2FY2A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
597
structure length
585
Chain Sequence
b'SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL'
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 228
structure length 585
sequence length 597
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A02
1NDBA 2FY5A 2H3PA 2FY4A 1NM8A 2FW3A 2H3WA 2FY3A 1T7QA 2H3UA 1T7OA 2DEBA 4EP9A 1T1UA 4EPHA 2RCUA 2FYOA 4EYWA 1NDFA 1NDIA 1Q6XA 2FY2A 1S5OA 1T7NA 2H4TA
chains in the Genus database with same CATH superfamily
2RKVA 2IHWA 3CLAA 1NM8A 1C4TA 2FY3A 1T7QA 1EADA 4EPHA 2RCUA 3FOTA 1EAFA 5FALA 1E2OA 4N72A 3MAEA 1NDBA 4JN3A 5KJVA 1EAAA 3U9FA 2II5A 1Q23A 2H3UA 1XMDA 2DEBA 1XL7A 4EP9A 1T1UA 1EACA 2I9DA 2RKTA 3U9BA 4KE4A 1PD5A 1S5OA 4G2MA 1T7NA 3B30A 1EABA 2XHGA 1NOCB 1SCZA 5FANA 3L60A 1Q9JA 4G22A 1DPBA 2H3PA 2VSQA 2E1VA 1XMCA 5DUAA 2JGPA 5DU9A 4CLAA 2II4A 1T7OA 5KJTA 1DPDA 3B2SA 2CLAA 4G0BA 3FP0A 2II3A 2FYOA 5KJWA 1DPCA 1NDIA 1L5AA 1Q6XA 2FY2A 2ZBAA 5T3EA 2FY5A 1QCAA 4JN5A 5KJUA 1XL8A 2FY4A 4KECA 5KJSA 2FW3A 2H3WA 2BGHA 2XR7A 1CIAA 2E1UA 1CLAA 2E1TA 4EYWA 1NDFA 4HVMA 1EAEA 2H4TA
chains in the Genus database with same CATH topology
2XHGA 1NDBA 2FY5A 4JN3A 4JN5A 1Q9JA 2H3PA 2FY4A 1NM8A 2FW3A 2VSQA 2H3WA 2FY3A 5DUAA 2JGPA 1T7QA 5DU9A 2H3UA 1T7OA 2DEBA 3FP0A 4EP9A 1T1UA 4EPHA 2RCUA 2FYOA 4EYWA 1NDFA 1NDIA 3FOTA 1L5AA 1Q6XA 2FY2A 1S5OA 5T3EA 4HVMA 1T7NA 2H4TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NDB A;  2FY5 A;  2H3P A;  2FY4 A;  1NM8 A;  2FW3 A;  2H3W A;  2FY3 A;  1T7Q A;  2H3U A;  1T7O A;  2DEB A;  4EP9 A;  1T1U A;  4EPH A;  2RCU A;  2FYO A;  4EYW A;  1NDF A;  1NDI A;  1Q6X A;  2FY2 A;  1S5O A;  1T7N A;  2H4T A; 
#chains in the Genus database with same CATH topology
 2RKV A;  2IHW A;  3CLA A;  1NM8 A;  1C4T A;  2FY3 A;  1T7Q A;  1EAD A;  4EPH A;  2RCU A;  3FOT A;  1EAF A;  5FAL A;  1E2O A;  4N72 A;  3MAE A;  1NDB A;  4JN3 A;  5KJV A;  1EAA A;  3U9F A;  2II5 A;  1Q23 A;  2H3U A;  1XMD A;  2DEB A;  1XL7 A;  4EP9 A;  1T1U A;  1EAC A;  2I9D A;  2RKT A;  3U9B A;  4KE4 A;  1PD5 A;  1S5O A;  4G2M A;  1T7N A;  3B30 A;  1EAB A;  2XHG A;  1NOC B;  1SCZ A;  5FAN A;  3L60 A;  1Q9J A;  4G22 A;  1DPB A;  2H3P A;  2VSQ A;  2E1V A;  1XMC A;  5DUA A;  2JGP A;  5DU9 A;  4CLA A;  2II4 A;  1T7O A;  5KJT A;  1DPD A;  3B2S A;  2CLA A;  4G0B A;  3FP0 A;  2II3 A;  2FYO A;  5KJW A;  1DPC A;  1NDI A;  1L5A A;  1Q6X A;  2FY2 A;  2ZBA A;  5T3E A;  2FY5 A;  1QCA A;  4JN5 A;  5KJU A;  1XL8 A;  2FY4 A;  4KEC A;  5KJS A;  2FW3 A;  2H3W A;  2BGH A;  2XR7 A;  1CIA A;  2E1U A;  1CLA A;  2E1T A;  4EYW A;  1NDF A;  4HVM A;  1EAE A;  2H4T A; 
#chains in the Genus database with same CATH homology
 2XHG A;  1NDB A;  2FY5 A;  4JN3 A;  4JN5 A;  1Q9J A;  2H3P A;  2FY4 A;  1NM8 A;  2FW3 A;  2VSQ A;  2H3W A;  2FY3 A;  5DUA A;  2JGP A;  1T7Q A;  5DU9 A;  2H3U A;  1T7O A;  2DEB A;  3FP0 A;  4EP9 A;  1T1U A;  4EPH A;  2RCU A;  2FYO A;  4EYW A;  1NDF A;  1NDI A;  3FOT A;  1L5A A;  1Q6X A;  2FY2 A;  1S5O A;  5T3E A;  4HVM A;  1T7N A;  2H4T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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