2FY2A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
597
structure length
585
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Choline O-acetyltransferase
publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
source organism Homo sapiens
molecule tags Transferase
total genus 228
structure length 585
sequence length 597
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A02
1NDIA 2FY4A 1Q6XA 1S5OA 2FYOA 2H3PA 4EP9A 2H4TA 4EPHA 1T7OA 2RCUA 2FY3A 1NDBA 2H3UA 2DEBA 2FW3A 2FY5A 2H3WA 1T1UA 4EYWA 2FY2A 1NM8A 1NDFA 1T7QA 1T7NA
chains in the Genus database with same CATH superfamily
1NDIA 1SCZA 5KJUA 1S5OA 4EP9A 4EPHA 1Q9JA 1CIAA 1CLAA 1EACA 4JN3A 4G2MA 4KECA 1L5AA 1NDFA 1T7QA 4KE4A 4G0BA 1NOCB 2E1UA 3B30A 2XHGA 2H4TA 4N72A 1T7OA 3U9BA 5KJTA 3CLAA 1NDBA 2I9DA 3B2SA 1QCAA 5FANA 5KJVA 3U9FA 2FY5A 1XL7A 3L60A 2E1VA 1T1UA 2FY2A 1C4TA 1NM8A 4CLAA 5DUAA 2II5A 1EABA 2ZBAA 2VSQA 2FY4A 2II3A 3FP0A 3MAEA 1Q6XA 5KJWA 2FYOA 2IHWA 2RKTA 2II4A 2RCUA 2CLAA 2FY3A 5DU9A 2XR7A 1PD5A 2H3UA 4JN5A 2RKVA 5KJSA 2H3WA 1DPBA 4G22A 1EAEA 1EAAA 1XMDA 5T3EA 1E2OA 3FOTA 1T7NA 2JGPA 1DPDA 1DPCA 4HVMA 2H3PA 2BGHA 1XL8A 1Q23A 1EADA 2DEBA 1EAFA 5FALA 2FW3A 2E1TA 4EYWA 1XMCA
chains in the Genus database with same CATH topology
1NDIA 2VSQA 2FY4A 2XHGA 3FP0A 1Q6XA 1S5OA 2FYOA 4HVMA 2H3PA 4EP9A 2H4TA 1Q9JA 4EPHA 1T7OA 2RCUA 2FY3A 5DU9A 1NDBA 2H3UA 4JN3A 2DEBA 4JN5A 2FW3A 2FY5A 2H3WA 1L5AA 1T1UA 4EYWA 2FY2A 1NM8A 1NDFA 5T3EA 1T7QA 3FOTA 5DUAA 1T7NA 2JGPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NDI A;  2FY4 A;  1Q6X A;  1S5O A;  2FYO A;  2H3P A;  4EP9 A;  2H4T A;  4EPH A;  1T7O A;  2RCU A;  2FY3 A;  1NDB A;  2H3U A;  2DEB A;  2FW3 A;  2FY5 A;  2H3W A;  1T1U A;  4EYW A;  2FY2 A;  1NM8 A;  1NDF A;  1T7Q A;  1T7N A; 
#chains in the Genus database with same CATH topology
 1NDI A;  1SCZ A;  5KJU A;  1S5O A;  4EP9 A;  4EPH A;  1Q9J A;  1CIA A;  1CLA A;  1EAC A;  4JN3 A;  4G2M A;  4KEC A;  1L5A A;  1NDF A;  1T7Q A;  4KE4 A;  4G0B A;  1NOC B;  2E1U A;  3B30 A;  2XHG A;  2H4T A;  4N72 A;  1T7O A;  3U9B A;  5KJT A;  3CLA A;  1NDB A;  2I9D A;  3B2S A;  1QCA A;  5FAN A;  5KJV A;  3U9F A;  2FY5 A;  1XL7 A;  3L60 A;  2E1V A;  1T1U A;  2FY2 A;  1C4T A;  1NM8 A;  4CLA A;  5DUA A;  2II5 A;  1EAB A;  2ZBA A;  2VSQ A;  2FY4 A;  2II3 A;  3FP0 A;  3MAE A;  1Q6X A;  5KJW A;  2FYO A;  2IHW A;  2RKT A;  2II4 A;  2RCU A;  2CLA A;  2FY3 A;  5DU9 A;  2XR7 A;  1PD5 A;  2H3U A;  4JN5 A;  2RKV A;  5KJS A;  2H3W A;  1DPB A;  4G22 A;  1EAE A;  1EAA A;  1XMD A;  5T3E A;  1E2O A;  3FOT A;  1T7N A;  2JGP A;  1DPD A;  1DPC A;  4HVM A;  2H3P A;  2BGH A;  1XL8 A;  1Q23 A;  1EAD A;  2DEB A;  1EAF A;  5FAL A;  2FW3 A;  2E1T A;  4EYW A;  1XMC A; 
#chains in the Genus database with same CATH homology
 1NDI A;  2VSQ A;  2FY4 A;  2XHG A;  3FP0 A;  1Q6X A;  1S5O A;  2FYO A;  4HVM A;  2H3P A;  4EP9 A;  2H4T A;  1Q9J A;  4EPH A;  1T7O A;  2RCU A;  2FY3 A;  5DU9 A;  1NDB A;  2H3U A;  4JN3 A;  2DEB A;  4JN5 A;  2FW3 A;  2FY5 A;  2H3W A;  1L5A A;  1T1U A;  4EYW A;  2FY2 A;  1NM8 A;  1NDF A;  5T3E A;  1T7Q A;  3FOT A;  5DUA A;  1T7N A;  2JGP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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