3MKPA

Crystal structure of 1k1 mutant of hepatocyte growth factor/scatter factor fragment nk1 in complex with heparin
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
173
structure length
173
Chain Sequence
RNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGEGESYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Engineering a fragment of Hepatocyte Growth Factor/Scatter Factor for tissue and organ regeneration
rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 38
structure length 173
sequence length 173
chains with identical sequence B, C, D
ec nomenclature
pdb deposition date 2010-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 3mkpA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3mkpA01
1NK1A 1Z40A 3ZWZA 4HZHA 1GMNA 3HMSA 3E6PL 4APLA 4BV7A 5I25A 1W81A 2FD6A 2SPTA 1I8NA 3KIVA 1YXEA 1W8KA 2DOHX 1PKRA 5CT1A 2QJ2A 5EOKA 1KIVA 3U73A 2HPPP 2J8JA 4A5TS 1A0HA 5CP9A 2Z8VA 4R1AA 4UV6A 3MKPA 3HMRA 2Q8BA 1URKA 1KI0A 1PMKA 2FEBA 3SRJA 4Z0EA 1B2IA 1TPKA 4R1BA 5CS1A 2K4RA 2K13X 2Y8RA 5COEA 2Q8AA 3HMTA 1HKYA 5EODA 2KNFA 2QJ4A 4IUAA 1JFNA 4R19A 4Z0FA 3SRIA 1NL2A 2DOIA 1I71A 1GP9A 2Z8WA 1HPKA 4BVVA 2X2ZA 4BVCA 2I9AA 2L0SA 2YILA 5CSQA 2PF1A 1I5KA 4BV5A 4BVWA 2PK4A 3BT1A 5CS9A 1CEAA 1KRNA 2HGFA 3ZLEA 4NZQA 2K51A 5CS5A 1PMLA 2KJ4A 3SP8A 2HPQP 2J8LA 2YIPA 4DURA 1HPJA 3K65A 3LAQA 1NL1A 1PK2A 1CEBA 4O03A 1PK4A 1KDUA 4APMA 2LL3A 4Z09A 2PF2A 4Z0DA 5CS3A 2I9BA 5CT3A 3NXPA 4KIVA 3BT2A 4D3CA 1GMOA 1BHTA 2YIOA 3HN4A 4R1CA 4CIKA 2F83A 2LL4M 5CT2A 4BVDA 5HPGA 4UAOA
chains in the Genus database with same CATH superfamily
1NK1A 1Z40A 3ZWZA 4HZHA 1GMNA 3HMSA 3E6PL 4APLA 4BV7A 2KL5A 5I25A 1W81A 2FD6A 2SPTA 1I8NA 3KIVA 1YXEA 1W8KA 2DOHX 1PKRA 5CT1A 2QJ2A 5EOKA 1KIVA 3U73A 2HPPP 2J8JA 4A5TS 1A0HA 5CP9A 2Z8VA 4R1AA 4UV6A 3MKPA 3HMRA 2Q8BA 1URKA 1KI0A 1PMKA 2FEBA 3SRJA 4Z0EA 1B2IA 1TPKA 4R1BA 5CS1A 2K4RA 2K13X 2Y8RA 5COEA 2Q8AA 3HMTA 1HKYA 5EODA 2KNFA 2QJ4A 4IUAA 1JFNA 4R19A 4Z0FA 3SRIA 1NL2A 2DOIA 1I71A 1GP9A 2Z8WA 1HPKA 4BVVA 2X2ZA 4BVCA 2I9AA 2L0SA 2YILA 5CSQA 2PF1A 1I5KA 4BV5A 4BVWA 2PK4A 3BT1A 4YIZA 5CS9A 1CEAA 1KRNA 2HGFA 3ZLEA 4NZQA 2K51A 5CS5A 1PMLA 2KJ4A 3SP8A 2HPQP 2J8LA 2YIPA 4DURA 1HPJA 3K65A 3LAQA 1NL1A 1PK2A 1CEBA 4O03A 1PK4A 1KDUA 4APMA 2LL3A 4Z09A 2PF2A 4Z0DA 5CS3A 2I9BA 5CT3A 3NXPA 4KIVA 4YIVA 3BT2A 4D3CA 1GMOA 1BHTA 2YIOA 3HN4A 4R1CA 4CIKA 2F83A 2LL4M 5CT2A 4BVDA 5HPGA 4UAOA
chains in the Genus database with same CATH topology
1NK1A 1Z40A 3ZWZA 4HZHA 1GMNA 3HMSA 3E6PL 4APLA 4BV7A 2KL5A 5I25A 1W81A 2FD6A 2SPTA 1I8NA 3KIVA 1YXEA 1W8KA 2DOHX 1PKRA 5CT1A 2QJ2A 5EOKA 1KIVA 3U73A 2HPPP 2J8JA 4A5TS 1A0HA 5CP9A 2Z8VA 4R1AA 4UV6A 3MKPA 3HMRA 2Q8BA 1URKA 1KI0A 1PMKA 2FEBA 3SRJA 4Z0EA 1B2IA 1TPKA 4R1BA 5CS1A 2K4RA 2K13X 2Y8RA 5COEA 2Q8AA 3HMTA 1HKYA 5EODA 2KNFA 2QJ4A 4IUAA 1JFNA 4R19A 4Z0FA 3SRIA 1NL2A 2DOIA 1I71A 1GP9A 2Z8WA 1HPKA 4BVVA 2X2ZA 4BVCA 2I9AA 2L0SA 2YILA 5CSQA 2PF1A 1I5KA 4BV5A 4BVWA 2PK4A 3BT1A 4YIZA 5CS9A 1CEAA 1KRNA 2HGFA 3ZLEA 4NZQA 2K51A 5CS5A 1PMLA 2KJ4A 3SP8A 2HPQP 2J8LA 2YIPA 4DURA 1HPJA 3K65A 3LAQA 1NL1A 1PK2A 1CEBA 4O03A 1PK4A 1KDUA 4APMA 2LL3A 4Z09A 2PF2A 4Z0DA 5CS3A 2I9BA 5CT3A 3NXPA 4KIVA 4YIVA 3BT2A 4D3CA 1GMOA 1BHTA 2YIOA 3HN4A 4R1CA 4CIKA 2F83A 2LL4M 5CT2A 4BVDA 5HPGA 4UAOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NK1 A;  1Z40 A;  3ZWZ A;  4HZH A;  1GMN A;  3HMS A;  3E6P L;  4APL A;  4BV7 A;  5I25 A;  1W81 A;  2FD6 A;  2SPT A;  1I8N A;  3KIV A;  1YXE A;  1W8K A;  2DOH X;  1PKR A;  5CT1 A;  2QJ2 A;  5EOK A;  1KIV A;  3U73 A;  2HPP P;  2J8J A;  4A5T S;  1A0H A;  5CP9 A;  2Z8V A;  4R1A A;  4UV6 A;  3MKP A;  3HMR A;  2Q8B A;  1URK A;  1KI0 A;  1PMK A;  2FEB A;  3SRJ A;  4Z0E A;  1B2I A;  1TPK A;  4R1B A;  5CS1 A;  2K4R A;  2K13 X;  2Y8R A;  5COE A;  2Q8A A;  3HMT A;  1HKY A;  5EOD A;  2KNF A;  2QJ4 A;  4IUA A;  1JFN A;  4R19 A;  4Z0F A;  3SRI A;  1NL2 A;  2DOI A;  1I71 A;  1GP9 A;  2Z8W A;  1HPK A;  4BVV A;  2X2Z A;  4BVC A;  2I9A A;  2L0S A;  2YIL A;  5CSQ A;  2PF1 A;  1I5K A;  4BV5 A;  4BVW A;  2PK4 A;  3BT1 A;  5CS9 A;  1CEA A;  1KRN A;  2HGF A;  3ZLE A;  4NZQ A;  2K51 A;  5CS5 A;  1PML A;  2KJ4 A;  3SP8 A;  2HPQ P;  2J8L A;  2YIP A;  4DUR A;  1HPJ A;  3K65 A;  3LAQ A;  1NL1 A;  1PK2 A;  1CEB A;  4O03 A;  1PK4 A;  1KDU A;  4APM A;  2LL3 A;  4Z09 A;  2PF2 A;  4Z0D A;  5CS3 A;  2I9B A;  5CT3 A;  3NXP A;  4KIV A;  3BT2 A;  4D3C A;  1GMO A;  1BHT A;  2YIO A;  3HN4 A;  4R1C A;  4CIK A;  2F83 A;  2LL4 M;  5CT2 A;  4BVD A;  5HPG A;  4UAO A; 
#chains in the Genus database with same CATH topology
 1NK1 A;  1Z40 A;  3ZWZ A;  4HZH A;  1GMN A;  3HMS A;  3E6P L;  4APL A;  4BV7 A;  2KL5 A;  5I25 A;  1W81 A;  2FD6 A;  2SPT A;  1I8N A;  3KIV A;  1YXE A;  1W8K A;  2DOH X;  1PKR A;  5CT1 A;  2QJ2 A;  5EOK A;  1KIV A;  3U73 A;  2HPP P;  2J8J A;  4A5T S;  1A0H A;  5CP9 A;  2Z8V A;  4R1A A;  4UV6 A;  3MKP A;  3HMR A;  2Q8B A;  1URK A;  1KI0 A;  1PMK A;  2FEB A;  3SRJ A;  4Z0E A;  1B2I A;  1TPK A;  4R1B A;  5CS1 A;  2K4R A;  2K13 X;  2Y8R A;  5COE A;  2Q8A A;  3HMT A;  1HKY A;  5EOD A;  2KNF A;  2QJ4 A;  4IUA A;  1JFN A;  4R19 A;  4Z0F A;  3SRI A;  1NL2 A;  2DOI A;  1I71 A;  1GP9 A;  2Z8W A;  1HPK A;  4BVV A;  2X2Z A;  4BVC A;  2I9A A;  2L0S A;  2YIL A;  5CSQ A;  2PF1 A;  1I5K A;  4BV5 A;  4BVW A;  2PK4 A;  3BT1 A;  4YIZ A;  5CS9 A;  1CEA A;  1KRN A;  2HGF A;  3ZLE A;  4NZQ A;  2K51 A;  5CS5 A;  1PML A;  2KJ4 A;  3SP8 A;  2HPQ P;  2J8L A;  2YIP A;  4DUR A;  1HPJ A;  3K65 A;  3LAQ A;  1NL1 A;  1PK2 A;  1CEB A;  4O03 A;  1PK4 A;  1KDU A;  4APM A;  2LL3 A;  4Z09 A;  2PF2 A;  4Z0D A;  5CS3 A;  2I9B A;  5CT3 A;  3NXP A;  4KIV A;  4YIV A;  3BT2 A;  4D3C A;  1GMO A;  1BHT A;  2YIO A;  3HN4 A;  4R1C A;  4CIK A;  2F83 A;  2LL4 M;  5CT2 A;  4BVD A;  5HPG A;  4UAO A; 
#chains in the Genus database with same CATH homology
 1NK1 A;  1Z40 A;  3ZWZ A;  4HZH A;  1GMN A;  3HMS A;  3E6P L;  4APL A;  4BV7 A;  2KL5 A;  5I25 A;  1W81 A;  2FD6 A;  2SPT A;  1I8N A;  3KIV A;  1YXE A;  1W8K A;  2DOH X;  1PKR A;  5CT1 A;  2QJ2 A;  5EOK A;  1KIV A;  3U73 A;  2HPP P;  2J8J A;  4A5T S;  1A0H A;  5CP9 A;  2Z8V A;  4R1A A;  4UV6 A;  3MKP A;  3HMR A;  2Q8B A;  1URK A;  1KI0 A;  1PMK A;  2FEB A;  3SRJ A;  4Z0E A;  1B2I A;  1TPK A;  4R1B A;  5CS1 A;  2K4R A;  2K13 X;  2Y8R A;  5COE A;  2Q8A A;  3HMT A;  1HKY A;  5EOD A;  2KNF A;  2QJ4 A;  4IUA A;  1JFN A;  4R19 A;  4Z0F A;  3SRI A;  1NL2 A;  2DOI A;  1I71 A;  1GP9 A;  2Z8W A;  1HPK A;  4BVV A;  2X2Z A;  4BVC A;  2I9A A;  2L0S A;  2YIL A;  5CSQ A;  2PF1 A;  1I5K A;  4BV5 A;  4BVW A;  2PK4 A;  3BT1 A;  4YIZ A;  5CS9 A;  1CEA A;  1KRN A;  2HGF A;  3ZLE A;  4NZQ A;  2K51 A;  5CS5 A;  1PML A;  2KJ4 A;  3SP8 A;  2HPQ P;  2J8L A;  2YIP A;  4DUR A;  1HPJ A;  3K65 A;  3LAQ A;  1NL1 A;  1PK2 A;  1CEB A;  4O03 A;  1PK4 A;  1KDU A;  4APM A;  2LL3 A;  4Z09 A;  2PF2 A;  4Z0D A;  5CS3 A;  2I9B A;  5CT3 A;  3NXP A;  4KIV A;  4YIV A;  3BT2 A;  4D3C A;  1GMO A;  1BHT A;  2YIO A;  3HN4 A;  4R1C A;  4CIK A;  2F83 A;  2LL4 M;  5CT2 A;  4BVD A;  5HPG A;  4UAO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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