2XDEA

Crystal structure of the complex of pf-3450074 with an engineered hiv capsid n terminal domain
Total Genus 47
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
47
sequence length
136
structure length
136
Chain Sequence
PIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVGEPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention.
pubmed doi rcsb
molecule tags Viral protein
source organism Human immunodeficiency virus 1
molecule keywords GAG POLYPROTEIN
total genus 47
structure length 136
sequence length 136
chains with identical sequence B
ec nomenclature ec 2.7.7.49: RNA-directed DNA polymerase.
pdb deposition date 2010-04-30
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.375.10 Mainly Alpha Orthogonal Bundle Human Immunodeficiency Virus Type 1 Capsid Protein Human Immunodeficiency Virus Type 1 Capsid Protein 2xdeA00
2PWMA 4XROA 1D1DA 4U0FA 2V4XA 3NTEA 4DGEC 4XFYA 4LQWC 5HGKA 4PH0A 4PH2A 2JPRA 4WYMA 1G03A 3BP9A 1EM9A 2M8LA 2X82A 4DGAC 3H47A 1M9YC 1AFVA 4E92A 1E6JP 4U0DA 2EIAA 4XFXA 5HGMA 2GONA 2X83A 1M9DC 1GWPA 2WLVB 3MGEA 3H4EA 4QNBA 1L6NA 4PH3A 4U0EA 1U7KA 1AK4C 2GOLB 2PWOA 2WLVA 1EIAA 1M9EC 4U0AA 2KGFA 4XFZA 2LF4A 2PXRC 2XGVA 4XRQA 4HTWA 1P7NA 1M9CC 1M9XC 4U0CA 2XGUA 4B4NA 5JPAA 5HGOA 4NX4C 4U0BA 5HGNA 2XGYA 2Y4ZA 2X2DD 2M8NA 4E91A 3P05A 2XDEA 1QRJA 5HGLA 4J93A 1M9FC 2M8PA 4INBA
chains in the Genus database with same CATH superfamily
2PWMA 4XROA 1D1DA 4U0FA 2V4XA 3NTEA 4DGEC 4XFYA 4LQWC 5HGKA 4PH0A 4PH2A 2JPRA 4WYMA 1G03A 3BP9A 1EM9A 2M8LA 2X82A 4DGAC 3H47A 1M9YC 1AFVA 4E92A 1E6JP 4U0DA 2EIAA 4XFXA 5HGMA 2GONA 2X83A 1M9DC 1GWPA 2WLVB 3MGEA 3H4EA 4QNBA 1L6NA 4PH3A 4U0EA 1U7KA 1AK4C 2GOLB 2PWOA 2WLVA 1EIAA 1M9EC 4U0AA 2KGFA 4XFZA 2LF4A 2PXRC 2XGVA 4XRQA 4HTWA 1P7NA 1M9CC 1M9XC 4U0CA 2XGUA 4B4NA 5JPAA 5HGOA 4NX4C 4U0BA 5HGNA 2XGYA 2Y4ZA 2X2DD 2M8NA 4E91A 3P05A 2XDEA 1QRJA 5HGLA 4J93A 1M9FC 2M8PA 4INBA
chains in the Genus database with same CATH topology
2PWMA 4XROA 1D1DA 4U0FA 2V4XA 3NTEA 4DGEC 4XFYA 4LQWC 5HGKA 4PH0A 4PH2A 2JPRA 4WYMA 1G03A 3BP9A 1EM9A 2M8LA 2X82A 4DGAC 3H47A 1M9YC 1AFVA 4E92A 1E6JP 4U0DA 2EIAA 4XFXA 5HGMA 2GONA 2X83A 1M9DC 1GWPA 2WLVB 3MGEA 3H4EA 4QNBA 1L6NA 4PH3A 4U0EA 1U7KA 1AK4C 2GOLB 2PWOA 2WLVA 1EIAA 1M9EC 4U0AA 2KGFA 4XFZA 2LF4A 2PXRC 2XGVA 4XRQA 4HTWA 1P7NA 1M9CC 1M9XC 4U0CA 2XGUA 4B4NA 5JPAA 5HGOA 4NX4C 4U0BA 5HGNA 2XGYA 2Y4ZA 2X2DD 2M8NA 4E91A 3P05A 2XDEA 1QRJA 5HGLA 4J93A 1M9FC 2M8PA 4INBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PWM A;  4XRO A;  1D1D A;  4U0F A;  2V4X A;  3NTE A;  4DGE C;  4XFY A;  4LQW C;  5HGK A;  4PH0 A;  4PH2 A;  2JPR A;  4WYM A;  1G03 A;  3BP9 A;  1EM9 A;  2M8L A;  2X82 A;  4DGA C;  3H47 A;  1M9Y C;  1AFV A;  4E92 A;  1E6J P;  4U0D A;  2EIA A;  4XFX A;  5HGM A;  2GON A;  2X83 A;  1M9D C;  1GWP A;  2WLV B;  3MGE A;  3H4E A;  4QNB A;  1L6N A;  4PH3 A;  4U0E A;  1U7K A;  1AK4 C;  2GOL B;  2PWO A;  2WLV A;  1EIA A;  1M9E C;  4U0A A;  2KGF A;  4XFZ A;  2LF4 A;  2PXR C;  2XGV A;  4XRQ A;  4HTW A;  1P7N A;  1M9C C;  1M9X C;  4U0C A;  2XGU A;  4B4N A;  5JPA A;  5HGO A;  4NX4 C;  4U0B A;  5HGN A;  2XGY A;  2Y4Z A;  2X2D D;  2M8N A;  4E91 A;  3P05 A;  2XDE A;  1QRJ A;  5HGL A;  4J93 A;  1M9F C;  2M8P A;  4INB A; 
#chains in the Genus database with same CATH topology
 2PWM A;  4XRO A;  1D1D A;  4U0F A;  2V4X A;  3NTE A;  4DGE C;  4XFY A;  4LQW C;  5HGK A;  4PH0 A;  4PH2 A;  2JPR A;  4WYM A;  1G03 A;  3BP9 A;  1EM9 A;  2M8L A;  2X82 A;  4DGA C;  3H47 A;  1M9Y C;  1AFV A;  4E92 A;  1E6J P;  4U0D A;  2EIA A;  4XFX A;  5HGM A;  2GON A;  2X83 A;  1M9D C;  1GWP A;  2WLV B;  3MGE A;  3H4E A;  4QNB A;  1L6N A;  4PH3 A;  4U0E A;  1U7K A;  1AK4 C;  2GOL B;  2PWO A;  2WLV A;  1EIA A;  1M9E C;  4U0A A;  2KGF A;  4XFZ A;  2LF4 A;  2PXR C;  2XGV A;  4XRQ A;  4HTW A;  1P7N A;  1M9C C;  1M9X C;  4U0C A;  2XGU A;  4B4N A;  5JPA A;  5HGO A;  4NX4 C;  4U0B A;  5HGN A;  2XGY A;  2Y4Z A;  2X2D D;  2M8N A;  4E91 A;  3P05 A;  2XDE A;  1QRJ A;  5HGL A;  4J93 A;  1M9F C;  2M8P A;  4INB A; 
#chains in the Genus database with same CATH homology
 2PWM A;  4XRO A;  1D1D A;  4U0F A;  2V4X A;  3NTE A;  4DGE C;  4XFY A;  4LQW C;  5HGK A;  4PH0 A;  4PH2 A;  2JPR A;  4WYM A;  1G03 A;  3BP9 A;  1EM9 A;  2M8L A;  2X82 A;  4DGA C;  3H47 A;  1M9Y C;  1AFV A;  4E92 A;  1E6J P;  4U0D A;  2EIA A;  4XFX A;  5HGM A;  2GON A;  2X83 A;  1M9D C;  1GWP A;  2WLV B;  3MGE A;  3H4E A;  4QNB A;  1L6N A;  4PH3 A;  4U0E A;  1U7K A;  1AK4 C;  2GOL B;  2PWO A;  2WLV A;  1EIA A;  1M9E C;  4U0A A;  2KGF A;  4XFZ A;  2LF4 A;  2PXR C;  2XGV A;  4XRQ A;  4HTW A;  1P7N A;  1M9C C;  1M9X C;  4U0C A;  2XGU A;  4B4N A;  5JPA A;  5HGO A;  4NX4 C;  4U0B A;  5HGN A;  2XGY A;  2Y4Z A;  2X2D D;  2M8N A;  4E91 A;  3P05 A;  2XDE A;  1QRJ A;  5HGL A;  4J93 A;  1M9F C;  2M8P A;  4INB A; 
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similar chains in the pdb database (?% sequence similarity)

 
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