1EADA

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
243
structure length
243
Chain Sequence
IPPIPPVDFAKYGEIEEVPMTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVAQKAVAKKAGVKLTVLPLLLKACAYLLKELPDFNSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIGGTAFTPIVNAPEVAILGVSKASMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIRAILL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).
pubmed doi rcsb
molecule tags Dihydrolipoamide acetyltransferase
source organism Azotobacter vinelandii
molecule keywords DIHYDROLIPOYL-TRANSACETYLASE
total genus 65
structure length 243
sequence length 243
ec nomenclature ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date 1992-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 1eadA00
3MAEA 1DPDA 1SCZA 2E1TA 1EABA 5KJSA 5T3EA 5FALA 4CLAA 1EAFA 1PD5A 1XL7A 3U9FA 2VSQA 1L5AA 2RKTA 1E2OA 3L60A 4JN3A 4KECA 5KJTA 2II3A 2II4A 1Q9JA 3FOTA 1Q23A 4JN5A 5FANA 2XR7A 1NOCB 1EACA 1XMCA 4G2MA 1QCAA 4HVMA 1CLAA 2JGPA 2CLAA 2E1UA 2II5A 2BGHA 1DPCA 2ZBAA 4KE4A 1XL8A 2I9DA 4G22A 1EAAA 5KJVA 2RKVA 2IHWA 1C4TA 1CIAA 5DUAA 1DPBA 3FP0A 2E1VA 3U9BA 3B30A 3B2SA 3CLAA 4G0BA 5DU9A 1EAEA 2XHGA 5KJWA 1EADA 5KJUA 1XMDA 4N72A
chains in the Genus database with same CATH superfamily
1DPDA 1SCZA 2E1TA 2H3PA 5FALA 1L5AA 4JN3A 3L60A 1NDIA 5FANA 1Q23A 1S5OA 1CLAA 2FY4A 2JGPA 2RCUA 1EAAA 1CIAA 5DUAA 2FY2A 4G0BA 5DU9A 4EP9A 1XMDA 1T7OA 2FY5A 2FY3A 5KJSA 3U9FA 2VSQA 1E2OA 2H3UA 4KECA 5KJTA 5KJWA 1XMCA 1NDBA 1QCAA 2CLAA 2BGHA 2ZBAA 4G22A 3U9BA 3B30A 1T1UA 2XHGA 1EADA 2H3WA 1T7NA 3MAEA 4CLAA 1EAFA 2RKTA 1Q9JA 4JN5A 2XR7A 4HVMA 2II5A 1NDFA 2H4TA 4KE4A 2I9DA 5KJVA 2RKVA 2IHWA 1C4TA 2FW3A 2E1VA 3B2SA 1T7QA 1EAEA 5KJUA 4N72A 1NM8A 2DEBA 1EABA 5T3EA 1PD5A 1XL7A 2II3A 2II4A 3FOTA 1NOCB 1EACA 1Q6XA 4G2MA 4EYWA 2FYOA 2E1UA 1DPCA 1XL8A 1DPBA 3FP0A 4EPHA 3CLAA
chains in the Genus database with same CATH topology
3MAEA 1DPDA 1SCZA 2E1TA 1EABA 5KJSA 5T3EA 5FALA 4CLAA 1EAFA 1PD5A 1XL7A 3U9FA 2VSQA 1L5AA 2RKTA 1E2OA 3L60A 4JN3A 4KECA 5KJTA 2II3A 2II4A 1Q9JA 3FOTA 1Q23A 4JN5A 5FANA 2XR7A 1NOCB 1EACA 1XMCA 4G2MA 1QCAA 4HVMA 1CLAA 2JGPA 2CLAA 2E1UA 2II5A 2BGHA 1DPCA 2ZBAA 4KE4A 1XL8A 2I9DA 4G22A 1EAAA 5KJVA 2RKVA 2IHWA 1C4TA 1CIAA 5DUAA 1DPBA 3FP0A 2E1VA 3U9BA 3B30A 3B2SA 3CLAA 4G0BA 5DU9A 1EAEA 2XHGA 5KJWA 1EADA 5KJUA 1XMDA 4N72A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MAE A;  1DPD A;  1SCZ A;  2E1T A;  1EAB A;  5KJS A;  5T3E A;  5FAL A;  4CLA A;  1EAF A;  1PD5 A;  1XL7 A;  3U9F A;  2VSQ A;  1L5A A;  2RKT A;  1E2O A;  3L60 A;  4JN3 A;  4KEC A;  5KJT A;  2II3 A;  2II4 A;  1Q9J A;  3FOT A;  1Q23 A;  4JN5 A;  5FAN A;  2XR7 A;  1NOC B;  1EAC A;  1XMC A;  4G2M A;  1QCA A;  4HVM A;  1CLA A;  2JGP A;  2CLA A;  2E1U A;  2II5 A;  2BGH A;  1DPC A;  2ZBA A;  4KE4 A;  1XL8 A;  2I9D A;  4G22 A;  1EAA A;  5KJV A;  2RKV A;  2IHW A;  1C4T A;  1CIA A;  5DUA A;  1DPB A;  3FP0 A;  2E1V A;  3U9B A;  3B30 A;  3B2S A;  3CLA A;  4G0B A;  5DU9 A;  1EAE A;  2XHG A;  5KJW A;  1EAD A;  5KJU A;  1XMD A;  4N72 A; 
#chains in the Genus database with same CATH topology
 1DPD A;  1SCZ A;  2E1T A;  2H3P A;  5FAL A;  1L5A A;  4JN3 A;  3L60 A;  1NDI A;  5FAN A;  1Q23 A;  1S5O A;  1CLA A;  2FY4 A;  2JGP A;  2RCU A;  1EAA A;  1CIA A;  5DUA A;  2FY2 A;  4G0B A;  5DU9 A;  4EP9 A;  1XMD A;  1T7O A;  2FY5 A;  2FY3 A;  5KJS A;  3U9F A;  2VSQ A;  1E2O A;  2H3U A;  4KEC A;  5KJT A;  5KJW A;  1XMC A;  1NDB A;  1QCA A;  2CLA A;  2BGH A;  2ZBA A;  4G22 A;  3U9B A;  3B30 A;  1T1U A;  2XHG A;  1EAD A;  2H3W A;  1T7N A;  3MAE A;  4CLA A;  1EAF A;  2RKT A;  1Q9J A;  4JN5 A;  2XR7 A;  4HVM A;  2II5 A;  1NDF A;  2H4T A;  4KE4 A;  2I9D A;  5KJV A;  2RKV A;  2IHW A;  1C4T A;  2FW3 A;  2E1V A;  3B2S A;  1T7Q A;  1EAE A;  5KJU A;  4N72 A;  1NM8 A;  2DEB A;  1EAB A;  5T3E A;  1PD5 A;  1XL7 A;  2II3 A;  2II4 A;  3FOT A;  1NOC B;  1EAC A;  1Q6X A;  4G2M A;  4EYW A;  2FYO A;  2E1U A;  1DPC A;  1XL8 A;  1DPB A;  3FP0 A;  4EPH A;  3CLA A; 
#chains in the Genus database with same CATH homology
 3MAE A;  1DPD A;  1SCZ A;  2E1T A;  1EAB A;  5KJS A;  5T3E A;  5FAL A;  4CLA A;  1EAF A;  1PD5 A;  1XL7 A;  3U9F A;  2VSQ A;  1L5A A;  2RKT A;  1E2O A;  3L60 A;  4JN3 A;  4KEC A;  5KJT A;  2II3 A;  2II4 A;  1Q9J A;  3FOT A;  1Q23 A;  4JN5 A;  5FAN A;  2XR7 A;  1NOC B;  1EAC A;  1XMC A;  4G2M A;  1QCA A;  4HVM A;  1CLA A;  2JGP A;  2CLA A;  2E1U A;  2II5 A;  2BGH A;  1DPC A;  2ZBA A;  4KE4 A;  1XL8 A;  2I9D A;  4G22 A;  1EAA A;  5KJV A;  2RKV A;  2IHW A;  1C4T A;  1CIA A;  5DUA A;  1DPB A;  3FP0 A;  2E1V A;  3U9B A;  3B30 A;  3B2S A;  3CLA A;  4G0B A;  5DU9 A;  1EAE A;  2XHG A;  5KJW A;  1EAD A;  5KJU A;  1XMD A;  4N72 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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