5CS5A

The structure of the nk1 fragment of hgf/sf complexed with pipes
Total Genus 43

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
43
sequence length
173
structure length
173
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
EMPTYTI6 (133-136)TI1 (54-57)S1 (42-52)TII2 (77-80)TIV1 (52-55)S3 (86-90)AH1 (67-76)S4 (95-99)TI2 (90-93)TI3 (91-94)TII3 (167-170)TI4 (102-105)O3 (128-206)S5 (108-121)3H3 (164-166)TVIb1 (155-158)TI8 (151-154)3H2 (122-124)TII'1 (130-133)TIV3 (129-132)TI7 (143-146)TVIII1 (156-159)S2 (60-63)TIV2 (105-108)3H1 (39-41)O1 (70-96)Updating...
connected with : NaN
molecule tags Hormone
source organism Homo sapiens
publication title Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
pubmed doi rcsb
molecule keywords Hepatocyte growth factor
total genus 43
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 5cs5A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 5cs5A01
1NK1A 4BVWA 4APLA 1YXEA 2DOIA 1PK4A 1URKA 3K65A 3SP8A 4BVVA 2Z8VA 4APMA 1B2IA 4R1CA 2HPPP 1GMNA 2K4RA 1CEAA 1KRNA 2K13X 2Q8BA 1HPJA 2KJ4A 5HPGA 2J8JA 1I5KA 5I25A 5CT1A 1I8NA 1W81A 2Y8RA 4R1AA 3SRIA 2QJ4A 2YILA 1KI0A 5CS5A 2FD6A 2HGFA 3HN4A 2J8LA 2I9BA 2FEBA 2X2ZA 2I9AA 4BV5A 3ZWZA 3SRJA 2KNFA 1Z40A 2PF1A 1JFNA 5CS9A 1TPKA 3ZLEA 4Z0FA 2DOHX 1PMKA 5CSQA 1KIVA 5CT3A 4BV7A 2L0SA 4Z0EA 2LL3A 4Z09A 1NL2A 3LAQA 4BVDA 2Q8AA 4DURA 2LL4M 1CEBA 1GP9A 3MKPA 3E6PL 1PMLA 1KDUA 5CT2A 5CS3A 5CP9A 1I71A 3NXPA 5EOKA 4BVCA 4UV6A 4O03A 2Z8WA 4CIKA 2PF2A 1HPKA 4UAOA 4IUAA 3U73A 5COEA 1PK2A 1NL1A 2PK4A 1BHTA 1HKYA 5CS1A 3BT1A 3HMSA 4HZHA 1A0HA 4A5TS 4R1BA 1PKRA 1GMOA 3HMTA 4R19A 4NZQA 3HMRA 2QJ2A 4D3CA 2HPQP 4Z0DA 4KIVA 2YIPA 2SPTA 2K51A 3BT2A 3KIVA 2YIOA 5EODA 1W8KA 2F83A
chains in the Genus database with same CATH superfamily
2KL5A 1NK1A 4BVWA 4APLA 1YXEA 2DOIA 1PK4A 1URKA 3K65A 4YIVA 3SP8A 4BVVA 2Z8VA 4APMA 1B2IA 4R1CA 2HPPP 1GMNA 2K4RA 1CEAA 1KRNA 2K13X 2Q8BA 1HPJA 2KJ4A 5HPGA 2J8JA 1I5KA 5I25A 5CT1A 1I8NA 1W81A 2Y8RA 4R1AA 3SRIA 2QJ4A 2YILA 1KI0A 5CS5A 2FD6A 2HGFA 3HN4A 2J8LA 2I9BA 2FEBA 2X2ZA 2I9AA 4BV5A 3ZWZA 3SRJA 2KNFA 1Z40A 2PF1A 1JFNA 5CS9A 1TPKA 4YIZA 3ZLEA 4Z0FA 2DOHX 1PMKA 5CSQA 1KIVA 5CT3A 4BV7A 2L0SA 4Z0EA 2LL3A 4Z09A 1NL2A 3LAQA 4BVDA 2Q8AA 4DURA 2LL4M 1CEBA 1GP9A 3MKPA 3E6PL 1PMLA 1KDUA 5CT2A 5CS3A 5CP9A 1I71A 3NXPA 5EOKA 4BVCA 4UV6A 4O03A 2Z8WA 4CIKA 2PF2A 1HPKA 4UAOA 4IUAA 3U73A 5COEA 1PK2A 1NL1A 2PK4A 1BHTA 1HKYA 5CS1A 3BT1A 3HMSA 4HZHA 1A0HA 4A5TS 4R1BA 1PKRA 1GMOA 3HMTA 4R19A 4NZQA 3HMRA 2QJ2A 4D3CA 2HPQP 4Z0DA 4KIVA 2YIPA 2SPTA 2K51A 3BT2A 3KIVA 2YIOA 5EODA 1W8KA 2F83A
chains in the Genus database with same CATH topology
2KL5A 1NK1A 4BVWA 4APLA 1YXEA 2DOIA 1PK4A 1URKA 3K65A 4YIVA 3SP8A 4BVVA 2Z8VA 4APMA 1B2IA 4R1CA 2HPPP 1GMNA 2K4RA 1CEAA 1KRNA 2K13X 2Q8BA 1HPJA 2KJ4A 5HPGA 2J8JA 1I5KA 5I25A 5CT1A 1I8NA 1W81A 2Y8RA 4R1AA 3SRIA 2QJ4A 2YILA 1KI0A 5CS5A 2FD6A 2HGFA 3HN4A 2J8LA 2I9BA 2FEBA 2X2ZA 2I9AA 4BV5A 3ZWZA 3SRJA 2KNFA 1Z40A 2PF1A 1JFNA 5CS9A 1TPKA 4YIZA 3ZLEA 4Z0FA 2DOHX 1PMKA 5CSQA 1KIVA 5CT3A 4BV7A 2L0SA 4Z0EA 2LL3A 4Z09A 1NL2A 3LAQA 4BVDA 2Q8AA 4DURA 2LL4M 1CEBA 1GP9A 3MKPA 3E6PL 1PMLA 1KDUA 5CT2A 5CS3A 5CP9A 1I71A 3NXPA 5EOKA 4BVCA 4UV6A 4O03A 2Z8WA 4CIKA 2PF2A 1HPKA 4UAOA 4IUAA 3U73A 5COEA 1PK2A 1NL1A 2PK4A 1BHTA 1HKYA 5CS1A 3BT1A 3HMSA 4HZHA 1A0HA 4A5TS 4R1BA 1PKRA 1GMOA 3HMTA 4R19A 4NZQA 3HMRA 2QJ2A 4D3CA 2HPQP 4Z0DA 4KIVA 2YIPA 2SPTA 2K51A 3BT2A 3KIVA 2YIOA 5EODA 1W8KA 2F83A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NK1 A;  4BVW A;  4APL A;  1YXE A;  2DOI A;  1PK4 A;  1URK A;  3K65 A;  3SP8 A;  4BVV A;  2Z8V A;  4APM A;  1B2I A;  4R1C A;  2HPP P;  1GMN A;  2K4R A;  1CEA A;  1KRN A;  2K13 X;  2Q8B A;  1HPJ A;  2KJ4 A;  5HPG A;  2J8J A;  1I5K A;  5I25 A;  5CT1 A;  1I8N A;  1W81 A;  2Y8R A;  4R1A A;  3SRI A;  2QJ4 A;  2YIL A;  1KI0 A;  5CS5 A;  2FD6 A;  2HGF A;  3HN4 A;  2J8L A;  2I9B A;  2FEB A;  2X2Z A;  2I9A A;  4BV5 A;  3ZWZ A;  3SRJ A;  2KNF A;  1Z40 A;  2PF1 A;  1JFN A;  5CS9 A;  1TPK A;  3ZLE A;  4Z0F A;  2DOH X;  1PMK A;  5CSQ A;  1KIV A;  5CT3 A;  4BV7 A;  2L0S A;  4Z0E A;  2LL3 A;  4Z09 A;  1NL2 A;  3LAQ A;  4BVD A;  2Q8A A;  4DUR A;  2LL4 M;  1CEB A;  1GP9 A;  3MKP A;  3E6P L;  1PML A;  1KDU A;  5CT2 A;  5CS3 A;  5CP9 A;  1I71 A;  3NXP A;  5EOK A;  4BVC A;  4UV6 A;  4O03 A;  2Z8W A;  4CIK A;  2PF2 A;  1HPK A;  4UAO A;  4IUA A;  3U73 A;  5COE A;  1PK2 A;  1NL1 A;  2PK4 A;  1BHT A;  1HKY A;  5CS1 A;  3BT1 A;  3HMS A;  4HZH A;  1A0H A;  4A5T S;  4R1B A;  1PKR A;  1GMO A;  3HMT A;  4R19 A;  4NZQ A;  3HMR A;  2QJ2 A;  4D3C A;  2HPQ P;  4Z0D A;  4KIV A;  2YIP A;  2SPT A;  2K51 A;  3BT2 A;  3KIV A;  2YIO A;  5EOD A;  1W8K A;  2F83 A; 
#chains in the Genus database with same CATH topology
 2KL5 A;  1NK1 A;  4BVW A;  4APL A;  1YXE A;  2DOI A;  1PK4 A;  1URK A;  3K65 A;  4YIV A;  3SP8 A;  4BVV A;  2Z8V A;  4APM A;  1B2I A;  4R1C A;  2HPP P;  1GMN A;  2K4R A;  1CEA A;  1KRN A;  2K13 X;  2Q8B A;  1HPJ A;  2KJ4 A;  5HPG A;  2J8J A;  1I5K A;  5I25 A;  5CT1 A;  1I8N A;  1W81 A;  2Y8R A;  4R1A A;  3SRI A;  2QJ4 A;  2YIL A;  1KI0 A;  5CS5 A;  2FD6 A;  2HGF A;  3HN4 A;  2J8L A;  2I9B A;  2FEB A;  2X2Z A;  2I9A A;  4BV5 A;  3ZWZ A;  3SRJ A;  2KNF A;  1Z40 A;  2PF1 A;  1JFN A;  5CS9 A;  1TPK A;  4YIZ A;  3ZLE A;  4Z0F A;  2DOH X;  1PMK A;  5CSQ A;  1KIV A;  5CT3 A;  4BV7 A;  2L0S A;  4Z0E A;  2LL3 A;  4Z09 A;  1NL2 A;  3LAQ A;  4BVD A;  2Q8A A;  4DUR A;  2LL4 M;  1CEB A;  1GP9 A;  3MKP A;  3E6P L;  1PML A;  1KDU A;  5CT2 A;  5CS3 A;  5CP9 A;  1I71 A;  3NXP A;  5EOK A;  4BVC A;  4UV6 A;  4O03 A;  2Z8W A;  4CIK A;  2PF2 A;  1HPK A;  4UAO A;  4IUA A;  3U73 A;  5COE A;  1PK2 A;  1NL1 A;  2PK4 A;  1BHT A;  1HKY A;  5CS1 A;  3BT1 A;  3HMS A;  4HZH A;  1A0H A;  4A5T S;  4R1B A;  1PKR A;  1GMO A;  3HMT A;  4R19 A;  4NZQ A;  3HMR A;  2QJ2 A;  4D3C A;  2HPQ P;  4Z0D A;  4KIV A;  2YIP A;  2SPT A;  2K51 A;  3BT2 A;  3KIV A;  2YIO A;  5EOD A;  1W8K A;  2F83 A; 
#chains in the Genus database with same CATH homology
 2KL5 A;  1NK1 A;  4BVW A;  4APL A;  1YXE A;  2DOI A;  1PK4 A;  1URK A;  3K65 A;  4YIV A;  3SP8 A;  4BVV A;  2Z8V A;  4APM A;  1B2I A;  4R1C A;  2HPP P;  1GMN A;  2K4R A;  1CEA A;  1KRN A;  2K13 X;  2Q8B A;  1HPJ A;  2KJ4 A;  5HPG A;  2J8J A;  1I5K A;  5I25 A;  5CT1 A;  1I8N A;  1W81 A;  2Y8R A;  4R1A A;  3SRI A;  2QJ4 A;  2YIL A;  1KI0 A;  5CS5 A;  2FD6 A;  2HGF A;  3HN4 A;  2J8L A;  2I9B A;  2FEB A;  2X2Z A;  2I9A A;  4BV5 A;  3ZWZ A;  3SRJ A;  2KNF A;  1Z40 A;  2PF1 A;  1JFN A;  5CS9 A;  1TPK A;  4YIZ A;  3ZLE A;  4Z0F A;  2DOH X;  1PMK A;  5CSQ A;  1KIV A;  5CT3 A;  4BV7 A;  2L0S A;  4Z0E A;  2LL3 A;  4Z09 A;  1NL2 A;  3LAQ A;  4BVD A;  2Q8A A;  4DUR A;  2LL4 M;  1CEB A;  1GP9 A;  3MKP A;  3E6P L;  1PML A;  1KDU A;  5CT2 A;  5CS3 A;  5CP9 A;  1I71 A;  3NXP A;  5EOK A;  4BVC A;  4UV6 A;  4O03 A;  2Z8W A;  4CIK A;  2PF2 A;  1HPK A;  4UAO A;  4IUA A;  3U73 A;  5COE A;  1PK2 A;  1NL1 A;  2PK4 A;  1BHT A;  1HKY A;  5CS1 A;  3BT1 A;  3HMS A;  4HZH A;  1A0H A;  4A5T S;  4R1B A;  1PKR A;  1GMO A;  3HMT A;  4R19 A;  4NZQ A;  3HMR A;  2QJ2 A;  4D3C A;  2HPQ P;  4Z0D A;  4KIV A;  2YIP A;  2SPT A;  2K51 A;  3BT2 A;  3KIV A;  2YIO A;  5EOD A;  1W8K A;  2F83 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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