2QJ2A

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Total Genus 46
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
174
structure length
174
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hormone
source organism Homo sapiens
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 46
structure length 174
sequence length 174
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 2qj2A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2qj2A01
2PF2A 2PF1A 1B2IA 1KRNA 2K13X 2Q8BA 4HZHA 5CS5A 2YIPA 1I5KA 1PMKA 2KNFA 3SRJA 1NL2A 1W8KA 1KI0A 1PK2A 2LL3A 2J8JA 1A0HA 2KJ4A 4APLA 3BT1A 5CS3A 2J8LA 1NL1A 5CS9A 4BVDA 4BVWA 2YILA 5CSQA 3BT2A 1W81A 1YXEA 2Z8VA 3U73A 4Z0EA 3LAQA 4Z0FA 3HMSA 5CS1A 5CP9A 2Q8AA 2L0SA 1Z40A 1KIVA 1PKRA 3ZLEA 5COEA 1I71A 5I25A 4DURA 5HPGA 1NK1A 3HN4A 4BVVA 3SRIA 2K51A 1JFNA 2QJ2A 4R1BA 3HMRA 4O03A 3ZWZA 4KIVA 3NXPA 4Z09A 4D3CA 1GP9A 4Z0DA 4IUAA 2HPPP 2Z8WA 3K65A 4CIKA 2I9AA 4BV7A 2I9BA 2QJ4A 1I8NA 1CEAA 2HPQP 1PMLA 4R1AA 2DOIA 3MKPA 4BV5A 5EOKA 4A5TS 1GMOA 3E6PL 4APMA 4R19A 2LL4M 4UAOA 3HMTA 2DOHX 3KIVA 1HPJA 2PK4A 5EODA 2YIOA 2FEBA 4NZQA 5CT1A 2K4RA 1HPKA 1URKA 1GMNA 5CT3A 1PK4A 3SP8A 4UV6A 1HKYA 1TPKA 2F83A 2HGFA 2SPTA 1KDUA 1BHTA 2Y8RA 1CEBA 5CT2A 4R1CA 2X2ZA 2FD6A 4BVCA
chains in the Genus database with same CATH superfamily
2PF2A 2PF1A 1B2IA 1KRNA 2K13X 2Q8BA 4HZHA 5CS5A 2YIPA 1I5KA 1PMKA 2KNFA 3SRJA 1NL2A 1W8KA 1KI0A 1PK2A 2LL3A 4YIVA 2J8JA 1A0HA 2KJ4A 4APLA 3BT1A 5CS3A 2J8LA 1NL1A 5CS9A 4BVDA 4BVWA 2YILA 5CSQA 3BT2A 1W81A 1YXEA 2Z8VA 3U73A 4Z0EA 3LAQA 4Z0FA 3HMSA 5CS1A 5CP9A 2Q8AA 2L0SA 1Z40A 1KIVA 1PKRA 3ZLEA 5COEA 1I71A 5I25A 4DURA 5HPGA 1NK1A 3HN4A 4BVVA 3SRIA 2K51A 1JFNA 2QJ2A 4R1BA 3HMRA 4YIZA 4O03A 3ZWZA 4KIVA 3NXPA 4Z09A 4D3CA 1GP9A 4Z0DA 4IUAA 2HPPP 2Z8WA 3K65A 4CIKA 2I9AA 4BV7A 2I9BA 2QJ4A 1I8NA 1CEAA 2HPQP 1PMLA 4R1AA 2DOIA 3MKPA 4BV5A 5EOKA 4A5TS 1GMOA 3E6PL 4APMA 4R19A 2LL4M 4UAOA 3HMTA 2DOHX 3KIVA 1HPJA 2PK4A 5EODA 2YIOA 2FEBA 4NZQA 5CT1A 2K4RA 1HPKA 1URKA 1GMNA 5CT3A 1PK4A 2KL5A 3SP8A 4UV6A 1HKYA 1TPKA 2F83A 2HGFA 2SPTA 1KDUA 1BHTA 2Y8RA 1CEBA 5CT2A 4R1CA 2X2ZA 2FD6A 4BVCA
chains in the Genus database with same CATH topology
2PF2A 2PF1A 1B2IA 1KRNA 2K13X 2Q8BA 4HZHA 5CS5A 2YIPA 1I5KA 1PMKA 2KNFA 3SRJA 1NL2A 1W8KA 1KI0A 1PK2A 2LL3A 4YIVA 2J8JA 1A0HA 2KJ4A 4APLA 3BT1A 5CS3A 2J8LA 1NL1A 5CS9A 4BVDA 4BVWA 2YILA 5CSQA 3BT2A 1W81A 1YXEA 2Z8VA 3U73A 4Z0EA 3LAQA 4Z0FA 3HMSA 5CS1A 5CP9A 2Q8AA 2L0SA 1Z40A 1KIVA 1PKRA 3ZLEA 5COEA 1I71A 5I25A 4DURA 5HPGA 1NK1A 3HN4A 4BVVA 3SRIA 2K51A 1JFNA 2QJ2A 4R1BA 3HMRA 4YIZA 4O03A 3ZWZA 4KIVA 3NXPA 4Z09A 4D3CA 1GP9A 4Z0DA 4IUAA 2HPPP 2Z8WA 3K65A 4CIKA 2I9AA 4BV7A 2I9BA 2QJ4A 1I8NA 1CEAA 2HPQP 1PMLA 4R1AA 2DOIA 3MKPA 4BV5A 5EOKA 4A5TS 1GMOA 3E6PL 4APMA 4R19A 2LL4M 4UAOA 3HMTA 2DOHX 3KIVA 1HPJA 2PK4A 5EODA 2YIOA 2FEBA 4NZQA 5CT1A 2K4RA 1HPKA 1URKA 1GMNA 5CT3A 1PK4A 2KL5A 3SP8A 4UV6A 1HKYA 1TPKA 2F83A 2HGFA 2SPTA 1KDUA 1BHTA 2Y8RA 1CEBA 5CT2A 4R1CA 2X2ZA 2FD6A 4BVCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PF2 A;  2PF1 A;  1B2I A;  1KRN A;  2K13 X;  2Q8B A;  4HZH A;  5CS5 A;  2YIP A;  1I5K A;  1PMK A;  2KNF A;  3SRJ A;  1NL2 A;  1W8K A;  1KI0 A;  1PK2 A;  2LL3 A;  2J8J A;  1A0H A;  2KJ4 A;  4APL A;  3BT1 A;  5CS3 A;  2J8L A;  1NL1 A;  5CS9 A;  4BVD A;  4BVW A;  2YIL A;  5CSQ A;  3BT2 A;  1W81 A;  1YXE A;  2Z8V A;  3U73 A;  4Z0E A;  3LAQ A;  4Z0F A;  3HMS A;  5CS1 A;  5CP9 A;  2Q8A A;  2L0S A;  1Z40 A;  1KIV A;  1PKR A;  3ZLE A;  5COE A;  1I71 A;  5I25 A;  4DUR A;  5HPG A;  1NK1 A;  3HN4 A;  4BVV A;  3SRI A;  2K51 A;  1JFN A;  2QJ2 A;  4R1B A;  3HMR A;  4O03 A;  3ZWZ A;  4KIV A;  3NXP A;  4Z09 A;  4D3C A;  1GP9 A;  4Z0D A;  4IUA A;  2HPP P;  2Z8W A;  3K65 A;  4CIK A;  2I9A A;  4BV7 A;  2I9B A;  2QJ4 A;  1I8N A;  1CEA A;  2HPQ P;  1PML A;  4R1A A;  2DOI A;  3MKP A;  4BV5 A;  5EOK A;  4A5T S;  1GMO A;  3E6P L;  4APM A;  4R19 A;  2LL4 M;  4UAO A;  3HMT A;  2DOH X;  3KIV A;  1HPJ A;  2PK4 A;  5EOD A;  2YIO A;  2FEB A;  4NZQ A;  5CT1 A;  2K4R A;  1HPK A;  1URK A;  1GMN A;  5CT3 A;  1PK4 A;  3SP8 A;  4UV6 A;  1HKY A;  1TPK A;  2F83 A;  2HGF A;  2SPT A;  1KDU A;  1BHT A;  2Y8R A;  1CEB A;  5CT2 A;  4R1C A;  2X2Z A;  2FD6 A;  4BVC A; 
#chains in the Genus database with same CATH topology
 2PF2 A;  2PF1 A;  1B2I A;  1KRN A;  2K13 X;  2Q8B A;  4HZH A;  5CS5 A;  2YIP A;  1I5K A;  1PMK A;  2KNF A;  3SRJ A;  1NL2 A;  1W8K A;  1KI0 A;  1PK2 A;  2LL3 A;  4YIV A;  2J8J A;  1A0H A;  2KJ4 A;  4APL A;  3BT1 A;  5CS3 A;  2J8L A;  1NL1 A;  5CS9 A;  4BVD A;  4BVW A;  2YIL A;  5CSQ A;  3BT2 A;  1W81 A;  1YXE A;  2Z8V A;  3U73 A;  4Z0E A;  3LAQ A;  4Z0F A;  3HMS A;  5CS1 A;  5CP9 A;  2Q8A A;  2L0S A;  1Z40 A;  1KIV A;  1PKR A;  3ZLE A;  5COE A;  1I71 A;  5I25 A;  4DUR A;  5HPG A;  1NK1 A;  3HN4 A;  4BVV A;  3SRI A;  2K51 A;  1JFN A;  2QJ2 A;  4R1B A;  3HMR A;  4YIZ A;  4O03 A;  3ZWZ A;  4KIV A;  3NXP A;  4Z09 A;  4D3C A;  1GP9 A;  4Z0D A;  4IUA A;  2HPP P;  2Z8W A;  3K65 A;  4CIK A;  2I9A A;  4BV7 A;  2I9B A;  2QJ4 A;  1I8N A;  1CEA A;  2HPQ P;  1PML A;  4R1A A;  2DOI A;  3MKP A;  4BV5 A;  5EOK A;  4A5T S;  1GMO A;  3E6P L;  4APM A;  4R19 A;  2LL4 M;  4UAO A;  3HMT A;  2DOH X;  3KIV A;  1HPJ A;  2PK4 A;  5EOD A;  2YIO A;  2FEB A;  4NZQ A;  5CT1 A;  2K4R A;  1HPK A;  1URK A;  1GMN A;  5CT3 A;  1PK4 A;  2KL5 A;  3SP8 A;  4UV6 A;  1HKY A;  1TPK A;  2F83 A;  2HGF A;  2SPT A;  1KDU A;  1BHT A;  2Y8R A;  1CEB A;  5CT2 A;  4R1C A;  2X2Z A;  2FD6 A;  4BVC A; 
#chains in the Genus database with same CATH homology
 2PF2 A;  2PF1 A;  1B2I A;  1KRN A;  2K13 X;  2Q8B A;  4HZH A;  5CS5 A;  2YIP A;  1I5K A;  1PMK A;  2KNF A;  3SRJ A;  1NL2 A;  1W8K A;  1KI0 A;  1PK2 A;  2LL3 A;  4YIV A;  2J8J A;  1A0H A;  2KJ4 A;  4APL A;  3BT1 A;  5CS3 A;  2J8L A;  1NL1 A;  5CS9 A;  4BVD A;  4BVW A;  2YIL A;  5CSQ A;  3BT2 A;  1W81 A;  1YXE A;  2Z8V A;  3U73 A;  4Z0E A;  3LAQ A;  4Z0F A;  3HMS A;  5CS1 A;  5CP9 A;  2Q8A A;  2L0S A;  1Z40 A;  1KIV A;  1PKR A;  3ZLE A;  5COE A;  1I71 A;  5I25 A;  4DUR A;  5HPG A;  1NK1 A;  3HN4 A;  4BVV A;  3SRI A;  2K51 A;  1JFN A;  2QJ2 A;  4R1B A;  3HMR A;  4YIZ A;  4O03 A;  3ZWZ A;  4KIV A;  3NXP A;  4Z09 A;  4D3C A;  1GP9 A;  4Z0D A;  4IUA A;  2HPP P;  2Z8W A;  3K65 A;  4CIK A;  2I9A A;  4BV7 A;  2I9B A;  2QJ4 A;  1I8N A;  1CEA A;  2HPQ P;  1PML A;  4R1A A;  2DOI A;  3MKP A;  4BV5 A;  5EOK A;  4A5T S;  1GMO A;  3E6P L;  4APM A;  4R19 A;  2LL4 M;  4UAO A;  3HMT A;  2DOH X;  3KIV A;  1HPJ A;  2PK4 A;  5EOD A;  2YIO A;  2FEB A;  4NZQ A;  5CT1 A;  2K4R A;  1HPK A;  1URK A;  1GMN A;  5CT3 A;  1PK4 A;  2KL5 A;  3SP8 A;  4UV6 A;  1HKY A;  1TPK A;  2F83 A;  2HGF A;  2SPT A;  1KDU A;  1BHT A;  2Y8R A;  1CEB A;  5CT2 A;  4R1C A;  2X2Z A;  2FD6 A;  4BVC A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...