2QJ2A

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Total Genus 46
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
174
structure length
174
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
molecule tags Hormone
source organism Homo sapiens
total genus 46
structure length 174
sequence length 174
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 2qj2A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2qj2A01
2Q8BA 4UV6A 2QJ2A 1BHTA 2I9AA 2YIOA 1PMKA 4R1AA 4APMA 2L0SA 2Z8VA 4R1CA 1W81A 2Q8AA 2HGFA 4R1BA 5CT2A 1HKYA 1PK2A 3ZLEA 2HPPP 1I71A 5CS9A 2F83A 1KRNA 1KI0A 2I9BA 2K51A 2FEBA 4Z09A 3KIVA 4R19A 2X2ZA 4IUAA 2Z8WA 1NL2A 5CS5A 5CT3A 5CP9A 2YILA 4HZHA 3BT2A 3K65A 1B2IA 4BVCA 3HMSA 3LAQA 2QJ4A 4BV7A 4D3CA 4DURA 2YIPA 3SRIA 1PMLA 5EOKA 2KNFA 4CIKA 5HPGA 2DOIA 3E6PL 2FD6A 1YXEA 1NK1A 2PF1A 4O03A 2SPTA 5CS1A 1I5KA 3SP8A 4APLA 1NL1A 1I8NA 3ZWZA 4BVVA 3U73A 4A5TS 1GP9A 1GMOA 5CSQA 1JFNA 3NXPA 2K4RA 2J8LA 4BVWA 4Z0DA 1A0HA 2KJ4A 4NZQA 1W8KA 2PK4A 3HMTA 3HMRA 1KDUA 5CS3A 1HPKA 1CEBA 5COEA 2J8JA 5EODA 1PK4A 1CEAA 2K13X 3MKPA 2LL4M 3HN4A 5I25A 4Z0FA 1GMNA 1TPKA 4BV5A 4KIVA 5CT1A 3BT1A 4Z0EA 1PKRA 3SRJA 1URKA 2LL3A 2Y8RA 2HPQP 1HPJA 1KIVA 4UAOA 4BVDA 1Z40A 2PF2A 2DOHX
chains in the Genus database with same CATH superfamily
2Q8BA 4UV6A 2QJ2A 1BHTA 2KL5A 2I9AA 2YIOA 1PMKA 4R1AA 4APMA 2L0SA 2Z8VA 4R1CA 1W81A 2Q8AA 2HGFA 4R1BA 5CT2A 1HKYA 1PK2A 3ZLEA 2HPPP 1I71A 5CS9A 2F83A 1KRNA 1KI0A 2I9BA 2K51A 2FEBA 4Z09A 3KIVA 4R19A 2X2ZA 4IUAA 2Z8WA 1NL2A 5CS5A 5CT3A 5CP9A 2YILA 4HZHA 3BT2A 3K65A 1B2IA 4BVCA 3HMSA 3LAQA 2QJ4A 4BV7A 4D3CA 4DURA 2YIPA 3SRIA 1PMLA 5EOKA 2KNFA 4CIKA 5HPGA 2DOIA 3E6PL 2FD6A 1YXEA 1NK1A 2PF1A 4O03A 2SPTA 5CS1A 1I5KA 3SP8A 4APLA 1NL1A 1I8NA 4YIZA 3ZWZA 4BVVA 3U73A 4A5TS 1GP9A 1GMOA 5CSQA 1JFNA 3NXPA 2K4RA 2J8LA 4BVWA 4Z0DA 1A0HA 2KJ4A 4NZQA 1W8KA 2PK4A 3HMTA 3HMRA 1KDUA 5CS3A 1HPKA 1CEBA 5COEA 2J8JA 5EODA 1PK4A 1CEAA 2K13X 3MKPA 2LL4M 3HN4A 5I25A 4Z0FA 1GMNA 1TPKA 4BV5A 4KIVA 5CT1A 3BT1A 4Z0EA 4YIVA 1PKRA 3SRJA 1URKA 2LL3A 2Y8RA 2HPQP 1HPJA 1KIVA 4UAOA 4BVDA 1Z40A 2PF2A 2DOHX
chains in the Genus database with same CATH topology
2Q8BA 4UV6A 2QJ2A 1BHTA 2KL5A 2I9AA 2YIOA 1PMKA 4R1AA 4APMA 2L0SA 2Z8VA 4R1CA 1W81A 2Q8AA 2HGFA 4R1BA 5CT2A 1HKYA 1PK2A 3ZLEA 2HPPP 1I71A 5CS9A 2F83A 1KRNA 1KI0A 2I9BA 2K51A 2FEBA 4Z09A 3KIVA 4R19A 2X2ZA 4IUAA 2Z8WA 1NL2A 5CS5A 5CT3A 5CP9A 2YILA 4HZHA 3BT2A 3K65A 1B2IA 4BVCA 3HMSA 3LAQA 2QJ4A 4BV7A 4D3CA 4DURA 2YIPA 3SRIA 1PMLA 5EOKA 2KNFA 4CIKA 5HPGA 2DOIA 3E6PL 2FD6A 1YXEA 1NK1A 2PF1A 4O03A 2SPTA 5CS1A 1I5KA 3SP8A 4APLA 1NL1A 1I8NA 4YIZA 3ZWZA 4BVVA 3U73A 4A5TS 1GP9A 1GMOA 5CSQA 1JFNA 3NXPA 2K4RA 2J8LA 4BVWA 4Z0DA 1A0HA 2KJ4A 4NZQA 1W8KA 2PK4A 3HMTA 3HMRA 1KDUA 5CS3A 1HPKA 1CEBA 5COEA 2J8JA 5EODA 1PK4A 1CEAA 2K13X 3MKPA 2LL4M 3HN4A 5I25A 4Z0FA 1GMNA 1TPKA 4BV5A 4KIVA 5CT1A 3BT1A 4Z0EA 4YIVA 1PKRA 3SRJA 1URKA 2LL3A 2Y8RA 2HPQP 1HPJA 1KIVA 4UAOA 4BVDA 1Z40A 2PF2A 2DOHX
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q8B A;  4UV6 A;  2QJ2 A;  1BHT A;  2I9A A;  2YIO A;  1PMK A;  4R1A A;  4APM A;  2L0S A;  2Z8V A;  4R1C A;  1W81 A;  2Q8A A;  2HGF A;  4R1B A;  5CT2 A;  1HKY A;  1PK2 A;  3ZLE A;  2HPP P;  1I71 A;  5CS9 A;  2F83 A;  1KRN A;  1KI0 A;  2I9B A;  2K51 A;  2FEB A;  4Z09 A;  3KIV A;  4R19 A;  2X2Z A;  4IUA A;  2Z8W A;  1NL2 A;  5CS5 A;  5CT3 A;  5CP9 A;  2YIL A;  4HZH A;  3BT2 A;  3K65 A;  1B2I A;  4BVC A;  3HMS A;  3LAQ A;  2QJ4 A;  4BV7 A;  4D3C A;  4DUR A;  2YIP A;  3SRI A;  1PML A;  5EOK A;  2KNF A;  4CIK A;  5HPG A;  2DOI A;  3E6P L;  2FD6 A;  1YXE A;  1NK1 A;  2PF1 A;  4O03 A;  2SPT A;  5CS1 A;  1I5K A;  3SP8 A;  4APL A;  1NL1 A;  1I8N A;  3ZWZ A;  4BVV A;  3U73 A;  4A5T S;  1GP9 A;  1GMO A;  5CSQ A;  1JFN A;  3NXP A;  2K4R A;  2J8L A;  4BVW A;  4Z0D A;  1A0H A;  2KJ4 A;  4NZQ A;  1W8K A;  2PK4 A;  3HMT A;  3HMR A;  1KDU A;  5CS3 A;  1HPK A;  1CEB A;  5COE A;  2J8J A;  5EOD A;  1PK4 A;  1CEA A;  2K13 X;  3MKP A;  2LL4 M;  3HN4 A;  5I25 A;  4Z0F A;  1GMN A;  1TPK A;  4BV5 A;  4KIV A;  5CT1 A;  3BT1 A;  4Z0E A;  1PKR A;  3SRJ A;  1URK A;  2LL3 A;  2Y8R A;  2HPQ P;  1HPJ A;  1KIV A;  4UAO A;  4BVD A;  1Z40 A;  2PF2 A;  2DOH X; 
#chains in the Genus database with same CATH topology
 2Q8B A;  4UV6 A;  2QJ2 A;  1BHT A;  2KL5 A;  2I9A A;  2YIO A;  1PMK A;  4R1A A;  4APM A;  2L0S A;  2Z8V A;  4R1C A;  1W81 A;  2Q8A A;  2HGF A;  4R1B A;  5CT2 A;  1HKY A;  1PK2 A;  3ZLE A;  2HPP P;  1I71 A;  5CS9 A;  2F83 A;  1KRN A;  1KI0 A;  2I9B A;  2K51 A;  2FEB A;  4Z09 A;  3KIV A;  4R19 A;  2X2Z A;  4IUA A;  2Z8W A;  1NL2 A;  5CS5 A;  5CT3 A;  5CP9 A;  2YIL A;  4HZH A;  3BT2 A;  3K65 A;  1B2I A;  4BVC A;  3HMS A;  3LAQ A;  2QJ4 A;  4BV7 A;  4D3C A;  4DUR A;  2YIP A;  3SRI A;  1PML A;  5EOK A;  2KNF A;  4CIK A;  5HPG A;  2DOI A;  3E6P L;  2FD6 A;  1YXE A;  1NK1 A;  2PF1 A;  4O03 A;  2SPT A;  5CS1 A;  1I5K A;  3SP8 A;  4APL A;  1NL1 A;  1I8N A;  4YIZ A;  3ZWZ A;  4BVV A;  3U73 A;  4A5T S;  1GP9 A;  1GMO A;  5CSQ A;  1JFN A;  3NXP A;  2K4R A;  2J8L A;  4BVW A;  4Z0D A;  1A0H A;  2KJ4 A;  4NZQ A;  1W8K A;  2PK4 A;  3HMT A;  3HMR A;  1KDU A;  5CS3 A;  1HPK A;  1CEB A;  5COE A;  2J8J A;  5EOD A;  1PK4 A;  1CEA A;  2K13 X;  3MKP A;  2LL4 M;  3HN4 A;  5I25 A;  4Z0F A;  1GMN A;  1TPK A;  4BV5 A;  4KIV A;  5CT1 A;  3BT1 A;  4Z0E A;  4YIV A;  1PKR A;  3SRJ A;  1URK A;  2LL3 A;  2Y8R A;  2HPQ P;  1HPJ A;  1KIV A;  4UAO A;  4BVD A;  1Z40 A;  2PF2 A;  2DOH X; 
#chains in the Genus database with same CATH homology
 2Q8B A;  4UV6 A;  2QJ2 A;  1BHT A;  2KL5 A;  2I9A A;  2YIO A;  1PMK A;  4R1A A;  4APM A;  2L0S A;  2Z8V A;  4R1C A;  1W81 A;  2Q8A A;  2HGF A;  4R1B A;  5CT2 A;  1HKY A;  1PK2 A;  3ZLE A;  2HPP P;  1I71 A;  5CS9 A;  2F83 A;  1KRN A;  1KI0 A;  2I9B A;  2K51 A;  2FEB A;  4Z09 A;  3KIV A;  4R19 A;  2X2Z A;  4IUA A;  2Z8W A;  1NL2 A;  5CS5 A;  5CT3 A;  5CP9 A;  2YIL A;  4HZH A;  3BT2 A;  3K65 A;  1B2I A;  4BVC A;  3HMS A;  3LAQ A;  2QJ4 A;  4BV7 A;  4D3C A;  4DUR A;  2YIP A;  3SRI A;  1PML A;  5EOK A;  2KNF A;  4CIK A;  5HPG A;  2DOI A;  3E6P L;  2FD6 A;  1YXE A;  1NK1 A;  2PF1 A;  4O03 A;  2SPT A;  5CS1 A;  1I5K A;  3SP8 A;  4APL A;  1NL1 A;  1I8N A;  4YIZ A;  3ZWZ A;  4BVV A;  3U73 A;  4A5T S;  1GP9 A;  1GMO A;  5CSQ A;  1JFN A;  3NXP A;  2K4R A;  2J8L A;  4BVW A;  4Z0D A;  1A0H A;  2KJ4 A;  4NZQ A;  1W8K A;  2PK4 A;  3HMT A;  3HMR A;  1KDU A;  5CS3 A;  1HPK A;  1CEB A;  5COE A;  2J8J A;  5EOD A;  1PK4 A;  1CEA A;  2K13 X;  3MKP A;  2LL4 M;  3HN4 A;  5I25 A;  4Z0F A;  1GMN A;  1TPK A;  4BV5 A;  4KIV A;  5CT1 A;  3BT1 A;  4Z0E A;  4YIV A;  1PKR A;  3SRJ A;  1URK A;  2LL3 A;  2Y8R A;  2HPQ P;  1HPJ A;  1KIV A;  4UAO A;  4BVD A;  1Z40 A;  2PF2 A;  2DOH X; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...