3SP8A

Crystal structure of nk2 in complex with fractionated heparin dp10
Total Genus 77
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
77
sequence length
255
structure length
255
Chain Sequence
RRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSDIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTSNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCKIKTCK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of NK2 in complex with fractionated Heparin DP10
rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor alpha chain
total genus 77
structure length 255
sequence length 255
chains with identical sequence B
ec nomenclature
pdb deposition date 2011-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 3sp8A02
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 3sp8A03
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 3sp8A01
1I71A 1NK1A 5CS3A 5COEA 4BVCA 4Z09A 3MKPA 2SPTA 5CS1A 3HMTA 4HZHA 3U73A 1CEBA 1GMNA 1W81A 1PMKA 1KIVA 2LL3A 4BVVA 2KJ4A 3K65A 2PF1A 2HGFA 1B2IA 4R1CA 3NXPA 4BVWA 1W8KA 1GMOA 2DOHX 5CP9A 3HMRA 4UAOA 4O03A 3ZWZA 5CS5A 4NZQA 4Z0FA 2J8LA 4BV7A 2PF2A 2Z8WA 5CT2A 1PK2A 2QJ4A 2J8JA 4APLA 2Q8AA 5EOKA 5CS9A 3BT2A 2K51A 1KDUA 2Z8VA 2YIPA 2I9BA 4R19A 1KRNA 3KIVA 2FD6A 3E6PL 2X2ZA 1PMLA 1HKYA 3HMSA 4UV6A 5CT1A 3HN4A 4R1AA 1HPKA 1GP9A 4DURA 2PK4A 1CEAA 3SRJA 1PK4A 2YILA 2K4RA 1HPJA 2DOIA 2I9AA 4Z0DA 1Z40A 1PKRA 5CT3A 3SRIA 2YIOA 1URKA 4APMA 4Z0EA 1JFNA 2L0SA 4CIKA 2Q8BA 1NL1A 1A0HA 1NL2A 3SP8A 5EODA 2Y8RA 1I5KA 1TPKA 4D3CA 2F83A 1I8NA 2HPPP 1YXEA 5HPGA 4BV5A 4R1BA 1BHTA 2LL4M 3LAQA 5I25A 3BT1A 4BVDA 2FEBA 2KNFA 4A5TS 2QJ2A 5CSQA 4IUAA 1KI0A 3ZLEA 2HPQP 4KIVA 2K13X
chains in the Genus database with same CATH superfamily
1I71A 1NK1A 5CS3A 5COEA 4BVCA 4Z09A 3MKPA 2SPTA 5CS1A 3HMTA 4HZHA 3U73A 1CEBA 1GMNA 1W81A 1PMKA 1KIVA 2LL3A 4BVVA 2KJ4A 3K65A 2PF1A 2HGFA 1B2IA 4R1CA 3NXPA 4BVWA 1W8KA 1GMOA 2DOHX 5CP9A 3HMRA 4UAOA 4O03A 3ZWZA 5CS5A 4NZQA 4Z0FA 2J8LA 4BV7A 2PF2A 2Z8WA 5CT2A 1PK2A 2QJ4A 2J8JA 4APLA 2Q8AA 5EOKA 5CS9A 3BT2A 2K51A 1KDUA 2Z8VA 2YIPA 2I9BA 4R19A 1KRNA 3KIVA 2FD6A 3E6PL 2X2ZA 1PMLA 1HKYA 3HMSA 4UV6A 5CT1A 3HN4A 4R1AA 1HPKA 1GP9A 4DURA 2PK4A 1CEAA 3SRJA 1PK4A 2YILA 2K4RA 1HPJA 2DOIA 2I9AA 4Z0DA 1Z40A 1PKRA 5CT3A 3SRIA 2YIOA 1URKA 4APMA 4Z0EA 1JFNA 2L0SA 4CIKA 2Q8BA 2KL5A 1NL1A 1A0HA 1NL2A 3SP8A 5EODA 2Y8RA 1I5KA 1TPKA 4D3CA 2F83A 1I8NA 2HPPP 1YXEA 5HPGA 4BV5A 4R1BA 1BHTA 2LL4M 3LAQA 5I25A 3BT1A 4BVDA 2FEBA 2KNFA 4YIZA 4A5TS 2QJ2A 4YIVA 5CSQA 4IUAA 1KI0A 3ZLEA 2HPQP 4KIVA 2K13X
chains in the Genus database with same CATH topology
1I71A 1NK1A 5CS3A 5COEA 4BVCA 4Z09A 3MKPA 2SPTA 5CS1A 3HMTA 4HZHA 3U73A 1CEBA 1GMNA 1W81A 1PMKA 1KIVA 2LL3A 4BVVA 2KJ4A 3K65A 2PF1A 2HGFA 1B2IA 4R1CA 3NXPA 4BVWA 1W8KA 1GMOA 2DOHX 5CP9A 3HMRA 4UAOA 4O03A 3ZWZA 5CS5A 4NZQA 4Z0FA 2J8LA 4BV7A 2PF2A 2Z8WA 5CT2A 1PK2A 2QJ4A 2J8JA 4APLA 2Q8AA 5EOKA 5CS9A 3BT2A 2K51A 1KDUA 2Z8VA 2YIPA 2I9BA 4R19A 1KRNA 3KIVA 2FD6A 3E6PL 2X2ZA 1PMLA 1HKYA 3HMSA 4UV6A 5CT1A 3HN4A 4R1AA 1HPKA 1GP9A 4DURA 2PK4A 1CEAA 3SRJA 1PK4A 2YILA 2K4RA 1HPJA 2DOIA 2I9AA 4Z0DA 1Z40A 1PKRA 5CT3A 3SRIA 2YIOA 1URKA 4APMA 4Z0EA 1JFNA 2L0SA 4CIKA 2Q8BA 2KL5A 1NL1A 1A0HA 1NL2A 3SP8A 5EODA 2Y8RA 1I5KA 1TPKA 4D3CA 2F83A 1I8NA 2HPPP 1YXEA 5HPGA 4BV5A 4R1BA 1BHTA 2LL4M 3LAQA 5I25A 3BT1A 4BVDA 2FEBA 2KNFA 4YIZA 4A5TS 2QJ2A 4YIVA 5CSQA 4IUAA 1KI0A 3ZLEA 2HPQP 4KIVA 2K13X
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I71 A;  1NK1 A;  5CS3 A;  5COE A;  4BVC A;  4Z09 A;  3MKP A;  2SPT A;  5CS1 A;  3HMT A;  4HZH A;  3U73 A;  1CEB A;  1GMN A;  1W81 A;  1PMK A;  1KIV A;  2LL3 A;  4BVV A;  2KJ4 A;  3K65 A;  2PF1 A;  2HGF A;  1B2I A;  4R1C A;  3NXP A;  4BVW A;  1W8K A;  1GMO A;  2DOH X;  5CP9 A;  3HMR A;  4UAO A;  4O03 A;  3ZWZ A;  5CS5 A;  4NZQ A;  4Z0F A;  2J8L A;  4BV7 A;  2PF2 A;  2Z8W A;  5CT2 A;  1PK2 A;  2QJ4 A;  2J8J A;  4APL A;  2Q8A A;  5EOK A;  5CS9 A;  3BT2 A;  2K51 A;  1KDU A;  2Z8V A;  2YIP A;  2I9B A;  4R19 A;  1KRN A;  3KIV A;  2FD6 A;  3E6P L;  2X2Z A;  1PML A;  1HKY A;  3HMS A;  4UV6 A;  5CT1 A;  3HN4 A;  4R1A A;  1HPK A;  1GP9 A;  4DUR A;  2PK4 A;  1CEA A;  3SRJ A;  1PK4 A;  2YIL A;  2K4R A;  1HPJ A;  2DOI A;  2I9A A;  4Z0D A;  1Z40 A;  1PKR A;  5CT3 A;  3SRI A;  2YIO A;  1URK A;  4APM A;  4Z0E A;  1JFN A;  2L0S A;  4CIK A;  2Q8B A;  1NL1 A;  1A0H A;  1NL2 A;  3SP8 A;  5EOD A;  2Y8R A;  1I5K A;  1TPK A;  4D3C A;  2F83 A;  1I8N A;  2HPP P;  1YXE A;  5HPG A;  4BV5 A;  4R1B A;  1BHT A;  2LL4 M;  3LAQ A;  5I25 A;  3BT1 A;  4BVD A;  2FEB A;  2KNF A;  4A5T S;  2QJ2 A;  5CSQ A;  4IUA A;  1KI0 A;  3ZLE A;  2HPQ P;  4KIV A;  2K13 X; 
#chains in the Genus database with same CATH topology
 1I71 A;  1NK1 A;  5CS3 A;  5COE A;  4BVC A;  4Z09 A;  3MKP A;  2SPT A;  5CS1 A;  3HMT A;  4HZH A;  3U73 A;  1CEB A;  1GMN A;  1W81 A;  1PMK A;  1KIV A;  2LL3 A;  4BVV A;  2KJ4 A;  3K65 A;  2PF1 A;  2HGF A;  1B2I A;  4R1C A;  3NXP A;  4BVW A;  1W8K A;  1GMO A;  2DOH X;  5CP9 A;  3HMR A;  4UAO A;  4O03 A;  3ZWZ A;  5CS5 A;  4NZQ A;  4Z0F A;  2J8L A;  4BV7 A;  2PF2 A;  2Z8W A;  5CT2 A;  1PK2 A;  2QJ4 A;  2J8J A;  4APL A;  2Q8A A;  5EOK A;  5CS9 A;  3BT2 A;  2K51 A;  1KDU A;  2Z8V A;  2YIP A;  2I9B A;  4R19 A;  1KRN A;  3KIV A;  2FD6 A;  3E6P L;  2X2Z A;  1PML A;  1HKY A;  3HMS A;  4UV6 A;  5CT1 A;  3HN4 A;  4R1A A;  1HPK A;  1GP9 A;  4DUR A;  2PK4 A;  1CEA A;  3SRJ A;  1PK4 A;  2YIL A;  2K4R A;  1HPJ A;  2DOI A;  2I9A A;  4Z0D A;  1Z40 A;  1PKR A;  5CT3 A;  3SRI A;  2YIO A;  1URK A;  4APM A;  4Z0E A;  1JFN A;  2L0S A;  4CIK A;  2Q8B A;  2KL5 A;  1NL1 A;  1A0H A;  1NL2 A;  3SP8 A;  5EOD A;  2Y8R A;  1I5K A;  1TPK A;  4D3C A;  2F83 A;  1I8N A;  2HPP P;  1YXE A;  5HPG A;  4BV5 A;  4R1B A;  1BHT A;  2LL4 M;  3LAQ A;  5I25 A;  3BT1 A;  4BVD A;  2FEB A;  2KNF A;  4YIZ A;  4A5T S;  2QJ2 A;  4YIV A;  5CSQ A;  4IUA A;  1KI0 A;  3ZLE A;  2HPQ P;  4KIV A;  2K13 X; 
#chains in the Genus database with same CATH homology
 1I71 A;  1NK1 A;  5CS3 A;  5COE A;  4BVC A;  4Z09 A;  3MKP A;  2SPT A;  5CS1 A;  3HMT A;  4HZH A;  3U73 A;  1CEB A;  1GMN A;  1W81 A;  1PMK A;  1KIV A;  2LL3 A;  4BVV A;  2KJ4 A;  3K65 A;  2PF1 A;  2HGF A;  1B2I A;  4R1C A;  3NXP A;  4BVW A;  1W8K A;  1GMO A;  2DOH X;  5CP9 A;  3HMR A;  4UAO A;  4O03 A;  3ZWZ A;  5CS5 A;  4NZQ A;  4Z0F A;  2J8L A;  4BV7 A;  2PF2 A;  2Z8W A;  5CT2 A;  1PK2 A;  2QJ4 A;  2J8J A;  4APL A;  2Q8A A;  5EOK A;  5CS9 A;  3BT2 A;  2K51 A;  1KDU A;  2Z8V A;  2YIP A;  2I9B A;  4R19 A;  1KRN A;  3KIV A;  2FD6 A;  3E6P L;  2X2Z A;  1PML A;  1HKY A;  3HMS A;  4UV6 A;  5CT1 A;  3HN4 A;  4R1A A;  1HPK A;  1GP9 A;  4DUR A;  2PK4 A;  1CEA A;  3SRJ A;  1PK4 A;  2YIL A;  2K4R A;  1HPJ A;  2DOI A;  2I9A A;  4Z0D A;  1Z40 A;  1PKR A;  5CT3 A;  3SRI A;  2YIO A;  1URK A;  4APM A;  4Z0E A;  1JFN A;  2L0S A;  4CIK A;  2Q8B A;  2KL5 A;  1NL1 A;  1A0H A;  1NL2 A;  3SP8 A;  5EOD A;  2Y8R A;  1I5K A;  1TPK A;  4D3C A;  2F83 A;  1I8N A;  2HPP P;  1YXE A;  5HPG A;  4BV5 A;  4R1B A;  1BHT A;  2LL4 M;  3LAQ A;  5I25 A;  3BT1 A;  4BVD A;  2FEB A;  2KNF A;  4YIZ A;  4A5T S;  2QJ2 A;  4YIV A;  5CSQ A;  4IUA A;  1KI0 A;  3ZLE A;  2HPQ P;  4KIV A;  2K13 X; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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