5T3EA

Crystal structure of a nonribosomal peptide synthetase heterocyclization domain.
Total Genus 149
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
149
sequence length
432
structure length
432
Chain Sequence
SEPFSLTEVQTAYMLGRNPQFELSGISPQTYFEYETELDIARLSRSFQKVIQRHPMLRAVILPEGKQQILRDVPEYEIEVESLVSMPPEKQAARLREERSRMIDHVFPLGQWPLFELKAFQLQEHTYLLCFRYDALLMDGASMNLVGQDLMHYYHQPDAQLPPLSFTFQDYMHIYDDMKRGTEYETAKAYWTNKLPDFPPAPSLLLAKDPAEIGTPNFQSLTTIITKDKWLKLRRLAQDKQVTPSALLCTVYGEVLAFWSNQRRLAINLTVFNRYPVHDEVEQIVGDFTSLILLDMDMDQKQPFFTKVEQTQSTLLDGLEHRHYDGVEFIRDYTRYHQMRPKAVMPIVFTSMLAGAGAFAWEEIGSLRHIHARTPQVYLDNVVIEKNGELLVSWNYVEELFDAEVMESMFTQFVELLDQLVEQGDINPLRIS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule keywords Bacillamide synthetase heterocyclization domain
publication title Structural and mutational analysis of the nonribosomal peptide synthetase heterocyclization domain provides insight into catalysis.
pubmed doi rcsb
source organism Thermoactinomyces vulgaris
molecule tags Ligase
total genus 149
structure length 432
sequence length 432
chains with identical sequence B
ec nomenclature
pdb deposition date 2016-08-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00668 Condensation Condensation domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 5t3eA01
3.30.559.30 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 5t3eA02
4G2MA 1EABA 4JN5A 4N72A 3MAEA 3B2SA 1QCAA 2ZBAA 2E1UA 2XR7A 4KECA 5KJTA 2II4A 3CLAA 3U9FA 1XMDA 4CLAA 5KJUA 1NOCB 1DPDA 1XMCA 4HVMA 5KJSA 1EAEA 2VSQA 2E1VA 1XL7A 5DUAA 1Q9JA 2XHGA 5FANA 2IHWA 3FOTA 2JGPA 5KJVA 2RKTA 1XL8A 2CLAA 2II3A 3FP0A 1CIAA 3U9BA 1SCZA 2RKVA 5T3EA 5DU9A 4KE4A 1EAFA 2BGHA 1EAAA 1DPCA 1L5AA 4JN3A 2I9DA 2II5A 4G0BA 3L60A 4G22A 1CLAA 1E2OA 1Q23A 5KJWA 5FALA 1EACA 1DPBA 1PD5A 3B30A 2E1TA 1C4TA 1EADA
chains in the Genus database with same CATH superfamily
2FYOA 2E1UA 2FY3A 5KJTA 3CLAA 1XMDA 1XMCA 4HVMA 1XL7A 2XHGA 2IHWA 2II3A 1SCZA 2II5A 1Q23A 5FALA 4EPHA 1EADA 3B2SA 1NDBA 4KECA 1T1UA 1DPDA 1Q9JA 5FANA 5KJVA 2CLAA 2RKVA 5T3EA 5DU9A 1EAFA 2I9DA 4G22A 5KJWA 1CLAA 1PD5A 1T7QA 2FY5A 4G2MA 4JN5A 4N72A 3MAEA 1QCAA 2RCUA 2XR7A 2II4A 2FY4A 5KJSA 1NDIA 1EAEA 2E1VA 2DEBA 3U9BA 1CIAA 1EAAA 1DPCA 2FY2A 1Q6XA 4JN3A 4G0BA 1E2OA 1T7OA 4EYWA 1DPBA 3B30A 2E1TA 1EABA 2ZBAA 2H3WA 1NDFA 3U9FA 5KJUA 4CLAA 1NOCB 2VSQA 2H3PA 5DUAA 1NM8A 3FOTA 2JGPA 2RKTA 1XL8A 3FP0A 4EP9A 2H4TA 4KE4A 2BGHA 1L5AA 2FW3A 2H3UA 3L60A 1S5OA 1EACA 1C4TA 1T7NA
chains in the Genus database with same CATH topology
2FYOA 2E1UA 2FY3A 5KJTA 3CLAA 1XMDA 1XMCA 4HVMA 1XL7A 2XHGA 2IHWA 2II3A 1SCZA 2II5A 1Q23A 5FALA 4EPHA 1EADA 3B2SA 1NDBA 4KECA 1T1UA 1DPDA 1Q9JA 5FANA 5KJVA 2CLAA 2RKVA 5T3EA 5DU9A 1EAFA 2I9DA 4G22A 5KJWA 1CLAA 1PD5A 1T7QA 2FY5A 4G2MA 4JN5A 4N72A 3MAEA 1QCAA 2XR7A 2RCUA 2II4A 2FY4A 5KJSA 1NDIA 1EAEA 2E1VA 2DEBA 3U9BA 1CIAA 1EAAA 1DPCA 2FY2A 1Q6XA 4JN3A 4G0BA 1E2OA 1T7OA 4EYWA 1DPBA 3B30A 2E1TA 1EABA 2ZBAA 2H3WA 1NDFA 3U9FA 5KJUA 4CLAA 1NOCB 2VSQA 2H3PA 5DUAA 1NM8A 3FOTA 2JGPA 2RKTA 1XL8A 3FP0A 4EP9A 2H4TA 4KE4A 2BGHA 1L5AA 2FW3A 2H3UA 3L60A 1S5OA 1EACA 1C4TA 1T7NA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G2M A;  1EAB A;  4JN5 A;  4N72 A;  3MAE A;  3B2S A;  1QCA A;  2ZBA A;  2E1U A;  2XR7 A;  4KEC A;  5KJT A;  2II4 A;  3CLA A;  3U9F A;  1XMD A;  4CLA A;  5KJU A;  1NOC B;  1DPD A;  1XMC A;  4HVM A;  5KJS A;  1EAE A;  2VSQ A;  2E1V A;  1XL7 A;  5DUA A;  1Q9J A;  2XHG A;  5FAN A;  2IHW A;  3FOT A;  2JGP A;  5KJV A;  2RKT A;  1XL8 A;  2CLA A;  2II3 A;  3FP0 A;  1CIA A;  3U9B A;  1SCZ A;  2RKV A;  5T3E A;  5DU9 A;  4KE4 A;  1EAF A;  2BGH A;  1EAA A;  1DPC A;  1L5A A;  4JN3 A;  2I9D A;  2II5 A;  4G0B A;  3L60 A;  4G22 A;  1CLA A;  1E2O A;  1Q23 A;  5KJW A;  5FAL A;  1EAC A;  1DPB A;  1PD5 A;  3B30 A;  2E1T A;  1C4T A;  1EAD A; 
#chains in the Genus database with same CATH topology
 2FYO A;  2E1U A;  2FY3 A;  5KJT A;  3CLA A;  1XMD A;  1XMC A;  4HVM A;  1XL7 A;  2XHG A;  2IHW A;  2II3 A;  1SCZ A;  2II5 A;  1Q23 A;  5FAL A;  4EPH A;  1EAD A;  3B2S A;  1NDB A;  4KEC A;  1T1U A;  1DPD A;  1Q9J A;  5FAN A;  5KJV A;  2CLA A;  2RKV A;  5T3E A;  5DU9 A;  1EAF A;  2I9D A;  4G22 A;  5KJW A;  1CLA A;  1PD5 A;  1T7Q A;  2FY5 A;  4G2M A;  4JN5 A;  4N72 A;  3MAE A;  1QCA A;  2RCU A;  2XR7 A;  2II4 A;  2FY4 A;  5KJS A;  1NDI A;  1EAE A;  2E1V A;  2DEB A;  3U9B A;  1CIA A;  1EAA A;  1DPC A;  2FY2 A;  1Q6X A;  4JN3 A;  4G0B A;  1E2O A;  1T7O A;  4EYW A;  1DPB A;  3B30 A;  2E1T A;  1EAB A;  2ZBA A;  2H3W A;  1NDF A;  3U9F A;  5KJU A;  4CLA A;  1NOC B;  2VSQ A;  2H3P A;  5DUA A;  1NM8 A;  3FOT A;  2JGP A;  2RKT A;  1XL8 A;  3FP0 A;  4EP9 A;  2H4T A;  4KE4 A;  2BGH A;  1L5A A;  2FW3 A;  2H3U A;  3L60 A;  1S5O A;  1EAC A;  1C4T A;  1T7N A; 
#chains in the Genus database with same CATH homology
 2FYO A;  2E1U A;  2FY3 A;  5KJT A;  3CLA A;  1XMD A;  1XMC A;  4HVM A;  1XL7 A;  2XHG A;  2IHW A;  2II3 A;  1SCZ A;  2II5 A;  1Q23 A;  5FAL A;  4EPH A;  1EAD A;  3B2S A;  1NDB A;  4KEC A;  1T1U A;  1DPD A;  1Q9J A;  5FAN A;  5KJV A;  2CLA A;  2RKV A;  5T3E A;  5DU9 A;  1EAF A;  2I9D A;  4G22 A;  5KJW A;  1CLA A;  1PD5 A;  1T7Q A;  2FY5 A;  4G2M A;  4JN5 A;  4N72 A;  3MAE A;  1QCA A;  2XR7 A;  2RCU A;  2II4 A;  2FY4 A;  5KJS A;  1NDI A;  1EAE A;  2E1V A;  2DEB A;  3U9B A;  1CIA A;  1EAA A;  1DPC A;  2FY2 A;  1Q6X A;  4JN3 A;  4G0B A;  1E2O A;  1T7O A;  4EYW A;  1DPB A;  3B30 A;  2E1T A;  1EAB A;  2ZBA A;  2H3W A;  1NDF A;  3U9F A;  5KJU A;  4CLA A;  1NOC B;  2VSQ A;  2H3P A;  5DUA A;  1NM8 A;  3FOT A;  2JGP A;  2RKT A;  1XL8 A;  3FP0 A;  4EP9 A;  2H4T A;  4KE4 A;  2BGH A;  1L5A A;  2FW3 A;  2H3U A;  3L60 A;  1S5O A;  1EAC A;  1C4T A;  1T7N A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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