5CT2A

The structure of the nk1 fragment of hgf/sf complexed with caps
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
173
structure length
173
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 39
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 5ct2A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 5ct2A01
3BT1A 4Z0FA 5CS9A 1GMNA 2Y8RA 1NL1A 4O03A 1CEAA 3MKPA 4R1AA 2HGFA 2X2ZA 4BVDA 2F83A 5EODA 1GP9A 3HN4A 3SRJA 5COEA 4UV6A 4UAOA 3HMSA 5CT3A 5CT2A 1KI0A 3HMTA 1NK1A 2Z8VA 1PMKA 3NXPA 5CS1A 4BVCA 1KDUA 2YIOA 1I71A 2LL4M 1PKRA 4HZHA 3HMRA 1W81A 2J8LA 2J8JA 2I9AA 1Z40A 2SPTA 4Z0DA 4DURA 4BV7A 4NZQA 2K4RA 3ZLEA 3E6PL 3KIVA 4BVVA 2KJ4A 2PF2A 3K65A 1PMLA 3SRIA 2LL3A 2K13X 1A0HA 4APMA 2Q8BA 2PK4A 5CT1A 1YXEA 3BT2A 2QJ4A 4Z0EA 5CS3A 4KIVA 2YILA 4R1CA 1W8KA 2Q8AA 1URKA 2Z8WA 5CSQA 1PK2A 2DOHX 1HPJA 2FD6A 1JFNA 2QJ2A 2K51A 4Z09A 1KRNA 2L0SA 1PK4A 3ZWZA 1TPKA 3U73A 1I5KA 2YIPA 2HPQP 5CS5A 5HPGA 4A5TS 1GMOA 5I25A 3SP8A 4R1BA 1KIVA 2HPPP 1BHTA 3LAQA 1B2IA 1HPKA 2I9BA 1I8NA 1CEBA 4R19A 1NL2A 4CIKA 4IUAA 4D3CA 5EOKA 4APLA 5CP9A 2DOIA 1HKYA 2FEBA 2PF1A 2KNFA 4BVWA 4BV5A
chains in the Genus database with same CATH superfamily
4YIVA 3BT1A 4Z0FA 5CS9A 1GMNA 2Y8RA 1NL1A 4O03A 1CEAA 3MKPA 4R1AA 2HGFA 2X2ZA 4BVDA 2F83A 5EODA 1GP9A 3HN4A 3SRJA 5COEA 4UV6A 4UAOA 3HMSA 5CT3A 5CT2A 1KI0A 3HMTA 1NK1A 2Z8VA 1PMKA 3NXPA 5CS1A 4BVCA 1KDUA 2YIOA 1I71A 2LL4M 1PKRA 4HZHA 3HMRA 1W81A 2J8LA 2J8JA 2I9AA 1Z40A 2SPTA 4Z0DA 4DURA 4BV7A 4NZQA 2K4RA 3ZLEA 3E6PL 3KIVA 4BVVA 2KJ4A 2PF2A 3K65A 1PMLA 3SRIA 2LL3A 2K13X 1A0HA 4APMA 2Q8BA 2PK4A 5CT1A 1YXEA 3BT2A 2QJ4A 4Z0EA 5CS3A 4KIVA 2YILA 4R1CA 1W8KA 2Q8AA 1URKA 2Z8WA 4YIZA 5CSQA 1PK2A 2DOHX 1HPJA 2FD6A 1JFNA 2QJ2A 2K51A 4Z09A 1KRNA 2L0SA 1PK4A 3ZWZA 1TPKA 3U73A 1I5KA 2YIPA 2HPQP 5CS5A 5HPGA 4A5TS 1GMOA 5I25A 3SP8A 4R1BA 1KIVA 2HPPP 1BHTA 3LAQA 1B2IA 1HPKA 2I9BA 1I8NA 1CEBA 4R19A 1NL2A 4CIKA 4IUAA 4D3CA 5EOKA 4APLA 5CP9A 2DOIA 2KL5A 1HKYA 2FEBA 2PF1A 2KNFA 4BVWA 4BV5A
chains in the Genus database with same CATH topology
4YIVA 3BT1A 4Z0FA 5CS9A 1GMNA 2Y8RA 1NL1A 4O03A 1CEAA 3MKPA 4R1AA 2HGFA 2X2ZA 4BVDA 2F83A 5EODA 1GP9A 3HN4A 3SRJA 5COEA 4UV6A 4UAOA 3HMSA 5CT3A 5CT2A 1KI0A 3HMTA 1NK1A 2Z8VA 1PMKA 3NXPA 5CS1A 4BVCA 1KDUA 2YIOA 1I71A 2LL4M 1PKRA 4HZHA 3HMRA 1W81A 2J8LA 2J8JA 2I9AA 1Z40A 2SPTA 4Z0DA 4DURA 4BV7A 4NZQA 2K4RA 3ZLEA 3E6PL 3KIVA 4BVVA 2KJ4A 2PF2A 3K65A 1PMLA 3SRIA 2LL3A 2K13X 1A0HA 4APMA 2Q8BA 2PK4A 5CT1A 1YXEA 3BT2A 2QJ4A 4Z0EA 5CS3A 4KIVA 2YILA 4R1CA 1W8KA 2Q8AA 1URKA 2Z8WA 4YIZA 5CSQA 1PK2A 2DOHX 1HPJA 2FD6A 1JFNA 2QJ2A 2K51A 4Z09A 1KRNA 2L0SA 1PK4A 3ZWZA 1TPKA 3U73A 1I5KA 2YIPA 2HPQP 5CS5A 5HPGA 4A5TS 1GMOA 5I25A 3SP8A 4R1BA 1KIVA 2HPPP 1BHTA 3LAQA 1B2IA 1HPKA 2I9BA 1I8NA 1CEBA 4R19A 1NL2A 4CIKA 4IUAA 4D3CA 5EOKA 4APLA 5CP9A 2DOIA 2KL5A 1HKYA 2FEBA 2PF1A 2KNFA 4BVWA 4BV5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BT1 A;  4Z0F A;  5CS9 A;  1GMN A;  2Y8R A;  1NL1 A;  4O03 A;  1CEA A;  3MKP A;  4R1A A;  2HGF A;  2X2Z A;  4BVD A;  2F83 A;  5EOD A;  1GP9 A;  3HN4 A;  3SRJ A;  5COE A;  4UV6 A;  4UAO A;  3HMS A;  5CT3 A;  5CT2 A;  1KI0 A;  3HMT A;  1NK1 A;  2Z8V A;  1PMK A;  3NXP A;  5CS1 A;  4BVC A;  1KDU A;  2YIO A;  1I71 A;  2LL4 M;  1PKR A;  4HZH A;  3HMR A;  1W81 A;  2J8L A;  2J8J A;  2I9A A;  1Z40 A;  2SPT A;  4Z0D A;  4DUR A;  4BV7 A;  4NZQ A;  2K4R A;  3ZLE A;  3E6P L;  3KIV A;  4BVV A;  2KJ4 A;  2PF2 A;  3K65 A;  1PML A;  3SRI A;  2LL3 A;  2K13 X;  1A0H A;  4APM A;  2Q8B A;  2PK4 A;  5CT1 A;  1YXE A;  3BT2 A;  2QJ4 A;  4Z0E A;  5CS3 A;  4KIV A;  2YIL A;  4R1C A;  1W8K A;  2Q8A A;  1URK A;  2Z8W A;  5CSQ A;  1PK2 A;  2DOH X;  1HPJ A;  2FD6 A;  1JFN A;  2QJ2 A;  2K51 A;  4Z09 A;  1KRN A;  2L0S A;  1PK4 A;  3ZWZ A;  1TPK A;  3U73 A;  1I5K A;  2YIP A;  2HPQ P;  5CS5 A;  5HPG A;  4A5T S;  1GMO A;  5I25 A;  3SP8 A;  4R1B A;  1KIV A;  2HPP P;  1BHT A;  3LAQ A;  1B2I A;  1HPK A;  2I9B A;  1I8N A;  1CEB A;  4R19 A;  1NL2 A;  4CIK A;  4IUA A;  4D3C A;  5EOK A;  4APL A;  5CP9 A;  2DOI A;  1HKY A;  2FEB A;  2PF1 A;  2KNF A;  4BVW A;  4BV5 A; 
#chains in the Genus database with same CATH topology
 4YIV A;  3BT1 A;  4Z0F A;  5CS9 A;  1GMN A;  2Y8R A;  1NL1 A;  4O03 A;  1CEA A;  3MKP A;  4R1A A;  2HGF A;  2X2Z A;  4BVD A;  2F83 A;  5EOD A;  1GP9 A;  3HN4 A;  3SRJ A;  5COE A;  4UV6 A;  4UAO A;  3HMS A;  5CT3 A;  5CT2 A;  1KI0 A;  3HMT A;  1NK1 A;  2Z8V A;  1PMK A;  3NXP A;  5CS1 A;  4BVC A;  1KDU A;  2YIO A;  1I71 A;  2LL4 M;  1PKR A;  4HZH A;  3HMR A;  1W81 A;  2J8L A;  2J8J A;  2I9A A;  1Z40 A;  2SPT A;  4Z0D A;  4DUR A;  4BV7 A;  4NZQ A;  2K4R A;  3ZLE A;  3E6P L;  3KIV A;  4BVV A;  2KJ4 A;  2PF2 A;  3K65 A;  1PML A;  3SRI A;  2LL3 A;  2K13 X;  1A0H A;  4APM A;  2Q8B A;  2PK4 A;  5CT1 A;  1YXE A;  3BT2 A;  2QJ4 A;  4Z0E A;  5CS3 A;  4KIV A;  2YIL A;  4R1C A;  1W8K A;  2Q8A A;  1URK A;  2Z8W A;  4YIZ A;  5CSQ A;  1PK2 A;  2DOH X;  1HPJ A;  2FD6 A;  1JFN A;  2QJ2 A;  2K51 A;  4Z09 A;  1KRN A;  2L0S A;  1PK4 A;  3ZWZ A;  1TPK A;  3U73 A;  1I5K A;  2YIP A;  2HPQ P;  5CS5 A;  5HPG A;  4A5T S;  1GMO A;  5I25 A;  3SP8 A;  4R1B A;  1KIV A;  2HPP P;  1BHT A;  3LAQ A;  1B2I A;  1HPK A;  2I9B A;  1I8N A;  1CEB A;  4R19 A;  1NL2 A;  4CIK A;  4IUA A;  4D3C A;  5EOK A;  4APL A;  5CP9 A;  2DOI A;  2KL5 A;  1HKY A;  2FEB A;  2PF1 A;  2KNF A;  4BVW A;  4BV5 A; 
#chains in the Genus database with same CATH homology
 4YIV A;  3BT1 A;  4Z0F A;  5CS9 A;  1GMN A;  2Y8R A;  1NL1 A;  4O03 A;  1CEA A;  3MKP A;  4R1A A;  2HGF A;  2X2Z A;  4BVD A;  2F83 A;  5EOD A;  1GP9 A;  3HN4 A;  3SRJ A;  5COE A;  4UV6 A;  4UAO A;  3HMS A;  5CT3 A;  5CT2 A;  1KI0 A;  3HMT A;  1NK1 A;  2Z8V A;  1PMK A;  3NXP A;  5CS1 A;  4BVC A;  1KDU A;  2YIO A;  1I71 A;  2LL4 M;  1PKR A;  4HZH A;  3HMR A;  1W81 A;  2J8L A;  2J8J A;  2I9A A;  1Z40 A;  2SPT A;  4Z0D A;  4DUR A;  4BV7 A;  4NZQ A;  2K4R A;  3ZLE A;  3E6P L;  3KIV A;  4BVV A;  2KJ4 A;  2PF2 A;  3K65 A;  1PML A;  3SRI A;  2LL3 A;  2K13 X;  1A0H A;  4APM A;  2Q8B A;  2PK4 A;  5CT1 A;  1YXE A;  3BT2 A;  2QJ4 A;  4Z0E A;  5CS3 A;  4KIV A;  2YIL A;  4R1C A;  1W8K A;  2Q8A A;  1URK A;  2Z8W A;  4YIZ A;  5CSQ A;  1PK2 A;  2DOH X;  1HPJ A;  2FD6 A;  1JFN A;  2QJ2 A;  2K51 A;  4Z09 A;  1KRN A;  2L0S A;  1PK4 A;  3ZWZ A;  1TPK A;  3U73 A;  1I5K A;  2YIP A;  2HPQ P;  5CS5 A;  5HPG A;  4A5T S;  1GMO A;  5I25 A;  3SP8 A;  4R1B A;  1KIV A;  2HPP P;  1BHT A;  3LAQ A;  1B2I A;  1HPK A;  2I9B A;  1I8N A;  1CEB A;  4R19 A;  1NL2 A;  4CIK A;  4IUA A;  4D3C A;  5EOK A;  4APL A;  5CP9 A;  2DOI A;  2KL5 A;  1HKY A;  2FEB A;  2PF1 A;  2KNF A;  4BVW A;  4BV5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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