1HM3A

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 245
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
245
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords CHONDROITINASE AC
publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
molecule tags Lyase
total genus 245
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hm3A01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hm3A03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hm3A02
1NSZA 3DYPA 3NJXA 3E80A 2BRVX 1N7RA 3VD3A 1JZ4A 3VDCA 2WMJA 2JKEA 1X1JA 4OZWA 2E24A 3T2QA 3K25A 2WW3A 1EGUA 2WMIB 1HM3A 2WVYA 3T0BA 4DUVA 2JKPA 3A0OA 2FUTA 1K1WA 4OZVA 1C82A 4OK2A 4FNVA 1F9GA 1OJOA 4D6JA 3IAQA 1F1SA 3NJVA 2X03A 1ULVA 1NSSA 2JKAA 1JYNA 4D6FA 2D73A 1F4AA 2CIQA 3IMHA 3MUY1 4MMHA 2WW1A 2CISA 1LXKA 3VDBA 1MMUA 3VDAA 4BZHA 1OJMA 1MMYA 1JYXA 2FUQA 1JZ3A 2WZSA 1JZ6A 1SO0A 2HTBA 1NSRA 1N7PA 5A1AA 1X1HA 3NNBA 1RWAA 1K1YA 1J0NA 2BRPA 4D6EA 1JYVA 3A24A 2WW2A 2HTAA 3OS7A 4OJZA 1NS8A 1NKGA 3NFVA 3VD5A 2WVZA 1N7QA 1JYWA 2XHNA 2XSGA 3OB8A 3VD4A 2WMGA 1JOVA 4MMIA 1HMUA 4F13A 1I8QA 3I3DA 1YGAA 1W3YA 1N7OA 3VSNA 4D6IA 1RW9A 1MMZA 3T2OA 1HN1A 4DUXA 1HMWA 1PX3A 3MUZ1 4D6HA 3VSMA 3VD9A 3T2PA 1NS7A 4E1YA 4AQ0A 4NEIA 3VD7A 1OJNA 4BZFA 2WMHA 4D6GA 1K1XA 4D72A 3DECA 2ZQ0A 1HN0A 1N7NA 3DYOA 1L7JA 3T08A 2E22A 3MV01 4RNLA 3DCDA 2WCOA 3Q1NA 3SEPA 3E1F1 3NREA 1YQ2A 1PX4A 2WW0A 1OJPA 5E1QA 4BZGA 1LF6A 3BGAA 1RWGA 1LXMA 1NS2A 1F4HA 1NS4A 1X1IA 4D71A 5JMDA 1TXKA 1JZ2A 4DUWA 1JZ5A 4OK4A 2CIRA 1MN0A 3T0AA 1RWCA 2WMIA 1LURA 3I3BA 3OBAA 3E7JA 4D6CA 1RWFA 1JZ7A 2WVXA 1QAZA 1NS0A 1JZ8A 2Q1FA 1L7KA 3MV11 3T0DA 4TTGA 1LF9A 1SNZA 1Z45A 1CB8A 1HV6A 1LOHA 1RWHA 2WDAA 1NSUA 2WVXB 1UG9A 3CZJA 5JMFA 3DYMA 4F10A 4D6DA 3ECQA 2BRWA 2WMKA 3IAPA 3T09A 2ZXQA 4BZEA 1NSXA 1J0MA 1NSMA 3I3EA 3AFLA 2WMFA 3MWXA 1NSVA 1HM2A 3WFAA 1MMXA 1DP0A 3J7HA
chains in the Genus database with same CATH superfamily
3P5RA 2BRVX 2GH4A 5EASA 1NL4B 2WMJA 3VDCA 1CLCA 2P0VA 4GTPB 3T2QA 3DSUB 2YIKA 1FBWA 2WGQA 2XQWA 2WW3A 5ILZA 4DUVA 1O1SB 3T0BA 1QBQB 2SQCA 2JKPA 1FCEA 3DSVB 4GTQB 1V5CA 3S4DA 1K72A 3RX7A 1W6CA 1OJOA 3IAQA 4FNPA 4YCRA 3QT9A 3DSSB 3ANJA 1L2AA 2JKAA 1G6IA 1UI7A 3GT5A 3MUY1 1D6UA 2V3PA 4LNGB 3QSPA 1QAKA 3X42A 1LXKA 4AYPA 4CJ1A 2ZL8A 3Q79B 1MMUA 1IS9A 3D4ZA 1KFGA 2EACA 4FNSA 4BZHA 3M7BA 1N20A 4KTPA 1JZ3A 1SO0A 2ZISB 3SQCA 3NBBA 4M76A 3W7XA 2BRPA 2WINB 5ILKA 1N23A 1SA4B 2HTAA 1GXMA 4Q88A 3NFVA 2WVZA 1QWNA 2ZBLA 1D6ZA 3A3VA 2CFGA 3WIRA 1JYWA 2XHNA 3OB8A 1IA7A 4D4DA 3UD2A 1JOVA 4GTOB 4RNQA 1CEMA 1I8QA 2EADA 4EL8A 1RQ5A 3M02A 5FO7B 1QSJA 4ZH5A 1MMZA 1IA6A 5ILDA 2B39A 3DSXB 3M74A 3BLBA 3TY1A 4K35A 1TNZB 3N0GA 2G02A 3PMMA 4FUSA 3T2PA 2DRQA 3EUVB 3KSLB 2YFOA 3M01A 3EJRA 1OJNA 4D72A 1JS4A 2F6DA 2E22A 3QR8A 4KTRA 4RNLA 5EAUA 1D8EB 3M7EA 3C72B 3M75A 4YDEB 3NREA 3E37B 1KZPB 3G4DA 4GTMB 4ONTA 4FXGB 4C1SA 5E1QA 3SDQA 2RI9A 3AMOB 1TXKA 4WVAA 4FJQA 3SDTA 3Q75B 1V5DA 2WMIA 1R33A 3X3XA 1H12A 4D1JA 1FPPB 1EKMA 1GAHA 1NC5A 2XN1A 1V7XA 3K7XA 1JZ8A 4L0GA 2OQEC 3HXBB 1LF9A 1SNZA 1CB8A 2XWBB 1H14A 1O6QA 1F9DA 1TQUA 3ECQA 3BS6A 1XWQA 3VXDA 2H6FB 2BEDB 1H37A 3QT3A 1NSXA 4D94A 1J0MA 4FXKB 3VW5A 2ONGA 1N4RB 3W7WA 1TQTA 4CJ0A 3MWXA 4UFCA 4GL3A 3N0FA 3CIHA 3E80A 3SAEA 1IU7A 3SXXA 1W6GA 1W5ZA 3ALAA 4OZWA 2FYVA 3PZ2B 5M7IA 1KZOB 2F7PA 3MPHA 3WVFA 3HIGA 4J5TA 4WVCA 3RJ3A 2WVYA 2NOJA 2FUTA 5IL8A 1TNYB 3ACTA 3WKHA 1F9GA 5M7YA 2GZ6A 4D4CA 1N4PB 1ULVA 2AHFA 4D6FA 2IEJB 4TF4A 1IVWA 4MMHA 1H13A 2ZIRB 4QT9A 4AYQA 2WW1A 4BTWA 3PYBA 1W6JA 3VDAA 1D8DB 2I07B 2OOVA 4XUVA 4L6XA 1JYXA 3W5MA 2WOFA 3D52A 2BBCA 3EJQA 1GSZA 3DSWB 1JZ6A 3M77A 1N7PA 4WVBA 1X1HA 3NNBA 1K1YA 5A1AA 5ILIA 1H3BA 3A24A 1AYXA 4AYRA 4DODA 4OJZA 1QQFA 1NS8A 3M72A 1XWTA 3RSYA 1H54A 3BLCA 3QXFA 1N1ZA 2XSGA 1TF4A 4MMIA 1IQXA 1DYUA 5ILJA 5GW7A 3VSNA 3GZKA 1FMIA 1HN1A 3ANIA 1HMWA 3WIQA 2R2LB 3KQ4A 2BT3A 1HX9A 2FV0A 3M71A 4DLOA 1NS7A 2D1WA 3KIIA 3WC3A 4EV2A 4D1IA 4LNVA 3CV5A 1KSCA 1LVNA 1HXAA 4BOJA 2KXSA 3VD7A 2CQSA 5IM1A 2WMHA 3NBJA 2C10A 2PNCA 4Z4LA 1N7NA 4GTSB 1O1TB 2F0YB 3DYOA 4JJJA 3ANKA 3T08A 4MU9A 3DCDA 2RGKA 3X41A 1YQ2A 2D8LA 1PX4A 2YFNA 3DX3A 5IK6A 2B4FA 3X3ZA 3BVUA 2H6HB 3X17A 1LF6A 4ZG8A 1KSDA 1SIHA 1NS2A 1LD7B 3BUIA 2J5CA 1NS4A 2DRSA 5IKHA 1UMPA 3S4AA 4DUWA 1JZ5A 2CFKA 4OK4A 4GTTB 2CIRA 1MN0A 4K3AA 1GAIA 2CWVA 1PU4A 2G0DA 3PYAA 3M73A 1JCQB 3RENA 3OBAA 1L1YA 1DCEB 4L9PB 4LIXA 2A73B 1QAZA 3Q7FB 5AGDA 2WVXA 2Q1FA 1JZ7A 3CZSA 3LOYA 3T0DA 2CQTA 1Z45A 2WDAA 3WA2X 1NSUA 1UG9A 5JMFA 3DYMA 3PGBA 2W0QA 3DX1A 1GA2A 1TU5A 3EU8A 3Q78B 1QAFA 1AVLA 2XN2A 1NSMA 3E73A 3LZ9A 3QPFA 2WMFA 1HM2A 3RX5A 2EABA 1V7WA 4LNBB 1C3DA 1N4SB 3EU5B 1F9OA 4ZRQA 2FV1A 3VD3A 2PMVA 1JZ4A 1NXCA 1AVKA 2CWUA 1X1JA 1N9AB 4EHMB 2E24A 1PS3A 1W6KA 3M7LA 2ALWA 1EGUA 3Q7AB 3WKGA 4KFFA 3A0OA 1KRFA 3ON6A 3D50A 4OZVA 5C05A 2F7QA 4FNUA 4D6JA 3HXDB 2V8IA 3SX1A 3PZ1B 1XW2A 1G9GA 1HWWA 4KFEA 1JYNA 3M76A 2JG0A 2WY8A 5IK0A 2NVPA 1AV4A 1TQWA 2D73A 2Y73A 2CIQA 3DX0A 3MI6A 1KREA 3H7LA 5FO9B 3BUPA 2A8ZA 3N9HA 4DI5A 4DOEA 1W2ZA 3KBTC 2BB5A 4KKIA 3AFJA 2PN5A 3OXUA 5DHIA 1SPUA 2FUQA 3S4BA 4BTYA 4FNQA 2HTBA 3GLYA 4D4BA 3D5SA 4FNTA 3Q73B 3QG0A 4D6EA 1JYVA 3QXQA 3S4CA 2WYHA 3DSTB 2F18A 4YDOB 1N1BA 2WW2A 3OS7A 3QDEA 1NKGA 1H35A 1S63B 2XWJB 4EV5A 1G9JA 1N7QA 4BOKA 1SIIA 3T33A 1KKTA 4Q2BA 2WMGA 2RDYA 1HMUA 3T0UA 5ILHA 3I3DA 3HXCB 2OKXA 1H3CA 5E2JA 1O79A 5GY3A 3WA3A 1MZCB 4GTRB 3T2OA 3QFYA 2CFLA 1PX3A 3W7UA 3E33B 1O6HA 3VSMA 3DDGA 3VD9A 1O6RA 2CG1A 1WU4A 1N94B 4E1YA 1HTYA 3HXFB 4AQ0A 2VN7A 1NI1B 1HN0A 3P2CA 1R34A 5CD2A 1L7JA 3M7CA 1RKYA 1WMNA 2C11A 3KN4A 3SEPA 1LD8B 3SDRA 3Q1NA 2GOXA 3E1F1 3X40A 1OACA 2V8JA 2ONHA 2CFDA 1SA5B 1OJPA 3QWTA 1VD5A 3EJUA 2WYNA 2WIIB 4BZGA 5IK9A 1RWGA 3WUXA 1F4HA 4KFDA 4D71A 1JZ2A 2H6GB 1TQVA 3BVTA 1N4QB 3KSQB 1QWUA 2Y74A 3RX8A 1RWCA 1LURA 2WY7A 1DOGA 1V7VA 2DROA 1N22A 5CA3A 1H36A 3E7JA 3PZ4B 5DHKA 4GTVB 1S64B 3SDVA 2AFAA 3M78A 1L7KA 3MV11 1N95B 3S9VA 2WVXB 3NJXA 1FP3A 4MBGB 4F10A 5IL3A 4D6DA 3DX2A 2BRWA 2WMKA 4BZEA 1IQYA 1O5MB 2AHGA 3RRSA 3BVXA 1W4NA 1WU6A 1D6YA 2CWTA 2OOVC 1DP0A 2WYIA 1GLMA 3UD1A 3SFYB 1NSZA 3DYPA 4BTXA 1QALA 1FBOA 1N7RA 5JPNB 1TNBB 3BUQA 2JKEA 2FUZA 4CE7A 4TXTA 3E30B 3EJPA 3EJTA 3M00A 3HXEB 1O7DD 3K25A 3QFZA 1FO2A 4V1RA 2WMIB 1HM3A 2KXRA 1TQSA 1W7CA 1K1WA 1C82A 4FNVA 4OK2A 2OW7A 1JCRB 3NJVA 1F1SA 4Z4JA 1TN8B 2X03A 2OQEA 3EZ8A 2CFWA 4WU0A 1NSSA 3CU7A 5KBPA 4DLQA 3IMHA 1F4AA 3E6UA 1N9EA 1DL2A 2JJBA 1N24A 2VN4A 2CISA 5CZLA 3VDBA 1GXOA 2OW6A 5JPMB 3EJSA 1OJMA 4ZH1A 1MMYA 1FT2B 1R76A 4D4AA 2WZSA 2F7RA 3BUDA 3WIWA 1NSRA 3P5PA 3PQIA 4ZRPA 1RWAA 1J0NA 3E34B 3K5TA 1TNUB 5ILYA 2F1BA 3W7SA 3HIIA 1GHQA 3TF4A 3VD5A 3DRAB 1KSIA 2Z07A 3G4FA 1FT1B 1KS8A 1WMOA 1LTXB 1GXNA 3VD4A 2ZZRA 3D3IA 2E2VA 2EAEA 4F13A 3WKIA 1YGAA 3BVWA 1W3YA 1N7OA 1IVXA 1TNOB 1G87A 4D6IA 1RW9A 4DUXA 1H3AA 5FOBB 3MUZ1 1JRQA 1FAEA 3WKFA 3OEDA 4D6HA 3DPYB 5DGRA 2BB6A 3H2WA 1FO3A 1A2VA 3SFXB 2XFGA 2V3NA 3F59A 1UI8A 2FBAA 4NEIA 5DGQA 1IVVA 4BZFA 2D5JA 1AGMA 4D6GA 4FNRA 1K1XA 1WZZA 1HZFA 1HXCA 2ZQ0A 1KWFA 3DECA 5MEHA 1TN6B 1US1A 3D4YA 3W7TA 2YX9A 3BVVA 2H6IB 4GAXA 1IVUA 1WMPA 3MV01 5IKAA 2WCOA 5GZKA 2JF4A 4AYOA 3BUBA 2WO0A 1O1RB 3AMOA 2WW0A 3DDFA 3J7HA 2F1AA 2QNOA 3X3YA 3KBUC 3BGAA 1JCSB 1LXMA 5EATA 1X1IA 1UT9A 2V8KA 5JMDA 3CZNA 2F7OA 3HI7A 3H3KA 4D8OA 3K11A 1X81B 1N21A 3LVTA 3T0AA 5FO8B 1HCUA 3KLSA 3I3BA 3DX4A 4D6CA 1RWFA 2DRRA 1NS0A 1WU5A 4KKJA 3E32B 1RJOA 2RI8A 3PZ3B 4TTGA 3QRYA 1HV6A 1LOHA 1RWHA 3SDUA 3CZJA 2WOHA 1QX1A 1SQCA 5KKBA 3ACSA 2ZXQA 3IAPA 3T09A 1X9DA 3I3EA 1H39A 3AFLA 1HXKA 3D5RA 3EQAA 4V1SA 3W5NA 2CG0A 2E2UA 1NSVA 2E2TA 1TN7B 3G6JB 3U7VA 1MMXA 2XN0A 3D51A 3WFAA 1HXGA
chains in the Genus database with same CATH topology
1NSZA 3DYPA 3NJXA 3E80A 2BRVX 1N7RA 3VD3A 1JZ4A 3VDCA 2WMJA 2JKEA 1X1JA 4OZWA 2E24A 3T2QA 3K25A 3WVFA 2WW3A 1EGUA 2WMIB 1HM3A 2WVYA 4J5TA 3T0BA 2JKPA 4DUVA 3A0OA 2FUTA 1K1WA 4OZVA 1C82A 4OK2A 4FNVA 1F9GA 1OJOA 4D6JA 3IAQA 1F1SA 3NJVA 2X03A 1ULVA 1NSSA 2JKAA 1JYNA 4D6FA 2D73A 1F4AA 2CIQA 3IMHA 3MUY1 4MMHA 2WW1A 2CISA 1LXKA 3VDBA 1MMUA 3VDAA 4BZHA 1OJMA 1MMYA 1JYXA 2FUQA 1JZ3A 2WZSA 1JZ6A 1SO0A 2HTBA 1NSRA 1N7PA 5A1AA 1X1HA 3NNBA 1RWAA 1K1YA 1J0NA 2BRPA 4D6EA 1JYVA 3A24A 2WW2A 2HTAA 3OS7A 4OJZA 1NS8A 1NKGA 3NFVA 3VD5A 2WVZA 1N7QA 3BLCA 1JYWA 2XHNA 2XSGA 3OB8A 3VD4A 2WMGA 1JOVA 4MMIA 1HMUA 4F13A 1I8QA 3I3DA 1YGAA 1W3YA 1N7OA 3VSNA 4D6IA 1RW9A 1MMZA 3T2OA 1HN1A 4DUXA 1HMWA 1PX3A 3MUZ1 3TY1A 4D6HA 3VSMA 3VD9A 3T2PA 1NS7A 4E1YA 4AQ0A 4NEIA 3VD7A 1OJNA 4BZFA 2WMHA 4D6GA 1K1XA 4D72A 3DECA 2ZQ0A 1HN0A 1N7NA 3DYOA 1L7JA 3T08A 2E22A 3MV01 4RNLA 3DCDA 2WCOA 3Q1NA 3SEPA 3E1F1 3NREA 1YQ2A 1PX4A 2WW0A 1OJPA 5E1QA 4BZGA 1LF6A 3BGAA 1RWGA 1LXMA 1NS2A 1F4HA 1NS4A 1X1IA 4D71A 5JMDA 1TXKA 1JZ2A 4DUWA 1JZ5A 4OK4A 2CIRA 1MN0A 3T0AA 1RWCA 2WMIA 1LURA 3I3BA 3OBAA 3E7JA 4D6CA 1RWFA 1JZ7A 2WVXA 1QAZA 1NS0A 1JZ8A 2Q1FA 1L7KA 3MV11 3T0DA 4TTGA 1LF9A 1SNZA 1Z45A 1CB8A 1HV6A 1LOHA 1RWHA 2WDAA 1NSUA 2WVXB 1UG9A 3CZJA 5JMFA 3DYMA 4F10A 4D6DA 3ECQA 3BS6A 2BRWA 2WMKA 3IAPA 3T09A 2ZXQA 4BZEA 1NSXA 1J0MA 1NSMA 3I3EA 3AFLA 2WMFA 3MWXA 1NSVA 1HM2A 3WFAA 1MMXA 1DP0A 3J7HA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NSZ A;  3DYP A;  3NJX A;  3E80 A;  2BRV X;  1N7R A;  3VD3 A;  1JZ4 A;  3VDC A;  2WMJ A;  2JKE A;  1X1J A;  4OZW A;  2E24 A;  3T2Q A;  3K25 A;  2WW3 A;  1EGU A;  2WMI B;  1HM3 A;  2WVY A;  3T0B A;  4DUV A;  2JKP A;  3A0O A;  2FUT A;  1K1W A;  4OZV A;  1C82 A;  4OK2 A;  4FNV A;  1F9G A;  1OJO A;  4D6J A;  3IAQ A;  1F1S A;  3NJV A;  2X03 A;  1ULV A;  1NSS A;  2JKA A;  1JYN A;  4D6F A;  2D73 A;  1F4A A;  2CIQ A;  3IMH A;  3MUY 1;  4MMH A;  2WW1 A;  2CIS A;  1LXK A;  3VDB A;  1MMU A;  3VDA A;  4BZH A;  1OJM A;  1MMY A;  1JYX A;  2FUQ A;  1JZ3 A;  2WZS A;  1JZ6 A;  1SO0 A;  2HTB A;  1NSR A;  1N7P A;  5A1A A;  1X1H A;  3NNB A;  1RWA A;  1K1Y A;  1J0N A;  2BRP A;  4D6E A;  1JYV A;  3A24 A;  2WW2 A;  2HTA A;  3OS7 A;  4OJZ A;  1NS8 A;  1NKG A;  3NFV A;  3VD5 A;  2WVZ A;  1N7Q A;  1JYW A;  2XHN A;  2XSG A;  3OB8 A;  3VD4 A;  2WMG A;  1JOV A;  4MMI A;  1HMU A;  4F13 A;  1I8Q A;  3I3D A;  1YGA A;  1W3Y A;  1N7O A;  3VSN A;  4D6I A;  1RW9 A;  1MMZ A;  3T2O A;  1HN1 A;  4DUX A;  1HMW A;  1PX3 A;  3MUZ 1;  4D6H A;  3VSM A;  3VD9 A;  3T2P A;  1NS7 A;  4E1Y A;  4AQ0 A;  4NEI A;  3VD7 A;  1OJN A;  4BZF A;  2WMH A;  4D6G A;  1K1X A;  4D72 A;  3DEC A;  2ZQ0 A;  1HN0 A;  1N7N A;  3DYO A;  1L7J A;  3T08 A;  2E22 A;  3MV0 1;  4RNL A;  3DCD A;  2WCO A;  3Q1N A;  3SEP A;  3E1F 1;  3NRE A;  1YQ2 A;  1PX4 A;  2WW0 A;  1OJP A;  5E1Q A;  4BZG A;  1LF6 A;  3BGA A;  1RWG A;  1LXM A;  1NS2 A;  1F4H A;  1NS4 A;  1X1I A;  4D71 A;  5JMD A;  1TXK A;  1JZ2 A;  4DUW A;  1JZ5 A;  4OK4 A;  2CIR A;  1MN0 A;  3T0A A;  1RWC A;  2WMI A;  1LUR A;  3I3B A;  3OBA A;  3E7J A;  4D6C A;  1RWF A;  1JZ7 A;  2WVX A;  1QAZ A;  1NS0 A;  1JZ8 A;  2Q1F A;  1L7K A;  3MV1 1;  3T0D A;  4TTG A;  1LF9 A;  1SNZ A;  1Z45 A;  1CB8 A;  1HV6 A;  1LOH A;  1RWH A;  2WDA A;  1NSU A;  2WVX B;  1UG9 A;  3CZJ A;  5JMF A;  3DYM A;  4F10 A;  4D6D A;  3ECQ A;  2BRW A;  2WMK A;  3IAP A;  3T09 A;  2ZXQ A;  4BZE A;  1NSX A;  1J0M A;  1NSM A;  3I3E A;  3AFL A;  2WMF A;  3MWX A;  1NSV A;  1HM2 A;  3WFA A;  1MMX A;  1DP0 A;  3J7H A; 
#chains in the Genus database with same CATH topology
 3P5R A;  2BRV X;  2GH4 A;  5EAS A;  1NL4 B;  2WMJ A;  3VDC A;  1CLC A;  2P0V A;  4GTP B;  3T2Q A;  3DSU B;  2YIK A;  1FBW A;  2WGQ A;  2XQW A;  2WW3 A;  5ILZ A;  4DUV A;  1O1S B;  3T0B A;  1QBQ B;  2SQC A;  2JKP A;  1FCE A;  3DSV B;  4GTQ B;  1V5C A;  3S4D A;  1K72 A;  3RX7 A;  1W6C A;  1OJO A;  3IAQ A;  4FNP A;  4YCR A;  3QT9 A;  3DSS B;  3ANJ A;  1L2A A;  2JKA A;  1G6I A;  1UI7 A;  3GT5 A;  3MUY 1;  1D6U A;  2V3P A;  4LNG B;  3QSP A;  1QAK A;  3X42 A;  1LXK A;  4AYP A;  4CJ1 A;  2ZL8 A;  3Q79 B;  1MMU A;  1IS9 A;  3D4Z A;  1KFG A;  2EAC A;  4FNS A;  4BZH A;  3M7B A;  1N20 A;  4KTP A;  1JZ3 A;  1SO0 A;  2ZIS B;  3SQC A;  3NBB A;  4M76 A;  3W7X A;  2BRP A;  2WIN B;  5ILK A;  1N23 A;  1SA4 B;  2HTA A;  1GXM A;  4Q88 A;  3NFV A;  2WVZ A;  1QWN A;  2ZBL A;  1D6Z A;  3A3V A;  2CFG A;  3WIR A;  1JYW A;  2XHN A;  3OB8 A;  1IA7 A;  4D4D A;  3UD2 A;  1JOV A;  4GTO B;  4RNQ A;  1CEM A;  1I8Q A;  2EAD A;  4EL8 A;  1RQ5 A;  3M02 A;  5FO7 B;  1QSJ A;  4ZH5 A;  1MMZ A;  1IA6 A;  5ILD A;  2B39 A;  3DSX B;  3M74 A;  3BLB A;  3TY1 A;  4K35 A;  1TNZ B;  3N0G A;  2G02 A;  3PMM A;  4FUS A;  3T2P A;  2DRQ A;  3EUV B;  3KSL B;  2YFO A;  3M01 A;  3EJR A;  1OJN A;  4D72 A;  1JS4 A;  2F6D A;  2E22 A;  3QR8 A;  4KTR A;  4RNL A;  5EAU A;  1D8E B;  3M7E A;  3C72 B;  3M75 A;  4YDE B;  3NRE A;  3E37 B;  1KZP B;  3G4D A;  4GTM B;  4ONT A;  4FXG B;  4C1S A;  5E1Q A;  3SDQ A;  2RI9 A;  3AMO B;  1TXK A;  4WVA A;  4FJQ A;  3SDT A;  3Q75 B;  1V5D A;  2WMI A;  1R33 A;  3X3X A;  1H12 A;  4D1J A;  1FPP B;  1EKM A;  1GAH A;  1NC5 A;  2XN1 A;  1V7X A;  3K7X A;  1JZ8 A;  4L0G A;  2OQE C;  3HXB B;  1LF9 A;  1SNZ A;  1CB8 A;  2XWB B;  1H14 A;  1O6Q A;  1F9D A;  1TQU A;  3ECQ A;  3BS6 A;  1XWQ A;  3VXD A;  2H6F B;  2BED B;  1H37 A;  3QT3 A;  1NSX A;  4D94 A;  1J0M A;  4FXK B;  3VW5 A;  2ONG A;  1N4R B;  3W7W A;  1TQT A;  4CJ0 A;  3MWX A;  4UFC A;  4GL3 A;  3N0F A;  3CIH A;  3E80 A;  3SAE A;  1IU7 A;  3SXX A;  1W6G A;  1W5Z A;  3ALA A;  4OZW A;  2FYV A;  3PZ2 B;  5M7I A;  1KZO B;  2F7P A;  3MPH A;  3WVF A;  3HIG A;  4J5T A;  4WVC A;  3RJ3 A;  2WVY A;  2NOJ A;  2FUT A;  5IL8 A;  1TNY B;  3ACT A;  3WKH A;  1F9G A;  5M7Y A;  2GZ6 A;  4D4C A;  1N4P B;  1ULV A;  2AHF A;  4D6F A;  2IEJ B;  4TF4 A;  1IVW A;  4MMH A;  1H13 A;  2ZIR B;  4QT9 A;  4AYQ A;  2WW1 A;  4BTW A;  3PYB A;  1W6J A;  3VDA A;  1D8D B;  2I07 B;  2OOV A;  4XUV A;  4L6X A;  1JYX A;  3W5M A;  2WOF A;  3D52 A;  2BBC A;  3EJQ A;  1GSZ A;  3DSW B;  1JZ6 A;  3M77 A;  1N7P A;  4WVB A;  1X1H A;  3NNB A;  1K1Y A;  5A1A A;  5ILI A;  1H3B A;  3A24 A;  1AYX A;  4AYR A;  4DOD A;  4OJZ A;  1QQF A;  1NS8 A;  3M72 A;  1XWT A;  3RSY A;  1H54 A;  3BLC A;  3QXF A;  1N1Z A;  2XSG A;  1TF4 A;  4MMI A;  1IQX A;  1DYU A;  5ILJ A;  5GW7 A;  3VSN A;  3GZK A;  1FMI A;  1HN1 A;  3ANI A;  1HMW A;  3WIQ A;  2R2L B;  3KQ4 A;  2BT3 A;  1HX9 A;  2FV0 A;  3M71 A;  4DLO A;  1NS7 A;  2D1W A;  3KII A;  3WC3 A;  4EV2 A;  4D1I A;  4LNV A;  3CV5 A;  1KSC A;  1LVN A;  1HXA A;  4BOJ A;  2KXS A;  3VD7 A;  2CQS A;  5IM1 A;  2WMH A;  3NBJ A;  2C10 A;  2PNC A;  4Z4L A;  1N7N A;  4GTS B;  1O1T B;  2F0Y B;  3DYO A;  4JJJ A;  3ANK A;  3T08 A;  4MU9 A;  3DCD A;  2RGK A;  3X41 A;  1YQ2 A;  2D8L A;  1PX4 A;  2YFN A;  3DX3 A;  5IK6 A;  2B4F A;  3X3Z A;  3BVU A;  2H6H B;  3X17 A;  1LF6 A;  4ZG8 A;  1KSD A;  1SIH A;  1NS2 A;  1LD7 B;  3BUI A;  2J5C A;  1NS4 A;  2DRS A;  5IKH A;  1UMP A;  3S4A A;  4DUW A;  1JZ5 A;  2CFK A;  4OK4 A;  4GTT B;  2CIR A;  1MN0 A;  4K3A A;  1GAI A;  2CWV A;  1PU4 A;  2G0D A;  3PYA A;  3M73 A;  1JCQ B;  3REN A;  3OBA A;  1L1Y A;  1DCE B;  4L9P B;  4LIX A;  2A73 B;  1QAZ A;  3Q7F B;  5AGD A;  2WVX A;  2Q1F A;  1JZ7 A;  3CZS A;  3LOY A;  3T0D A;  2CQT A;  1Z45 A;  2WDA A;  3WA2 X;  1NSU A;  1UG9 A;  5JMF A;  3DYM A;  3PGB A;  2W0Q A;  3DX1 A;  1GA2 A;  1TU5 A;  3EU8 A;  3Q78 B;  1QAF A;  1AVL A;  2XN2 A;  1NSM A;  3E73 A;  3LZ9 A;  3QPF A;  2WMF A;  1HM2 A;  3RX5 A;  2EAB A;  1V7W A;  4LNB B;  1C3D A;  1N4S B;  3EU5 B;  1F9O A;  4ZRQ A;  2FV1 A;  3VD3 A;  2PMV A;  1JZ4 A;  1NXC A;  1AVK A;  2CWU A;  1X1J A;  1N9A B;  4EHM B;  2E24 A;  1PS3 A;  1W6K A;  3M7L A;  2ALW A;  1EGU A;  3Q7A B;  3WKG A;  4KFF A;  3A0O A;  1KRF A;  3ON6 A;  3D50 A;  4OZV A;  5C05 A;  2F7Q A;  4FNU A;  4D6J A;  3HXD B;  2V8I A;  3SX1 A;  3PZ1 B;  1XW2 A;  1G9G A;  1HWW A;  4KFE A;  1JYN A;  3M76 A;  2JG0 A;  2WY8 A;  5IK0 A;  2NVP A;  1AV4 A;  1TQW A;  2D73 A;  2Y73 A;  2CIQ A;  3DX0 A;  3MI6 A;  1KRE A;  3H7L A;  5FO9 B;  3BUP A;  2A8Z A;  3N9H A;  4DI5 A;  4DOE A;  1W2Z A;  3KBT C;  2BB5 A;  4KKI A;  3AFJ A;  2PN5 A;  3OXU A;  5DHI A;  1SPU A;  2FUQ A;  3S4B A;  4BTY A;  4FNQ A;  2HTB A;  3GLY A;  4D4B A;  3D5S A;  4FNT A;  3Q73 B;  3QG0 A;  4D6E A;  1JYV A;  3QXQ A;  3S4C A;  2WYH A;  3DST B;  2F18 A;  4YDO B;  1N1B A;  2WW2 A;  3OS7 A;  3QDE A;  1NKG A;  1H35 A;  1S63 B;  2XWJ B;  4EV5 A;  1G9J A;  1N7Q A;  4BOK A;  1SII A;  3T33 A;  1KKT A;  4Q2B A;  2WMG A;  2RDY A;  1HMU A;  3T0U A;  5ILH A;  3I3D A;  3HXC B;  2OKX A;  1H3C A;  5E2J A;  1O79 A;  5GY3 A;  3WA3 A;  1MZC B;  4GTR B;  3T2O A;  3QFY A;  2CFL A;  1PX3 A;  3W7U A;  3E33 B;  1O6H A;  3VSM A;  3DDG A;  3VD9 A;  1O6R A;  2CG1 A;  1WU4 A;  1N94 B;  4E1Y A;  1HTY A;  3HXF B;  4AQ0 A;  2VN7 A;  1NI1 B;  1HN0 A;  3P2C A;  1R34 A;  5CD2 A;  1L7J A;  3M7C A;  1RKY A;  1WMN A;  2C11 A;  3KN4 A;  3SEP A;  1LD8 B;  3SDR A;  3Q1N A;  2GOX A;  3E1F 1;  3X40 A;  1OAC A;  2V8J A;  2ONH A;  2CFD A;  1SA5 B;  1OJP A;  3QWT A;  1VD5 A;  3EJU A;  2WYN A;  2WII B;  4BZG A;  5IK9 A;  1RWG A;  3WUX A;  1F4H A;  4KFD A;  4D71 A;  1JZ2 A;  2H6G B;  1TQV A;  3BVT A;  1N4Q B;  3KSQ B;  1QWU A;  2Y74 A;  3RX8 A;  1RWC A;  1LUR A;  2WY7 A;  1DOG A;  1V7V A;  2DRO A;  1N22 A;  5CA3 A;  1H36 A;  3E7J A;  3PZ4 B;  5DHK A;  4GTV B;  1S64 B;  3SDV A;  2AFA A;  3M78 A;  1L7K A;  3MV1 1;  1N95 B;  3S9V A;  2WVX B;  3NJX A;  1FP3 A;  4MBG B;  4F10 A;  5IL3 A;  4D6D A;  3DX2 A;  2BRW A;  2WMK A;  4BZE A;  1IQY A;  1O5M B;  2AHG A;  3RRS A;  3BVX A;  1W4N A;  1WU6 A;  1D6Y A;  2CWT A;  2OOV C;  1DP0 A;  2WYI A;  1GLM A;  3UD1 A;  3SFY B;  1NSZ A;  3DYP A;  4BTX A;  1QAL A;  1FBO A;  1N7R A;  5JPN B;  1TNB B;  3BUQ A;  2JKE A;  2FUZ A;  4CE7 A;  4TXT A;  3E30 B;  3EJP A;  3EJT A;  3M00 A;  3HXE B;  1O7D D;  3K25 A;  3QFZ A;  1FO2 A;  4V1R A;  2WMI B;  1HM3 A;  2KXR A;  1TQS A;  1W7C A;  1K1W A;  1C82 A;  4FNV A;  4OK2 A;  2OW7 A;  1JCR B;  3NJV A;  1F1S A;  4Z4J A;  1TN8 B;  2X03 A;  2OQE A;  3EZ8 A;  2CFW A;  4WU0 A;  1NSS A;  3CU7 A;  5KBP A;  4DLQ A;  3IMH A;  1F4A A;  3E6U A;  1N9E A;  1DL2 A;  2JJB A;  1N24 A;  2VN4 A;  2CIS A;  5CZL A;  3VDB A;  1GXO A;  2OW6 A;  5JPM B;  3EJS A;  1OJM A;  4ZH1 A;  1MMY A;  1FT2 B;  1R76 A;  4D4A A;  2WZS A;  2F7R A;  3BUD A;  3WIW A;  1NSR A;  3P5P A;  3PQI A;  4ZRP A;  1RWA A;  1J0N A;  3E34 B;  3K5T A;  1TNU B;  5ILY A;  2F1B A;  3W7S A;  3HII A;  1GHQ A;  3TF4 A;  3VD5 A;  3DRA B;  1KSI A;  2Z07 A;  3G4F A;  1FT1 B;  1KS8 A;  1WMO A;  1LTX B;  1GXN A;  3VD4 A;  2ZZR A;  3D3I A;  2E2V A;  2EAE A;  4F13 A;  3WKI A;  1YGA A;  3BVW A;  1W3Y A;  1N7O A;  1IVX A;  1TNO B;  1G87 A;  4D6I A;  1RW9 A;  4DUX A;  1H3A A;  5FOB B;  3MUZ 1;  1JRQ A;  1FAE A;  3WKF A;  3OED A;  4D6H A;  3DPY B;  5DGR A;  2BB6 A;  3H2W A;  1FO3 A;  1A2V A;  3SFX B;  2XFG A;  2V3N A;  3F59 A;  1UI8 A;  2FBA A;  4NEI A;  5DGQ A;  1IVV A;  4BZF A;  2D5J A;  1AGM A;  4D6G A;  4FNR A;  1K1X A;  1WZZ A;  1HZF A;  1HXC A;  2ZQ0 A;  1KWF A;  3DEC A;  5MEH A;  1TN6 B;  1US1 A;  3D4Y A;  3W7T A;  2YX9 A;  3BVV A;  2H6I B;  4GAX A;  1IVU A;  1WMP A;  3MV0 1;  5IKA A;  2WCO A;  5GZK A;  2JF4 A;  4AYO A;  3BUB A;  2WO0 A;  1O1R B;  3AMO A;  2WW0 A;  3DDF A;  3J7H A;  2F1A A;  2QNO A;  3X3Y A;  3KBU C;  3BGA A;  1JCS B;  1LXM A;  5EAT A;  1X1I A;  1UT9 A;  2V8K A;  5JMD A;  3CZN A;  2F7O A;  3HI7 A;  3H3K A;  4D8O A;  3K11 A;  1X81 B;  1N21 A;  3LVT A;  3T0A A;  5FO8 B;  1HCU A;  3KLS A;  3I3B A;  3DX4 A;  4D6C A;  1RWF A;  2DRR A;  1NS0 A;  1WU5 A;  4KKJ A;  3E32 B;  1RJO A;  2RI8 A;  3PZ3 B;  4TTG A;  3QRY A;  1HV6 A;  1LOH A;  1RWH A;  3SDU A;  3CZJ A;  2WOH A;  1QX1 A;  1SQC A;  5KKB A;  3ACS A;  2ZXQ A;  3IAP A;  3T09 A;  1X9D A;  3I3E A;  1H39 A;  3AFL A;  1HXK A;  3D5R A;  3EQA A;  4V1S A;  3W5N A;  2CG0 A;  2E2U A;  1NSV A;  2E2T A;  1TN7 B;  3G6J B;  3U7V A;  1MMX A;  2XN0 A;  3D51 A;  3WFA A;  1HXG A; 
#chains in the Genus database with same CATH homology
 1NSZ A;  3DYP A;  3NJX A;  3E80 A;  2BRV X;  1N7R A;  3VD3 A;  1JZ4 A;  3VDC A;  2WMJ A;  2JKE A;  1X1J A;  4OZW A;  2E24 A;  3T2Q A;  3K25 A;  3WVF A;  2WW3 A;  1EGU A;  2WMI B;  1HM3 A;  2WVY A;  4J5T A;  3T0B A;  2JKP A;  4DUV A;  3A0O A;  2FUT A;  1K1W A;  4OZV A;  1C82 A;  4OK2 A;  4FNV A;  1F9G A;  1OJO A;  4D6J A;  3IAQ A;  1F1S A;  3NJV A;  2X03 A;  1ULV A;  1NSS A;  2JKA A;  1JYN A;  4D6F A;  2D73 A;  1F4A A;  2CIQ A;  3IMH A;  3MUY 1;  4MMH A;  2WW1 A;  2CIS A;  1LXK A;  3VDB A;  1MMU A;  3VDA A;  4BZH A;  1OJM A;  1MMY A;  1JYX A;  2FUQ A;  1JZ3 A;  2WZS A;  1JZ6 A;  1SO0 A;  2HTB A;  1NSR A;  1N7P A;  5A1A A;  1X1H A;  3NNB A;  1RWA A;  1K1Y A;  1J0N A;  2BRP A;  4D6E A;  1JYV A;  3A24 A;  2WW2 A;  2HTA A;  3OS7 A;  4OJZ A;  1NS8 A;  1NKG A;  3NFV A;  3VD5 A;  2WVZ A;  1N7Q A;  3BLC A;  1JYW A;  2XHN A;  2XSG A;  3OB8 A;  3VD4 A;  2WMG A;  1JOV A;  4MMI A;  1HMU A;  4F13 A;  1I8Q A;  3I3D A;  1YGA A;  1W3Y A;  1N7O A;  3VSN A;  4D6I A;  1RW9 A;  1MMZ A;  3T2O A;  1HN1 A;  4DUX A;  1HMW A;  1PX3 A;  3MUZ 1;  3TY1 A;  4D6H A;  3VSM A;  3VD9 A;  3T2P A;  1NS7 A;  4E1Y A;  4AQ0 A;  4NEI A;  3VD7 A;  1OJN A;  4BZF A;  2WMH A;  4D6G A;  1K1X A;  4D72 A;  3DEC A;  2ZQ0 A;  1HN0 A;  1N7N A;  3DYO A;  1L7J A;  3T08 A;  2E22 A;  3MV0 1;  4RNL A;  3DCD A;  2WCO A;  3Q1N A;  3SEP A;  3E1F 1;  3NRE A;  1YQ2 A;  1PX4 A;  2WW0 A;  1OJP A;  5E1Q A;  4BZG A;  1LF6 A;  3BGA A;  1RWG A;  1LXM A;  1NS2 A;  1F4H A;  1NS4 A;  1X1I A;  4D71 A;  5JMD A;  1TXK A;  1JZ2 A;  4DUW A;  1JZ5 A;  4OK4 A;  2CIR A;  1MN0 A;  3T0A A;  1RWC A;  2WMI A;  1LUR A;  3I3B A;  3OBA A;  3E7J A;  4D6C A;  1RWF A;  1JZ7 A;  2WVX A;  1QAZ A;  1NS0 A;  1JZ8 A;  2Q1F A;  1L7K A;  3MV1 1;  3T0D A;  4TTG A;  1LF9 A;  1SNZ A;  1Z45 A;  1CB8 A;  1HV6 A;  1LOH A;  1RWH A;  2WDA A;  1NSU A;  2WVX B;  1UG9 A;  3CZJ A;  5JMF A;  3DYM A;  4F10 A;  4D6D A;  3ECQ A;  3BS6 A;  2BRW A;  2WMK A;  3IAP A;  3T09 A;  2ZXQ A;  4BZE A;  1NSX A;  1J0M A;  1NSM A;  3I3E A;  3AFL A;  2WMF A;  3MWX A;  1NSV A;  1HM2 A;  3WFA A;  1MMX A;  1DP0 A;  3J7H A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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