5CT2A

The structure of the nk1 fragment of hgf/sf complexed with caps
Total Genus 39
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
173
structure length
173
Chain Sequence
TIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding.
pubmed doi rcsb
molecule tags Hormone
source organism Homo sapiens
molecule keywords Hepatocyte growth factor
total genus 39
structure length 173
sequence length 173
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00024 PAN_1 PAN domain
A PF00051 Kringle Kringle domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.20.10 Mainly Beta Beta Barrel Plasminogen Kringle 4 Plasminogen Kringle 4 5ct2A02
3.50.4.10 Alpha Beta 3-Layer(bba) Sandwich Hepatocyte Growth Factor Hepatocyte Growth Factor 5ct2A01
4O03A 4CIKA 4BVCA 2YIOA 2Q8BA 4NZQA 2FD6A 5CS5A 2KNFA 1URKA 3BT2A 3ZLEA 4APLA 1HPKA 5CS1A 1GP9A 4R19A 1I8NA 3U73A 2K51A 1W8KA 4BV5A 4DURA 1PK2A 3K65A 3KIVA 5CP9A 4BVDA 5CT3A 1KI0A 3NXPA 3SP8A 5CS3A 3SRJA 5HPGA 2PF1A 2DOHX 1NL1A 4D3CA 2Z8WA 4R1AA 2HGFA 4Z0DA 1GMOA 2Q8AA 1PMLA 2X2ZA 2QJ4A 2KJ4A 1KRNA 1BHTA 1GMNA 2I9BA 4R1BA 3MKPA 1B2IA 2Y8RA 1HPJA 4UV6A 1PK4A 1Z40A 5CT2A 1KIVA 5CS9A 1JFNA 3SRIA 2L0SA 1NK1A 1I71A 1I5KA 2HPPP 2PK4A 2PF2A 4Z09A 4BVWA 2YIPA 1NL2A 1TPKA 2FEBA 2QJ2A 2K13X 1CEBA 4IUAA 2LL3A 5I25A 2DOIA 1KDUA 2HPQP 4APMA 2LL4M 1CEAA 3LAQA 4BVVA 4HZHA 1W81A 4Z0EA 4Z0FA 4A5TS 3HMSA 2J8LA 2Z8VA 1HKYA 1PMKA 2J8JA 4UAOA 2YILA 1PKRA 3E6PL 3HMRA 5CSQA 5CT1A 3HMTA 2SPTA 2F83A 4KIVA 2I9AA 1YXEA 5EODA 5EOKA 2K4RA 3HN4A 1A0HA 4BV7A 3ZWZA 5COEA 4R1CA 3BT1A
chains in the Genus database with same CATH superfamily
4O03A 4CIKA 4BVCA 2YIOA 2Q8BA 4YIZA 4NZQA 2FD6A 5CS5A 2KNFA 1URKA 3BT2A 3ZLEA 4APLA 1HPKA 5CS1A 1GP9A 4R19A 1I8NA 3U73A 2K51A 1W8KA 4BV5A 4DURA 1PK2A 3K65A 3KIVA 5CP9A 4BVDA 5CT3A 1KI0A 3NXPA 3SP8A 5CS3A 3SRJA 5HPGA 2PF1A 2DOHX 1NL1A 4D3CA 2Z8WA 4R1AA 2HGFA 4Z0DA 1GMOA 2Q8AA 1PMLA 2X2ZA 2QJ4A 2KJ4A 1KRNA 1BHTA 1GMNA 2I9BA 4R1BA 3MKPA 1B2IA 2Y8RA 1HPJA 4UV6A 1PK4A 1Z40A 5CT2A 1KIVA 5CS9A 1JFNA 3SRIA 2L0SA 1NK1A 1I71A 1I5KA 2HPPP 2PK4A 2PF2A 4Z09A 4BVWA 2YIPA 1NL2A 1TPKA 2FEBA 2QJ2A 2K13X 1CEBA 4IUAA 2LL3A 5I25A 2DOIA 1KDUA 2HPQP 4APMA 2LL4M 1CEAA 4YIVA 3LAQA 4BVVA 4HZHA 1W81A 4Z0EA 4Z0FA 2KL5A 4A5TS 3HMSA 2J8LA 2Z8VA 1HKYA 1PMKA 2J8JA 4UAOA 2YILA 1PKRA 3E6PL 3HMRA 5CSQA 5CT1A 3HMTA 2SPTA 2F83A 4KIVA 2I9AA 1YXEA 5EODA 5EOKA 2K4RA 3HN4A 1A0HA 4BV7A 3ZWZA 5COEA 4R1CA 3BT1A
chains in the Genus database with same CATH topology
4O03A 4CIKA 4BVCA 2YIOA 2Q8BA 4YIZA 4NZQA 2FD6A 5CS5A 2KNFA 1URKA 3BT2A 3ZLEA 4APLA 1HPKA 5CS1A 1GP9A 4R19A 1I8NA 3U73A 2K51A 1W8KA 4BV5A 4DURA 1PK2A 3K65A 3KIVA 5CP9A 4BVDA 5CT3A 1KI0A 3NXPA 3SP8A 5CS3A 3SRJA 5HPGA 2PF1A 2DOHX 1NL1A 4D3CA 2Z8WA 4R1AA 2HGFA 4Z0DA 1GMOA 2Q8AA 1PMLA 2X2ZA 2QJ4A 2KJ4A 1KRNA 1BHTA 1GMNA 2I9BA 4R1BA 3MKPA 1B2IA 2Y8RA 1HPJA 4UV6A 1PK4A 1Z40A 5CT2A 1KIVA 5CS9A 1JFNA 3SRIA 2L0SA 1NK1A 1I71A 1I5KA 2HPPP 2PK4A 2PF2A 4Z09A 4BVWA 2YIPA 1NL2A 1TPKA 2FEBA 2QJ2A 2K13X 1CEBA 4IUAA 2LL3A 5I25A 2DOIA 1KDUA 2HPQP 4APMA 2LL4M 1CEAA 4YIVA 3LAQA 4BVVA 4HZHA 1W81A 4Z0EA 4Z0FA 2KL5A 4A5TS 3HMSA 2J8LA 2Z8VA 1HKYA 1PMKA 2J8JA 4UAOA 2YILA 1PKRA 3E6PL 3HMRA 5CSQA 5CT1A 3HMTA 2SPTA 2F83A 4KIVA 2I9AA 1YXEA 5EODA 5EOKA 2K4RA 3HN4A 1A0HA 4BV7A 3ZWZA 5COEA 4R1CA 3BT1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4O03 A;  4CIK A;  4BVC A;  2YIO A;  2Q8B A;  4NZQ A;  2FD6 A;  5CS5 A;  2KNF A;  1URK A;  3BT2 A;  3ZLE A;  4APL A;  1HPK A;  5CS1 A;  1GP9 A;  4R19 A;  1I8N A;  3U73 A;  2K51 A;  1W8K A;  4BV5 A;  4DUR A;  1PK2 A;  3K65 A;  3KIV A;  5CP9 A;  4BVD A;  5CT3 A;  1KI0 A;  3NXP A;  3SP8 A;  5CS3 A;  3SRJ A;  5HPG A;  2PF1 A;  2DOH X;  1NL1 A;  4D3C A;  2Z8W A;  4R1A A;  2HGF A;  4Z0D A;  1GMO A;  2Q8A A;  1PML A;  2X2Z A;  2QJ4 A;  2KJ4 A;  1KRN A;  1BHT A;  1GMN A;  2I9B A;  4R1B A;  3MKP A;  1B2I A;  2Y8R A;  1HPJ A;  4UV6 A;  1PK4 A;  1Z40 A;  5CT2 A;  1KIV A;  5CS9 A;  1JFN A;  3SRI A;  2L0S A;  1NK1 A;  1I71 A;  1I5K A;  2HPP P;  2PK4 A;  2PF2 A;  4Z09 A;  4BVW A;  2YIP A;  1NL2 A;  1TPK A;  2FEB A;  2QJ2 A;  2K13 X;  1CEB A;  4IUA A;  2LL3 A;  5I25 A;  2DOI A;  1KDU A;  2HPQ P;  4APM A;  2LL4 M;  1CEA A;  3LAQ A;  4BVV A;  4HZH A;  1W81 A;  4Z0E A;  4Z0F A;  4A5T S;  3HMS A;  2J8L A;  2Z8V A;  1HKY A;  1PMK A;  2J8J A;  4UAO A;  2YIL A;  1PKR A;  3E6P L;  3HMR A;  5CSQ A;  5CT1 A;  3HMT A;  2SPT A;  2F83 A;  4KIV A;  2I9A A;  1YXE A;  5EOD A;  5EOK A;  2K4R A;  3HN4 A;  1A0H A;  4BV7 A;  3ZWZ A;  5COE A;  4R1C A;  3BT1 A; 
#chains in the Genus database with same CATH topology
 4O03 A;  4CIK A;  4BVC A;  2YIO A;  2Q8B A;  4YIZ A;  4NZQ A;  2FD6 A;  5CS5 A;  2KNF A;  1URK A;  3BT2 A;  3ZLE A;  4APL A;  1HPK A;  5CS1 A;  1GP9 A;  4R19 A;  1I8N A;  3U73 A;  2K51 A;  1W8K A;  4BV5 A;  4DUR A;  1PK2 A;  3K65 A;  3KIV A;  5CP9 A;  4BVD A;  5CT3 A;  1KI0 A;  3NXP A;  3SP8 A;  5CS3 A;  3SRJ A;  5HPG A;  2PF1 A;  2DOH X;  1NL1 A;  4D3C A;  2Z8W A;  4R1A A;  2HGF A;  4Z0D A;  1GMO A;  2Q8A A;  1PML A;  2X2Z A;  2QJ4 A;  2KJ4 A;  1KRN A;  1BHT A;  1GMN A;  2I9B A;  4R1B A;  3MKP A;  1B2I A;  2Y8R A;  1HPJ A;  4UV6 A;  1PK4 A;  1Z40 A;  5CT2 A;  1KIV A;  5CS9 A;  1JFN A;  3SRI A;  2L0S A;  1NK1 A;  1I71 A;  1I5K A;  2HPP P;  2PK4 A;  2PF2 A;  4Z09 A;  4BVW A;  2YIP A;  1NL2 A;  1TPK A;  2FEB A;  2QJ2 A;  2K13 X;  1CEB A;  4IUA A;  2LL3 A;  5I25 A;  2DOI A;  1KDU A;  2HPQ P;  4APM A;  2LL4 M;  1CEA A;  4YIV A;  3LAQ A;  4BVV A;  4HZH A;  1W81 A;  4Z0E A;  4Z0F A;  2KL5 A;  4A5T S;  3HMS A;  2J8L A;  2Z8V A;  1HKY A;  1PMK A;  2J8J A;  4UAO A;  2YIL A;  1PKR A;  3E6P L;  3HMR A;  5CSQ A;  5CT1 A;  3HMT A;  2SPT A;  2F83 A;  4KIV A;  2I9A A;  1YXE A;  5EOD A;  5EOK A;  2K4R A;  3HN4 A;  1A0H A;  4BV7 A;  3ZWZ A;  5COE A;  4R1C A;  3BT1 A; 
#chains in the Genus database with same CATH homology
 4O03 A;  4CIK A;  4BVC A;  2YIO A;  2Q8B A;  4YIZ A;  4NZQ A;  2FD6 A;  5CS5 A;  2KNF A;  1URK A;  3BT2 A;  3ZLE A;  4APL A;  1HPK A;  5CS1 A;  1GP9 A;  4R19 A;  1I8N A;  3U73 A;  2K51 A;  1W8K A;  4BV5 A;  4DUR A;  1PK2 A;  3K65 A;  3KIV A;  5CP9 A;  4BVD A;  5CT3 A;  1KI0 A;  3NXP A;  3SP8 A;  5CS3 A;  3SRJ A;  5HPG A;  2PF1 A;  2DOH X;  1NL1 A;  4D3C A;  2Z8W A;  4R1A A;  2HGF A;  4Z0D A;  1GMO A;  2Q8A A;  1PML A;  2X2Z A;  2QJ4 A;  2KJ4 A;  1KRN A;  1BHT A;  1GMN A;  2I9B A;  4R1B A;  3MKP A;  1B2I A;  2Y8R A;  1HPJ A;  4UV6 A;  1PK4 A;  1Z40 A;  5CT2 A;  1KIV A;  5CS9 A;  1JFN A;  3SRI A;  2L0S A;  1NK1 A;  1I71 A;  1I5K A;  2HPP P;  2PK4 A;  2PF2 A;  4Z09 A;  4BVW A;  2YIP A;  1NL2 A;  1TPK A;  2FEB A;  2QJ2 A;  2K13 X;  1CEB A;  4IUA A;  2LL3 A;  5I25 A;  2DOI A;  1KDU A;  2HPQ P;  4APM A;  2LL4 M;  1CEA A;  4YIV A;  3LAQ A;  4BVV A;  4HZH A;  1W81 A;  4Z0E A;  4Z0F A;  2KL5 A;  4A5T S;  3HMS A;  2J8L A;  2Z8V A;  1HKY A;  1PMK A;  2J8J A;  4UAO A;  2YIL A;  1PKR A;  3E6P L;  3HMR A;  5CSQ A;  5CT1 A;  3HMT A;  2SPT A;  2F83 A;  4KIV A;  2I9A A;  1YXE A;  5EOD A;  5EOK A;  2K4R A;  3HN4 A;  1A0H A;  4BV7 A;  3ZWZ A;  5COE A;  4R1C A;  3BT1 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...