5CT2 | Genus

Total Genus 39

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	39
sequence length	173
structure length	173
Chain Sequence	TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hormone
source organism	Homo sapiens
publication title	Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. pubmed doi rcsb
molecule keywords	Hepatocyte growth factor
total genus	39
structure length	173
sequence length	173
chains with identical sequence	B
ec nomenclature
pdb deposition date	2015-07-23

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00024	PAN_1	PAN domain
A	PF00051	Kringle	Kringle domain

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
2.40.20.10	Mainly Beta	Beta Barrel	Plasminogen Kringle 4	Plasminogen Kringle 4	5ct2A02
3.50.4.10	Alpha Beta	3-Layer(bba) Sandwich	Hepatocyte Growth Factor	Hepatocyte Growth Factor	5ct2A01

4R1AA 1PKRA 4BV7A 4R19A 5I25A 4DURA 2F83A 1BHTA 3K65A 2L0SA 2J8LA 4R1CA 4BVWA 2Q8BA 1GMNA 4BVDA 1NL2A 1I5KA 5CS1A 2KJ4A 2SPTA 5CS3A 5CT3A 2HPQP 4UAOA 2HPPP 4KIVA 2PK4A 2HGFA 5CT2A 5CT1A 3SP8A 4Z0DA 2Z8VA 3LAQA 1CEBA 2FD6A 2PF2A 3NXPA 1KI0A 1Z40A 4Z0FA 3HN4A 2Z8WA 3U73A 2YIPA 2K4RA 1URKA 4APMA 2FEBA 1PMKA 1YXEA 1HKYA 2DOHX 4Z0EA 3BT2A 1KRNA 1HPJA 3ZWZA 2YIOA 1GMOA 4BVVA 3ZLEA 1PK2A 5COEA 1W81A 2K13X 1HPKA 1B2IA 3KIVA 3HMSA 2KNFA 5CSQA 4BVCA 3SRIA 2I9BA 2Y8RA 3E6PL 5CP9A 3MKPA 1PMLA 4R1BA 5CS5A 2QJ2A 2DOIA 1W8KA 3HMRA 1NL1A 5EODA 4APLA 2Q8AA 5EOKA 2YILA 5CS9A 4O03A 3BT1A 2LL3A 4BV5A 1I71A 1TPKA 4Z09A 5HPGA 1KDUA 4CIKA 4UV6A 2QJ4A 1CEAA 3SRJA 2LL4M 4NZQA 2J8JA 1NK1A 4A5TS 4HZHA 4D3CA 1GP9A 1A0HA 2PF1A 2I9AA 1JFNA 2K51A 1I8NA 1KIVA 1PK4A 2X2ZA 3HMTA 4IUAA
chains in the Genus database with same CATH superfamily

4R1AA 1PKRA 4BV7A 4R19A 5I25A 4DURA 2F83A 1BHTA 3K65A 2L0SA 2J8LA 4R1CA 4YIZA 4BVWA 2Q8BA 1GMNA 4BVDA 1NL2A 1I5KA 5CS1A 2KJ4A 2SPTA 5CS3A 5CT3A 2HPQP 4UAOA 2HPPP 4KIVA 2PK4A 2HGFA 5CT2A 5CT1A 3SP8A 4Z0DA 2Z8VA 3LAQA 1CEBA 2FD6A 2PF2A 3NXPA 1KI0A 1Z40A 4Z0FA 3HN4A 4YIVA 2Z8WA 3U73A 2YIPA 2K4RA 1URKA 4APMA 2KL5A 2FEBA 1PMKA 1YXEA 1HKYA 2DOHX 4Z0EA 3BT2A 1KRNA 1HPJA 3ZWZA 2YIOA 1GMOA 4BVVA 3ZLEA 1PK2A 5COEA 1W81A 2K13X 1HPKA 1B2IA 3KIVA 3HMSA 2KNFA 5CSQA 4BVCA 3SRIA 2I9BA 2Y8RA 3E6PL 5CP9A 3MKPA 1PMLA 4R1BA 5CS5A 2QJ2A 2DOIA 1W8KA 3HMRA 1NL1A 5EODA 4APLA 2Q8AA 5EOKA 2YILA 5CS9A 4O03A 3BT1A 2LL3A 4BV5A 1I71A 1TPKA 4Z09A 5HPGA 1KDUA 4CIKA 4UV6A 2QJ4A 1CEAA 3SRJA 2LL4M 4NZQA 2J8JA 1NK1A 4A5TS 4HZHA 4D3CA 1GP9A 1A0HA 2PF1A 2I9AA 1JFNA 2K51A 1I8NA 1KIVA 1PK4A 2X2ZA 3HMTA 4IUAA
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4R1A A;  1PKR A;  4BV7 A;  4R19 A;  5I25 A;  4DUR A;  2F83 A;  1BHT A;  3K65 A;  2L0S A;  2J8L A;  4R1C A;  4BVW A;  2Q8B A;  1GMN A;  4BVD A;  1NL2 A;  1I5K A;  5CS1 A;  2KJ4 A;  2SPT A;  5CS3 A;  5CT3 A;  2HPQ P;  4UAO A;  2HPP P;  4KIV A;  2PK4 A;  2HGF A;  5CT2 A;  5CT1 A;  3SP8 A;  4Z0D A;  2Z8V A;  3LAQ A;  1CEB A;  2FD6 A;  2PF2 A;  3NXP A;  1KI0 A;  1Z40 A;  4Z0F A;  3HN4 A;  2Z8W A;  3U73 A;  2YIP A;  2K4R A;  1URK A;  4APM A;  2FEB A;  1PMK A;  1YXE A;  1HKY A;  2DOH X;  4Z0E A;  3BT2 A;  1KRN A;  1HPJ A;  3ZWZ A;  2YIO A;  1GMO A;  4BVV A;  3ZLE A;  1PK2 A;  5COE A;  1W81 A;  2K13 X;  1HPK A;  1B2I A;  3KIV A;  3HMS A;  2KNF A;  5CSQ A;  4BVC A;  3SRI A;  2I9B A;  2Y8R A;  3E6P L;  5CP9 A;  3MKP A;  1PML A;  4R1B A;  5CS5 A;  2QJ2 A;  2DOI A;  1W8K A;  3HMR A;  1NL1 A;  5EOD A;  4APL A;  2Q8A A;  5EOK A;  2YIL A;  5CS9 A;  4O03 A;  3BT1 A;  2LL3 A;  4BV5 A;  1I71 A;  1TPK A;  4Z09 A;  5HPG A;  1KDU A;  4CIK A;  4UV6 A;  2QJ4 A;  1CEA A;  3SRJ A;  2LL4 M;  4NZQ A;  2J8J A;  1NK1 A;  4A5T S;  4HZH A;  4D3C A;  1GP9 A;  1A0H A;  2PF1 A;  2I9A A;  1JFN A;  2K51 A;  1I8N A;  1KIV A;  1PK4 A;  2X2Z A;  3HMT A;  4IUA A; 
#chains in the Genus database with same CATH topology
 4R1A A;  1PKR A;  4BV7 A;  4R19 A;  5I25 A;  4DUR A;  2F83 A;  1BHT A;  3K65 A;  2L0S A;  2J8L A;  4R1C A;  4YIZ A;  4BVW A;  2Q8B A;  1GMN A;  4BVD A;  1NL2 A;  1I5K A;  5CS1 A;  2KJ4 A;  2SPT A;  5CS3 A;  5CT3 A;  2HPQ P;  4UAO A;  2HPP P;  4KIV A;  2PK4 A;  2HGF A;  5CT2 A;  5CT1 A;  3SP8 A;  4Z0D A;  2Z8V A;  3LAQ A;  1CEB A;  2FD6 A;  2PF2 A;  3NXP A;  1KI0 A;  1Z40 A;  4Z0F A;  3HN4 A;  4YIV A;  2Z8W A;  3U73 A;  2YIP A;  2K4R A;  1URK A;  4APM A;  2KL5 A;  2FEB A;  1PMK A;  1YXE A;  1HKY A;  2DOH X;  4Z0E A;  3BT2 A;  1KRN A;  1HPJ A;  3ZWZ A;  2YIO A;  1GMO A;  4BVV A;  3ZLE A;  1PK2 A;  5COE A;  1W81 A;  2K13 X;  1HPK A;  1B2I A;  3KIV A;  3HMS A;  2KNF A;  5CSQ A;  4BVC A;  3SRI A;  2I9B A;  2Y8R A;  3E6P L;  5CP9 A;  3MKP A;  1PML A;  4R1B A;  5CS5 A;  2QJ2 A;  2DOI A;  1W8K A;  3HMR A;  1NL1 A;  5EOD A;  4APL A;  2Q8A A;  5EOK A;  2YIL A;  5CS9 A;  4O03 A;  3BT1 A;  2LL3 A;  4BV5 A;  1I71 A;  1TPK A;  4Z09 A;  5HPG A;  1KDU A;  4CIK A;  4UV6 A;  2QJ4 A;  1CEA A;  3SRJ A;  2LL4 M;  4NZQ A;  2J8J A;  1NK1 A;  4A5T S;  4HZH A;  4D3C A;  1GP9 A;  1A0H A;  2PF1 A;  2I9A A;  1JFN A;  2K51 A;  1I8N A;  1KIV A;  1PK4 A;  2X2Z A;  3HMT A;  4IUA A; 
#chains in the Genus database with same CATH homology
 4R1A A;  1PKR A;  4BV7 A;  4R19 A;  5I25 A;  4DUR A;  2F83 A;  1BHT A;  3K65 A;  2L0S A;  2J8L A;  4R1C A;  4YIZ A;  4BVW A;  2Q8B A;  1GMN A;  4BVD A;  1NL2 A;  1I5K A;  5CS1 A;  2KJ4 A;  2SPT A;  5CS3 A;  5CT3 A;  2HPQ P;  4UAO A;  2HPP P;  4KIV A;  2PK4 A;  2HGF A;  5CT2 A;  5CT1 A;  3SP8 A;  4Z0D A;  2Z8V A;  3LAQ A;  1CEB A;  2FD6 A;  2PF2 A;  3NXP A;  1KI0 A;  1Z40 A;  4Z0F A;  3HN4 A;  4YIV A;  2Z8W A;  3U73 A;  2YIP A;  2K4R A;  1URK A;  4APM A;  2KL5 A;  2FEB A;  1PMK A;  1YXE A;  1HKY A;  2DOH X;  4Z0E A;  3BT2 A;  1KRN A;  1HPJ A;  3ZWZ A;  2YIO A;  1GMO A;  4BVV A;  3ZLE A;  1PK2 A;  5COE A;  1W81 A;  2K13 X;  1HPK A;  1B2I A;  3KIV A;  3HMS A;  2KNF A;  5CSQ A;  4BVC A;  3SRI A;  2I9B A;  2Y8R A;  3E6P L;  5CP9 A;  3MKP A;  1PML A;  4R1B A;  5CS5 A;  2QJ2 A;  2DOI A;  1W8K A;  3HMR A;  1NL1 A;  5EOD A;  4APL A;  2Q8A A;  5EOK A;  2YIL A;  5CS9 A;  4O03 A;  3BT1 A;  2LL3 A;  4BV5 A;  1I71 A;  1TPK A;  4Z09 A;  5HPG A;  1KDU A;  4CIK A;  4UV6 A;  2QJ4 A;  1CEA A;  3SRJ A;  2LL4 M;  4NZQ A;  2J8J A;  1NK1 A;  4A5T S;  4HZH A;  4D3C A;  1GP9 A;  1A0H A;  2PF1 A;  2I9A A;  1JFN A;  2K51 A;  1I8N A;  1KIV A;  1PK4 A;  2X2Z A;  3HMT A;  4IUA A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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5CT2A

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations