5CS3A

The structure of the nk1 fragment of hgf/sf complexed with (h)epps
Total Genus 33

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
173
structure length
173
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI4 (133-136)S1 (42-48)TIV1 (38-41)S3 (60-63)S2 (51-52)TII2 (77-80)TIV3 (52-55)TIV4 (54-57)S4 (86-90)AH1 (67-76)TI6 (164-167)TIV5 (90-93)TII4 (167-170)S5 (95-99)TI1 (91-94)TIV8 (165-168)O4 (128-206)TI2 (102-105)S7 (112-121)TIV7 (163-166)S6 (108-109)TII3 (105-108)TVIb1 (155-158)TIV6 (151-154)3H1 (122-124)TII'1 (130-133)TI5 (143-146)TVIII1 (156-159)TIV9 (168-171)O1 (80-82)O2 (70-96)Updating...
connected with : NaN
molecule tags Hormone
source organism Homo sapiens
publication title Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 33
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 5cs3A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 5cs3A01
2KNFA 1URKA 5CS1A 2YILA 1KIVA 3SRIA 3U73A 5CT1A 3ZLEA 1NL1A 1Z40A 3K65A 2FD6A 1I8NA 2K13X 1NL2A 1HPKA 5HPGA 1TPKA 5CT2A 1KI0A 1KDUA 5EODA 3SRJA 2Z8VA 1B2IA 4BV5A 3HMRA 1PMLA 5CT3A 4D3CA 1YXEA 2Y8RA 2I9BA 3MKPA 1CEAA 4Z0DA 4BV7A 4BVVA 4R19A 4Z09A 2YIPA 4IUAA 1W8KA 4R1AA 3HMTA 2DOHX 4R1CA 1W81A 4HZHA 1PK4A 2HGFA 2F83A 5EOKA 2J8LA 4BVDA 2YIOA 3KIVA 2QJ4A 5COEA 4NZQA 5CSQA 1HPJA 2LL3A 1NK1A 3BT1A 2QJ2A 5CS3A 3E6PL 3SP8A 4BVCA 4CIKA 5CP9A 2J8JA 3BT2A 2HPPP 4Z0EA 4KIVA 1GMNA 1A0HA 4DURA 2X2ZA 1PK2A 2I9AA 2PF1A 5CS9A 2L0SA 1BHTA 4APMA 1GP9A 1KRNA 1I71A 3NXPA 1GMOA 4UV6A 4APLA 1PKRA 1I5KA 2Z8WA 3HN4A 2PK4A 3ZWZA 4O03A 1PMKA 2K4RA 2Q8AA 2Q8BA 4UAOA 2HPQP 2K51A 1CEBA 2FEBA 5I25A 3HMSA 4A5TS 2KJ4A 5CS5A 2LL4M 2DOIA 2SPTA 4BVWA 1HKYA 2PF2A 1JFNA 4Z0FA 3LAQA 4R1BA
chains in the Genus database with same CATH superfamily
2KNFA 1URKA 5CS1A 2YILA 1KIVA 3SRIA 3U73A 5CT1A 3ZLEA 1NL1A 1Z40A 3K65A 2FD6A 1I8NA 2K13X 1NL2A 1HPKA 5HPGA 1TPKA 5CT2A 1KI0A 1KDUA 5EODA 3SRJA 2Z8VA 1B2IA 4BV5A 3HMRA 1PMLA 5CT3A 4D3CA 1YXEA 4YIZA 2Y8RA 2I9BA 3MKPA 1CEAA 4Z0DA 4BV7A 4BVVA 4R19A 4Z09A 2YIPA 4IUAA 1W8KA 4R1AA 3HMTA 2DOHX 4R1CA 1W81A 4HZHA 1PK4A 2HGFA 2F83A 5EOKA 2J8LA 4BVDA 2YIOA 4YIVA 3KIVA 2QJ4A 5COEA 4NZQA 5CSQA 1HPJA 2LL3A 1NK1A 3BT1A 2QJ2A 5CS3A 3E6PL 3SP8A 4BVCA 4CIKA 5CP9A 2J8JA 3BT2A 2HPPP 4Z0EA 4KIVA 1GMNA 1A0HA 4DURA 2X2ZA 1PK2A 2I9AA 2PF1A 5CS9A 2L0SA 1BHTA 4APMA 1GP9A 1KRNA 1I71A 3NXPA 1GMOA 4UV6A 4APLA 1PKRA 1I5KA 2Z8WA 3HN4A 2PK4A 3ZWZA 4O03A 1PMKA 2K4RA 2Q8AA 2Q8BA 4UAOA 2HPQP 2K51A 1CEBA 2FEBA 2KL5A 5I25A 3HMSA 4A5TS 2KJ4A 5CS5A 2LL4M 2DOIA 2SPTA 4BVWA 1HKYA 2PF2A 1JFNA 4Z0FA 3LAQA 4R1BA
chains in the Genus database with same CATH topology
2KNFA 1URKA 5CS1A 2YILA 1KIVA 3SRIA 3U73A 5CT1A 3ZLEA 1NL1A 1Z40A 3K65A 2FD6A 1I8NA 2K13X 1NL2A 1HPKA 5HPGA 1TPKA 5CT2A 1KI0A 1KDUA 5EODA 3SRJA 2Z8VA 1B2IA 4BV5A 3HMRA 1PMLA 5CT3A 4D3CA 1YXEA 4YIZA 2Y8RA 2I9BA 3MKPA 1CEAA 4Z0DA 4BV7A 4BVVA 4R19A 4Z09A 2YIPA 4IUAA 1W8KA 4R1AA 3HMTA 2DOHX 4R1CA 1W81A 4HZHA 1PK4A 2HGFA 2F83A 5EOKA 2J8LA 4BVDA 2YIOA 4YIVA 3KIVA 2QJ4A 5COEA 4NZQA 5CSQA 1HPJA 2LL3A 1NK1A 3BT1A 2QJ2A 5CS3A 3E6PL 3SP8A 4BVCA 4CIKA 5CP9A 2J8JA 3BT2A 2HPPP 4Z0EA 4KIVA 1GMNA 1A0HA 4DURA 2X2ZA 1PK2A 2I9AA 2PF1A 5CS9A 2L0SA 1BHTA 4APMA 1GP9A 1KRNA 1I71A 3NXPA 1GMOA 4UV6A 4APLA 1PKRA 1I5KA 2Z8WA 3HN4A 2PK4A 3ZWZA 4O03A 1PMKA 2K4RA 2Q8AA 2Q8BA 4UAOA 2HPQP 2K51A 1CEBA 2FEBA 2KL5A 5I25A 3HMSA 4A5TS 2KJ4A 5CS5A 2LL4M 2DOIA 2SPTA 4BVWA 1HKYA 2PF2A 1JFNA 4Z0FA 3LAQA 4R1BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KNF A;  1URK A;  5CS1 A;  2YIL A;  1KIV A;  3SRI A;  3U73 A;  5CT1 A;  3ZLE A;  1NL1 A;  1Z40 A;  3K65 A;  2FD6 A;  1I8N A;  2K13 X;  1NL2 A;  1HPK A;  5HPG A;  1TPK A;  5CT2 A;  1KI0 A;  1KDU A;  5EOD A;  3SRJ A;  2Z8V A;  1B2I A;  4BV5 A;  3HMR A;  1PML A;  5CT3 A;  4D3C A;  1YXE A;  2Y8R A;  2I9B A;  3MKP A;  1CEA A;  4Z0D A;  4BV7 A;  4BVV A;  4R19 A;  4Z09 A;  2YIP A;  4IUA A;  1W8K A;  4R1A A;  3HMT A;  2DOH X;  4R1C A;  1W81 A;  4HZH A;  1PK4 A;  2HGF A;  2F83 A;  5EOK A;  2J8L A;  4BVD A;  2YIO A;  3KIV A;  2QJ4 A;  5COE A;  4NZQ A;  5CSQ A;  1HPJ A;  2LL3 A;  1NK1 A;  3BT1 A;  2QJ2 A;  5CS3 A;  3E6P L;  3SP8 A;  4BVC A;  4CIK A;  5CP9 A;  2J8J A;  3BT2 A;  2HPP P;  4Z0E A;  4KIV A;  1GMN A;  1A0H A;  4DUR A;  2X2Z A;  1PK2 A;  2I9A A;  2PF1 A;  5CS9 A;  2L0S A;  1BHT A;  4APM A;  1GP9 A;  1KRN A;  1I71 A;  3NXP A;  1GMO A;  4UV6 A;  4APL A;  1PKR A;  1I5K A;  2Z8W A;  3HN4 A;  2PK4 A;  3ZWZ A;  4O03 A;  1PMK A;  2K4R A;  2Q8A A;  2Q8B A;  4UAO A;  2HPQ P;  2K51 A;  1CEB A;  2FEB A;  5I25 A;  3HMS A;  4A5T S;  2KJ4 A;  5CS5 A;  2LL4 M;  2DOI A;  2SPT A;  4BVW A;  1HKY A;  2PF2 A;  1JFN A;  4Z0F A;  3LAQ A;  4R1B A; 
#chains in the Genus database with same CATH topology
 2KNF A;  1URK A;  5CS1 A;  2YIL A;  1KIV A;  3SRI A;  3U73 A;  5CT1 A;  3ZLE A;  1NL1 A;  1Z40 A;  3K65 A;  2FD6 A;  1I8N A;  2K13 X;  1NL2 A;  1HPK A;  5HPG A;  1TPK A;  5CT2 A;  1KI0 A;  1KDU A;  5EOD A;  3SRJ A;  2Z8V A;  1B2I A;  4BV5 A;  3HMR A;  1PML A;  5CT3 A;  4D3C A;  1YXE A;  4YIZ A;  2Y8R A;  2I9B A;  3MKP A;  1CEA A;  4Z0D A;  4BV7 A;  4BVV A;  4R19 A;  4Z09 A;  2YIP A;  4IUA A;  1W8K A;  4R1A A;  3HMT A;  2DOH X;  4R1C A;  1W81 A;  4HZH A;  1PK4 A;  2HGF A;  2F83 A;  5EOK A;  2J8L A;  4BVD A;  2YIO A;  4YIV A;  3KIV A;  2QJ4 A;  5COE A;  4NZQ A;  5CSQ A;  1HPJ A;  2LL3 A;  1NK1 A;  3BT1 A;  2QJ2 A;  5CS3 A;  3E6P L;  3SP8 A;  4BVC A;  4CIK A;  5CP9 A;  2J8J A;  3BT2 A;  2HPP P;  4Z0E A;  4KIV A;  1GMN A;  1A0H A;  4DUR A;  2X2Z A;  1PK2 A;  2I9A A;  2PF1 A;  5CS9 A;  2L0S A;  1BHT A;  4APM A;  1GP9 A;  1KRN A;  1I71 A;  3NXP A;  1GMO A;  4UV6 A;  4APL A;  1PKR A;  1I5K A;  2Z8W A;  3HN4 A;  2PK4 A;  3ZWZ A;  4O03 A;  1PMK A;  2K4R A;  2Q8A A;  2Q8B A;  4UAO A;  2HPQ P;  2K51 A;  1CEB A;  2FEB A;  2KL5 A;  5I25 A;  3HMS A;  4A5T S;  2KJ4 A;  5CS5 A;  2LL4 M;  2DOI A;  2SPT A;  4BVW A;  1HKY A;  2PF2 A;  1JFN A;  4Z0F A;  3LAQ A;  4R1B A; 
#chains in the Genus database with same CATH homology
 2KNF A;  1URK A;  5CS1 A;  2YIL A;  1KIV A;  3SRI A;  3U73 A;  5CT1 A;  3ZLE A;  1NL1 A;  1Z40 A;  3K65 A;  2FD6 A;  1I8N A;  2K13 X;  1NL2 A;  1HPK A;  5HPG A;  1TPK A;  5CT2 A;  1KI0 A;  1KDU A;  5EOD A;  3SRJ A;  2Z8V A;  1B2I A;  4BV5 A;  3HMR A;  1PML A;  5CT3 A;  4D3C A;  1YXE A;  4YIZ A;  2Y8R A;  2I9B A;  3MKP A;  1CEA A;  4Z0D A;  4BV7 A;  4BVV A;  4R19 A;  4Z09 A;  2YIP A;  4IUA A;  1W8K A;  4R1A A;  3HMT A;  2DOH X;  4R1C A;  1W81 A;  4HZH A;  1PK4 A;  2HGF A;  2F83 A;  5EOK A;  2J8L A;  4BVD A;  2YIO A;  4YIV A;  3KIV A;  2QJ4 A;  5COE A;  4NZQ A;  5CSQ A;  1HPJ A;  2LL3 A;  1NK1 A;  3BT1 A;  2QJ2 A;  5CS3 A;  3E6P L;  3SP8 A;  4BVC A;  4CIK A;  5CP9 A;  2J8J A;  3BT2 A;  2HPP P;  4Z0E A;  4KIV A;  1GMN A;  1A0H A;  4DUR A;  2X2Z A;  1PK2 A;  2I9A A;  2PF1 A;  5CS9 A;  2L0S A;  1BHT A;  4APM A;  1GP9 A;  1KRN A;  1I71 A;  3NXP A;  1GMO A;  4UV6 A;  4APL A;  1PKR A;  1I5K A;  2Z8W A;  3HN4 A;  2PK4 A;  3ZWZ A;  4O03 A;  1PMK A;  2K4R A;  2Q8A A;  2Q8B A;  4UAO A;  2HPQ P;  2K51 A;  1CEB A;  2FEB A;  2KL5 A;  5I25 A;  3HMS A;  4A5T S;  2KJ4 A;  5CS5 A;  2LL4 M;  2DOI A;  2SPT A;  4BVW A;  1HKY A;  2PF2 A;  1JFN A;  4Z0F A;  3LAQ A;  4R1B A; 
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