4J93A

Crystal structure of the n-terminal domain of hiv-1 capsid in complex with inhibitor bi-1
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
146
structure length
146
Chain Sequence
PIVQNLQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRLHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTHNPPIPVGEIYKRWIILGLNKIVRMYS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes.
pubmed doi rcsb
molecule tags Viral protein/viral protein inhibitor
source organism Human immunodeficiency virus 1
molecule keywords Gag protein
total genus 50
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2013-02-15
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.375.10 Mainly Alpha Orthogonal Bundle Human Immunodeficiency Virus Type 1 Capsid Protein Human Immunodeficiency Virus Type 1 Capsid Protein 4j93A00
2M8PA 1G03A 1P7NA 4QNBA 5HGKA 1AFVA 2XGYA 3P05A 4PH0A 2XDEA 2X83A 3BP9A 2PXRC 1QRJA 4U0EA 1AK4C 2JPRA 1L6NA 1U7KA 2LF4A 4U0FA 5JPAA 4XFXA 1M9CC 4PH3A 2X2DD 1GWPA 2KGFA 4DGEC 1EM9A 4J93A 2GOLB 4B4NA 5HGLA 4XROA 2XGUA 1M9FC 1E6JP 1M9EC 4LQWC 2WLVA 2XGVA 2Y4ZA 3H4EA 4U0DA 4PH2A 4U0BA 4XFYA 2M8LA 1M9DC 2X82A 4E92A 4U0CA 4E91A 1M9XC 3MGEA 2V4XA 4HTWA 3H47A 5HGNA 5HGMA 1EIAA 4XRQA 4U0AA 4WYMA 2WLVB 4XFZA 4INBA 2EIAA 2M8NA 2PWOA 5HGOA 3NTEA 4NX4C 1M9YC 1D1DA 2GONA 4DGAC 2PWMA
chains in the Genus database with same CATH superfamily
2M8PA 1G03A 1P7NA 4QNBA 5HGKA 1AFVA 2XGYA 3P05A 4PH0A 2XDEA 2X83A 3BP9A 2PXRC 1QRJA 4U0EA 1AK4C 2JPRA 1L6NA 1U7KA 2LF4A 4U0FA 5JPAA 4XFXA 1M9CC 4PH3A 2X2DD 1GWPA 2KGFA 4DGEC 1EM9A 4J93A 2GOLB 4B4NA 5HGLA 4XROA 2XGUA 1M9FC 1E6JP 1M9EC 4LQWC 2WLVA 2XGVA 2Y4ZA 3H4EA 4U0DA 4PH2A 4U0BA 4XFYA 2M8LA 1M9DC 2X82A 4E92A 4U0CA 4E91A 1M9XC 3MGEA 2V4XA 4HTWA 3H47A 5HGNA 5HGMA 1EIAA 4XRQA 4U0AA 4WYMA 2WLVB 4XFZA 4INBA 2EIAA 2M8NA 2PWOA 5HGOA 3NTEA 4NX4C 1M9YC 1D1DA 2GONA 4DGAC 2PWMA
chains in the Genus database with same CATH topology
2M8PA 1G03A 1P7NA 4QNBA 5HGKA 1AFVA 2XGYA 3P05A 4PH0A 2XDEA 2X83A 3BP9A 2PXRC 1QRJA 4U0EA 1AK4C 2JPRA 1L6NA 1U7KA 2LF4A 4U0FA 5JPAA 4XFXA 1M9CC 4PH3A 2X2DD 1GWPA 2KGFA 4DGEC 1EM9A 4J93A 2GOLB 4B4NA 5HGLA 4XROA 2XGUA 1M9FC 1E6JP 1M9EC 4LQWC 2WLVA 2XGVA 2Y4ZA 3H4EA 4U0DA 4PH2A 4U0BA 4XFYA 2M8LA 1M9DC 2X82A 4E92A 4U0CA 4E91A 1M9XC 3MGEA 2V4XA 4HTWA 3H47A 5HGNA 5HGMA 1EIAA 4XRQA 4U0AA 4WYMA 2WLVB 4XFZA 4INBA 2EIAA 2M8NA 2PWOA 5HGOA 3NTEA 4NX4C 1M9YC 1D1DA 2GONA 4DGAC 2PWMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2M8P A;  1G03 A;  1P7N A;  4QNB A;  5HGK A;  1AFV A;  2XGY A;  3P05 A;  4PH0 A;  2XDE A;  2X83 A;  3BP9 A;  2PXR C;  1QRJ A;  4U0E A;  1AK4 C;  2JPR A;  1L6N A;  1U7K A;  2LF4 A;  4U0F A;  5JPA A;  4XFX A;  1M9C C;  4PH3 A;  2X2D D;  1GWP A;  2KGF A;  4DGE C;  1EM9 A;  4J93 A;  2GOL B;  4B4N A;  5HGL A;  4XRO A;  2XGU A;  1M9F C;  1E6J P;  1M9E C;  4LQW C;  2WLV A;  2XGV A;  2Y4Z A;  3H4E A;  4U0D A;  4PH2 A;  4U0B A;  4XFY A;  2M8L A;  1M9D C;  2X82 A;  4E92 A;  4U0C A;  4E91 A;  1M9X C;  3MGE A;  2V4X A;  4HTW A;  3H47 A;  5HGN A;  5HGM A;  1EIA A;  4XRQ A;  4U0A A;  4WYM A;  2WLV B;  4XFZ A;  4INB A;  2EIA A;  2M8N A;  2PWO A;  5HGO A;  3NTE A;  4NX4 C;  1M9Y C;  1D1D A;  2GON A;  4DGA C;  2PWM A; 
#chains in the Genus database with same CATH topology
 2M8P A;  1G03 A;  1P7N A;  4QNB A;  5HGK A;  1AFV A;  2XGY A;  3P05 A;  4PH0 A;  2XDE A;  2X83 A;  3BP9 A;  2PXR C;  1QRJ A;  4U0E A;  1AK4 C;  2JPR A;  1L6N A;  1U7K A;  2LF4 A;  4U0F A;  5JPA A;  4XFX A;  1M9C C;  4PH3 A;  2X2D D;  1GWP A;  2KGF A;  4DGE C;  1EM9 A;  4J93 A;  2GOL B;  4B4N A;  5HGL A;  4XRO A;  2XGU A;  1M9F C;  1E6J P;  1M9E C;  4LQW C;  2WLV A;  2XGV A;  2Y4Z A;  3H4E A;  4U0D A;  4PH2 A;  4U0B A;  4XFY A;  2M8L A;  1M9D C;  2X82 A;  4E92 A;  4U0C A;  4E91 A;  1M9X C;  3MGE A;  2V4X A;  4HTW A;  3H47 A;  5HGN A;  5HGM A;  1EIA A;  4XRQ A;  4U0A A;  4WYM A;  2WLV B;  4XFZ A;  4INB A;  2EIA A;  2M8N A;  2PWO A;  5HGO A;  3NTE A;  4NX4 C;  1M9Y C;  1D1D A;  2GON A;  4DGA C;  2PWM A; 
#chains in the Genus database with same CATH homology
 2M8P A;  1G03 A;  1P7N A;  4QNB A;  5HGK A;  1AFV A;  2XGY A;  3P05 A;  4PH0 A;  2XDE A;  2X83 A;  3BP9 A;  2PXR C;  1QRJ A;  4U0E A;  1AK4 C;  2JPR A;  1L6N A;  1U7K A;  2LF4 A;  4U0F A;  5JPA A;  4XFX A;  1M9C C;  4PH3 A;  2X2D D;  1GWP A;  2KGF A;  4DGE C;  1EM9 A;  4J93 A;  2GOL B;  4B4N A;  5HGL A;  4XRO A;  2XGU A;  1M9F C;  1E6J P;  1M9E C;  4LQW C;  2WLV A;  2XGV A;  2Y4Z A;  3H4E A;  4U0D A;  4PH2 A;  4U0B A;  4XFY A;  2M8L A;  1M9D C;  2X82 A;  4E92 A;  4U0C A;  4E91 A;  1M9X C;  3MGE A;  2V4X A;  4HTW A;  3H47 A;  5HGN A;  5HGM A;  1EIA A;  4XRQ A;  4U0A A;  4WYM A;  2WLV B;  4XFZ A;  4INB A;  2EIA A;  2M8N A;  2PWO A;  5HGO A;  3NTE A;  4NX4 C;  1M9Y C;  1D1D A;  2GON A;  4DGA C;  2PWM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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