5T3EA

Crystal structure of a nonribosomal peptide synthetase heterocyclization domain.
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
432
structure length
432
Chain Sequence
SEPFSLTEVQTAYMLGRNPQFELSGISPQTYFEYETELDIARLSRSFQKVIQRHPMLRAVILPEGKQQILRDVPEYEIEVESLVSMPPEKQAARLREERSRMIDHVFPLGQWPLFELKAFQLQEHTYLLCFRYDALLMDGASMNLVGQDLMHYYHQPDAQLPPLSFTFQDYMHIYDDMKRGTEYETAKAYWTNKLPDFPPAPSLLLAKDPAEIGTPNFQSLTTIITKDKWLKLRRLAQDKQVTPSALLCTVYGEVLAFWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDMDMDQKQPFFTKVEQTQSTLLDGLEHRHYDGVEFIRDYTRYHQMRPKAVMPIVFTSMLAGAGAFAWEEIGSLRHIHARTPQVYLDNVVIEKNGELLVSWNYVEELFDAEVMESMFTQFVELLDQLVEQGDINPLRIS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Ligase
molecule keywords Bacillamide synthetase heterocyclization domain
publication title Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis.
pubmed doi rcsb
source organism Thermoactinomyces vulgaris
total genus 149
structure length 432
sequence length 432
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-08-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00668 Condensation Condensation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 5t3eA01
3.30.559.30 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 5t3eA02
2VSQA 2II3A 2II4A 1XMDA 5DU9A 1QCAA 3B2SA 5T3EA 1XMCA 4KE4A 1EABA 3MAEA 2XR7A 2E1VA 1SCZA 4KECA 1L5AA 1NOCB 1DPBA 5FALA 1EADA 1Q9JA 3CLAA 3L60A 5DUAA 2RKVA 2II5A 1EAFA 2IHWA 5FANA 4HVMA 5KJSA 3U9BA 5KJUA 2XHGA 3U9FA 4N72A 2E1TA 2BGHA 4JN3A 1XL7A 2ZBAA 5KJVA 1CLAA 2CLAA 2RKTA 1E2OA 5KJTA 1EAEA 1PD5A 3FOTA 1DPCA 1CIAA 2E1UA 4G0BA 1EAAA 3B30A 4G22A 1EACA 1Q23A 1C4TA 3FP0A 4JN5A 4CLAA 2JGPA 1XL8A 2I9DA 5KJWA 1DPDA 4G2MA
chains in the Genus database with same CATH superfamily
2II3A 5T3EA 1NM8A 1T7OA 1NOCB 1EADA 2II5A 2XHGA 3U9FA 4N72A 1XL7A 1NDBA 5KJVA 1CLAA 2CLAA 1E2OA 2H3PA 1CIAA 2FYOA 4G22A 1EACA 3FP0A 4EPHA 5DU9A 3MAEA 2XR7A 2E1VA 1DPBA 3CLAA 5KJSA 2H3WA 5KJUA 2BGHA 2ZBAA 2FY3A 2RKTA 5KJTA 3FOTA 2FY4A 4G0BA 3B30A 4CLAA 1C4TA 1T7NA 2I9DA 2II4A 1XMDA 1QCAA 3B2SA 1NDIA 1L5AA 1SCZA 5FALA 1NDFA 1T7QA 4HVMA 5FANA 4JN3A 1T1UA 2FY5A 2FY2A 2H3UA 4EP9A 2E1UA 2FW3A 1EAAA 1Q23A 2JGPA 1XL8A 5KJWA 1DPDA 4G2MA 2VSQA 1XMCA 4KE4A 1EABA 2RCUA 1S5OA 4KECA 1Q9JA 3L60A 5DUAA 2RKVA 1EAFA 2IHWA 3U9BA 2E1TA 1Q6XA 1EAEA 1PD5A 1DPCA 4EYWA 2H4TA 4JN5A 2DEBA
chains in the Genus database with same CATH topology
2II3A 5T3EA 1NM8A 1T7OA 1NOCB 1EADA 2II5A 2XHGA 3U9FA 4N72A 1XL7A 5KJVA 1NDBA 1CLAA 2CLAA 1E2OA 2H3PA 1CIAA 4G22A 2FYOA 1EACA 3FP0A 4EPHA 5DU9A 3MAEA 2XR7A 2E1VA 1DPBA 3CLAA 5KJSA 2H3WA 5KJUA 2BGHA 2ZBAA 2FY3A 2RKTA 5KJTA 3FOTA 2FY4A 4G0BA 3B30A 4CLAA 1C4TA 1T7NA 2I9DA 2II4A 1XMDA 1QCAA 3B2SA 1NDIA 1L5AA 1SCZA 5FALA 1NDFA 1T7QA 4HVMA 5FANA 4JN3A 1T1UA 2FY5A 2FY2A 2H3UA 4EP9A 2E1UA 2FW3A 1EAAA 1Q23A 2JGPA 1XL8A 5KJWA 1DPDA 4G2MA 2VSQA 1XMCA 4KE4A 1EABA 2RCUA 1S5OA 4KECA 1Q9JA 3L60A 5DUAA 2RKVA 1EAFA 2IHWA 3U9BA 2E1TA 1Q6XA 1EAEA 1PD5A 1DPCA 4EYWA 2H4TA 4JN5A 2DEBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VSQ A;  2II3 A;  2II4 A;  1XMD A;  5DU9 A;  1QCA A;  3B2S A;  5T3E A;  1XMC A;  4KE4 A;  1EAB A;  3MAE A;  2XR7 A;  2E1V A;  1SCZ A;  4KEC A;  1L5A A;  1NOC B;  1DPB A;  5FAL A;  1EAD A;  1Q9J A;  3CLA A;  3L60 A;  5DUA A;  2RKV A;  2II5 A;  1EAF A;  2IHW A;  5FAN A;  4HVM A;  5KJS A;  3U9B A;  5KJU A;  2XHG A;  3U9F A;  4N72 A;  2E1T A;  2BGH A;  4JN3 A;  1XL7 A;  2ZBA A;  5KJV A;  1CLA A;  2CLA A;  2RKT A;  1E2O A;  5KJT A;  1EAE A;  1PD5 A;  3FOT A;  1DPC A;  1CIA A;  2E1U A;  4G0B A;  1EAA A;  3B30 A;  4G22 A;  1EAC A;  1Q23 A;  1C4T A;  3FP0 A;  4JN5 A;  4CLA A;  2JGP A;  1XL8 A;  2I9D A;  5KJW A;  1DPD A;  4G2M A; 
#chains in the Genus database with same CATH topology
 2II3 A;  5T3E A;  1NM8 A;  1T7O A;  1NOC B;  1EAD A;  2II5 A;  2XHG A;  3U9F A;  4N72 A;  1XL7 A;  1NDB A;  5KJV A;  1CLA A;  2CLA A;  1E2O A;  2H3P A;  1CIA A;  2FYO A;  4G22 A;  1EAC A;  3FP0 A;  4EPH A;  5DU9 A;  3MAE A;  2XR7 A;  2E1V A;  1DPB A;  3CLA A;  5KJS A;  2H3W A;  5KJU A;  2BGH A;  2ZBA A;  2FY3 A;  2RKT A;  5KJT A;  3FOT A;  2FY4 A;  4G0B A;  3B30 A;  4CLA A;  1C4T A;  1T7N A;  2I9D A;  2II4 A;  1XMD A;  1QCA A;  3B2S A;  1NDI A;  1L5A A;  1SCZ A;  5FAL A;  1NDF A;  1T7Q A;  4HVM A;  5FAN A;  4JN3 A;  1T1U A;  2FY5 A;  2FY2 A;  2H3U A;  4EP9 A;  2E1U A;  2FW3 A;  1EAA A;  1Q23 A;  2JGP A;  1XL8 A;  5KJW A;  1DPD A;  4G2M A;  2VSQ A;  1XMC A;  4KE4 A;  1EAB A;  2RCU A;  1S5O A;  4KEC A;  1Q9J A;  3L60 A;  5DUA A;  2RKV A;  1EAF A;  2IHW A;  3U9B A;  2E1T A;  1Q6X A;  1EAE A;  1PD5 A;  1DPC A;  4EYW A;  2H4T A;  4JN5 A;  2DEB A; 
#chains in the Genus database with same CATH homology
 2II3 A;  5T3E A;  1NM8 A;  1T7O A;  1NOC B;  1EAD A;  2II5 A;  2XHG A;  3U9F A;  4N72 A;  1XL7 A;  5KJV A;  1NDB A;  1CLA A;  2CLA A;  1E2O A;  2H3P A;  1CIA A;  4G22 A;  2FYO A;  1EAC A;  3FP0 A;  4EPH A;  5DU9 A;  3MAE A;  2XR7 A;  2E1V A;  1DPB A;  3CLA A;  5KJS A;  2H3W A;  5KJU A;  2BGH A;  2ZBA A;  2FY3 A;  2RKT A;  5KJT A;  3FOT A;  2FY4 A;  4G0B A;  3B30 A;  4CLA A;  1C4T A;  1T7N A;  2I9D A;  2II4 A;  1XMD A;  1QCA A;  3B2S A;  1NDI A;  1L5A A;  1SCZ A;  5FAL A;  1NDF A;  1T7Q A;  4HVM A;  5FAN A;  4JN3 A;  1T1U A;  2FY5 A;  2FY2 A;  2H3U A;  4EP9 A;  2E1U A;  2FW3 A;  1EAA A;  1Q23 A;  2JGP A;  1XL8 A;  5KJW A;  1DPD A;  4G2M A;  2VSQ A;  1XMC A;  4KE4 A;  1EAB A;  2RCU A;  1S5O A;  4KEC A;  1Q9J A;  3L60 A;  5DUA A;  2RKV A;  1EAF A;  2IHW A;  3U9B A;  2E1T A;  1Q6X A;  1EAE A;  1PD5 A;  1DPC A;  4EYW A;  2H4T A;  4JN5 A;  2DEB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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