4FNRA 1YQ2A 1QALA 3HIGA 1PX4A 2CQTA 2F1AA 3WIQA 2ALWA 2Q1FA 1JZ4A 1RKYA 3T2PA 1TU5A 1NS8A 1I8QA 3A0OA 3I3EA 2XN1A 3D51A 3BGAA 2JKAA 1IQYA 4RNLA 1RWFA 4DUXA 3NJVA 2EABA 3IAPA 2CG0A 1X1HA 1TQVA 1NSUA 4K35A 1JYWA 2EADA 1X1JA 1V7VA 2CISA 1C82A 1L7JA 1SNZA 5E1QA 1X1IA 4BZHA 3BUQA 3KIIA 2ZQ0A 3X3XA 2JKPA 3BVUA 4FNPA 2WDAA 1JOVA 2EACA 4UFCA 3SEPA 1NS7A 3BS6A 1OJNA 5CA3A 3ACTA 4FNUA 3WA2X 1JYNA 1US1A 3IMHA 1W5ZA 2F7QA 3E1F1 1MMZA 4DUWA 1EKMA 1K1YA 3WIRA 2E24A 2XN0A 4EV2A 1IQXA 2BRWA 3RSYA 3VDCA 3QFYA 2WVXB 1OJPA 3EJUA 2YX9A 3VD9A 2F7RA 1R34A 3MUZ1 1W2ZA 3BVWA 3WVFA 3NBJA 3VSMA 4EV5A 3VDAA 3D4YA 1HM2A 2WYHA 1H54A 1HXKA 2OQEA 3X40A 3I3DA 3MUY1 1IVXA 4KTPA 3W7UA 2XHNA 1QWUA 2FYVA 2FUTA 1QAKA 1CB8A 3EJTA 2OW7A 3D52A 3OB8A 1JZ7A 1NSRA 1RW9A 2WW1A 2OOVC 4OK4A 1UI8A 1RWCA 1WMPA 2WZSA 3LOYA 3DDGA 3I3BA 1WMOA 3AMOA 1QWNA 4BZFA 1F9GA 3J7HA 3ACSA 3NREA 3T0DA 2OQEC 1OJOA 2JKEA 1N7RA 4BZGA 3W7XA 2XSGA 1HTYA 3BLBA 4KTRA 1DYUA 2CIQA 4J5TA 2CFKA 1K1XA 1AVKA 5JMDA 4AQ0A 1NSXA 3CZSA 4BTYA 3TY1A 4TTGA 1N9EA 2CQSA 1HWWA 1F1SA 1LVNA 3Q1NA 4K3AA 1N7PA 1DP0A 1JYVA 1LOHA 2CFWA 3HIIA 3EJRA 1MMUA 1JZ8A 1R33A 3X42A 4MMIA 3KN4A 1F4AA 2YFNA 2D1WA 1SIHA 3QG0A 4FNVA 1O7DD 1TQTA 4MMHA 1NSZA 1SPUA 1V7WA 1LURA 3NJXA 4KFEA 2E2UA 2XN2A 3EJSA 3T0UA 5A1AA 1W3YA 1HMUA 4FNSA 3E80A 2D73A 3DX4A 2CWTA 4BTXA 1UG9A 1QAFA 2C10A 1PX3A 3BLCA 2WO0A 1KSIA 3QDEA 1K1WA 1NS0A 3AFLA 1JRQA 5KBPA 4DUVA 1RJOA 1YGAA 3MV11 2OOVA 3MI6A 1LF6A 1MN0A 2E2TA 4OK2A 3MPHA 4BZEA 1PU4A 3DCDA 1JZ3A 3T08A 3DYMA 3VD4A 2CWVA 2F7PA 3BUPA 3CZNA 1N7QA 1NSSA 3E7JA 3X3YA 2BRPA 1IU7A 3ALAA 3BVXA 1JZ2A 3A24A 3K25A 3CZJA 2CG1A 3NBBA 2PNCA 3WA3A 2CFGA 3W7WA 2E22A 3K5TA 3DX1A 2WW3A 1NSVA 4BTWA 2BRVX 3MV01 3OBAA 1TQWA 3VD3A 3W7SA 1NS2A 2W0QA 3QFZA 3S4BA 3SX1A 3EJQA 3X3ZA 2HTAA 3VDBA 1LXKA 1AV4A 3PGBA 1N7OA 2FUQA 4FNTA 1TXKA 2WW0A
chains in the Genus database with same CATH topology
1R33A 3D4YA 3DX1A 2WYHA 2WYIA 3BVVA 2F1BA 3BUQA 3LVTA 3DX4A 2F7PA 2OW6A 3BUPA 1HXKA 3BVUA 3D50A 3BUDA 3D51A 3CZNA 3DDGA 1QX1A 1QWNA 3DX0A 3CZSA 3BUBA 1TQWA 3D4ZA 1O7DD 1TQTA 3DDFA 3EJRA 3BVXA 1HWWA 2F18A 1QWUA 2FYVA 3EJUA 2F7OA 1PS3A 1TQVA 3BUIA 2F7RA 2F1AA 3DX3A 3EJQA 4K3AA 5KBPA 1TQSA 1R34A 4K35A 3EJPA 3BVWA 3EJSA 2ALWA 3DX2A 1TQUA 3BVTA 2OW7A 3EJTA 1HTYA 3BLBA 3CV5A 3D52A 2F7QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1R33 A;  3D4Y A;  3DX1 A;  2WYH A;  2WYI A;  3BVV A;  2F1B A;  3BUQ A;  3LVT A;  3DX4 A;  2F7P A;  2OW6 A;  3BUP A;  1HXK A;  3BVU A;  3D50 A;  3BUD A;  3D51 A;  3CZN A;  3DDG A;  1QX1 A;  1QWN A;  3DX0 A;  3CZS A;  3BUB A;  1TQW A;  3D4Z A;  1O7D D;  1TQT A;  3DDF A;  3EJR A;  3BVX A;  1HWW A;  2F18 A;  1QWU A;  2FYV A;  3EJU A;  2F7O A;  1PS3 A;  1TQV A;  3BUI A;  2F7R A;  2F1A A;  3DX3 A;  3EJQ A;  4K3A A;  5KBP A;  1TQS A;  1R34 A;  4K35 A;  3EJP A;  3BVW A;  3EJS A;  2ALW A;  3DX2 A;  1TQU A;  3BVT A;  2OW7 A;  3EJT A;  1HTY A;  3BLB A;  3CV5 A;  3D52 A;  2F7Q A; 
#chains in the Genus database with same CATH topology
 1V7X A;  2WYI A;  1D6Y A;  1SO0 A;  1NKG A;  1A2V A;  5GW7 A;  1IVU A;  1L7K A;  1IVW A;  1HM3 A;  1OJM A;  1Z45 A;  3S4A A;  1W6C A;  3VD5 A;  3AFJ A;  2Y74 A;  1RWH A;  3HI7 A;  1LF9 A;  2CWU A;  3EJP A;  1F4H A;  1HN1 A;  3S4D A;  3T2O A;  3CV5 A;  1W4N A;  1WMN A;  4KFD A;  2CIR A;  3T2Q A;  2ZXQ A;  3WFA A;  3VD7 A;  1JZ6 A;  3BVV A;  2WOF A;  2Y73 A;  3DX0 A;  1HMW A;  3W7T A;  2WVY A;  2RDY A;  3RRS A;  1UI7 A;  3VSN A;  1N7N A;  2BT3 A;  1SII A;  3DEC A;  1TQU A;  4KFF A;  2CFD A;  3LVT A;  4OJZ A;  2OW6 A;  3DYP A;  3D50 A;  3BUD A;  2WOH A;  1QX1 A;  1EGU A;  3D4Z A;  1RWA A;  3DYO A;  3S4C A;  1NSM A;  2WVX A;  1W6G A;  1W7C A;  1TQS A;  1RWG A;  5JMF A;  3BVT A;  2C11 A;  3X41 A;  1JYX A;  3T0A A;  1HN0 A;  2WW2 A;  2ZL8 A;  1D6Z A;  1MMX A;  1IVV A;  1PS3 A;  1J0M A;  3IAQ A;  1JZ5 A;  2EAE A;  1NS4 A;  1OAC A;  3SXX A;  2F1B A;  1D6U A;  3MWX A;  3DDF A;  2F18 A;  2F7O A;  1MMY A;  3BUI A;  3DX3 A;  3T0B A;  2E2V A;  4NEI A;  3N9H A;  3ECQ A;  3DX2 A;  3T09 A;  1ULV A;  2HTB A;  1J0N A;  2WCO A;  3OS7 A;  3D3I A;  2YFO A;  2CFL A;  2WGQ A;  3AMO B;  4FNQ A;  3BUB A;  2WVZ A;  1LXM A;  1AVL A;  2X03 A;  4FNR A;  1YQ2 A;  1QAL A;  3HIG A;  1PX4 A;  2CQT A;  2F1A A;  3WIQ A;  2ALW A;  2Q1F A;  1JZ4 A;  1RKY A;  3T2P A;  1TU5 A;  1NS8 A;  1I8Q A;  3A0O A;  3I3E A;  2XN1 A;  3D51 A;  3BGA A;  2JKA A;  1IQY A;  4RNL A;  1RWF A;  4DUX A;  3NJV A;  2EAB A;  3IAP A;  2CG0 A;  1X1H A;  1TQV A;  1NSU A;  4K35 A;  1JYW A;  2EAD A;  1X1J A;  1V7V A;  2CIS A;  1C82 A;  1L7J A;  1SNZ A;  5E1Q A;  1X1I A;  4BZH A;  3BUQ A;  3KII A;  2ZQ0 A;  3X3X A;  2JKP A;  3BVU A;  4FNP A;  2WDA A;  1JOV A;  2EAC A;  4UFC A;  3SEP A;  1NS7 A;  3BS6 A;  1OJN A;  5CA3 A;  3ACT A;  4FNU A;  3WA2 X;  1JYN A;  1US1 A;  3IMH A;  1W5Z A;  2F7Q A;  3E1F 1;  1MMZ A;  4DUW A;  1EKM A;  1K1Y A;  3WIR A;  2E24 A;  2XN0 A;  4EV2 A;  1IQX A;  2BRW A;  3RSY A;  3VDC A;  3QFY A;  2WVX B;  1OJP A;  3EJU A;  2YX9 A;  3VD9 A;  2F7R A;  1R34 A;  3MUZ 1;  1W2Z A;  3BVW A;  3WVF A;  3NBJ A;  3VSM A;  4EV5 A;  3VDA A;  3D4Y A;  1HM2 A;  2WYH A;  1H54 A;  1HXK A;  2OQE A;  3X40 A;  3I3D A;  3MUY 1;  1IVX A;  4KTP A;  3W7U A;  2XHN A;  1QWU A;  2FYV A;  2FUT A;  1QAK A;  1CB8 A;  3EJT A;  2OW7 A;  3D52 A;  3OB8 A;  1JZ7 A;  1NSR A;  1RW9 A;  2WW1 A;  2OOV C;  4OK4 A;  1UI8 A;  1RWC A;  1WMP A;  2WZS A;  3LOY A;  3DDG A;  3I3B A;  1WMO A;  3AMO A;  1QWN A;  4BZF A;  1F9G A;  3J7H A;  3ACS A;  3NRE A;  3T0D A;  2OQE C;  1OJO A;  2JKE A;  1N7R A;  4BZG A;  3W7X A;  2XSG A;  1HTY A;  3BLB A;  4KTR A;  1DYU A;  2CIQ A;  4J5T A;  2CFK A;  1K1X A;  1AVK A;  5JMD A;  4AQ0 A;  1NSX A;  3CZS A;  4BTY A;  3TY1 A;  4TTG A;  1N9E A;  2CQS A;  1HWW A;  1F1S A;  1LVN A;  3Q1N A;  4K3A A;  1N7P A;  1DP0 A;  1JYV A;  1LOH A;  2CFW A;  3HII A;  3EJR A;  1MMU A;  1JZ8 A;  1R33 A;  3X42 A;  4MMI A;  3KN4 A;  1F4A A;  2YFN A;  2D1W A;  1SIH A;  3QG0 A;  4FNV A;  1O7D D;  1TQT A;  4MMH A;  1NSZ A;  1SPU A;  1V7W A;  1LUR A;  3NJX A;  4KFE A;  2E2U A;  2XN2 A;  3EJS A;  3T0U A;  5A1A A;  1W3Y A;  1HMU A;  4FNS A;  3E80 A;  2D73 A;  3DX4 A;  2CWT A;  4BTX A;  1UG9 A;  1QAF A;  2C10 A;  1PX3 A;  3BLC A;  2WO0 A;  1KSI A;  3QDE A;  1K1W A;  1NS0 A;  3AFL A;  1JRQ A;  5KBP A;  4DUV A;  1RJO A;  1YGA A;  3MV1 1;  2OOV A;  3MI6 A;  1LF6 A;  1MN0 A;  2E2T A;  4OK2 A;  3MPH A;  4BZE A;  1PU4 A;  3DCD A;  1JZ3 A;  3T08 A;  3DYM A;  3VD4 A;  2CWV A;  2F7P A;  3BUP A;  3CZN A;  1N7Q A;  1NSS A;  3E7J A;  3X3Y A;  2BRP A;  1IU7 A;  3ALA A;  3BVX A;  1JZ2 A;  3A24 A;  3K25 A;  3CZJ A;  2CG1 A;  3NBB A;  2PNC A;  3WA3 A;  2CFG A;  3W7W A;  2E22 A;  3K5T A;  3DX1 A;  2WW3 A;  1NSV A;  4BTW A;  2BRV X;  3MV0 1;  3OBA A;  1TQW A;  3VD3 A;  3W7S A;  1NS2 A;  2W0Q A;  3QFZ A;  3S4B A;  3SX1 A;  3EJQ A;  3X3Z A;  2HTA A;  3VDB A;  1LXK A;  1AV4 A;  3PGB A;  1N7O A;  2FUQ A;  4FNT A;  1TXK A;  2WW0 A; 
#chains in the Genus database with same CATH homology
 1R33 A;  3D4Y A;  3DX1 A;  2WYH A;  2WYI A;  3BVV A;  2F1B A;  3BUQ A;  3LVT A;  3DX4 A;  2F7P A;  2OW6 A;  3BUP A;  1HXK A;  3BVU A;  3D50 A;  3BUD A;  3D51 A;  3CZN A;  3DDG A;  1QX1 A;  1QWN A;  3DX0 A;  3CZS A;  3BUB A;  1TQW A;  3D4Z A;  1O7D D;  1TQT A;  3DDF A;  3EJR A;  3BVX A;  1HWW A;  2F18 A;  1QWU A;  2FYV A;  3EJU A;  2F7O A;  1PS3 A;  1TQV A;  3BUI A;  2F7R A;  2F1A A;  3DX3 A;  3EJQ A;  4K3A A;  5KBP A;  1TQS A;  1R34 A;  4K35 A;  3EJP A;  3BVW A;  3EJS A;  2ALW A;  3DX2 A;  1TQU A;  3BVT A;  2OW7 A;  3EJT A;  1HTY A;  3BLB A;  3CV5 A;  3D52 A;  2F7Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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