5COEA

The structure of the nk1 fragment of hgf/sf complexed with hepes
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
173
structure length
173
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hormone
source organism Homo sapiens
publication title Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 36
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 5coeA02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 5coeA01
1NK1A 3HMTA 1GMNA 1GP9A 5CT1A 2KJ4A 4D3CA 1URKA 3SP8A 4Z0EA 2HGFA 1PKRA 3LAQA 5EOKA 3U73A 2X2ZA 1JFNA 2PF2A 4APLA 2YILA 4Z0DA 1NL1A 5I25A 1W8KA 1I71A 4BVVA 4KIVA 3BT2A 1HKYA 1I5KA 1W81A 4DURA 2QJ2A 4R1CA 2LL3A 2FEBA 2PK4A 2I9BA 1CEAA 3HMRA 1A0HA 5CP9A 3HMSA 1KIVA 1KRNA 1CEBA 4BV7A 5CSQA 5CS3A 4BVCA 4R1BA 2HPQP 1PMLA 2LL4M 4Z0FA 1TPKA 1KI0A 3E6PL 1Z40A 1BHTA 3SRIA 1KDUA 3ZLEA 3MKPA 3HN4A 5CS5A 2Y8RA 3KIVA 4IUAA 4BVDA 1YXEA 4UV6A 1HPKA 4R1AA 4O03A 4HZHA 2DOHX 5CT2A 1I8NA 2L0SA 2Q8AA 2DOIA 3BT1A 1B2IA 1NL2A 4APMA 4R19A 2Z8VA 3K65A 4NZQA 2J8LA 1PMKA 2SPTA 2F83A 2PF1A 2I9AA 3NXPA 3ZWZA 4A5TS 5CT3A 5EODA 4BVWA 5CS1A 2YIOA 2FD6A 5CS9A 4Z09A 4CIKA 1PK4A 1GMOA 1PK2A 2Z8WA 4UAOA 2YIPA 2Q8BA 3SRJA 2K4RA 2QJ4A 2KNFA 2HPPP 2K13X 1HPJA 5COEA 2K51A 5HPGA 2J8JA 4BV5A
chains in the Genus database with same CATH superfamily
1NK1A 3HMTA 1GMNA 1GP9A 5CT1A 2KJ4A 4D3CA 1URKA 3SP8A 4Z0EA 2HGFA 1PKRA 3LAQA 5EOKA 3U73A 2X2ZA 1JFNA 2PF2A 4APLA 2YILA 4Z0DA 1NL1A 5I25A 1W8KA 1I71A 4YIZA 4BVVA 4KIVA 3BT2A 1HKYA 1I5KA 1W81A 4DURA 2QJ2A 4R1CA 2LL3A 2FEBA 2PK4A 2I9BA 1CEAA 3HMRA 1A0HA 5CP9A 3HMSA 1KIVA 1KRNA 1CEBA 4BV7A 5CSQA 5CS3A 4BVCA 4R1BA 2HPQP 1PMLA 2LL4M 4Z0FA 1TPKA 1KI0A 3E6PL 1Z40A 1BHTA 3SRIA 1KDUA 3ZLEA 3MKPA 3HN4A 5CS5A 2Y8RA 3KIVA 4IUAA 4BVDA 1YXEA 4UV6A 1HPKA 4R1AA 4O03A 4HZHA 2DOHX 5CT2A 1I8NA 2L0SA 2Q8AA 2DOIA 3BT1A 1B2IA 1NL2A 4APMA 4R19A 2Z8VA 3K65A 4NZQA 2J8LA 1PMKA 2SPTA 2F83A 2PF1A 2I9AA 3NXPA 3ZWZA 4A5TS 5CT3A 5EODA 4BVWA 5CS1A 2YIOA 2FD6A 5CS9A 4Z09A 2KL5A 4CIKA 1PK4A 1GMOA 1PK2A 2Z8WA 4UAOA 2YIPA 2Q8BA 3SRJA 2K4RA 2QJ4A 2KNFA 2HPPP 4YIVA 2K13X 1HPJA 5COEA 2K51A 5HPGA 2J8JA 4BV5A
chains in the Genus database with same CATH topology
1NK1A 3HMTA 1GMNA 1GP9A 5CT1A 2KJ4A 4D3CA 1URKA 3SP8A 4Z0EA 2HGFA 1PKRA 3LAQA 5EOKA 3U73A 2X2ZA 1JFNA 2PF2A 4APLA 2YILA 4Z0DA 1NL1A 5I25A 1W8KA 1I71A 4YIZA 4BVVA 4KIVA 3BT2A 1HKYA 1I5KA 1W81A 4DURA 2QJ2A 4R1CA 2LL3A 2FEBA 2PK4A 2I9BA 1CEAA 3HMRA 1A0HA 5CP9A 3HMSA 1KIVA 1KRNA 1CEBA 4BV7A 5CSQA 5CS3A 4BVCA 4R1BA 2HPQP 1PMLA 2LL4M 4Z0FA 1TPKA 1KI0A 3E6PL 1Z40A 1BHTA 3SRIA 1KDUA 3ZLEA 3MKPA 3HN4A 5CS5A 2Y8RA 3KIVA 4IUAA 4BVDA 1YXEA 4UV6A 1HPKA 4R1AA 4O03A 4HZHA 2DOHX 5CT2A 1I8NA 2L0SA 2Q8AA 2DOIA 3BT1A 1B2IA 1NL2A 4APMA 4R19A 2Z8VA 3K65A 4NZQA 2J8LA 1PMKA 2SPTA 2F83A 2PF1A 2I9AA 3NXPA 3ZWZA 4A5TS 5CT3A 5EODA 4BVWA 5CS1A 2YIOA 2FD6A 5CS9A 4Z09A 2KL5A 4CIKA 1PK4A 1GMOA 1PK2A 2Z8WA 4UAOA 2YIPA 2Q8BA 3SRJA 2K4RA 2QJ4A 2KNFA 2HPPP 4YIVA 2K13X 1HPJA 5COEA 2K51A 5HPGA 2J8JA 4BV5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NK1 A;  3HMT A;  1GMN A;  1GP9 A;  5CT1 A;  2KJ4 A;  4D3C A;  1URK A;  3SP8 A;  4Z0E A;  2HGF A;  1PKR A;  3LAQ A;  5EOK A;  3U73 A;  2X2Z A;  1JFN A;  2PF2 A;  4APL A;  2YIL A;  4Z0D A;  1NL1 A;  5I25 A;  1W8K A;  1I71 A;  4BVV A;  4KIV A;  3BT2 A;  1HKY A;  1I5K A;  1W81 A;  4DUR A;  2QJ2 A;  4R1C A;  2LL3 A;  2FEB A;  2PK4 A;  2I9B A;  1CEA A;  3HMR A;  1A0H A;  5CP9 A;  3HMS A;  1KIV A;  1KRN A;  1CEB A;  4BV7 A;  5CSQ A;  5CS3 A;  4BVC A;  4R1B A;  2HPQ P;  1PML A;  2LL4 M;  4Z0F A;  1TPK A;  1KI0 A;  3E6P L;  1Z40 A;  1BHT A;  3SRI A;  1KDU A;  3ZLE A;  3MKP A;  3HN4 A;  5CS5 A;  2Y8R A;  3KIV A;  4IUA A;  4BVD A;  1YXE A;  4UV6 A;  1HPK A;  4R1A A;  4O03 A;  4HZH A;  2DOH X;  5CT2 A;  1I8N A;  2L0S A;  2Q8A A;  2DOI A;  3BT1 A;  1B2I A;  1NL2 A;  4APM A;  4R19 A;  2Z8V A;  3K65 A;  4NZQ A;  2J8L A;  1PMK A;  2SPT A;  2F83 A;  2PF1 A;  2I9A A;  3NXP A;  3ZWZ A;  4A5T S;  5CT3 A;  5EOD A;  4BVW A;  5CS1 A;  2YIO A;  2FD6 A;  5CS9 A;  4Z09 A;  4CIK A;  1PK4 A;  1GMO A;  1PK2 A;  2Z8W A;  4UAO A;  2YIP A;  2Q8B A;  3SRJ A;  2K4R A;  2QJ4 A;  2KNF A;  2HPP P;  2K13 X;  1HPJ A;  5COE A;  2K51 A;  5HPG A;  2J8J A;  4BV5 A; 
#chains in the Genus database with same CATH topology
 1NK1 A;  3HMT A;  1GMN A;  1GP9 A;  5CT1 A;  2KJ4 A;  4D3C A;  1URK A;  3SP8 A;  4Z0E A;  2HGF A;  1PKR A;  3LAQ A;  5EOK A;  3U73 A;  2X2Z A;  1JFN A;  2PF2 A;  4APL A;  2YIL A;  4Z0D A;  1NL1 A;  5I25 A;  1W8K A;  1I71 A;  4YIZ A;  4BVV A;  4KIV A;  3BT2 A;  1HKY A;  1I5K A;  1W81 A;  4DUR A;  2QJ2 A;  4R1C A;  2LL3 A;  2FEB A;  2PK4 A;  2I9B A;  1CEA A;  3HMR A;  1A0H A;  5CP9 A;  3HMS A;  1KIV A;  1KRN A;  1CEB A;  4BV7 A;  5CSQ A;  5CS3 A;  4BVC A;  4R1B A;  2HPQ P;  1PML A;  2LL4 M;  4Z0F A;  1TPK A;  1KI0 A;  3E6P L;  1Z40 A;  1BHT A;  3SRI A;  1KDU A;  3ZLE A;  3MKP A;  3HN4 A;  5CS5 A;  2Y8R A;  3KIV A;  4IUA A;  4BVD A;  1YXE A;  4UV6 A;  1HPK A;  4R1A A;  4O03 A;  4HZH A;  2DOH X;  5CT2 A;  1I8N A;  2L0S A;  2Q8A A;  2DOI A;  3BT1 A;  1B2I A;  1NL2 A;  4APM A;  4R19 A;  2Z8V A;  3K65 A;  4NZQ A;  2J8L A;  1PMK A;  2SPT A;  2F83 A;  2PF1 A;  2I9A A;  3NXP A;  3ZWZ A;  4A5T S;  5CT3 A;  5EOD A;  4BVW A;  5CS1 A;  2YIO A;  2FD6 A;  5CS9 A;  4Z09 A;  2KL5 A;  4CIK A;  1PK4 A;  1GMO A;  1PK2 A;  2Z8W A;  4UAO A;  2YIP A;  2Q8B A;  3SRJ A;  2K4R A;  2QJ4 A;  2KNF A;  2HPP P;  4YIV A;  2K13 X;  1HPJ A;  5COE A;  2K51 A;  5HPG A;  2J8J A;  4BV5 A; 
#chains in the Genus database with same CATH homology
 1NK1 A;  3HMT A;  1GMN A;  1GP9 A;  5CT1 A;  2KJ4 A;  4D3C A;  1URK A;  3SP8 A;  4Z0E A;  2HGF A;  1PKR A;  3LAQ A;  5EOK A;  3U73 A;  2X2Z A;  1JFN A;  2PF2 A;  4APL A;  2YIL A;  4Z0D A;  1NL1 A;  5I25 A;  1W8K A;  1I71 A;  4YIZ A;  4BVV A;  4KIV A;  3BT2 A;  1HKY A;  1I5K A;  1W81 A;  4DUR A;  2QJ2 A;  4R1C A;  2LL3 A;  2FEB A;  2PK4 A;  2I9B A;  1CEA A;  3HMR A;  1A0H A;  5CP9 A;  3HMS A;  1KIV A;  1KRN A;  1CEB A;  4BV7 A;  5CSQ A;  5CS3 A;  4BVC A;  4R1B A;  2HPQ P;  1PML A;  2LL4 M;  4Z0F A;  1TPK A;  1KI0 A;  3E6P L;  1Z40 A;  1BHT A;  3SRI A;  1KDU A;  3ZLE A;  3MKP A;  3HN4 A;  5CS5 A;  2Y8R A;  3KIV A;  4IUA A;  4BVD A;  1YXE A;  4UV6 A;  1HPK A;  4R1A A;  4O03 A;  4HZH A;  2DOH X;  5CT2 A;  1I8N A;  2L0S A;  2Q8A A;  2DOI A;  3BT1 A;  1B2I A;  1NL2 A;  4APM A;  4R19 A;  2Z8V A;  3K65 A;  4NZQ A;  2J8L A;  1PMK A;  2SPT A;  2F83 A;  2PF1 A;  2I9A A;  3NXP A;  3ZWZ A;  4A5T S;  5CT3 A;  5EOD A;  4BVW A;  5CS1 A;  2YIO A;  2FD6 A;  5CS9 A;  4Z09 A;  2KL5 A;  4CIK A;  1PK4 A;  1GMO A;  1PK2 A;  2Z8W A;  4UAO A;  2YIP A;  2Q8B A;  3SRJ A;  2K4R A;  2QJ4 A;  2KNF A;  2HPP P;  4YIV A;  2K13 X;  1HPJ A;  5COE A;  2K51 A;  5HPG A;  2J8J A;  4BV5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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