1EAAA

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
243
structure length
243
Chain Sequence
IPPIPPVDFAKYGEIEEVPMTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVAQKAVAKKAGVKLTVLPLLLKACAYLLKELPDFNSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIGGTAFTPIVNAPEVAILGVSKASMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIRAILL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).
pubmed doi rcsb
molecule tags Dihydrolipoamide acetyltransferase
source organism Azotobacter vinelandii
molecule keywords DIHYDROLIPOYL-TRANSACETYLASE
total genus 67
structure length 243
sequence length 243
ec nomenclature ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date 1992-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 1eaaA00
2E1TA 4KECA 3CLAA 2E1UA 5KJVA 1EAAA 1DPDA 1Q9JA 2RKVA 2JGPA 5T3EA 2II5A 5KJWA 2XR7A 4G22A 3B30A 3U9FA 4CLAA 4G0BA 1DPBA 3L60A 1XL7A 4HVMA 2CLAA 1CIAA 3B2SA 1XMDA 1QCAA 1Q23A 1DPCA 3FOTA 2BGHA 1XMCA 1EABA 2XHGA 4N72A 5DU9A 1EAEA 1NOCB 1XL8A 2VSQA 2ZBAA 4JN5A 5FALA 3U9BA 2IHWA 3MAEA 1C4TA 4G2MA 1L5AA 5KJTA 3FP0A 4KE4A 1E2OA 1EACA 2II4A 1SCZA 5KJUA 1EADA 5KJSA 1CLAA 2II3A 1PD5A 4JN3A 2E1VA 5FANA 2I9DA 5DUAA 1EAFA 2RKTA
chains in the Genus database with same CATH superfamily
1NDFA 2E1UA 2H3WA 2FY5A 4EPHA 2RKVA 2II5A 1NDIA 3U9FA 4G0BA 2H4TA 3FOTA 1XL8A 4JN5A 3MAEA 1C4TA 4G2MA 5KJTA 2FY3A 3FP0A 5FANA 2I9DA 5KJWA 1EAFA 2E1TA 1EAAA 2FW3A 5T3EA 4G22A 3B30A 1DPBA 3L60A 1CIAA 3B2SA 1QCAA 4N72A 2FY2A 2H3UA 2VSQA 2ZBAA 2IHWA 1NDBA 1SCZA 1EADA 5KJSA 1Q6XA 5FALA 2RCUA 4EYWA 3CLAA 5KJVA 1DPDA 2JGPA 1T7QA 4CLAA 4HVMA 1T7NA 1XMDA 1S5OA 2FY4A 1Q23A 1DPCA 2BGHA 1XMCA 2XHGA 5DU9A 1EAEA 1NOCB 2FYOA 3U9BA 1NM8A 4KE4A 1EACA 2II4A 2II3A 1PD5A 2RKTA 4KECA 1Q9JA 4EP9A 2XR7A 1T7OA 1T1UA 1XL7A 2CLAA 1EABA 2H3PA 1L5AA 1E2OA 5KJUA 1CLAA 4JN3A 2E1VA 2DEBA 5DUAA
chains in the Genus database with same CATH topology
2E1TA 4KECA 3CLAA 2E1UA 5KJVA 1EAAA 1DPDA 1Q9JA 2RKVA 2JGPA 5T3EA 2II5A 5KJWA 2XR7A 4G22A 3B30A 3U9FA 4CLAA 4G0BA 1DPBA 3L60A 1XL7A 4HVMA 2CLAA 1CIAA 3B2SA 1XMDA 1QCAA 1Q23A 1DPCA 3FOTA 2BGHA 1XMCA 1EABA 2XHGA 4N72A 5DU9A 1EAEA 1NOCB 1XL8A 2VSQA 2ZBAA 4JN5A 5FALA 3U9BA 2IHWA 3MAEA 1C4TA 4G2MA 1L5AA 5KJTA 3FP0A 4KE4A 1E2OA 1EACA 2II4A 1SCZA 5KJUA 1EADA 5KJSA 1CLAA 2II3A 1PD5A 4JN3A 2E1VA 5FANA 2I9DA 5DUAA 1EAFA 2RKTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E1T A;  4KEC A;  3CLA A;  2E1U A;  5KJV A;  1EAA A;  1DPD A;  1Q9J A;  2RKV A;  2JGP A;  5T3E A;  2II5 A;  5KJW A;  2XR7 A;  4G22 A;  3B30 A;  3U9F A;  4CLA A;  4G0B A;  1DPB A;  3L60 A;  1XL7 A;  4HVM A;  2CLA A;  1CIA A;  3B2S A;  1XMD A;  1QCA A;  1Q23 A;  1DPC A;  3FOT A;  2BGH A;  1XMC A;  1EAB A;  2XHG A;  4N72 A;  5DU9 A;  1EAE A;  1NOC B;  1XL8 A;  2VSQ A;  2ZBA A;  4JN5 A;  5FAL A;  3U9B A;  2IHW A;  3MAE A;  1C4T A;  4G2M A;  1L5A A;  5KJT A;  3FP0 A;  4KE4 A;  1E2O A;  1EAC A;  2II4 A;  1SCZ A;  5KJU A;  1EAD A;  5KJS A;  1CLA A;  2II3 A;  1PD5 A;  4JN3 A;  2E1V A;  5FAN A;  2I9D A;  5DUA A;  1EAF A;  2RKT A; 
#chains in the Genus database with same CATH topology
 1NDF A;  2E1U A;  2H3W A;  2FY5 A;  4EPH A;  2RKV A;  2II5 A;  1NDI A;  3U9F A;  4G0B A;  2H4T A;  3FOT A;  1XL8 A;  4JN5 A;  3MAE A;  1C4T A;  4G2M A;  5KJT A;  2FY3 A;  3FP0 A;  5FAN A;  2I9D A;  5KJW A;  1EAF A;  2E1T A;  1EAA A;  2FW3 A;  5T3E A;  4G22 A;  3B30 A;  1DPB A;  3L60 A;  1CIA A;  3B2S A;  1QCA A;  4N72 A;  2FY2 A;  2H3U A;  2VSQ A;  2ZBA A;  2IHW A;  1NDB A;  1SCZ A;  1EAD A;  5KJS A;  1Q6X A;  5FAL A;  2RCU A;  4EYW A;  3CLA A;  5KJV A;  1DPD A;  2JGP A;  1T7Q A;  4CLA A;  4HVM A;  1T7N A;  1XMD A;  1S5O A;  2FY4 A;  1Q23 A;  1DPC A;  2BGH A;  1XMC A;  2XHG A;  5DU9 A;  1EAE A;  1NOC B;  2FYO A;  3U9B A;  1NM8 A;  4KE4 A;  1EAC A;  2II4 A;  2II3 A;  1PD5 A;  2RKT A;  4KEC A;  1Q9J A;  4EP9 A;  2XR7 A;  1T7O A;  1T1U A;  1XL7 A;  2CLA A;  1EAB A;  2H3P A;  1L5A A;  1E2O A;  5KJU A;  1CLA A;  4JN3 A;  2E1V A;  2DEB A;  5DUA A; 
#chains in the Genus database with same CATH homology
 2E1T A;  4KEC A;  3CLA A;  2E1U A;  5KJV A;  1EAA A;  1DPD A;  1Q9J A;  2RKV A;  2JGP A;  5T3E A;  2II5 A;  5KJW A;  2XR7 A;  4G22 A;  3B30 A;  3U9F A;  4CLA A;  4G0B A;  1DPB A;  3L60 A;  1XL7 A;  4HVM A;  2CLA A;  1CIA A;  3B2S A;  1XMD A;  1QCA A;  1Q23 A;  1DPC A;  3FOT A;  2BGH A;  1XMC A;  1EAB A;  2XHG A;  4N72 A;  5DU9 A;  1EAE A;  1NOC B;  1XL8 A;  2VSQ A;  2ZBA A;  4JN5 A;  5FAL A;  3U9B A;  2IHW A;  3MAE A;  1C4T A;  4G2M A;  1L5A A;  5KJT A;  3FP0 A;  4KE4 A;  1E2O A;  1EAC A;  2II4 A;  1SCZ A;  5KJU A;  1EAD A;  5KJS A;  1CLA A;  2II3 A;  1PD5 A;  4JN3 A;  2E1V A;  5FAN A;  2I9D A;  5DUA A;  1EAF A;  2RKT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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