5CSQ | Genus

Total Genus 39

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	39
sequence length	173
structure length	173
Chain Sequence	TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hormone
source organism	Homo sapiens
publication title	Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. pubmed doi rcsb
molecule keywords	Hepatocyte growth factor
total genus	39
structure length	173
sequence length	173
chains with identical sequence	B
ec nomenclature
pdb deposition date	2015-07-23

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00024	PAN_1	PAN domain
A	PF00051	Kringle	Kringle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.40.20.10	Mainly Beta	Beta Barrel	Plasminogen Kringle 4	Plasminogen Kringle 4	5csqA02
3.50.4.10	Alpha Beta	3-Layer(bba) Sandwich	Hepatocyte Growth Factor	Hepatocyte Growth Factor	5csqA01

4HZHA 2Z8VA 4KIVA 2I9AA 3HMRA 5COEA 4Z0EA 1KI0A 4UAOA 3KIVA 3U73A 4R1CA 1W8KA 2DOHX 4Z0FA 2QJ2A 4D3CA 5CS1A 1B2IA 1YXEA 1KRNA 4BVWA 1CEBA 2Y8RA 4BVVA 2J8JA 3SRIA 1GP9A 2Q8BA 5EOKA 4R19A 1I71A 2FD6A 2L0SA 1PMLA 2KJ4A 5CS3A 1URKA 4R1AA 2K13X 1CEAA 4DURA 4Z0DA 4APMA 1GMOA 1PKRA 2K4RA 2DOIA 3ZLEA 4BV5A 1I8NA 5CSQA 2PF1A 2LL4M 2PF2A 5CT1A 1A0HA 3E6PL 1PK4A 5HPGA 1BHTA 1PMKA 5CP9A 1HKYA 5CT2A 4NZQA 4A5TS 2FEBA 3ZWZA 1NL2A 4CIKA 4UV6A 2LL3A 4R1BA 5CS9A 4APLA 3LAQA 1Z40A 3NXPA 4BVDA 1NL1A 2Z8WA 4IUAA 3HN4A 2YILA 2YIOA 2HPPP 2J8LA 2X2ZA 2HPQP 3K65A 1HPJA 2PK4A 3SRJA 2QJ4A 2KNFA 3HMSA 1KIVA 2HGFA 2K51A 3BT1A 5I25A 1NK1A 4Z09A 1HPKA 2SPTA 4O03A 2YIPA 2I9BA 1W81A 3BT2A 2F83A 1GMNA 5EODA 4BV7A 1I5KA 1TPKA 3HMTA 4BVCA 1PK2A 2Q8AA 3SP8A 5CS5A 5CT3A 1KDUA 3MKPA 1JFNA
chains in the Genus database with same CATH superfamily

4HZHA 2Z8VA 4KIVA 2I9AA 3HMRA 5COEA 4Z0EA 4YIZA 1KI0A 4UAOA 3KIVA 3U73A 4R1CA 1W8KA 2DOHX 4Z0FA 2QJ2A 4D3CA 5CS1A 1B2IA 1YXEA 1KRNA 4BVWA 1CEBA 2Y8RA 4BVVA 2J8JA 3SRIA 1GP9A 2Q8BA 5EOKA 4R19A 1I71A 2FD6A 2L0SA 1PMLA 2KJ4A 5CS3A 1URKA 4R1AA 2K13X 1CEAA 4DURA 4Z0DA 4APMA 1GMOA 1PKRA 2K4RA 2DOIA 3ZLEA 4BV5A 1I8NA 5CSQA 2PF1A 2LL4M 2PF2A 5CT1A 1A0HA 3E6PL 1PK4A 5HPGA 1BHTA 1PMKA 5CP9A 1HKYA 5CT2A 4NZQA 4A5TS 2FEBA 3ZWZA 1NL2A 4CIKA 4UV6A 4YIVA 2LL3A 4R1BA 5CS9A 4APLA 3LAQA 1Z40A 3NXPA 4BVDA 1NL1A 2Z8WA 4IUAA 3HN4A 2YILA 2YIOA 2HPPP 2J8LA 2X2ZA 2HPQP 3K65A 1HPJA 2PK4A 3SRJA 2QJ4A 2KNFA 3HMSA 1KIVA 2HGFA 2K51A 3BT1A 5I25A 1NK1A 4Z09A 1HPKA 2SPTA 4O03A 2YIPA 2I9BA 1W81A 3BT2A 2F83A 1GMNA 5EODA 4BV7A 1I5KA 1TPKA 3HMTA 4BVCA 1PK2A 2Q8AA 3SP8A 2KL5A 5CS5A 5CT3A 1KDUA 3MKPA 1JFNA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4HZH A;  2Z8V A;  4KIV A;  2I9A A;  3HMR A;  5COE A;  4Z0E A;  1KI0 A;  4UAO A;  3KIV A;  3U73 A;  4R1C A;  1W8K A;  2DOH X;  4Z0F A;  2QJ2 A;  4D3C A;  5CS1 A;  1B2I A;  1YXE A;  1KRN A;  4BVW A;  1CEB A;  2Y8R A;  4BVV A;  2J8J A;  3SRI A;  1GP9 A;  2Q8B A;  5EOK A;  4R19 A;  1I71 A;  2FD6 A;  2L0S A;  1PML A;  2KJ4 A;  5CS3 A;  1URK A;  4R1A A;  2K13 X;  1CEA A;  4DUR A;  4Z0D A;  4APM A;  1GMO A;  1PKR A;  2K4R A;  2DOI A;  3ZLE A;  4BV5 A;  1I8N A;  5CSQ A;  2PF1 A;  2LL4 M;  2PF2 A;  5CT1 A;  1A0H A;  3E6P L;  1PK4 A;  5HPG A;  1BHT A;  1PMK A;  5CP9 A;  1HKY A;  5CT2 A;  4NZQ A;  4A5T S;  2FEB A;  3ZWZ A;  1NL2 A;  4CIK A;  4UV6 A;  2LL3 A;  4R1B A;  5CS9 A;  4APL A;  3LAQ A;  1Z40 A;  3NXP A;  4BVD A;  1NL1 A;  2Z8W A;  4IUA A;  3HN4 A;  2YIL A;  2YIO A;  2HPP P;  2J8L A;  2X2Z A;  2HPQ P;  3K65 A;  1HPJ A;  2PK4 A;  3SRJ A;  2QJ4 A;  2KNF A;  3HMS A;  1KIV A;  2HGF A;  2K51 A;  3BT1 A;  5I25 A;  1NK1 A;  4Z09 A;  1HPK A;  2SPT A;  4O03 A;  2YIP A;  2I9B A;  1W81 A;  3BT2 A;  2F83 A;  1GMN A;  5EOD A;  4BV7 A;  1I5K A;  1TPK A;  3HMT A;  4BVC A;  1PK2 A;  2Q8A A;  3SP8 A;  5CS5 A;  5CT3 A;  1KDU A;  3MKP A;  1JFN A; 
#chains in the Genus database with same CATH topology
 4HZH A;  2Z8V A;  4KIV A;  2I9A A;  3HMR A;  5COE A;  4Z0E A;  4YIZ A;  1KI0 A;  4UAO A;  3KIV A;  3U73 A;  4R1C A;  1W8K A;  2DOH X;  4Z0F A;  2QJ2 A;  4D3C A;  5CS1 A;  1B2I A;  1YXE A;  1KRN A;  4BVW A;  1CEB A;  2Y8R A;  4BVV A;  2J8J A;  3SRI A;  1GP9 A;  2Q8B A;  5EOK A;  4R19 A;  1I71 A;  2FD6 A;  2L0S A;  1PML A;  2KJ4 A;  5CS3 A;  1URK A;  4R1A A;  2K13 X;  1CEA A;  4DUR A;  4Z0D A;  4APM A;  1GMO A;  1PKR A;  2K4R A;  2DOI A;  3ZLE A;  4BV5 A;  1I8N A;  5CSQ A;  2PF1 A;  2LL4 M;  2PF2 A;  5CT1 A;  1A0H A;  3E6P L;  1PK4 A;  5HPG A;  1BHT A;  1PMK A;  5CP9 A;  1HKY A;  5CT2 A;  4NZQ A;  4A5T S;  2FEB A;  3ZWZ A;  1NL2 A;  4CIK A;  4UV6 A;  4YIV A;  2LL3 A;  4R1B A;  5CS9 A;  4APL A;  3LAQ A;  1Z40 A;  3NXP A;  4BVD A;  1NL1 A;  2Z8W A;  4IUA A;  3HN4 A;  2YIL A;  2YIO A;  2HPP P;  2J8L A;  2X2Z A;  2HPQ P;  3K65 A;  1HPJ A;  2PK4 A;  3SRJ A;  2QJ4 A;  2KNF A;  3HMS A;  1KIV A;  2HGF A;  2K51 A;  3BT1 A;  5I25 A;  1NK1 A;  4Z09 A;  1HPK A;  2SPT A;  4O03 A;  2YIP A;  2I9B A;  1W81 A;  3BT2 A;  2F83 A;  1GMN A;  5EOD A;  4BV7 A;  1I5K A;  1TPK A;  3HMT A;  4BVC A;  1PK2 A;  2Q8A A;  3SP8 A;  2KL5 A;  5CS5 A;  5CT3 A;  1KDU A;  3MKP A;  1JFN A; 
#chains in the Genus database with same CATH homology
 4HZH A;  2Z8V A;  4KIV A;  2I9A A;  3HMR A;  5COE A;  4Z0E A;  4YIZ A;  1KI0 A;  4UAO A;  3KIV A;  3U73 A;  4R1C A;  1W8K A;  2DOH X;  4Z0F A;  2QJ2 A;  4D3C A;  5CS1 A;  1B2I A;  1YXE A;  1KRN A;  4BVW A;  1CEB A;  2Y8R A;  4BVV A;  2J8J A;  3SRI A;  1GP9 A;  2Q8B A;  5EOK A;  4R19 A;  1I71 A;  2FD6 A;  2L0S A;  1PML A;  2KJ4 A;  5CS3 A;  1URK A;  4R1A A;  2K13 X;  1CEA A;  4DUR A;  4Z0D A;  4APM A;  1GMO A;  1PKR A;  2K4R A;  2DOI A;  3ZLE A;  4BV5 A;  1I8N A;  5CSQ A;  2PF1 A;  2LL4 M;  2PF2 A;  5CT1 A;  1A0H A;  3E6P L;  1PK4 A;  5HPG A;  1BHT A;  1PMK A;  5CP9 A;  1HKY A;  5CT2 A;  4NZQ A;  4A5T S;  2FEB A;  3ZWZ A;  1NL2 A;  4CIK A;  4UV6 A;  4YIV A;  2LL3 A;  4R1B A;  5CS9 A;  4APL A;  3LAQ A;  1Z40 A;  3NXP A;  4BVD A;  1NL1 A;  2Z8W A;  4IUA A;  3HN4 A;  2YIL A;  2YIO A;  2HPP P;  2J8L A;  2X2Z A;  2HPQ P;  3K65 A;  1HPJ A;  2PK4 A;  3SRJ A;  2QJ4 A;  2KNF A;  3HMS A;  1KIV A;  2HGF A;  2K51 A;  3BT1 A;  5I25 A;  1NK1 A;  4Z09 A;  1HPK A;  2SPT A;  4O03 A;  2YIP A;  2I9B A;  1W81 A;  3BT2 A;  2F83 A;  1GMN A;  5EOD A;  4BV7 A;  1I5K A;  1TPK A;  3HMT A;  4BVC A;  1PK2 A;  2Q8A A;  3SP8 A;  2KL5 A;  5CS5 A;  5CT3 A;  1KDU A;  3MKP A;  1JFN A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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5CSQA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations