3MKPA

Crystal structure of 1k1 mutant of hepatocyte growth factor/scatter factor fragment nk1 in complex with heparin
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
173
structure length
173
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGEGESYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
source organism Homo sapiens
publication title Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration
rcsb
molecule keywords Hepatocyte growth factor
total genus 38
structure length 173
sequence length 173
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 3mkpA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3mkpA01
1BHTA 2SPTA 1JFNA 4A5TS 3SP8A 2HGFA 4HZHA 3NXPA 3SRJA 4NZQA 2YIPA 5HPGA 1KRNA 1GP9A 2QJ2A 1CEBA 5EODA 5CT1A 1PK4A 4APMA 2HPPP 4BVVA 3U73A 3BT1A 4DURA 4APLA 1TPKA 5CP9A 4CIKA 3HN4A 2I9AA 3MKPA 1HKYA 5COEA 2DOIA 1PMKA 4Z0EA 2X2ZA 2PF2A 4UV6A 4Z0FA 2K51A 1CEAA 4BV7A 2YIOA 2KJ4A 2LL3A 2Z8WA 1GMOA 1PMLA 2K13X 2L0SA 2YILA 3KIVA 4BV5A 4R1CA 2Q8BA 3LAQA 4O03A 2J8LA 2PK4A 5I25A 1GMNA 1PKRA 1I5KA 2LL4M 4R19A 4KIVA 3SRIA 3ZWZA 4R1AA 1I8NA 1B2IA 1KI0A 1URKA 5CS5A 3BT2A 1HPJA 1W81A 5EOKA 5CS9A 2PF1A 5CT3A 2Z8VA 1NL1A 3K65A 1KIVA 5CT2A 4Z09A 2FEBA 2QJ4A 4BVCA 4BVDA 2J8JA 1PK2A 1YXEA 4Z0DA 2F83A 1A0HA 3HMTA 2DOHX 2I9BA 1NL2A 1HPKA 5CSQA 1W8KA 2Q8AA 4R1BA 3ZLEA 4BVWA 2Y8RA 1I71A 2K4RA 2HPQP 4IUAA 3HMRA 1KDUA 5CS1A 2KNFA 3E6PL 1Z40A 2FD6A 5CS3A 4D3CA 4UAOA 1NK1A 3HMSA
chains in the Genus database with same CATH superfamily
1BHTA 2SPTA 1JFNA 4A5TS 3SP8A 2HGFA 4HZHA 3NXPA 3SRJA 4NZQA 2YIPA 5HPGA 1KRNA 1GP9A 2QJ2A 1CEBA 5EODA 5CT1A 1PK4A 4APMA 2HPPP 4BVVA 3U73A 3BT1A 4DURA 4APLA 1TPKA 4YIZA 5CP9A 4CIKA 3HN4A 2I9AA 3MKPA 1HKYA 5COEA 2DOIA 1PMKA 4Z0EA 2X2ZA 2PF2A 4UV6A 4Z0FA 2K51A 1CEAA 4BV7A 2YIOA 2KJ4A 2LL3A 2Z8WA 1GMOA 1PMLA 2K13X 2L0SA 2YILA 3KIVA 4BV5A 4R1CA 2Q8BA 2KL5A 3LAQA 4O03A 2J8LA 2PK4A 5I25A 1GMNA 1PKRA 1I5KA 2LL4M 4R19A 4KIVA 3SRIA 3ZWZA 4R1AA 1I8NA 1B2IA 1KI0A 1URKA 5CS5A 3BT2A 1HPJA 1W81A 5EOKA 5CS9A 2PF1A 5CT3A 2Z8VA 1NL1A 3K65A 1KIVA 5CT2A 4Z09A 2FEBA 2QJ4A 4BVCA 4BVDA 2J8JA 1PK2A 1YXEA 4Z0DA 2F83A 1A0HA 3HMTA 2DOHX 2I9BA 1NL2A 4YIVA 1HPKA 5CSQA 1W8KA 2Q8AA 4R1BA 3ZLEA 4BVWA 2Y8RA 1I71A 2K4RA 2HPQP 4IUAA 3HMRA 1KDUA 5CS1A 2KNFA 3E6PL 1Z40A 2FD6A 5CS3A 4D3CA 4UAOA 1NK1A 3HMSA
chains in the Genus database with same CATH topology
1BHTA 2SPTA 1JFNA 4A5TS 3SP8A 2HGFA 4HZHA 3NXPA 3SRJA 4NZQA 2YIPA 5HPGA 1KRNA 1GP9A 2QJ2A 1CEBA 5EODA 5CT1A 1PK4A 4APMA 2HPPP 4BVVA 3U73A 3BT1A 4DURA 4APLA 1TPKA 4YIZA 5CP9A 4CIKA 3HN4A 2I9AA 3MKPA 1HKYA 5COEA 2DOIA 1PMKA 4Z0EA 2X2ZA 2PF2A 4UV6A 4Z0FA 2K51A 1CEAA 4BV7A 2YIOA 2KJ4A 2LL3A 2Z8WA 1GMOA 1PMLA 2K13X 2L0SA 2YILA 3KIVA 4BV5A 4R1CA 2Q8BA 2KL5A 3LAQA 4O03A 2J8LA 2PK4A 5I25A 1GMNA 1PKRA 1I5KA 2LL4M 4R19A 4KIVA 3SRIA 3ZWZA 4R1AA 1I8NA 1B2IA 1KI0A 1URKA 5CS5A 3BT2A 1HPJA 1W81A 5EOKA 5CS9A 2PF1A 5CT3A 2Z8VA 1NL1A 3K65A 1KIVA 5CT2A 4Z09A 2FEBA 2QJ4A 4BVCA 4BVDA 2J8JA 1PK2A 1YXEA 4Z0DA 2F83A 1A0HA 3HMTA 2DOHX 2I9BA 1NL2A 4YIVA 1HPKA 5CSQA 1W8KA 2Q8AA 4R1BA 3ZLEA 4BVWA 2Y8RA 1I71A 2K4RA 2HPQP 4IUAA 3HMRA 1KDUA 5CS1A 2KNFA 3E6PL 1Z40A 2FD6A 5CS3A 4D3CA 4UAOA 1NK1A 3HMSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BHT A;  2SPT A;  1JFN A;  4A5T S;  3SP8 A;  2HGF A;  4HZH A;  3NXP A;  3SRJ A;  4NZQ A;  2YIP A;  5HPG A;  1KRN A;  1GP9 A;  2QJ2 A;  1CEB A;  5EOD A;  5CT1 A;  1PK4 A;  4APM A;  2HPP P;  4BVV A;  3U73 A;  3BT1 A;  4DUR A;  4APL A;  1TPK A;  5CP9 A;  4CIK A;  3HN4 A;  2I9A A;  3MKP A;  1HKY A;  5COE A;  2DOI A;  1PMK A;  4Z0E A;  2X2Z A;  2PF2 A;  4UV6 A;  4Z0F A;  2K51 A;  1CEA A;  4BV7 A;  2YIO A;  2KJ4 A;  2LL3 A;  2Z8W A;  1GMO A;  1PML A;  2K13 X;  2L0S A;  2YIL A;  3KIV A;  4BV5 A;  4R1C A;  2Q8B A;  3LAQ A;  4O03 A;  2J8L A;  2PK4 A;  5I25 A;  1GMN A;  1PKR A;  1I5K A;  2LL4 M;  4R19 A;  4KIV A;  3SRI A;  3ZWZ A;  4R1A A;  1I8N A;  1B2I A;  1KI0 A;  1URK A;  5CS5 A;  3BT2 A;  1HPJ A;  1W81 A;  5EOK A;  5CS9 A;  2PF1 A;  5CT3 A;  2Z8V A;  1NL1 A;  3K65 A;  1KIV A;  5CT2 A;  4Z09 A;  2FEB A;  2QJ4 A;  4BVC A;  4BVD A;  2J8J A;  1PK2 A;  1YXE A;  4Z0D A;  2F83 A;  1A0H A;  3HMT A;  2DOH X;  2I9B A;  1NL2 A;  1HPK A;  5CSQ A;  1W8K A;  2Q8A A;  4R1B A;  3ZLE A;  4BVW A;  2Y8R A;  1I71 A;  2K4R A;  2HPQ P;  4IUA A;  3HMR A;  1KDU A;  5CS1 A;  2KNF A;  3E6P L;  1Z40 A;  2FD6 A;  5CS3 A;  4D3C A;  4UAO A;  1NK1 A;  3HMS A; 
#chains in the Genus database with same CATH topology
 1BHT A;  2SPT A;  1JFN A;  4A5T S;  3SP8 A;  2HGF A;  4HZH A;  3NXP A;  3SRJ A;  4NZQ A;  2YIP A;  5HPG A;  1KRN A;  1GP9 A;  2QJ2 A;  1CEB A;  5EOD A;  5CT1 A;  1PK4 A;  4APM A;  2HPP P;  4BVV A;  3U73 A;  3BT1 A;  4DUR A;  4APL A;  1TPK A;  4YIZ A;  5CP9 A;  4CIK A;  3HN4 A;  2I9A A;  3MKP A;  1HKY A;  5COE A;  2DOI A;  1PMK A;  4Z0E A;  2X2Z A;  2PF2 A;  4UV6 A;  4Z0F A;  2K51 A;  1CEA A;  4BV7 A;  2YIO A;  2KJ4 A;  2LL3 A;  2Z8W A;  1GMO A;  1PML A;  2K13 X;  2L0S A;  2YIL A;  3KIV A;  4BV5 A;  4R1C A;  2Q8B A;  2KL5 A;  3LAQ A;  4O03 A;  2J8L A;  2PK4 A;  5I25 A;  1GMN A;  1PKR A;  1I5K A;  2LL4 M;  4R19 A;  4KIV A;  3SRI A;  3ZWZ A;  4R1A A;  1I8N A;  1B2I A;  1KI0 A;  1URK A;  5CS5 A;  3BT2 A;  1HPJ A;  1W81 A;  5EOK A;  5CS9 A;  2PF1 A;  5CT3 A;  2Z8V A;  1NL1 A;  3K65 A;  1KIV A;  5CT2 A;  4Z09 A;  2FEB A;  2QJ4 A;  4BVC A;  4BVD A;  2J8J A;  1PK2 A;  1YXE A;  4Z0D A;  2F83 A;  1A0H A;  3HMT A;  2DOH X;  2I9B A;  1NL2 A;  4YIV A;  1HPK A;  5CSQ A;  1W8K A;  2Q8A A;  4R1B A;  3ZLE A;  4BVW A;  2Y8R A;  1I71 A;  2K4R A;  2HPQ P;  4IUA A;  3HMR A;  1KDU A;  5CS1 A;  2KNF A;  3E6P L;  1Z40 A;  2FD6 A;  5CS3 A;  4D3C A;  4UAO A;  1NK1 A;  3HMS A; 
#chains in the Genus database with same CATH homology
 1BHT A;  2SPT A;  1JFN A;  4A5T S;  3SP8 A;  2HGF A;  4HZH A;  3NXP A;  3SRJ A;  4NZQ A;  2YIP A;  5HPG A;  1KRN A;  1GP9 A;  2QJ2 A;  1CEB A;  5EOD A;  5CT1 A;  1PK4 A;  4APM A;  2HPP P;  4BVV A;  3U73 A;  3BT1 A;  4DUR A;  4APL A;  1TPK A;  4YIZ A;  5CP9 A;  4CIK A;  3HN4 A;  2I9A A;  3MKP A;  1HKY A;  5COE A;  2DOI A;  1PMK A;  4Z0E A;  2X2Z A;  2PF2 A;  4UV6 A;  4Z0F A;  2K51 A;  1CEA A;  4BV7 A;  2YIO A;  2KJ4 A;  2LL3 A;  2Z8W A;  1GMO A;  1PML A;  2K13 X;  2L0S A;  2YIL A;  3KIV A;  4BV5 A;  4R1C A;  2Q8B A;  2KL5 A;  3LAQ A;  4O03 A;  2J8L A;  2PK4 A;  5I25 A;  1GMN A;  1PKR A;  1I5K A;  2LL4 M;  4R19 A;  4KIV A;  3SRI A;  3ZWZ A;  4R1A A;  1I8N A;  1B2I A;  1KI0 A;  1URK A;  5CS5 A;  3BT2 A;  1HPJ A;  1W81 A;  5EOK A;  5CS9 A;  2PF1 A;  5CT3 A;  2Z8V A;  1NL1 A;  3K65 A;  1KIV A;  5CT2 A;  4Z09 A;  2FEB A;  2QJ4 A;  4BVC A;  4BVD A;  2J8J A;  1PK2 A;  1YXE A;  4Z0D A;  2F83 A;  1A0H A;  3HMT A;  2DOH X;  2I9B A;  1NL2 A;  4YIV A;  1HPK A;  5CSQ A;  1W8K A;  2Q8A A;  4R1B A;  3ZLE A;  4BVW A;  2Y8R A;  1I71 A;  2K4R A;  2HPQ P;  4IUA A;  3HMR A;  1KDU A;  5CS1 A;  2KNF A;  3E6P L;  1Z40 A;  2FD6 A;  5CS3 A;  4D3C A;  4UAO A;  1NK1 A;  3HMS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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