3MKPA

Crystal structure of 1k1 mutant of hepatocyte growth factor/scatter factor fragment nk1 in complex with heparin
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
173
structure length
173
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGEGESYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration
rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 38
structure length 173
sequence length 173
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 3mkpA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3mkpA01
4DURA 4R1AA 1JFNA 2KNFA 4Z0DA 4HZHA 1PMLA 3SP8A 3ZLEA 4BV5A 5I25A 4APMA 5CT1A 1HPJA 2Q8BA 1I5KA 1Z40A 3BT1A 3LAQA 4BV7A 4UAOA 2K13X 2PK4A 2Z8WA 4BVCA 2HPQP 1A0HA 4KIVA 1TPKA 2PF2A 1I71A 2PF1A 1W81A 3U73A 1I8NA 4O03A 2J8JA 1HKYA 1CEAA 4BVDA 1NL1A 2YIPA 1KRNA 3SRIA 4BVWA 2I9BA 3NXPA 5CS3A 2F83A 4Z0EA 5CP9A 5CSQA 2KJ4A 1GMNA 2HPPP 1NL2A 5COEA 3ZWZA 3HN4A 1W8KA 4R1CA 3HMRA 1PK4A 2DOHX 3BT2A 4APLA 3KIVA 1B2IA 1URKA 1PMKA 2Z8VA 1KDUA 1GP9A 1NK1A 2QJ4A 5CS9A 2LL3A 2K4RA 2L0SA 4Z0FA 1PK2A 4R1BA 2FEBA 3HMSA 1CEBA 4Z09A 5CT2A 2SPTA 1BHTA 5EODA 3HMTA 3SRJA 1GMOA 5CS5A 4D3CA 1HPKA 1YXEA 4CIKA 5HPGA 5EOKA 4BVVA 2HGFA 1KI0A 3K65A 4A5TS 2DOIA 2K51A 1KIVA 2FD6A 3E6PL 5CT3A 2X2ZA 4R19A 5CS1A 2YILA 2YIOA 2Y8RA 2I9AA 3MKPA 4IUAA 2LL4M 4UV6A 2J8LA 4NZQA 2QJ2A 2Q8AA 1PKRA
chains in the Genus database with same CATH superfamily
4DURA 4R1AA 1JFNA 2KNFA 4Z0DA 4HZHA 1PMLA 3SP8A 3ZLEA 4BV5A 5I25A 4APMA 5CT1A 1HPJA 2Q8BA 1I5KA 1Z40A 3BT1A 3LAQA 4BV7A 4UAOA 2K13X 2PK4A 2Z8WA 4BVCA 2HPQP 1A0HA 4KIVA 1TPKA 2PF2A 1I71A 2PF1A 1W81A 3U73A 1I8NA 4O03A 2J8JA 1HKYA 1CEAA 4BVDA 1NL1A 2YIPA 1KRNA 3SRIA 4BVWA 2I9BA 3NXPA 5CS3A 2F83A 4Z0EA 5CP9A 5CSQA 2KJ4A 1GMNA 2HPPP 1NL2A 5COEA 3ZWZA 3HN4A 1W8KA 4R1CA 3HMRA 1PK4A 2DOHX 3BT2A 4APLA 3KIVA 1B2IA 1URKA 1PMKA 2Z8VA 4YIVA 1KDUA 1GP9A 1NK1A 2QJ4A 5CS9A 2LL3A 2K4RA 2L0SA 4Z0FA 1PK2A 4R1BA 2FEBA 3HMSA 1CEBA 4Z09A 5CT2A 2SPTA 1BHTA 5EODA 3HMTA 3SRJA 1GMOA 5CS5A 2KL5A 4D3CA 1HPKA 1YXEA 4CIKA 5HPGA 5EOKA 4BVVA 2HGFA 1KI0A 3K65A 4A5TS 2DOIA 2K51A 1KIVA 2FD6A 3E6PL 5CT3A 2X2ZA 4R19A 4YIZA 5CS1A 2YILA 2YIOA 2Y8RA 2I9AA 3MKPA 4IUAA 2LL4M 4UV6A 2J8LA 4NZQA 2QJ2A 2Q8AA 1PKRA
chains in the Genus database with same CATH topology
4DURA 4R1AA 1JFNA 2KNFA 4Z0DA 4HZHA 1PMLA 3SP8A 3ZLEA 4BV5A 5I25A 4APMA 5CT1A 1HPJA 2Q8BA 1I5KA 1Z40A 3BT1A 3LAQA 4BV7A 4UAOA 2K13X 2PK4A 2Z8WA 4BVCA 2HPQP 1A0HA 4KIVA 1TPKA 2PF2A 1I71A 2PF1A 1W81A 3U73A 1I8NA 4O03A 2J8JA 1HKYA 1CEAA 4BVDA 1NL1A 2YIPA 1KRNA 3SRIA 4BVWA 2I9BA 3NXPA 5CS3A 2F83A 4Z0EA 5CP9A 5CSQA 2KJ4A 1GMNA 2HPPP 1NL2A 5COEA 3ZWZA 3HN4A 1W8KA 4R1CA 3HMRA 1PK4A 2DOHX 3BT2A 4APLA 3KIVA 1B2IA 1URKA 1PMKA 2Z8VA 4YIVA 1KDUA 1GP9A 1NK1A 2QJ4A 5CS9A 2LL3A 2K4RA 2L0SA 4Z0FA 1PK2A 4R1BA 2FEBA 3HMSA 1CEBA 4Z09A 5CT2A 2SPTA 1BHTA 5EODA 3HMTA 3SRJA 1GMOA 5CS5A 2KL5A 4D3CA 1HPKA 1YXEA 4CIKA 5HPGA 5EOKA 4BVVA 2HGFA 1KI0A 3K65A 4A5TS 2DOIA 2K51A 1KIVA 2FD6A 3E6PL 5CT3A 2X2ZA 4R19A 4YIZA 5CS1A 2YILA 2YIOA 2Y8RA 2I9AA 3MKPA 4IUAA 2LL4M 4UV6A 2J8LA 4NZQA 2QJ2A 2Q8AA 1PKRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DUR A;  4R1A A;  1JFN A;  2KNF A;  4Z0D A;  4HZH A;  1PML A;  3SP8 A;  3ZLE A;  4BV5 A;  5I25 A;  4APM A;  5CT1 A;  1HPJ A;  2Q8B A;  1I5K A;  1Z40 A;  3BT1 A;  3LAQ A;  4BV7 A;  4UAO A;  2K13 X;  2PK4 A;  2Z8W A;  4BVC A;  2HPQ P;  1A0H A;  4KIV A;  1TPK A;  2PF2 A;  1I71 A;  2PF1 A;  1W81 A;  3U73 A;  1I8N A;  4O03 A;  2J8J A;  1HKY A;  1CEA A;  4BVD A;  1NL1 A;  2YIP A;  1KRN A;  3SRI A;  4BVW A;  2I9B A;  3NXP A;  5CS3 A;  2F83 A;  4Z0E A;  5CP9 A;  5CSQ A;  2KJ4 A;  1GMN A;  2HPP P;  1NL2 A;  5COE A;  3ZWZ A;  3HN4 A;  1W8K A;  4R1C A;  3HMR A;  1PK4 A;  2DOH X;  3BT2 A;  4APL A;  3KIV A;  1B2I A;  1URK A;  1PMK A;  2Z8V A;  1KDU A;  1GP9 A;  1NK1 A;  2QJ4 A;  5CS9 A;  2LL3 A;  2K4R A;  2L0S A;  4Z0F A;  1PK2 A;  4R1B A;  2FEB A;  3HMS A;  1CEB A;  4Z09 A;  5CT2 A;  2SPT A;  1BHT A;  5EOD A;  3HMT A;  3SRJ A;  1GMO A;  5CS5 A;  4D3C A;  1HPK A;  1YXE A;  4CIK A;  5HPG A;  5EOK A;  4BVV A;  2HGF A;  1KI0 A;  3K65 A;  4A5T S;  2DOI A;  2K51 A;  1KIV A;  2FD6 A;  3E6P L;  5CT3 A;  2X2Z A;  4R19 A;  5CS1 A;  2YIL A;  2YIO A;  2Y8R A;  2I9A A;  3MKP A;  4IUA A;  2LL4 M;  4UV6 A;  2J8L A;  4NZQ A;  2QJ2 A;  2Q8A A;  1PKR A; 
#chains in the Genus database with same CATH topology
 4DUR A;  4R1A A;  1JFN A;  2KNF A;  4Z0D A;  4HZH A;  1PML A;  3SP8 A;  3ZLE A;  4BV5 A;  5I25 A;  4APM A;  5CT1 A;  1HPJ A;  2Q8B A;  1I5K A;  1Z40 A;  3BT1 A;  3LAQ A;  4BV7 A;  4UAO A;  2K13 X;  2PK4 A;  2Z8W A;  4BVC A;  2HPQ P;  1A0H A;  4KIV A;  1TPK A;  2PF2 A;  1I71 A;  2PF1 A;  1W81 A;  3U73 A;  1I8N A;  4O03 A;  2J8J A;  1HKY A;  1CEA A;  4BVD A;  1NL1 A;  2YIP A;  1KRN A;  3SRI A;  4BVW A;  2I9B A;  3NXP A;  5CS3 A;  2F83 A;  4Z0E A;  5CP9 A;  5CSQ A;  2KJ4 A;  1GMN A;  2HPP P;  1NL2 A;  5COE A;  3ZWZ A;  3HN4 A;  1W8K A;  4R1C A;  3HMR A;  1PK4 A;  2DOH X;  3BT2 A;  4APL A;  3KIV A;  1B2I A;  1URK A;  1PMK A;  2Z8V A;  4YIV A;  1KDU A;  1GP9 A;  1NK1 A;  2QJ4 A;  5CS9 A;  2LL3 A;  2K4R A;  2L0S A;  4Z0F A;  1PK2 A;  4R1B A;  2FEB A;  3HMS A;  1CEB A;  4Z09 A;  5CT2 A;  2SPT A;  1BHT A;  5EOD A;  3HMT A;  3SRJ A;  1GMO A;  5CS5 A;  2KL5 A;  4D3C A;  1HPK A;  1YXE A;  4CIK A;  5HPG A;  5EOK A;  4BVV A;  2HGF A;  1KI0 A;  3K65 A;  4A5T S;  2DOI A;  2K51 A;  1KIV A;  2FD6 A;  3E6P L;  5CT3 A;  2X2Z A;  4R19 A;  4YIZ A;  5CS1 A;  2YIL A;  2YIO A;  2Y8R A;  2I9A A;  3MKP A;  4IUA A;  2LL4 M;  4UV6 A;  2J8L A;  4NZQ A;  2QJ2 A;  2Q8A A;  1PKR A; 
#chains in the Genus database with same CATH homology
 4DUR A;  4R1A A;  1JFN A;  2KNF A;  4Z0D A;  4HZH A;  1PML A;  3SP8 A;  3ZLE A;  4BV5 A;  5I25 A;  4APM A;  5CT1 A;  1HPJ A;  2Q8B A;  1I5K A;  1Z40 A;  3BT1 A;  3LAQ A;  4BV7 A;  4UAO A;  2K13 X;  2PK4 A;  2Z8W A;  4BVC A;  2HPQ P;  1A0H A;  4KIV A;  1TPK A;  2PF2 A;  1I71 A;  2PF1 A;  1W81 A;  3U73 A;  1I8N A;  4O03 A;  2J8J A;  1HKY A;  1CEA A;  4BVD A;  1NL1 A;  2YIP A;  1KRN A;  3SRI A;  4BVW A;  2I9B A;  3NXP A;  5CS3 A;  2F83 A;  4Z0E A;  5CP9 A;  5CSQ A;  2KJ4 A;  1GMN A;  2HPP P;  1NL2 A;  5COE A;  3ZWZ A;  3HN4 A;  1W8K A;  4R1C A;  3HMR A;  1PK4 A;  2DOH X;  3BT2 A;  4APL A;  3KIV A;  1B2I A;  1URK A;  1PMK A;  2Z8V A;  4YIV A;  1KDU A;  1GP9 A;  1NK1 A;  2QJ4 A;  5CS9 A;  2LL3 A;  2K4R A;  2L0S A;  4Z0F A;  1PK2 A;  4R1B A;  2FEB A;  3HMS A;  1CEB A;  4Z09 A;  5CT2 A;  2SPT A;  1BHT A;  5EOD A;  3HMT A;  3SRJ A;  1GMO A;  5CS5 A;  2KL5 A;  4D3C A;  1HPK A;  1YXE A;  4CIK A;  5HPG A;  5EOK A;  4BVV A;  2HGF A;  1KI0 A;  3K65 A;  4A5T S;  2DOI A;  2K51 A;  1KIV A;  2FD6 A;  3E6P L;  5CT3 A;  2X2Z A;  4R19 A;  4YIZ A;  5CS1 A;  2YIL A;  2YIO A;  2Y8R A;  2I9A A;  3MKP A;  4IUA A;  2LL4 M;  4UV6 A;  2J8L A;  4NZQ A;  2QJ2 A;  2Q8A A;  1PKR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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