1HM3A

Active site of chondroitinase ac lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis
Total Genus 245
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
245
sequence length
674
structure length
674
Chain Sequence
GTAELIMKRVMLDLKKPLRNMDKVAEKNLNTLQPDGSWKDVPYKDDAMTNWLPNNHLLQLETIIQAYIEKDSHYYGDDKVFDQISKAFKYWYDSDPKSRNWWHNEIATPQALGEMLILMRYGKKPLDEALVHKLTERMKRGEPEKKTGANKTDIALHYFYRALLTSDEALLSFAVKELFYPVQFVHYEEGLQYDYSYLQHGPQLQISSYGAVFITGVLKLANYVRDTPYALSTEKLAIFSKYYRDSYLKAIRGSYMDFNVEGRGVSRPDILNKKAEKKRLLVAKMIDLKHTEEWADAIARTDSTVAAGYKIEPYHHQFWNGDYVQHLRPAYSFNVRMVSKRTRRSESGNKENLLGRYLSDGATNIQLRGPEYYNIMPVWEWDKIPGITSRDYLTDRPLTKLWGEQGSNDFAGGVSDGVYGASAYALDYDSLQAKKAWFFFDKEIVCLGAGINSNAPENITTTLNQSWLNGPVISTAGKTGRGKITTFKAQGQFWLLHDAIGYYFPEGANLSLSTQSQKGNWFHINNSHSKDEVSGDVFKLWINHGARPENAQYAYIVLPGINKPEEIKKYNGTAPKVLANTNQLQAVYHQQLDMVQAIFYTAGKLSVAGIEIETDKPCAVLIKHINGKQVIWAADPLQKEKTAVLSIRDLKTGKTNRVKIDFPQQEFAGATVEL
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Lyase
molecule keywords CHONDROITINASE AC
publication title Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
pubmed doi rcsb
source organism Pedobacter heparinus
total genus 245
structure length 674
sequence length 674
ec nomenclature ec 4.2.2.5: Chondroitin AC lyase.
pdb deposition date 2000-12-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02278 Lyase_8 Polysaccharide lyase family 8, super-sandwich domain
A PF02884 Lyase_8_C Polysaccharide lyase family 8, C-terminal beta-sandwich domain
A PF08124 Lyase_8_N Polysaccharide lyase family 8, N terminal alpha-helical domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.50.10.100 Mainly Alpha Alpha/alpha barrel Glycosyltransferase Chondroitin AC/alginate lyase 1hm3A01
2.60.220.10 Mainly Beta Sandwich Chondroitinase Ac; Chain A, domain 3 Polysaccharide lyase family 8-like, C-terminal 1hm3A03
2.70.98.10 Mainly Beta Distorted Sandwich Beta-galactosidase; Chain A, domain 5 Beta-galactosidase; Chain A, domain 5 1hm3A02
1SO0A 2WMHA 2BRVX 1NSXA 2WW2A 3NNBA 3BGAA 1TXKA 4NEIA 1MMUA 4D72A 4FNVA 1OJNA 4OK2A 2XSGA 1J0NA 2XHNA 3WFAA 3IAQA 1NSSA 5A1AA 1N7QA 1MN0A 1DP0A 3MWXA 3E80A 1OJOA 3K25A 1RW9A 3A24A 1NSZA 1LOHA 1PX4A 3I3EA 1NSUA 3OBAA 3MV11 1NSVA 1JZ2A 1HM3A 1NS7A 1YQ2A 3CZJA 3IAPA 4OZVA 1MMZA 2HTBA 4RNLA 1L7JA 1N7PA 1LF6A 3T0DA 3ECQA 1X1IA 4D6FA 3T2OA 1JZ3A 4MMIA 4F10A 2WZSA 1F4HA 2FUQA 2JKEA 1F4AA 2WW1A 3NREA 1CB8A 4OJZA 4BZEA 1LURA 1RWFA 4TTGA 3VSMA 1NS0A 4D71A 4AQ0A 1JZ8A 1JZ6A 2HTAA 3VSNA 2X03A 1N7NA 1OJPA 3DYPA 1N7RA 2WMFA 1LXKA 3I3BA 3T2QA 4D6JA 1J0MA 1JZ7A 1L7KA 1K1YA 4D6GA 4MMHA 2JKPA 3IMHA 2E24A 5E1QA 1LXMA 3OS7A 4DUVA 2WCOA 4F13A 2Q1FA 3T2PA 3DYOA 3DECA 3NJVA 5JMFA 1QAZA 2CIRA 1NS8A 3VD4A 1EGUA 3T08A 4E1YA 2WVXA 1JYXA 3VD5A 1RWCA 1OJMA 1JZ5A 1PX3A 2CISA 4D6CA 1JYVA 3VD7A 1YGAA 1NKGA 5JMDA 1ULVA 1F1SA 1HN1A 2WVYA 4D6DA 1NSMA 3I3DA 4D6IA 3OB8A 1JYNA 1MMXA 3T09A 1NS2A 3DYMA 4DUWA 1LF9A 1C82A 1RWAA 1JOVA 3MUY1 2WMJA 1I8QA 1JZ4A 3VD9A 4OK4A 3MUZ1 3SEPA 1X1HA 3DCDA 1HV6A 3Q1NA 4DUXA 1N7OA 2FUTA 2WMIA 3J7HA 4BZHA 1HM2A 3E7JA 1UG9A 1SNZA 2WW3A 3VDCA 2D73A 3E1F1 2WMIB 1HMUA 3VD3A 4BZFA 1JYWA 1X1JA 3A0OA 1NSRA 2WVXB 1Z45A 2ZXQA 1MMYA 3MV01 2WVZA 1W3YA 2BRWA 2WW0A 1RWHA 2ZQ0A 1K1XA 3NFVA 3VDBA 3AFLA 2CIQA 2BRPA 1NS4A 1HMWA 3NJXA 2JKAA 3T0BA 4BZGA 2E22A 2WMKA 4D6EA 3T0AA 2WDAA 1F9GA 1RWGA 4OZWA 2WMGA 1K1WA 3VDAA 4D6HA 1HN0A
chains in the Genus database with same CATH superfamily
1TNUB 2WW2A 3PZ3B 3D3IA 4YCRA 2CG0A 3SXXA 3TF4A 3UD1A 3K7XA 1JRQA 3QFZA 3RX5A 2BB6A 3CU7A 4NEIA 2ALWA 1PU4A 4D1JA 2WIIB 3OXUA 4FNVA 4Q88A 1N20A 1GXNA 4D4DA 2XHNA 3WFAA 4WVCA 3RENA 3KIIA 3IAQA 5A1AA 1UMPA 2AFAA 2P0VA 1DP0A 3MWXA 1QWUA 1OJOA 2YIKA 5EATA 5ILYA 1QWNA 5DGRA 3A24A 4GTPB 1WU6A 1NSZA 5FO8B 2V3NA 3PYAA 2OW7A 2FBAA 1GXMA 3I3EA 3DX3A 3P5PA 4Z4JA 3MV11 3GT5A 1HM3A 1YQ2A 2CFDA 3GZKA 1O1SB 4OZVA 1LF6A 3QR8A 1MMZA 2WO0A 3AMOA 3BVTA 3CZNA 3DX4A 3DSVB 1X1IA 3M71A 3QT3A 4FNPA 1H36A 1JZ3A 3SFXB 1O1TB 4FNRA 1H13A 5FOBB 2FUQA 3Q73B 2FYVA 3M78A 1F4AA 3NREA 4BZEA 4OJZA 3S4CA 3DX1A 3C72B 1NS0A 2EADA 1JZ8A 3PYBA 3E73A 3ANIA 3X3ZA 2HTAA 1O79A 5FO7B 5C05A 1OJPA 2GOXA 1N7RA 3T33A 1KZPB 3T2QA 2XN0A 4WVAA 1JZ7A 3SDRA 2E24A 2WY7A 4BTWA 1LXMA 3WKGA 3OS7A 4DUVA 1WU4A 1W6CA 1VD5A 2DRQA 3DECA 5FO9B 1QAZA 1GHQA 2CIRA 3HXBB 3QSPA 2OQEA 2WVXA 1H35A 3M7EA 1RWCA 1G9JA 2KXSA 3H2WA 2CISA 3ACSA 2WINB 3DSUB 4K3AA 3VD7A 4D4CA 1YGAA 4D4AA 2ZIRB 5JMDA 3N0GA 1F1SA 4LNBB 1HN1A 2WVYA 1CLCA 4D6DA 1N22A 3KSLB 2DRRA 1OACA 5GW7A 1X81B 5CD2A 1MMXA 1TQWA 5M7IA 3W5MA 4DUWA 2EABA 2FUZA 3MUY1 1I8QA 1V7WA 2YFNA 1N95B 4OK4A 3ALAA 3MUZ1 1H54A 1H3BA 2Y74A 4V1SA 1X9DA 3Q1NA 1TU5A 2A8ZA 3QRYA 3G6JB 3IAPA 3X3XA 3MPHA 1UG9A 2WW3A 2ZL8A 4JJJA 3LZ9A 1WU5A 3QXQA 4BZFA 3M77A 3QPFA 4TXTA 1FBWA 2A73B 1IA7A 3A0OA 5EASA 3MV01 2D1WA 1NXCA 2WVZA 1W3YA 2BRWA 2RI9A 3D5SA 1KZOB 3M75A 1W2ZA 2WW0A 3BUPA 2CIQA 2BRPA 4KKIA 3EZ8A 2JKAA 3D4ZA 4BTXA 1FO2A 2Y73A 2ONHA 1XWTA 4DOEA 2E22A 3WIWA 2WDAA 1F9GA 2AHFA 4D6HA 1N1BA 4UFCA 3K11A 2WMHA 3KBUC 1KSDA 3AFJA 2OW6A 5IL3A 5IM1A 3T0UA 4ZG8A 2ZZRA 2AHGA 3CIHA 1FT2B 1GAIA 1OJNA 1W6GA 1HXKA 3X3YA 1D8DB 2NVPA 4D1IA 2ZBLA 2F7PA 2F7RA 5EAUA 1QAFA 1TQTA 3A3VA 1MN0A 1QSJA 1QX1A 3E80A 3D50A 1RW9A 3WKHA 1R33A 4M76A 1PX4A 3X40A 1N4QB 1FBOA 5CZLA 1NSUA 1LD7B 2D5JA 4GTTB 1R34A 3SDQA 3MI6A 1H37A 1NS7A 1JZ2A 3NBBA 1O7DD 2HTBA 1L7JA 1IS9A 3T0DA 1F9OA 2PMVA 2VN4A 4D6FA 3T2OA 1UI8A 3AMOB 4AYOA 3KBTC 3KN4A 2V8KA 1H14A 3EU8A 1FCEA 1XW2A 1AVLA 2JKEA 4K35A 2V8JA 4DI5A 4TTGA 1W6JA 3VSMA 3E37B 3EJUA 4D71A 3Q7AB 4AQ0A 3PZ4B 2V3PA 2XWJB 1N7NA 1DL2A 3DYPA 3BVUA 1IU7A 4Q2BA 1GAHA 2RI8A 4WVBA 1FAEA 2E2VA 3M76A 4DLQA 1IQYA 2JKPA 3BVXA 5E1QA 1HWWA 1D8EB 1N9EA 4LNVA 1GXOA 2H6HB 2WCOA 3T2PA 3TY1A 3E30B 2CFLA 1NL4B 5ILJA 3HXDB 2CFWA 2F7OA 2YFOA 3VD4A 1EGUA 4KTRA 2EAEA 2XWBB 3DSXB 4D4BA 3D4YA 4D6CA 1TNBB 2D8LA 1FT1B 3QT9A 3PGBA 3DPYB 4BTYA 1SA4B 3M73A 1R76A 2J5CA 4KFEA 1NSMA 3I3DA 4YDOB 1D6UA 4GTSB 1HTYA 2OOVA 3T09A 2WYHA 2DRSA 5AGDA 2XN2A 1WZZA 1GLMA 1C82A 3WIQA 3EJRA 1TN6B 3X17A 2F18A 1JZ4A 3VD9A 1DOGA 1LD8B 4RNQA 3P5RA 2CWVA 4FNQA 1N7OA 2H6FB 3VW5A 1KKTA 4DUXA 1HXGA 3E34B 3VXDA 4DLOA 4BZHA 1KWFA 1SNZA 3D5RA 3E1F1 1HMUA 2W0QA 3H3KA 3SFYB 3VD3A 1JYWA 1MZCB 5DHIA 1NSRA 1HX9A 1Z45A 4FXKB 4EV5A 3NFVA 3AFLA 1GSZA 1HMWA 3NJXA 4CE7A 3HXEB 3M7BA 3BLCA 3SDTA 2VN7A 1TQSA 2B4FA 3E6UA 3RX7A 1K72A 3P2CA 1WMNA 3K5TA 1HZFA 2WMGA 1TNZB 1G87A 4C1SA 1AV4A 1SO0A 1NSXA 3LVTA 1O6RA 3EU5B 4LNGB 3NNBA 2CFGA 3DX0A 2JJBA 3BGAA 2H6IB 1MMUA 1TQUA 1JCSB 4OK2A 1J0NA 1DCEB 2GH4A 2H6GB 1KREA 3M7LA 1RKYA 2WYNA 2QNOA 4L6XA 3E33B 3BLBA 4YDEB 3Q78B 4ZRQA 3WUXA 3RSYA 5JPNB 1N23A 1H39A 4GTQB 1LOHA 4KTPA 3BS6A 5DHKA 2F0YB 3OBAA 1NC5A 3NBJA 2XQWA 2GZ6A 1N7PA 3ECQA 1RQ5A 1AGMA 2I07B 2WZSA 4KFFA 1TNYB 1IVUA 1F4HA 1JS4A 1AYXA 2V8IA 3DRAB 2WW1A 3LOYA 1LURA 1RWFA 3DSWB 5IL8A 3WVFA 1GA2A 1JZ6A 1QQFA 1G9GA 3VSNA 2X03A 5CA3A 1N4PB 1G6IA 2WMFA 1LXKA 1A2VA 2C10A 3HIIA 3I3BA 4D6JA 2SQCA 3OEDA 1N1ZA 1AVKA 1L7KA 5IK9A 5JPMB 1N24A 3RX8A 3BUDA 1L2AA 2WOFA 1F9DA 3KSQB 5GY3A 5IKHA 3S4AA 3RJ3A 3NJVA 4LIXA 4ZH5A 1O6HA 4EL8A 5JMFA 2RDYA 2NOJA 3T08A 5KBPA 4E1YA 1JYXA 3VD5A 4XUVA 3D51A 1PX3A 2CQSA 1V5CA 3WKFA 1H12A 1KFGA 4AYPA 5ILZA 1NKGA 4FNUA 3F59A 1W5ZA 2WYIA 4D6IA 1CEMA 2XN1A 3OB8A 3EQAA 1NI1B 1O5MB 4J5TA 1NS2A 3DYMA 1V5DA 1RWAA 3WIRA 1JOVA 3BUQA 1TN7B 3M72A 3SEPA 3PMMA 4ZH1A 3N9HA 4GAXA 3DCDA 1HV6A 3EUVB 3WKIA 2FUTA 3W7SA 3PZ2B 2WMIA 1IVXA 1HM2A 2BT3A 2YX9A 1XWQA 3E7JA 3ANJA 4FNTA 1HXAA 2OKXA 2F7QA 2CFKA 2CWUA 2E2UA 1SPUA 4GTMB 1WMOA 2OQEC 1V7XA 1KSIA 3EJQA 1KSCA 2WVXB 3H7LA 1MMYA 2ZQ0A 2PNCA 1RWHA 3ACTA 3M01A 3DDFA 1WMPA 1FMIA 1US1A 3BVWA 4GL3A 1RJOA 2CG1A 2G02A 4BZGA 2WMKA 1IVWA 2F1BA 3T0AA 3SX1A 3HXFB 3SDVA 3KLSA 3QG0A 1RWGA 4V1RA 1V7VA 1FPPB 1H3AA 3VDAA 1O1RB 1HN0A 3QDEA 4EHMB 4EV2A 4MU9A 2BRVX 1C3DA 5KKBA 4CJ1A 4CJ0A 3WA3A 3W7UA 3PZ1B 3SDUA 4BOKA 2C11A 4FNSA 1TXKA 2EACA 2BEDB 1SIHA 4D72A 1SIIA 4GTOB 1TNOB 3QWTA 1D6ZA 3IMHA 3UD2A 3BVVA 1FP3A 2CWTA 2XSGA 3CZSA 2JG0A 2WOHA 2BB5A 1NSSA 1N7QA 2DROA 2ONGA 2CQTA 3N0FA 5E2JA 3K25A 5ILIA 3W7WA 1D6YA 3ON6A 3S4BA 4MBGB 1W6KA 5MEHA 3ANKA 1QBQB 1NSVA 1SQCA 3CZJA 4RNLA 3HIGA 2Z07A 1N4RB 4GTVB 2FV0A 5ILKA 1N94B 3QFYA 3Q75B 4MMIA 1JCRB 4F10A 1O6QA 1SA5B 3RRSA 1KRFA 1QAKA 2WGQA 2ZISB 1CB8A 3BUBA 4GTRB 3X41A 1L1YA 2RGKA 3KQ4A 1DYUA 4ZRPA 3PQIA 1N9AB 5IKAA 1TQVA 1J0MA 2B39A 1TN8B 4D6GA 2F6DA 1N4SB 2PN5A 2WY8A 4MMHA 1LTXB 2IEJB 4WU0A 1UI7A 4Z4LA 2R2LB 4KFDA 4FUSA 4ONTA 2Q1FA 4F13A 3DYOA 1LVNA 3W5NA 3EJTA 3Q7FB 2BBCA 1NS8A 1N21A 2KXRA 4FXGB 3G4DA 4D8OA 1OJMA 2XFGA 1W7CA 1JZ5A 1JYVA 1KS8A 3WA2X 3SAEA 1ULVA 3M00A 1HXCA 5DGQA 1IQXA 1UT9A 3EJPA 1JYNA 5IK0A 1IVVA 1JCQB 4AYQA 3CV5A 3M74A 3EJSA 3GLYA 3WC3A 1S63B 4KKJA 2F1AA 1LF9A 3G4FA 3W7TA 5M7YA 2WMJA 3DX2A 4TF4A 1PS3A 3E32B 1X1HA 2JF4A 4FJQA 1S64B 3HI7A 3Q79B 3HXCB 3DDGA 3J7HA 1W4NA 1H3CA 3VDCA 2D73A 2WMIB 3BUIA 1EKMA 1HCUA 2G0DA 1TF4A 3M7CA 5ILHA 3S4DA 1QALA 3QXFA 1X1JA 3W7XA 3D52A 2E2TA 1FO3A 4DODA 2ZXQA 4AYRA 5ILDA 1K1XA 3VDBA 4L9PB 1NS4A 4QT9A 2FV1A 3DSSB 3DSTB 3T0BA 5GZKA 3S9VA 3M02A 1IA6A 4L0GA 4D6EA 3X42A 5IK6A 4BOJA 1K1YA 4OZWA 3SQCA 3U7VA 1K1WA 4D94A 2OOVC
chains in the Genus database with same CATH topology
1SO0A 2WMHA 2BRVX 1NSXA 2WW2A 3NNBA 3BGAA 1TXKA 4NEIA 1MMUA 4D72A 4FNVA 1OJNA 4OK2A 2XSGA 1J0NA 2XHNA 3WFAA 3IAQA 1NSSA 5A1AA 1N7QA 1MN0A 1DP0A 3MWXA 3E80A 1OJOA 3K25A 1RW9A 3A24A 1NSZA 1LOHA 1PX4A 3I3EA 3BS6A 1NSUA 3OBAA 3MV11 1NSVA 1JZ2A 1HM3A 1NS7A 1YQ2A 3CZJA 3IAPA 4OZVA 1MMZA 2HTBA 4RNLA 1L7JA 1N7PA 1LF6A 3T0DA 3ECQA 1X1IA 4D6FA 3T2OA 1JZ3A 4MMIA 4F10A 2WZSA 1F4HA 2FUQA 2JKEA 1F4AA 2WW1A 3NREA 1CB8A 4OJZA 4BZEA 1LURA 1RWFA 4TTGA 3VSMA 1NS0A 4D71A 4AQ0A 1JZ8A 3WVFA 1JZ6A 2HTAA 3VSNA 2X03A 1N7NA 1OJPA 3DYPA 1N7RA 2WMFA 1LXKA 3I3BA 3T2QA 4D6JA 1J0MA 1JZ7A 1L7KA 1K1YA 4D6GA 4MMHA 2JKPA 3IMHA 2E24A 5E1QA 1LXMA 3OS7A 4DUVA 2WCOA 4F13A 2Q1FA 3T2PA 3TY1A 3DYOA 3DECA 3NJVA 5JMFA 1QAZA 2CIRA 1NS8A 3VD4A 1EGUA 3T08A 4E1YA 2WVXA 1JYXA 3VD5A 1RWCA 1OJMA 1JZ5A 1PX3A 2CISA 4D6CA 1JYVA 3VD7A 1YGAA 1NKGA 5JMDA 1ULVA 1F1SA 1HN1A 2WVYA 4D6DA 1NSMA 3I3DA 4D6IA 3OB8A 1JYNA 1MMXA 4J5TA 3T09A 1NS2A 3DYMA 4DUWA 1LF9A 1C82A 1RWAA 1JOVA 3MUY1 2WMJA 1I8QA 1JZ4A 3VD9A 4OK4A 3MUZ1 3SEPA 1X1HA 3DCDA 1HV6A 3Q1NA 4DUXA 1N7OA 2FUTA 2WMIA 3J7HA 4BZHA 1HM2A 3E7JA 1UG9A 1SNZA 2WW3A 3VDCA 2D73A 3E1F1 2WMIB 1HMUA 3VD3A 4BZFA 1JYWA 1X1JA 3A0OA 1NSRA 2WVXB 1Z45A 2ZXQA 1MMYA 3MV01 2WVZA 1W3YA 2BRWA 2WW0A 1RWHA 2ZQ0A 1K1XA 3NFVA 3VDBA 3AFLA 2CIQA 2BRPA 1NS4A 1HMWA 3NJXA 2JKAA 3T0BA 3BLCA 4BZGA 2E22A 2WMKA 4D6EA 3T0AA 2WDAA 1F9GA 1RWGA 4OZWA 2WMGA 1K1WA 3VDAA 4D6HA 1HN0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1SO0 A;  2WMH A;  2BRV X;  1NSX A;  2WW2 A;  3NNB A;  3BGA A;  1TXK A;  4NEI A;  1MMU A;  4D72 A;  4FNV A;  1OJN A;  4OK2 A;  2XSG A;  1J0N A;  2XHN A;  3WFA A;  3IAQ A;  1NSS A;  5A1A A;  1N7Q A;  1MN0 A;  1DP0 A;  3MWX A;  3E80 A;  1OJO A;  3K25 A;  1RW9 A;  3A24 A;  1NSZ A;  1LOH A;  1PX4 A;  3I3E A;  1NSU A;  3OBA A;  3MV1 1;  1NSV A;  1JZ2 A;  1HM3 A;  1NS7 A;  1YQ2 A;  3CZJ A;  3IAP A;  4OZV A;  1MMZ A;  2HTB A;  4RNL A;  1L7J A;  1N7P A;  1LF6 A;  3T0D A;  3ECQ A;  1X1I A;  4D6F A;  3T2O A;  1JZ3 A;  4MMI A;  4F10 A;  2WZS A;  1F4H A;  2FUQ A;  2JKE A;  1F4A A;  2WW1 A;  3NRE A;  1CB8 A;  4OJZ A;  4BZE A;  1LUR A;  1RWF A;  4TTG A;  3VSM A;  1NS0 A;  4D71 A;  4AQ0 A;  1JZ8 A;  1JZ6 A;  2HTA A;  3VSN A;  2X03 A;  1N7N A;  1OJP A;  3DYP A;  1N7R A;  2WMF A;  1LXK A;  3I3B A;  3T2Q A;  4D6J A;  1J0M A;  1JZ7 A;  1L7K A;  1K1Y A;  4D6G A;  4MMH A;  2JKP A;  3IMH A;  2E24 A;  5E1Q A;  1LXM A;  3OS7 A;  4DUV A;  2WCO A;  4F13 A;  2Q1F A;  3T2P A;  3DYO A;  3DEC A;  3NJV A;  5JMF A;  1QAZ A;  2CIR A;  1NS8 A;  3VD4 A;  1EGU A;  3T08 A;  4E1Y A;  2WVX A;  1JYX A;  3VD5 A;  1RWC A;  1OJM A;  1JZ5 A;  1PX3 A;  2CIS A;  4D6C A;  1JYV A;  3VD7 A;  1YGA A;  1NKG A;  5JMD A;  1ULV A;  1F1S A;  1HN1 A;  2WVY A;  4D6D A;  1NSM A;  3I3D A;  4D6I A;  3OB8 A;  1JYN A;  1MMX A;  3T09 A;  1NS2 A;  3DYM A;  4DUW A;  1LF9 A;  1C82 A;  1RWA A;  1JOV A;  3MUY 1;  2WMJ A;  1I8Q A;  1JZ4 A;  3VD9 A;  4OK4 A;  3MUZ 1;  3SEP A;  1X1H A;  3DCD A;  1HV6 A;  3Q1N A;  4DUX A;  1N7O A;  2FUT A;  2WMI A;  3J7H A;  4BZH A;  1HM2 A;  3E7J A;  1UG9 A;  1SNZ A;  2WW3 A;  3VDC A;  2D73 A;  3E1F 1;  2WMI B;  1HMU A;  3VD3 A;  4BZF A;  1JYW A;  1X1J A;  3A0O A;  1NSR A;  2WVX B;  1Z45 A;  2ZXQ A;  1MMY A;  3MV0 1;  2WVZ A;  1W3Y A;  2BRW A;  2WW0 A;  1RWH A;  2ZQ0 A;  1K1X A;  3NFV A;  3VDB A;  3AFL A;  2CIQ A;  2BRP A;  1NS4 A;  1HMW A;  3NJX A;  2JKA A;  3T0B A;  4BZG A;  2E22 A;  2WMK A;  4D6E A;  3T0A A;  2WDA A;  1F9G A;  1RWG A;  4OZW A;  2WMG A;  1K1W A;  3VDA A;  4D6H A;  1HN0 A; 
#chains in the Genus database with same CATH topology
 1TNU B;  2WW2 A;  3PZ3 B;  3D3I A;  4YCR A;  2CG0 A;  3SXX A;  3TF4 A;  3UD1 A;  3K7X A;  1JRQ A;  3QFZ A;  3RX5 A;  2BB6 A;  3CU7 A;  4NEI A;  2ALW A;  1PU4 A;  4D1J A;  2WII B;  3OXU A;  4FNV A;  4Q88 A;  1N20 A;  1GXN A;  4D4D A;  2XHN A;  3WFA A;  4WVC A;  3REN A;  3KII A;  3IAQ A;  5A1A A;  1UMP A;  2AFA A;  2P0V A;  1DP0 A;  3MWX A;  1QWU A;  1OJO A;  2YIK A;  5EAT A;  5ILY A;  1QWN A;  5DGR A;  3A24 A;  4GTP B;  1WU6 A;  1NSZ A;  5FO8 B;  2V3N A;  3PYA A;  2OW7 A;  2FBA A;  1GXM A;  3I3E A;  3DX3 A;  3P5P A;  4Z4J A;  3MV1 1;  3GT5 A;  1HM3 A;  1YQ2 A;  2CFD A;  3GZK A;  1O1S B;  4OZV A;  1LF6 A;  3QR8 A;  1MMZ A;  2WO0 A;  3AMO A;  3BVT A;  3CZN A;  3DX4 A;  3DSV B;  1X1I A;  3M71 A;  3QT3 A;  4FNP A;  1H36 A;  1JZ3 A;  3SFX B;  1O1T B;  4FNR A;  1H13 A;  5FOB B;  2FUQ A;  3Q73 B;  2FYV A;  3M78 A;  1F4A A;  3NRE A;  4BZE A;  4OJZ A;  3S4C A;  3DX1 A;  3C72 B;  1NS0 A;  2EAD A;  1JZ8 A;  3PYB A;  3E73 A;  3ANI A;  3X3Z A;  2HTA A;  1O79 A;  5FO7 B;  5C05 A;  1OJP A;  2GOX A;  1N7R A;  3T33 A;  1KZP B;  3T2Q A;  2XN0 A;  4WVA A;  1JZ7 A;  3SDR A;  2E24 A;  2WY7 A;  4BTW A;  1LXM A;  3WKG A;  3OS7 A;  4DUV A;  1WU4 A;  1W6C A;  1VD5 A;  2DRQ A;  3DEC A;  5FO9 B;  1QAZ A;  1GHQ A;  2CIR A;  3HXB B;  3QSP A;  2OQE A;  2WVX A;  1H35 A;  3M7E A;  1RWC A;  1G9J A;  2KXS A;  3H2W A;  2CIS A;  3ACS A;  2WIN B;  3DSU B;  4K3A A;  3VD7 A;  4D4C A;  1YGA A;  4D4A A;  2ZIR B;  5JMD A;  3N0G A;  1F1S A;  4LNB B;  1HN1 A;  2WVY A;  1CLC A;  4D6D A;  1N22 A;  3KSL B;  2DRR A;  1OAC A;  5GW7 A;  1X81 B;  5CD2 A;  1MMX A;  1TQW A;  5M7I A;  3W5M A;  4DUW A;  2EAB A;  2FUZ A;  3MUY 1;  1I8Q A;  1V7W A;  2YFN A;  1N95 B;  4OK4 A;  3ALA A;  3MUZ 1;  1H54 A;  1H3B A;  2Y74 A;  4V1S A;  1X9D A;  3Q1N A;  1TU5 A;  2A8Z A;  3QRY A;  3G6J B;  3IAP A;  3X3X A;  3MPH A;  1UG9 A;  2WW3 A;  2ZL8 A;  4JJJ A;  3LZ9 A;  1WU5 A;  3QXQ A;  4BZF A;  3M77 A;  3QPF A;  4TXT A;  1FBW A;  2A73 B;  1IA7 A;  3A0O A;  5EAS A;  3MV0 1;  2D1W A;  1NXC A;  2WVZ A;  1W3Y A;  2BRW A;  2RI9 A;  3D5S A;  1KZO B;  3M75 A;  1W2Z A;  2WW0 A;  3BUP A;  2CIQ A;  2BRP A;  4KKI A;  3EZ8 A;  2JKA A;  3D4Z A;  4BTX A;  1FO2 A;  2Y73 A;  2ONH A;  1XWT A;  4DOE A;  2E22 A;  3WIW A;  2WDA A;  1F9G A;  2AHF A;  4D6H A;  1N1B A;  4UFC A;  3K11 A;  2WMH A;  3KBU C;  1KSD A;  3AFJ A;  2OW6 A;  5IL3 A;  5IM1 A;  3T0U A;  4ZG8 A;  2ZZR A;  2AHG A;  3CIH A;  1FT2 B;  1GAI A;  1OJN A;  1W6G A;  1HXK A;  3X3Y A;  1D8D B;  2NVP A;  4D1I A;  2ZBL A;  2F7P A;  2F7R A;  5EAU A;  1QAF A;  1TQT A;  3A3V A;  1MN0 A;  1QSJ A;  1QX1 A;  3E80 A;  3D50 A;  1RW9 A;  3WKH A;  1R33 A;  4M76 A;  1PX4 A;  3X40 A;  1N4Q B;  1FBO A;  5CZL A;  1NSU A;  1LD7 B;  2D5J A;  4GTT B;  1R34 A;  3SDQ A;  3MI6 A;  1H37 A;  1NS7 A;  1JZ2 A;  3NBB A;  1O7D D;  2HTB A;  1L7J A;  1IS9 A;  3T0D A;  1F9O A;  2PMV A;  2VN4 A;  4D6F A;  3T2O A;  1UI8 A;  3AMO B;  4AYO A;  3KBT C;  3KN4 A;  2V8K A;  1H14 A;  3EU8 A;  1FCE A;  1XW2 A;  1AVL A;  2JKE A;  4K35 A;  2V8J A;  4DI5 A;  4TTG A;  1W6J A;  3VSM A;  3E37 B;  3EJU A;  4D71 A;  3Q7A B;  4AQ0 A;  3PZ4 B;  2V3P A;  2XWJ B;  1N7N A;  1DL2 A;  3DYP A;  3BVU A;  1IU7 A;  4Q2B A;  1GAH A;  2RI8 A;  4WVB A;  1FAE A;  2E2V A;  3M76 A;  4DLQ A;  1IQY A;  2JKP A;  3BVX A;  5E1Q A;  1HWW A;  1D8E B;  1N9E A;  4LNV A;  1GXO A;  2H6H B;  2WCO A;  3T2P A;  3TY1 A;  3E30 B;  2CFL A;  1NL4 B;  5ILJ A;  3HXD B;  2CFW A;  2F7O A;  2YFO A;  3VD4 A;  1EGU A;  4KTR A;  2EAE A;  2XWB B;  3DSX B;  4D4B A;  3D4Y A;  4D6C A;  1TNB B;  2D8L A;  1FT1 B;  3QT9 A;  3PGB A;  3DPY B;  4BTY A;  1SA4 B;  3M73 A;  1R76 A;  2J5C A;  4KFE A;  1NSM A;  3I3D A;  4YDO B;  1D6U A;  4GTS B;  1HTY A;  2OOV A;  3T09 A;  2WYH A;  2DRS A;  5AGD A;  2XN2 A;  1WZZ A;  1GLM A;  1C82 A;  3WIQ A;  3EJR A;  1TN6 B;  3X17 A;  2F18 A;  1JZ4 A;  3VD9 A;  1DOG A;  1LD8 B;  4RNQ A;  3P5R A;  2CWV A;  4FNQ A;  1N7O A;  2H6F B;  3VW5 A;  1KKT A;  4DUX A;  1HXG A;  3E34 B;  3VXD A;  4DLO A;  4BZH A;  1KWF A;  1SNZ A;  3D5R A;  3E1F 1;  1HMU A;  2W0Q A;  3H3K A;  3SFY B;  3VD3 A;  1JYW A;  1MZC B;  5DHI A;  1NSR A;  1HX9 A;  1Z45 A;  4FXK B;  4EV5 A;  3NFV A;  3AFL A;  1GSZ A;  1HMW A;  3NJX A;  4CE7 A;  3HXE B;  3M7B A;  3BLC A;  3SDT A;  2VN7 A;  1TQS A;  2B4F A;  3E6U A;  3RX7 A;  1K72 A;  3P2C A;  1WMN A;  3K5T A;  1HZF A;  2WMG A;  1TNZ B;  1G87 A;  4C1S A;  1AV4 A;  1SO0 A;  1NSX A;  3LVT A;  1O6R A;  3EU5 B;  4LNG B;  3NNB A;  2CFG A;  3DX0 A;  2JJB A;  3BGA A;  2H6I B;  1MMU A;  1TQU A;  1JCS B;  4OK2 A;  1J0N A;  1DCE B;  2GH4 A;  2H6G B;  1KRE A;  3M7L A;  1RKY A;  2WYN A;  2QNO A;  4L6X A;  3E33 B;  3BLB A;  4YDE B;  3Q78 B;  4ZRQ A;  3WUX A;  3RSY A;  5JPN B;  1N23 A;  1H39 A;  4GTQ B;  1LOH A;  4KTP A;  3BS6 A;  5DHK A;  2F0Y B;  3OBA A;  1NC5 A;  3NBJ A;  2XQW A;  2GZ6 A;  1N7P A;  3ECQ A;  1RQ5 A;  1AGM A;  2I07 B;  2WZS A;  4KFF A;  1TNY B;  1IVU A;  1F4H A;  1JS4 A;  1AYX A;  2V8I A;  3DRA B;  2WW1 A;  3LOY A;  1LUR A;  1RWF A;  3DSW B;  5IL8 A;  3WVF A;  1GA2 A;  1JZ6 A;  1QQF A;  1G9G A;  3VSN A;  2X03 A;  5CA3 A;  1N4P B;  1G6I A;  2WMF A;  1LXK A;  1A2V A;  2C10 A;  3HII A;  3I3B A;  4D6J A;  2SQC A;  3OED A;  1N1Z A;  1AVK A;  1L7K A;  5IK9 A;  5JPM B;  1N24 A;  3RX8 A;  3BUD A;  1L2A A;  2WOF A;  1F9D A;  3KSQ B;  5GY3 A;  5IKH A;  3S4A A;  3RJ3 A;  3NJV A;  4LIX A;  4ZH5 A;  1O6H A;  4EL8 A;  5JMF A;  2RDY A;  2NOJ A;  3T08 A;  5KBP A;  4E1Y A;  1JYX A;  3VD5 A;  4XUV A;  3D51 A;  1PX3 A;  2CQS A;  1V5C A;  3WKF A;  1H12 A;  1KFG A;  4AYP A;  5ILZ A;  1NKG A;  4FNU A;  3F59 A;  1W5Z A;  2WYI A;  4D6I A;  1CEM A;  2XN1 A;  3OB8 A;  3EQA A;  1NI1 B;  1O5M B;  4J5T A;  1NS2 A;  3DYM A;  1V5D A;  1RWA A;  3WIR A;  1JOV A;  3BUQ A;  1TN7 B;  3M72 A;  3SEP A;  3PMM A;  4ZH1 A;  3N9H A;  4GAX A;  3DCD A;  1HV6 A;  3EUV B;  3WKI A;  2FUT A;  3W7S A;  3PZ2 B;  2WMI A;  1IVX A;  1HM2 A;  2BT3 A;  2YX9 A;  1XWQ A;  3E7J A;  3ANJ A;  4FNT A;  1HXA A;  2OKX A;  2F7Q A;  2CFK A;  2CWU A;  2E2U A;  1SPU A;  4GTM B;  1WMO A;  2OQE C;  1V7X A;  1KSI A;  3EJQ A;  1KSC A;  2WVX B;  3H7L A;  1MMY A;  2ZQ0 A;  2PNC A;  1RWH A;  3ACT A;  3M01 A;  3DDF A;  1WMP A;  1FMI A;  1US1 A;  3BVW A;  4GL3 A;  1RJO A;  2CG1 A;  2G02 A;  4BZG A;  2WMK A;  1IVW A;  2F1B A;  3T0A A;  3SX1 A;  3HXF B;  3SDV A;  3KLS A;  3QG0 A;  1RWG A;  4V1R A;  1V7V A;  1FPP B;  1H3A A;  3VDA A;  1O1R B;  1HN0 A;  3QDE A;  4EHM B;  4EV2 A;  4MU9 A;  2BRV X;  1C3D A;  5KKB A;  4CJ1 A;  4CJ0 A;  3WA3 A;  3W7U A;  3PZ1 B;  3SDU A;  4BOK A;  2C11 A;  4FNS A;  1TXK A;  2EAC A;  2BED B;  1SIH A;  4D72 A;  1SII A;  4GTO B;  1TNO B;  3QWT A;  1D6Z A;  3IMH A;  3UD2 A;  3BVV A;  1FP3 A;  2CWT A;  2XSG A;  3CZS A;  2JG0 A;  2WOH A;  2BB5 A;  1NSS A;  1N7Q A;  2DRO A;  2ONG A;  2CQT A;  3N0F A;  5E2J A;  3K25 A;  5ILI A;  3W7W A;  1D6Y A;  3ON6 A;  3S4B A;  4MBG B;  1W6K A;  5MEH A;  3ANK A;  1QBQ B;  1NSV A;  1SQC A;  3CZJ A;  4RNL A;  3HIG A;  2Z07 A;  1N4R B;  4GTV B;  2FV0 A;  5ILK A;  1N94 B;  3QFY A;  3Q75 B;  4MMI A;  1JCR B;  4F10 A;  1O6Q A;  1SA5 B;  3RRS A;  1KRF A;  1QAK A;  2WGQ A;  2ZIS B;  1CB8 A;  3BUB A;  4GTR B;  3X41 A;  1L1Y A;  2RGK A;  3KQ4 A;  1DYU A;  4ZRP A;  3PQI A;  1N9A B;  5IKA A;  1TQV A;  1J0M A;  2B39 A;  1TN8 B;  4D6G A;  2F6D A;  1N4S B;  2PN5 A;  2WY8 A;  4MMH A;  1LTX B;  2IEJ B;  4WU0 A;  1UI7 A;  4Z4L A;  2R2L B;  4KFD A;  4FUS A;  4ONT A;  2Q1F A;  4F13 A;  3DYO A;  1LVN A;  3W5N A;  3EJT A;  3Q7F B;  2BBC A;  1NS8 A;  1N21 A;  2KXR A;  4FXG B;  3G4D A;  4D8O A;  1OJM A;  2XFG A;  1W7C A;  1JZ5 A;  1JYV A;  1KS8 A;  3WA2 X;  3SAE A;  1ULV A;  3M00 A;  1HXC A;  5DGQ A;  1IQX A;  1UT9 A;  3EJP A;  1JYN A;  5IK0 A;  1IVV A;  1JCQ B;  4AYQ A;  3CV5 A;  3M74 A;  3EJS A;  3GLY A;  3WC3 A;  1S63 B;  4KKJ A;  2F1A A;  1LF9 A;  3G4F A;  3W7T A;  5M7Y A;  2WMJ A;  3DX2 A;  4TF4 A;  1PS3 A;  3E32 B;  1X1H A;  2JF4 A;  4FJQ A;  1S64 B;  3HI7 A;  3Q79 B;  3HXC B;  3DDG A;  3J7H A;  1W4N A;  1H3C A;  3VDC A;  2D73 A;  2WMI B;  3BUI A;  1EKM A;  1HCU A;  2G0D A;  1TF4 A;  3M7C A;  5ILH A;  3S4D A;  1QAL A;  3QXF A;  1X1J A;  3W7X A;  3D52 A;  2E2T A;  1FO3 A;  4DOD A;  2ZXQ A;  4AYR A;  5ILD A;  1K1X A;  3VDB A;  4L9P B;  1NS4 A;  4QT9 A;  2FV1 A;  3DSS B;  3DST B;  3T0B A;  5GZK A;  3S9V A;  3M02 A;  1IA6 A;  4L0G A;  4D6E A;  3X42 A;  5IK6 A;  4BOJ A;  1K1Y A;  4OZW A;  3SQC A;  3U7V A;  1K1W A;  4D94 A;  2OOV C; 
#chains in the Genus database with same CATH homology
 1SO0 A;  2WMH A;  2BRV X;  1NSX A;  2WW2 A;  3NNB A;  3BGA A;  1TXK A;  4NEI A;  1MMU A;  4D72 A;  4FNV A;  1OJN A;  4OK2 A;  2XSG A;  1J0N A;  2XHN A;  3WFA A;  3IAQ A;  1NSS A;  5A1A A;  1N7Q A;  1MN0 A;  1DP0 A;  3MWX A;  3E80 A;  1OJO A;  3K25 A;  1RW9 A;  3A24 A;  1NSZ A;  1LOH A;  1PX4 A;  3I3E A;  3BS6 A;  1NSU A;  3OBA A;  3MV1 1;  1NSV A;  1JZ2 A;  1HM3 A;  1NS7 A;  1YQ2 A;  3CZJ A;  3IAP A;  4OZV A;  1MMZ A;  2HTB A;  4RNL A;  1L7J A;  1N7P A;  1LF6 A;  3T0D A;  3ECQ A;  1X1I A;  4D6F A;  3T2O A;  1JZ3 A;  4MMI A;  4F10 A;  2WZS A;  1F4H A;  2FUQ A;  2JKE A;  1F4A A;  2WW1 A;  3NRE A;  1CB8 A;  4OJZ A;  4BZE A;  1LUR A;  1RWF A;  4TTG A;  3VSM A;  1NS0 A;  4D71 A;  4AQ0 A;  1JZ8 A;  3WVF A;  1JZ6 A;  2HTA A;  3VSN A;  2X03 A;  1N7N A;  1OJP A;  3DYP A;  1N7R A;  2WMF A;  1LXK A;  3I3B A;  3T2Q A;  4D6J A;  1J0M A;  1JZ7 A;  1L7K A;  1K1Y A;  4D6G A;  4MMH A;  2JKP A;  3IMH A;  2E24 A;  5E1Q A;  1LXM A;  3OS7 A;  4DUV A;  2WCO A;  4F13 A;  2Q1F A;  3T2P A;  3TY1 A;  3DYO A;  3DEC A;  3NJV A;  5JMF A;  1QAZ A;  2CIR A;  1NS8 A;  3VD4 A;  1EGU A;  3T08 A;  4E1Y A;  2WVX A;  1JYX A;  3VD5 A;  1RWC A;  1OJM A;  1JZ5 A;  1PX3 A;  2CIS A;  4D6C A;  1JYV A;  3VD7 A;  1YGA A;  1NKG A;  5JMD A;  1ULV A;  1F1S A;  1HN1 A;  2WVY A;  4D6D A;  1NSM A;  3I3D A;  4D6I A;  3OB8 A;  1JYN A;  1MMX A;  4J5T A;  3T09 A;  1NS2 A;  3DYM A;  4DUW A;  1LF9 A;  1C82 A;  1RWA A;  1JOV A;  3MUY 1;  2WMJ A;  1I8Q A;  1JZ4 A;  3VD9 A;  4OK4 A;  3MUZ 1;  3SEP A;  1X1H A;  3DCD A;  1HV6 A;  3Q1N A;  4DUX A;  1N7O A;  2FUT A;  2WMI A;  3J7H A;  4BZH A;  1HM2 A;  3E7J A;  1UG9 A;  1SNZ A;  2WW3 A;  3VDC A;  2D73 A;  3E1F 1;  2WMI B;  1HMU A;  3VD3 A;  4BZF A;  1JYW A;  1X1J A;  3A0O A;  1NSR A;  2WVX B;  1Z45 A;  2ZXQ A;  1MMY A;  3MV0 1;  2WVZ A;  1W3Y A;  2BRW A;  2WW0 A;  1RWH A;  2ZQ0 A;  1K1X A;  3NFV A;  3VDB A;  3AFL A;  2CIQ A;  2BRP A;  1NS4 A;  1HMW A;  3NJX A;  2JKA A;  3T0B A;  3BLC A;  4BZG A;  2E22 A;  2WMK A;  4D6E A;  3T0A A;  2WDA A;  1F9G A;  1RWG A;  4OZW A;  2WMG A;  1K1W A;  3VDA A;  4D6H A;  1HN0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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