2QJ4A

A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
172
structure length
172
Chain Sequence
TLHEFKKSAKTTLTKEDPLLKIKTKKVNSADECANRCIRNRGFTFTCKAFVFDKSRKRCYWYPFNSMSSGVKKGFGHEFDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQPWNSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
source organism Mus musculus
publication title A mechanistic basis for converting a receptor tyrosine kinase agonist to an antagonist
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 32
structure length 172
sequence length 172
chains with identical sequence B
ec nomenclature
pdb deposition date 2007-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 2qj4A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 2qj4A01
4BV5A 1W8KA 3BT1A 5CS5A 2Q8AA 4APLA 3HMRA 1GMNA 1B2IA 4DURA 3E6PL 3ZLEA 1GP9A 3HMSA 5EOKA 5I25A 4KIVA 3ZWZA 2PF1A 2YILA 1PK4A 2J8LA 2QJ2A 3K65A 5CS3A 1KI0A 2FEBA 1URKA 1Z40A 4R1BA 2PF2A 4HZHA 2Q8BA 1BHTA 1PMKA 1GMOA 1YXEA 3NXPA 4R19A 2KJ4A 5CT2A 4Z0FA 4D3CA 1NK1A 2PK4A 3SP8A 3HMTA 5CP9A 3LAQA 2L0SA 1PKRA 1CEBA 3HN4A 4Z09A 4IUAA 4CIKA 4R1CA 1PK2A 4UV6A 2HPPP 2I9AA 1HPKA 3MKPA 1W81A 2K13X 3SRIA 1HPJA 5CT1A 5EODA 2SPTA 4NZQA 4R1AA 5CT3A 2J8JA 3U73A 4BVDA 3SRJA 2DOHX 2LL3A 2QJ4A 1KIVA 1NL2A 2YIOA 2DOIA 5HPGA 2Z8VA 2K4RA 1NL1A 4O03A 2HPQP 1I8NA 4BVVA 4APMA 1PMLA 1I71A 2LL4M 2YIPA 3KIVA 1HKYA 2FD6A 4UAOA 1CEAA 5CSQA 2X2ZA 2Y8RA 2F83A 1KDUA 1I5KA 4BV7A 4Z0EA 5COEA 4BVCA 2HGFA 1TPKA 5CS9A 4A5TS 4Z0DA 4BVWA 2I9BA 1A0HA 3BT2A 2KNFA 2K51A 1JFNA 5CS1A 1KRNA 2Z8WA
chains in the Genus database with same CATH superfamily
4BV5A 1W8KA 3BT1A 5CS5A 2Q8AA 4APLA 3HMRA 1GMNA 1B2IA 4DURA 3E6PL 3ZLEA 1GP9A 3HMSA 5EOKA 5I25A 4KIVA 3ZWZA 2PF1A 2YILA 1PK4A 2J8LA 2QJ2A 3K65A 5CS3A 1KI0A 2FEBA 1URKA 1Z40A 4R1BA 2PF2A 4HZHA 2Q8BA 1BHTA 1PMKA 1GMOA 1YXEA 3NXPA 4R19A 2KJ4A 5CT2A 4Z0FA 4D3CA 1NK1A 2PK4A 3SP8A 3HMTA 5CP9A 3LAQA 4YIVA 2L0SA 1PKRA 1CEBA 3HN4A 4Z09A 4IUAA 4CIKA 4R1CA 1PK2A 4UV6A 2HPPP 2I9AA 4YIZA 1HPKA 3MKPA 1W81A 2K13X 3SRIA 1HPJA 5CT1A 5EODA 2SPTA 4NZQA 4R1AA 5CT3A 2J8JA 3U73A 4BVDA 3SRJA 2DOHX 2LL3A 2QJ4A 1KIVA 1NL2A 2YIOA 2DOIA 5HPGA 2Z8VA 2K4RA 1NL1A 4O03A 2HPQP 1I8NA 2KL5A 4BVVA 4APMA 1PMLA 1I71A 2LL4M 2YIPA 3KIVA 1HKYA 2FD6A 4UAOA 1CEAA 5CSQA 2X2ZA 2Y8RA 2F83A 1KDUA 1I5KA 4BV7A 4Z0EA 5COEA 4BVCA 2HGFA 1TPKA 5CS9A 4A5TS 4Z0DA 4BVWA 2I9BA 1A0HA 3BT2A 2KNFA 2K51A 1JFNA 5CS1A 1KRNA 2Z8WA
chains in the Genus database with same CATH topology
4BV5A 1W8KA 3BT1A 5CS5A 2Q8AA 4APLA 3HMRA 1GMNA 1B2IA 4DURA 3E6PL 3ZLEA 1GP9A 3HMSA 5EOKA 5I25A 4KIVA 3ZWZA 2PF1A 2YILA 1PK4A 2J8LA 2QJ2A 3K65A 5CS3A 1KI0A 2FEBA 1URKA 1Z40A 4R1BA 2PF2A 4HZHA 2Q8BA 1BHTA 1PMKA 1GMOA 1YXEA 3NXPA 4R19A 2KJ4A 5CT2A 4Z0FA 4D3CA 1NK1A 2PK4A 3SP8A 3HMTA 5CP9A 3LAQA 4YIVA 2L0SA 1PKRA 1CEBA 3HN4A 4Z09A 4IUAA 4CIKA 4R1CA 1PK2A 4UV6A 2HPPP 2I9AA 4YIZA 1HPKA 3MKPA 1W81A 2K13X 3SRIA 1HPJA 5CT1A 5EODA 2SPTA 4NZQA 4R1AA 5CT3A 2J8JA 3U73A 4BVDA 3SRJA 2DOHX 2LL3A 2QJ4A 1KIVA 1NL2A 2YIOA 2DOIA 5HPGA 2Z8VA 2K4RA 1NL1A 4O03A 2HPQP 1I8NA 2KL5A 4BVVA 4APMA 1PMLA 1I71A 2LL4M 2YIPA 3KIVA 1HKYA 2FD6A 4UAOA 1CEAA 5CSQA 2X2ZA 2Y8RA 2F83A 1KDUA 1I5KA 4BV7A 4Z0EA 5COEA 4BVCA 2HGFA 1TPKA 5CS9A 4A5TS 4Z0DA 4BVWA 2I9BA 1A0HA 3BT2A 2KNFA 2K51A 1JFNA 5CS1A 1KRNA 2Z8WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BV5 A;  1W8K A;  3BT1 A;  5CS5 A;  2Q8A A;  4APL A;  3HMR A;  1GMN A;  1B2I A;  4DUR A;  3E6P L;  3ZLE A;  1GP9 A;  3HMS A;  5EOK A;  5I25 A;  4KIV A;  3ZWZ A;  2PF1 A;  2YIL A;  1PK4 A;  2J8L A;  2QJ2 A;  3K65 A;  5CS3 A;  1KI0 A;  2FEB A;  1URK A;  1Z40 A;  4R1B A;  2PF2 A;  4HZH A;  2Q8B A;  1BHT A;  1PMK A;  1GMO A;  1YXE A;  3NXP A;  4R19 A;  2KJ4 A;  5CT2 A;  4Z0F A;  4D3C A;  1NK1 A;  2PK4 A;  3SP8 A;  3HMT A;  5CP9 A;  3LAQ A;  2L0S A;  1PKR A;  1CEB A;  3HN4 A;  4Z09 A;  4IUA A;  4CIK A;  4R1C A;  1PK2 A;  4UV6 A;  2HPP P;  2I9A A;  1HPK A;  3MKP A;  1W81 A;  2K13 X;  3SRI A;  1HPJ A;  5CT1 A;  5EOD A;  2SPT A;  4NZQ A;  4R1A A;  5CT3 A;  2J8J A;  3U73 A;  4BVD A;  3SRJ A;  2DOH X;  2LL3 A;  2QJ4 A;  1KIV A;  1NL2 A;  2YIO A;  2DOI A;  5HPG A;  2Z8V A;  2K4R A;  1NL1 A;  4O03 A;  2HPQ P;  1I8N A;  4BVV A;  4APM A;  1PML A;  1I71 A;  2LL4 M;  2YIP A;  3KIV A;  1HKY A;  2FD6 A;  4UAO A;  1CEA A;  5CSQ A;  2X2Z A;  2Y8R A;  2F83 A;  1KDU A;  1I5K A;  4BV7 A;  4Z0E A;  5COE A;  4BVC A;  2HGF A;  1TPK A;  5CS9 A;  4A5T S;  4Z0D A;  4BVW A;  2I9B A;  1A0H A;  3BT2 A;  2KNF A;  2K51 A;  1JFN A;  5CS1 A;  1KRN A;  2Z8W A; 
#chains in the Genus database with same CATH topology
 4BV5 A;  1W8K A;  3BT1 A;  5CS5 A;  2Q8A A;  4APL A;  3HMR A;  1GMN A;  1B2I A;  4DUR A;  3E6P L;  3ZLE A;  1GP9 A;  3HMS A;  5EOK A;  5I25 A;  4KIV A;  3ZWZ A;  2PF1 A;  2YIL A;  1PK4 A;  2J8L A;  2QJ2 A;  3K65 A;  5CS3 A;  1KI0 A;  2FEB A;  1URK A;  1Z40 A;  4R1B A;  2PF2 A;  4HZH A;  2Q8B A;  1BHT A;  1PMK A;  1GMO A;  1YXE A;  3NXP A;  4R19 A;  2KJ4 A;  5CT2 A;  4Z0F A;  4D3C A;  1NK1 A;  2PK4 A;  3SP8 A;  3HMT A;  5CP9 A;  3LAQ A;  4YIV A;  2L0S A;  1PKR A;  1CEB A;  3HN4 A;  4Z09 A;  4IUA A;  4CIK A;  4R1C A;  1PK2 A;  4UV6 A;  2HPP P;  2I9A A;  4YIZ A;  1HPK A;  3MKP A;  1W81 A;  2K13 X;  3SRI A;  1HPJ A;  5CT1 A;  5EOD A;  2SPT A;  4NZQ A;  4R1A A;  5CT3 A;  2J8J A;  3U73 A;  4BVD A;  3SRJ A;  2DOH X;  2LL3 A;  2QJ4 A;  1KIV A;  1NL2 A;  2YIO A;  2DOI A;  5HPG A;  2Z8V A;  2K4R A;  1NL1 A;  4O03 A;  2HPQ P;  1I8N A;  2KL5 A;  4BVV A;  4APM A;  1PML A;  1I71 A;  2LL4 M;  2YIP A;  3KIV A;  1HKY A;  2FD6 A;  4UAO A;  1CEA A;  5CSQ A;  2X2Z A;  2Y8R A;  2F83 A;  1KDU A;  1I5K A;  4BV7 A;  4Z0E A;  5COE A;  4BVC A;  2HGF A;  1TPK A;  5CS9 A;  4A5T S;  4Z0D A;  4BVW A;  2I9B A;  1A0H A;  3BT2 A;  2KNF A;  2K51 A;  1JFN A;  5CS1 A;  1KRN A;  2Z8W A; 
#chains in the Genus database with same CATH homology
 4BV5 A;  1W8K A;  3BT1 A;  5CS5 A;  2Q8A A;  4APL A;  3HMR A;  1GMN A;  1B2I A;  4DUR A;  3E6P L;  3ZLE A;  1GP9 A;  3HMS A;  5EOK A;  5I25 A;  4KIV A;  3ZWZ A;  2PF1 A;  2YIL A;  1PK4 A;  2J8L A;  2QJ2 A;  3K65 A;  5CS3 A;  1KI0 A;  2FEB A;  1URK A;  1Z40 A;  4R1B A;  2PF2 A;  4HZH A;  2Q8B A;  1BHT A;  1PMK A;  1GMO A;  1YXE A;  3NXP A;  4R19 A;  2KJ4 A;  5CT2 A;  4Z0F A;  4D3C A;  1NK1 A;  2PK4 A;  3SP8 A;  3HMT A;  5CP9 A;  3LAQ A;  4YIV A;  2L0S A;  1PKR A;  1CEB A;  3HN4 A;  4Z09 A;  4IUA A;  4CIK A;  4R1C A;  1PK2 A;  4UV6 A;  2HPP P;  2I9A A;  4YIZ A;  1HPK A;  3MKP A;  1W81 A;  2K13 X;  3SRI A;  1HPJ A;  5CT1 A;  5EOD A;  2SPT A;  4NZQ A;  4R1A A;  5CT3 A;  2J8J A;  3U73 A;  4BVD A;  3SRJ A;  2DOH X;  2LL3 A;  2QJ4 A;  1KIV A;  1NL2 A;  2YIO A;  2DOI A;  5HPG A;  2Z8V A;  2K4R A;  1NL1 A;  4O03 A;  2HPQ P;  1I8N A;  2KL5 A;  4BVV A;  4APM A;  1PML A;  1I71 A;  2LL4 M;  2YIP A;  3KIV A;  1HKY A;  2FD6 A;  4UAO A;  1CEA A;  5CSQ A;  2X2Z A;  2Y8R A;  2F83 A;  1KDU A;  1I5K A;  4BV7 A;  4Z0E A;  5COE A;  4BVC A;  2HGF A;  1TPK A;  5CS9 A;  4A5T S;  4Z0D A;  4BVW A;  2I9B A;  1A0H A;  3BT2 A;  2KNF A;  2K51 A;  1JFN A;  5CS1 A;  1KRN A;  2Z8W A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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