1EAAA

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
243
structure length
243
Chain Sequence
IPPIPPVDFAKYGEIEEVPMTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVAQKAVAKKAGVKLTVLPLLLKACAYLLKELPDFNSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIGGTAFTPIVNAPEVAILGVSKASMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIRAILL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).
pubmed doi rcsb
molecule tags Dihydrolipoamide acetyltransferase
source organism Azotobacter vinelandii
molecule keywords DIHYDROLIPOYL-TRANSACETYLASE
total genus 67
structure length 243
sequence length 243
ec nomenclature ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date 1992-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 1eaaA00
4G22A 1DPBA 1DPDA 1CLAA 2E1VA 4JN5A 4G0BA 1E2OA 2RKTA 1EAAA 4KE4A 4KECA 5DUAA 1QCAA 4N72A 3FOTA 3U9FA 1PD5A 2II5A 1XL8A 1Q9JA 3B2SA 3CLAA 4CLAA 1EAFA 2BGHA 5KJTA 5KJSA 1CIAA 1DPCA 5FANA 2E1TA 1C4TA 2XR7A 5KJWA 3L60A 1XMCA 1EACA 3FP0A 5KJVA 4JN3A 5T3EA 5KJUA 3U9BA 4HVMA 2I9DA 2E1UA 5FALA 1XL7A 3MAEA 2II4A 2XHGA 1EAEA 2CLAA 3B30A 1XMDA 2II3A 1SCZA 2ZBAA 1EADA 1EABA 1L5AA 1NOCB 2VSQA 5DU9A 1Q23A 4G2MA 2RKVA 2JGPA 2IHWA
chains in the Genus database with same CATH superfamily
1CLAA 2RKTA 1EAAA 4EPHA 4N72A 2FY5A 3CLAA 2FW3A 2H4TA 5KJSA 2E1TA 2XR7A 4EP9A 5T3EA 2H3WA 1XL7A 2XHGA 3B30A 2ZBAA 1EADA 1NOCB 4KE4A 4G22A 1DPBA 1DPDA 2E1VA 1T7NA 4G0BA 1E2OA 4KECA 2FY4A 1QCAA 2FY2A 1EAFA 1CIAA 2H3UA 1XMCA 5KJVA 4HVMA 2DEBA 5FALA 2RCUA 1EAEA 2VSQA 1Q23A 4G2MA 2IHWA 1NDBA 5DUAA 3FOTA 1PD5A 2II5A 3B2SA 1Q9JA 4CLAA 1DPCA 1C4TA 5KJWA 1EACA 3FP0A 4JN3A 5KJUA 4EYWA 2I9DA 1T1UA 2E1UA 1S5OA 2II3A 1SCZA 2H3PA 1EABA 1NDIA 4JN5A 3U9FA 1XL8A 2BGHA 5KJTA 5FANA 1NM8A 2FY3A 3L60A 1T7OA 1T7QA 3U9BA 3MAEA 2FYOA 2II4A 2CLAA 1XMDA 1L5AA 1NDFA 1Q6XA 5DU9A 2RKVA 2JGPA
chains in the Genus database with same CATH topology
4G22A 1DPBA 1DPDA 1CLAA 2E1VA 4JN5A 4G0BA 1E2OA 2RKTA 1EAAA 4KE4A 4KECA 5DUAA 1QCAA 4N72A 3FOTA 3U9FA 1PD5A 2II5A 1XL8A 1Q9JA 3B2SA 3CLAA 4CLAA 1EAFA 2BGHA 5KJTA 5KJSA 1CIAA 1DPCA 5FANA 2E1TA 1C4TA 2XR7A 5KJWA 3L60A 1XMCA 1EACA 3FP0A 5KJVA 4JN3A 5T3EA 5KJUA 3U9BA 4HVMA 2I9DA 2E1UA 5FALA 1XL7A 3MAEA 2II4A 2XHGA 1EAEA 2CLAA 3B30A 1XMDA 2II3A 1SCZA 2ZBAA 1EADA 1EABA 1L5AA 1NOCB 2VSQA 5DU9A 1Q23A 4G2MA 2RKVA 2JGPA 2IHWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G22 A;  1DPB A;  1DPD A;  1CLA A;  2E1V A;  4JN5 A;  4G0B A;  1E2O A;  2RKT A;  1EAA A;  4KE4 A;  4KEC A;  5DUA A;  1QCA A;  4N72 A;  3FOT A;  3U9F A;  1PD5 A;  2II5 A;  1XL8 A;  1Q9J A;  3B2S A;  3CLA A;  4CLA A;  1EAF A;  2BGH A;  5KJT A;  5KJS A;  1CIA A;  1DPC A;  5FAN A;  2E1T A;  1C4T A;  2XR7 A;  5KJW A;  3L60 A;  1XMC A;  1EAC A;  3FP0 A;  5KJV A;  4JN3 A;  5T3E A;  5KJU A;  3U9B A;  4HVM A;  2I9D A;  2E1U A;  5FAL A;  1XL7 A;  3MAE A;  2II4 A;  2XHG A;  1EAE A;  2CLA A;  3B30 A;  1XMD A;  2II3 A;  1SCZ A;  2ZBA A;  1EAD A;  1EAB A;  1L5A A;  1NOC B;  2VSQ A;  5DU9 A;  1Q23 A;  4G2M A;  2RKV A;  2JGP A;  2IHW A; 
#chains in the Genus database with same CATH topology
 1CLA A;  2RKT A;  1EAA A;  4EPH A;  4N72 A;  2FY5 A;  3CLA A;  2FW3 A;  2H4T A;  5KJS A;  2E1T A;  2XR7 A;  4EP9 A;  5T3E A;  2H3W A;  1XL7 A;  2XHG A;  3B30 A;  2ZBA A;  1EAD A;  1NOC B;  4KE4 A;  4G22 A;  1DPB A;  1DPD A;  2E1V A;  1T7N A;  4G0B A;  1E2O A;  4KEC A;  2FY4 A;  1QCA A;  2FY2 A;  1EAF A;  1CIA A;  2H3U A;  1XMC A;  5KJV A;  4HVM A;  2DEB A;  5FAL A;  2RCU A;  1EAE A;  2VSQ A;  1Q23 A;  4G2M A;  2IHW A;  1NDB A;  5DUA A;  3FOT A;  1PD5 A;  2II5 A;  3B2S A;  1Q9J A;  4CLA A;  1DPC A;  1C4T A;  5KJW A;  1EAC A;  3FP0 A;  4JN3 A;  5KJU A;  4EYW A;  2I9D A;  1T1U A;  2E1U A;  1S5O A;  2II3 A;  1SCZ A;  2H3P A;  1EAB A;  1NDI A;  4JN5 A;  3U9F A;  1XL8 A;  2BGH A;  5KJT A;  5FAN A;  1NM8 A;  2FY3 A;  3L60 A;  1T7O A;  1T7Q A;  3U9B A;  3MAE A;  2FYO A;  2II4 A;  2CLA A;  1XMD A;  1L5A A;  1NDF A;  1Q6X A;  5DU9 A;  2RKV A;  2JGP A; 
#chains in the Genus database with same CATH homology
 4G22 A;  1DPB A;  1DPD A;  1CLA A;  2E1V A;  4JN5 A;  4G0B A;  1E2O A;  2RKT A;  1EAA A;  4KE4 A;  4KEC A;  5DUA A;  1QCA A;  4N72 A;  3FOT A;  3U9F A;  1PD5 A;  2II5 A;  1XL8 A;  1Q9J A;  3B2S A;  3CLA A;  4CLA A;  1EAF A;  2BGH A;  5KJT A;  5KJS A;  1CIA A;  1DPC A;  5FAN A;  2E1T A;  1C4T A;  2XR7 A;  5KJW A;  3L60 A;  1XMC A;  1EAC A;  3FP0 A;  5KJV A;  4JN3 A;  5T3E A;  5KJU A;  3U9B A;  4HVM A;  2I9D A;  2E1U A;  5FAL A;  1XL7 A;  3MAE A;  2II4 A;  2XHG A;  1EAE A;  2CLA A;  3B30 A;  1XMD A;  2II3 A;  1SCZ A;  2ZBA A;  1EAD A;  1EAB A;  1L5A A;  1NOC B;  2VSQ A;  5DU9 A;  1Q23 A;  4G2M A;  2RKV A;  2JGP A;  2IHW A; 
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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