2QJ2A

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Total Genus 46

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
174
structure length
174
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI5 (133-136)O3 (128-206)3H1 (39-41)S1 (42-45)S2 (48-52)O1 (70-96)TI1 (54-57)S3 (60-63)TII1 (77-80)AH1 (67-76)S4 (86-90)TI3 (102-105)TIV2 (90-93)TI2 (91-94)TII3 (167-170)TIV5 (168-171)S5 (95-99)TI6 (143-146)TI4 (113-116)TII2 (105-108)3H3 (164-166)S6 (108-112)S7 (116-121)3H2 (122-124)TVIII1 (156-159)TIV3 (130-133)TI7 (151-154)TVIb1 (155-158)TIV6 (173-176)Updating...
connected with : NaN
molecule tags Hormone
source organism Homo sapiens
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 46
structure length 174
sequence length 174
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 2qj2A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2qj2A01
1GMNA 5CSQA 1I71A 3SP8A 1HPJA 2Q8BA 4BV7A 1W8KA 4A5TS 4R1AA 1URKA 1PMKA 1JFNA 2LL4M 3BT2A 3HMTA 4UAOA 4NZQA 4D3CA 2YIPA 2L0SA 4Z0EA 2I9BA 2J8LA 1W81A 2K13X 1B2IA 2DOHX 3HMSA 4R19A 2HPPP 1KRNA 4APLA 4BVVA 4BV5A 3HMRA 3SRJA 5CT1A 3LAQA 2SPTA 3NXPA 4O03A 4BVCA 1CEAA 1A0HA 2I9AA 2Y8RA 4KIVA 1KI0A 1GP9A 3K65A 2Z8VA 5EOKA 4APMA 1NK1A 1PMLA 1PKRA 5HPGA 2QJ2A 1CEBA 1KDUA 3E6PL 5COEA 2YIOA 1GMOA 4Z0DA 1HPKA 2QJ4A 5CT3A 2PF1A 2F83A 5CP9A 4IUAA 3MKPA 1YXEA 2KNFA 1KIVA 1BHTA 5CS5A 3BT1A 2YILA 4BVWA 1Z40A 2K4RA 2Z8WA 4R1BA 1HKYA 2FD6A 1I5KA 2PF2A 4Z0FA 4BVDA 1I8NA 4CIKA 2LL3A 5I25A 1TPKA 2J8JA 2KJ4A 2HPQP 2Q8AA 1PK4A 3U73A 3SRIA 3HN4A 4UV6A 4DURA 2DOIA 3ZWZA 4R1CA 1NL2A 5CT2A 1PK2A 2PK4A 4Z09A 2FEBA 4HZHA 2X2ZA 3KIVA 3ZLEA 1NL1A 5CS1A 5CS3A 2HGFA 5EODA 2K51A 5CS9A
chains in the Genus database with same CATH superfamily
1GMNA 5CSQA 1I71A 3SP8A 1HPJA 2Q8BA 4BV7A 1W8KA 4A5TS 4R1AA 1URKA 1PMKA 1JFNA 2LL4M 3BT2A 3HMTA 4UAOA 4NZQA 4D3CA 2YIPA 2L0SA 4Z0EA 2I9BA 2J8LA 1W81A 2K13X 1B2IA 2DOHX 3HMSA 4R19A 2HPPP 1KRNA 4APLA 4BVVA 4BV5A 3HMRA 3SRJA 5CT1A 3LAQA 2SPTA 3NXPA 4O03A 4BVCA 1CEAA 1A0HA 2I9AA 2Y8RA 4KIVA 1KI0A 4YIVA 1GP9A 3K65A 2Z8VA 4YIZA 5EOKA 4APMA 1NK1A 1PMLA 1PKRA 5HPGA 2QJ2A 1CEBA 1KDUA 3E6PL 5COEA 2YIOA 1GMOA 4Z0DA 1HPKA 2QJ4A 5CT3A 2PF1A 2F83A 5CP9A 4IUAA 3MKPA 1YXEA 2KNFA 1KIVA 1BHTA 5CS5A 3BT1A 2YILA 4BVWA 1Z40A 2K4RA 2Z8WA 4R1BA 1HKYA 2FD6A 1I5KA 2KL5A 2PF2A 4Z0FA 4BVDA 1I8NA 4CIKA 2LL3A 5I25A 1TPKA 2J8JA 2KJ4A 2HPQP 2Q8AA 1PK4A 3U73A 3SRIA 3HN4A 4UV6A 4DURA 2DOIA 3ZWZA 4R1CA 1NL2A 5CT2A 1PK2A 2PK4A 4Z09A 2FEBA 4HZHA 2X2ZA 3KIVA 3ZLEA 1NL1A 5CS1A 5CS3A 2HGFA 5EODA 2K51A 5CS9A
chains in the Genus database with same CATH topology
1GMNA 5CSQA 1I71A 3SP8A 1HPJA 2Q8BA 4BV7A 1W8KA 4A5TS 4R1AA 1URKA 1PMKA 1JFNA 2LL4M 3BT2A 3HMTA 4UAOA 4NZQA 4D3CA 2YIPA 2L0SA 4Z0EA 2I9BA 2J8LA 1W81A 2K13X 1B2IA 2DOHX 3HMSA 4R19A 2HPPP 1KRNA 4APLA 4BVVA 4BV5A 3HMRA 3SRJA 5CT1A 3LAQA 2SPTA 3NXPA 4O03A 4BVCA 1CEAA 1A0HA 2I9AA 2Y8RA 4KIVA 1KI0A 4YIVA 1GP9A 3K65A 2Z8VA 4YIZA 5EOKA 4APMA 1NK1A 1PMLA 1PKRA 5HPGA 2QJ2A 1CEBA 1KDUA 3E6PL 5COEA 2YIOA 1GMOA 4Z0DA 1HPKA 2QJ4A 5CT3A 2PF1A 2F83A 5CP9A 4IUAA 3MKPA 1YXEA 2KNFA 1KIVA 1BHTA 5CS5A 3BT1A 2YILA 4BVWA 1Z40A 2K4RA 2Z8WA 4R1BA 1HKYA 2FD6A 1I5KA 2KL5A 2PF2A 4Z0FA 4BVDA 1I8NA 4CIKA 2LL3A 5I25A 1TPKA 2J8JA 2KJ4A 2HPQP 2Q8AA 1PK4A 3U73A 3SRIA 3HN4A 4UV6A 4DURA 2DOIA 3ZWZA 4R1CA 1NL2A 5CT2A 1PK2A 2PK4A 4Z09A 2FEBA 4HZHA 2X2ZA 3KIVA 3ZLEA 1NL1A 5CS1A 5CS3A 2HGFA 5EODA 2K51A 5CS9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1GMN A;  5CSQ A;  1I71 A;  3SP8 A;  1HPJ A;  2Q8B A;  4BV7 A;  1W8K A;  4A5T S;  4R1A A;  1URK A;  1PMK A;  1JFN A;  2LL4 M;  3BT2 A;  3HMT A;  4UAO A;  4NZQ A;  4D3C A;  2YIP A;  2L0S A;  4Z0E A;  2I9B A;  2J8L A;  1W81 A;  2K13 X;  1B2I A;  2DOH X;  3HMS A;  4R19 A;  2HPP P;  1KRN A;  4APL A;  4BVV A;  4BV5 A;  3HMR A;  3SRJ A;  5CT1 A;  3LAQ A;  2SPT A;  3NXP A;  4O03 A;  4BVC A;  1CEA A;  1A0H A;  2I9A A;  2Y8R A;  4KIV A;  1KI0 A;  1GP9 A;  3K65 A;  2Z8V A;  5EOK A;  4APM A;  1NK1 A;  1PML A;  1PKR A;  5HPG A;  2QJ2 A;  1CEB A;  1KDU A;  3E6P L;  5COE A;  2YIO A;  1GMO A;  4Z0D A;  1HPK A;  2QJ4 A;  5CT3 A;  2PF1 A;  2F83 A;  5CP9 A;  4IUA A;  3MKP A;  1YXE A;  2KNF A;  1KIV A;  1BHT A;  5CS5 A;  3BT1 A;  2YIL A;  4BVW A;  1Z40 A;  2K4R A;  2Z8W A;  4R1B A;  1HKY A;  2FD6 A;  1I5K A;  2PF2 A;  4Z0F A;  4BVD A;  1I8N A;  4CIK A;  2LL3 A;  5I25 A;  1TPK A;  2J8J A;  2KJ4 A;  2HPQ P;  2Q8A A;  1PK4 A;  3U73 A;  3SRI A;  3HN4 A;  4UV6 A;  4DUR A;  2DOI A;  3ZWZ A;  4R1C A;  1NL2 A;  5CT2 A;  1PK2 A;  2PK4 A;  4Z09 A;  2FEB A;  4HZH A;  2X2Z A;  3KIV A;  3ZLE A;  1NL1 A;  5CS1 A;  5CS3 A;  2HGF A;  5EOD A;  2K51 A;  5CS9 A; 
#chains in the Genus database with same CATH topology
 1GMN A;  5CSQ A;  1I71 A;  3SP8 A;  1HPJ A;  2Q8B A;  4BV7 A;  1W8K A;  4A5T S;  4R1A A;  1URK A;  1PMK A;  1JFN A;  2LL4 M;  3BT2 A;  3HMT A;  4UAO A;  4NZQ A;  4D3C A;  2YIP A;  2L0S A;  4Z0E A;  2I9B A;  2J8L A;  1W81 A;  2K13 X;  1B2I A;  2DOH X;  3HMS A;  4R19 A;  2HPP P;  1KRN A;  4APL A;  4BVV A;  4BV5 A;  3HMR A;  3SRJ A;  5CT1 A;  3LAQ A;  2SPT A;  3NXP A;  4O03 A;  4BVC A;  1CEA A;  1A0H A;  2I9A A;  2Y8R A;  4KIV A;  1KI0 A;  4YIV A;  1GP9 A;  3K65 A;  2Z8V A;  4YIZ A;  5EOK A;  4APM A;  1NK1 A;  1PML A;  1PKR A;  5HPG A;  2QJ2 A;  1CEB A;  1KDU A;  3E6P L;  5COE A;  2YIO A;  1GMO A;  4Z0D A;  1HPK A;  2QJ4 A;  5CT3 A;  2PF1 A;  2F83 A;  5CP9 A;  4IUA A;  3MKP A;  1YXE A;  2KNF A;  1KIV A;  1BHT A;  5CS5 A;  3BT1 A;  2YIL A;  4BVW A;  1Z40 A;  2K4R A;  2Z8W A;  4R1B A;  1HKY A;  2FD6 A;  1I5K A;  2KL5 A;  2PF2 A;  4Z0F A;  4BVD A;  1I8N A;  4CIK A;  2LL3 A;  5I25 A;  1TPK A;  2J8J A;  2KJ4 A;  2HPQ P;  2Q8A A;  1PK4 A;  3U73 A;  3SRI A;  3HN4 A;  4UV6 A;  4DUR A;  2DOI A;  3ZWZ A;  4R1C A;  1NL2 A;  5CT2 A;  1PK2 A;  2PK4 A;  4Z09 A;  2FEB A;  4HZH A;  2X2Z A;  3KIV A;  3ZLE A;  1NL1 A;  5CS1 A;  5CS3 A;  2HGF A;  5EOD A;  2K51 A;  5CS9 A; 
#chains in the Genus database with same CATH homology
 1GMN A;  5CSQ A;  1I71 A;  3SP8 A;  1HPJ A;  2Q8B A;  4BV7 A;  1W8K A;  4A5T S;  4R1A A;  1URK A;  1PMK A;  1JFN A;  2LL4 M;  3BT2 A;  3HMT A;  4UAO A;  4NZQ A;  4D3C A;  2YIP A;  2L0S A;  4Z0E A;  2I9B A;  2J8L A;  1W81 A;  2K13 X;  1B2I A;  2DOH X;  3HMS A;  4R19 A;  2HPP P;  1KRN A;  4APL A;  4BVV A;  4BV5 A;  3HMR A;  3SRJ A;  5CT1 A;  3LAQ A;  2SPT A;  3NXP A;  4O03 A;  4BVC A;  1CEA A;  1A0H A;  2I9A A;  2Y8R A;  4KIV A;  1KI0 A;  4YIV A;  1GP9 A;  3K65 A;  2Z8V A;  4YIZ A;  5EOK A;  4APM A;  1NK1 A;  1PML A;  1PKR A;  5HPG A;  2QJ2 A;  1CEB A;  1KDU A;  3E6P L;  5COE A;  2YIO A;  1GMO A;  4Z0D A;  1HPK A;  2QJ4 A;  5CT3 A;  2PF1 A;  2F83 A;  5CP9 A;  4IUA A;  3MKP A;  1YXE A;  2KNF A;  1KIV A;  1BHT A;  5CS5 A;  3BT1 A;  2YIL A;  4BVW A;  1Z40 A;  2K4R A;  2Z8W A;  4R1B A;  1HKY A;  2FD6 A;  1I5K A;  2KL5 A;  2PF2 A;  4Z0F A;  4BVD A;  1I8N A;  4CIK A;  2LL3 A;  5I25 A;  1TPK A;  2J8J A;  2KJ4 A;  2HPQ P;  2Q8A A;  1PK4 A;  3U73 A;  3SRI A;  3HN4 A;  4UV6 A;  4DUR A;  2DOI A;  3ZWZ A;  4R1C A;  1NL2 A;  5CT2 A;  1PK2 A;  2PK4 A;  4Z09 A;  2FEB A;  4HZH A;  2X2Z A;  3KIV A;  3ZLE A;  1NL1 A;  5CS1 A;  5CS3 A;  2HGF A;  5EOD A;  2K51 A;  5CS9 A; 
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