2QJ2 | Genus

Total Genus 46

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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	46
sequence length	174
structure length	174
Chain Sequence	RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hormone
source organism	Homo sapiens
publication title	A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist pubmed doi rcsb
molecule keywords	Hepatocyte growth factor
total genus	46
structure length	174
sequence length	174
chains with identical sequence	B
ec nomenclature
pdb deposition date	2007-07-06

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00024	PAN_1	PAN domain
A	PF00051	Kringle	Kringle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.40.20.10	Mainly Beta	Beta Barrel	Plasminogen Kringle 4	Plasminogen Kringle 4	2qj2A02
3.50.4.10	Alpha Beta	3-Layer(bba) Sandwich	Hepatocyte Growth Factor	Hepatocyte Growth Factor	2qj2A01

2PF2A 4IUAA 2HGFA 1BHTA 4BVWA 4R1AA 1HPJA 5CS1A 2PK4A 1Z40A 3HMRA 3ZLEA 2LL3A 4R1BA 1KIVA 2Y8RA 5EOKA 2FD6A 1KI0A 3HMSA 5CS9A 3SRJA 1I71A 4R1CA 3HMTA 1GMOA 4BV5A 1HKYA 4CIKA 4APMA 1NK1A 1B2IA 1CEBA 2Q8AA 2YIOA 2KJ4A 2J8LA 4HZHA 3HN4A 4R19A 1NL2A 1KDUA 5CT2A 3SP8A 4O03A 3SRIA 3K65A 4BVCA 3LAQA 5CT1A 2K4RA 2YILA 2K51A 5HPGA 5CP9A 4Z09A 2FEBA 2HPPP 2L0SA 2KNFA 4DURA 2Z8VA 4BV7A 4BVDA 3E6PL 2J8JA 4BVVA 1PK4A 3BT2A 4UV6A 1PMLA 1I8NA 3KIVA 5CT3A 1YXEA 4D3CA 2X2ZA 5EODA 1TPKA 5CS3A 2YIPA 3MKPA 2SPTA 1W81A 3NXPA 1PK2A 4Z0EA 2PF1A 1HPKA 1GMNA 5CS5A 1PKRA 2Q8BA 2DOIA 3U73A 1GP9A 2DOHX 1KRNA 1I5KA 3BT1A 4KIVA 5COEA 4UAOA 2I9BA 4Z0FA 1PMKA 4NZQA 1JFNA 2K13X 4Z0DA 3ZWZA 1A0HA 5CSQA 2QJ4A 2LL4M 2F83A 4A5TS 1CEAA 2I9AA 2QJ2A 5I25A 4APLA 1URKA 2HPQP 1NL1A 2Z8WA 1W8KA
chains in the Genus database with same CATH superfamily

2PF2A 4IUAA 2HGFA 1BHTA 4BVWA 4R1AA 1HPJA 5CS1A 2PK4A 1Z40A 3HMRA 3ZLEA 2LL3A 4R1BA 4YIZA 1KIVA 2Y8RA 5EOKA 2FD6A 1KI0A 3HMSA 5CS9A 3SRJA 1I71A 4R1CA 3HMTA 1GMOA 4BV5A 1HKYA 4CIKA 4APMA 1NK1A 1B2IA 1CEBA 2Q8AA 2YIOA 2KJ4A 2J8LA 4HZHA 3HN4A 4R19A 1NL2A 1KDUA 5CT2A 3SP8A 4O03A 3SRIA 3K65A 4BVCA 3LAQA 5CT1A 2K4RA 2YILA 2K51A 5HPGA 4YIVA 5CP9A 4Z09A 2FEBA 2HPPP 2L0SA 2KNFA 4DURA 2Z8VA 4BV7A 4BVDA 3E6PL 2J8JA 4BVVA 2KL5A 1PK4A 3BT2A 4UV6A 1PMLA 1I8NA 3KIVA 5CT3A 1YXEA 4D3CA 2X2ZA 5EODA 1TPKA 5CS3A 2YIPA 3MKPA 2SPTA 1W81A 3NXPA 1PK2A 4Z0EA 2PF1A 1HPKA 1GMNA 5CS5A 1PKRA 2Q8BA 2DOIA 3U73A 1GP9A 2DOHX 1KRNA 1I5KA 3BT1A 4KIVA 5COEA 4UAOA 2I9BA 4Z0FA 1PMKA 4NZQA 1JFNA 2K13X 4Z0DA 3ZWZA 1A0HA 5CSQA 2QJ4A 2LL4M 2F83A 4A5TS 1CEAA 2I9AA 2QJ2A 5I25A 4APLA 1URKA 2HPQP 1NL1A 2Z8WA 1W8KA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 2PF2 A;  4IUA A;  2HGF A;  1BHT A;  4BVW A;  4R1A A;  1HPJ A;  5CS1 A;  2PK4 A;  1Z40 A;  3HMR A;  3ZLE A;  2LL3 A;  4R1B A;  1KIV A;  2Y8R A;  5EOK A;  2FD6 A;  1KI0 A;  3HMS A;  5CS9 A;  3SRJ A;  1I71 A;  4R1C A;  3HMT A;  1GMO A;  4BV5 A;  1HKY A;  4CIK A;  4APM A;  1NK1 A;  1B2I A;  1CEB A;  2Q8A A;  2YIO A;  2KJ4 A;  2J8L A;  4HZH A;  3HN4 A;  4R19 A;  1NL2 A;  1KDU A;  5CT2 A;  3SP8 A;  4O03 A;  3SRI A;  3K65 A;  4BVC A;  3LAQ A;  5CT1 A;  2K4R A;  2YIL A;  2K51 A;  5HPG A;  5CP9 A;  4Z09 A;  2FEB A;  2HPP P;  2L0S A;  2KNF A;  4DUR A;  2Z8V A;  4BV7 A;  4BVD A;  3E6P L;  2J8J A;  4BVV A;  1PK4 A;  3BT2 A;  4UV6 A;  1PML A;  1I8N A;  3KIV A;  5CT3 A;  1YXE A;  4D3C A;  2X2Z A;  5EOD A;  1TPK A;  5CS3 A;  2YIP A;  3MKP A;  2SPT A;  1W81 A;  3NXP A;  1PK2 A;  4Z0E A;  2PF1 A;  1HPK A;  1GMN A;  5CS5 A;  1PKR A;  2Q8B A;  2DOI A;  3U73 A;  1GP9 A;  2DOH X;  1KRN A;  1I5K A;  3BT1 A;  4KIV A;  5COE A;  4UAO A;  2I9B A;  4Z0F A;  1PMK A;  4NZQ A;  1JFN A;  2K13 X;  4Z0D A;  3ZWZ A;  1A0H A;  5CSQ A;  2QJ4 A;  2LL4 M;  2F83 A;  4A5T S;  1CEA A;  2I9A A;  2QJ2 A;  5I25 A;  4APL A;  1URK A;  2HPQ P;  1NL1 A;  2Z8W A;  1W8K A; 
#chains in the Genus database with same CATH topology
 2PF2 A;  4IUA A;  2HGF A;  1BHT A;  4BVW A;  4R1A A;  1HPJ A;  5CS1 A;  2PK4 A;  1Z40 A;  3HMR A;  3ZLE A;  2LL3 A;  4R1B A;  4YIZ A;  1KIV A;  2Y8R A;  5EOK A;  2FD6 A;  1KI0 A;  3HMS A;  5CS9 A;  3SRJ A;  1I71 A;  4R1C A;  3HMT A;  1GMO A;  4BV5 A;  1HKY A;  4CIK A;  4APM A;  1NK1 A;  1B2I A;  1CEB A;  2Q8A A;  2YIO A;  2KJ4 A;  2J8L A;  4HZH A;  3HN4 A;  4R19 A;  1NL2 A;  1KDU A;  5CT2 A;  3SP8 A;  4O03 A;  3SRI A;  3K65 A;  4BVC A;  3LAQ A;  5CT1 A;  2K4R A;  2YIL A;  2K51 A;  5HPG A;  4YIV A;  5CP9 A;  4Z09 A;  2FEB A;  2HPP P;  2L0S A;  2KNF A;  4DUR A;  2Z8V A;  4BV7 A;  4BVD A;  3E6P L;  2J8J A;  4BVV A;  2KL5 A;  1PK4 A;  3BT2 A;  4UV6 A;  1PML A;  1I8N A;  3KIV A;  5CT3 A;  1YXE A;  4D3C A;  2X2Z A;  5EOD A;  1TPK A;  5CS3 A;  2YIP A;  3MKP A;  2SPT A;  1W81 A;  3NXP A;  1PK2 A;  4Z0E A;  2PF1 A;  1HPK A;  1GMN A;  5CS5 A;  1PKR A;  2Q8B A;  2DOI A;  3U73 A;  1GP9 A;  2DOH X;  1KRN A;  1I5K A;  3BT1 A;  4KIV A;  5COE A;  4UAO A;  2I9B A;  4Z0F A;  1PMK A;  4NZQ A;  1JFN A;  2K13 X;  4Z0D A;  3ZWZ A;  1A0H A;  5CSQ A;  2QJ4 A;  2LL4 M;  2F83 A;  4A5T S;  1CEA A;  2I9A A;  2QJ2 A;  5I25 A;  4APL A;  1URK A;  2HPQ P;  1NL1 A;  2Z8W A;  1W8K A; 
#chains in the Genus database with same CATH homology
 2PF2 A;  4IUA A;  2HGF A;  1BHT A;  4BVW A;  4R1A A;  1HPJ A;  5CS1 A;  2PK4 A;  1Z40 A;  3HMR A;  3ZLE A;  2LL3 A;  4R1B A;  4YIZ A;  1KIV A;  2Y8R A;  5EOK A;  2FD6 A;  1KI0 A;  3HMS A;  5CS9 A;  3SRJ A;  1I71 A;  4R1C A;  3HMT A;  1GMO A;  4BV5 A;  1HKY A;  4CIK A;  4APM A;  1NK1 A;  1B2I A;  1CEB A;  2Q8A A;  2YIO A;  2KJ4 A;  2J8L A;  4HZH A;  3HN4 A;  4R19 A;  1NL2 A;  1KDU A;  5CT2 A;  3SP8 A;  4O03 A;  3SRI A;  3K65 A;  4BVC A;  3LAQ A;  5CT1 A;  2K4R A;  2YIL A;  2K51 A;  5HPG A;  4YIV A;  5CP9 A;  4Z09 A;  2FEB A;  2HPP P;  2L0S A;  2KNF A;  4DUR A;  2Z8V A;  4BV7 A;  4BVD A;  3E6P L;  2J8J A;  4BVV A;  2KL5 A;  1PK4 A;  3BT2 A;  4UV6 A;  1PML A;  1I8N A;  3KIV A;  5CT3 A;  1YXE A;  4D3C A;  2X2Z A;  5EOD A;  1TPK A;  5CS3 A;  2YIP A;  3MKP A;  2SPT A;  1W81 A;  3NXP A;  1PK2 A;  4Z0E A;  2PF1 A;  1HPK A;  1GMN A;  5CS5 A;  1PKR A;  2Q8B A;  2DOI A;  3U73 A;  1GP9 A;  2DOH X;  1KRN A;  1I5K A;  3BT1 A;  4KIV A;  5COE A;  4UAO A;  2I9B A;  4Z0F A;  1PMK A;  4NZQ A;  1JFN A;  2K13 X;  4Z0D A;  3ZWZ A;  1A0H A;  5CSQ A;  2QJ4 A;  2LL4 M;  2F83 A;  4A5T S;  1CEA A;  2I9A A;  2QJ2 A;  5I25 A;  4APL A;  1URK A;  2HPQ P;  1NL1 A;  2Z8W A;  1W8K A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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2QJ2A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations