1EAEA

Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
243
structure length
243
Chain Sequence
IPPIPPVDFAKYGEIEEVPMTRLMQIGATNLHRSWLNVPHVTQFESADITELEAFRVAQKAVAKKAGVKLTVLPLLLKACAYLLKELPDFNSSLAPSGQALIRKKYVHIGFAVDTPDGLLVPVIRNVDQKSLLQLAAEAAELAEKARSKKLGADAMQGACFTISSLGHIGGTAFTPIVNAPEVAILGVSKASMQPVWDGKAFQPRLMLPLSLSYDHRVINGAAAARFTKRLGDLLADIRAILL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p).
pubmed doi rcsb
molecule tags Dihydrolipoamide acetyltransferase
source organism Azotobacter vinelandii
molecule keywords DIHYDROLIPOYL-TRANSACETYLASE
total genus 67
structure length 243
sequence length 243
ec nomenclature ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date 1992-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 1eaeA00
2XHGA 1CIAA 3FOTA 4JN5A 5KJUA 2JGPA 1L5AA 1CLAA 1DPBA 1EADA 2XR7A 5FALA 1DPDA 2IHWA 5KJTA 3MAEA 1C4TA 4G0BA 5KJWA 3FP0A 1XMCA 5KJSA 2II5A 3B2SA 5KJVA 4G22A 1DPCA 1EABA 3CLAA 4N72A 2I9DA 5FANA 2II3A 2II4A 3U9FA 1EAEA 4JN3A 2RKTA 1E2OA 1EACA 1Q23A 1XL7A 4KECA 4HVMA 2CLAA 1XMDA 3U9BA 2ZBAA 2VSQA 2E1UA 2E1TA 3B30A 2RKVA 1EAFA 1QCAA 3L60A 5DU9A 1XL8A 1NOCB 4KE4A 2E1VA 1Q9JA 5T3EA 1SCZA 2BGHA 4G2MA 4CLAA 1EAAA 5DUAA 1PD5A
chains in the Genus database with same CATH superfamily
2H3UA 1CIAA 1NDFA 5FALA 1NDBA 1Q6XA 2FY4A 4G0BA 5KJWA 1T7NA 2II5A 1T1UA 2FY2A 4N72A 2II4A 1S5OA 4KECA 2H4TA 1XL7A 2VSQA 2E1UA 3B30A 1XL8A 1NM8A 4G2MA 2FW3A 2FY5A 2H3PA 1L5AA 4EPHA 1DPDA 2RCUA 1C4TA 5KJVA 1EABA 3CLAA 2I9DA 2II3A 1EAEA 4JN3A 2RKTA 1EACA 2CLAA 3U9BA 2FYOA 4KE4A 1Q9JA 2BGHA 4EYWA 3FOTA 5KJUA 2JGPA 1EADA 2XR7A 2DEBA 1T7OA 2IHWA 3MAEA 3FP0A 1XMCA 3B2SA 1DPCA 5FANA 3U9FA 1E2OA 2E1TA 1T7QA 1QCAA 5DU9A 5T3EA 2E1VA 1SCZA 1EAAA 5DUAA 2XHGA 4JN5A 1CLAA 1DPBA 2FY3A 5KJTA 4EP9A 5KJSA 4G22A 1Q23A 4HVMA 1XMDA 2ZBAA 1NDIA 2RKVA 1EAFA 3L60A 1NOCB 2H3WA 4CLAA 1PD5A
chains in the Genus database with same CATH topology
2XHGA 1CIAA 3FOTA 4JN5A 5KJUA 2JGPA 1L5AA 1CLAA 1DPBA 1EADA 2XR7A 5FALA 1DPDA 2IHWA 5KJTA 3MAEA 1C4TA 4G0BA 5KJWA 3FP0A 1XMCA 5KJSA 2II5A 3B2SA 5KJVA 4G22A 1DPCA 1EABA 3CLAA 4N72A 2I9DA 5FANA 2II3A 2II4A 3U9FA 1EAEA 4JN3A 2RKTA 1E2OA 1EACA 1Q23A 1XL7A 4KECA 4HVMA 2CLAA 1XMDA 3U9BA 2ZBAA 2VSQA 2E1UA 2E1TA 3B30A 2RKVA 1EAFA 1QCAA 3L60A 5DU9A 1XL8A 1NOCB 4KE4A 2E1VA 1Q9JA 5T3EA 1SCZA 2BGHA 4G2MA 4CLAA 1EAAA 5DUAA 1PD5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2XHG A;  1CIA A;  3FOT A;  4JN5 A;  5KJU A;  2JGP A;  1L5A A;  1CLA A;  1DPB A;  1EAD A;  2XR7 A;  5FAL A;  1DPD A;  2IHW A;  5KJT A;  3MAE A;  1C4T A;  4G0B A;  5KJW A;  3FP0 A;  1XMC A;  5KJS A;  2II5 A;  3B2S A;  5KJV A;  4G22 A;  1DPC A;  1EAB A;  3CLA A;  4N72 A;  2I9D A;  5FAN A;  2II3 A;  2II4 A;  3U9F A;  1EAE A;  4JN3 A;  2RKT A;  1E2O A;  1EAC A;  1Q23 A;  1XL7 A;  4KEC A;  4HVM A;  2CLA A;  1XMD A;  3U9B A;  2ZBA A;  2VSQ A;  2E1U A;  2E1T A;  3B30 A;  2RKV A;  1EAF A;  1QCA A;  3L60 A;  5DU9 A;  1XL8 A;  1NOC B;  4KE4 A;  2E1V A;  1Q9J A;  5T3E A;  1SCZ A;  2BGH A;  4G2M A;  4CLA A;  1EAA A;  5DUA A;  1PD5 A; 
#chains in the Genus database with same CATH topology
 2H3U A;  1CIA A;  1NDF A;  5FAL A;  1NDB A;  1Q6X A;  2FY4 A;  4G0B A;  5KJW A;  1T7N A;  2II5 A;  1T1U A;  2FY2 A;  4N72 A;  2II4 A;  1S5O A;  4KEC A;  2H4T A;  1XL7 A;  2VSQ A;  2E1U A;  3B30 A;  1XL8 A;  1NM8 A;  4G2M A;  2FW3 A;  2FY5 A;  2H3P A;  1L5A A;  4EPH A;  1DPD A;  2RCU A;  1C4T A;  5KJV A;  1EAB A;  3CLA A;  2I9D A;  2II3 A;  1EAE A;  4JN3 A;  2RKT A;  1EAC A;  2CLA A;  3U9B A;  2FYO A;  4KE4 A;  1Q9J A;  2BGH A;  4EYW A;  3FOT A;  5KJU A;  2JGP A;  1EAD A;  2XR7 A;  2DEB A;  1T7O A;  2IHW A;  3MAE A;  3FP0 A;  1XMC A;  3B2S A;  1DPC A;  5FAN A;  3U9F A;  1E2O A;  2E1T A;  1T7Q A;  1QCA A;  5DU9 A;  5T3E A;  2E1V A;  1SCZ A;  1EAA A;  5DUA A;  2XHG A;  4JN5 A;  1CLA A;  1DPB A;  2FY3 A;  5KJT A;  4EP9 A;  5KJS A;  4G22 A;  1Q23 A;  4HVM A;  1XMD A;  2ZBA A;  1NDI A;  2RKV A;  1EAF A;  3L60 A;  1NOC B;  2H3W A;  4CLA A;  1PD5 A; 
#chains in the Genus database with same CATH homology
 2XHG A;  1CIA A;  3FOT A;  4JN5 A;  5KJU A;  2JGP A;  1L5A A;  1CLA A;  1DPB A;  1EAD A;  2XR7 A;  5FAL A;  1DPD A;  2IHW A;  5KJT A;  3MAE A;  1C4T A;  4G0B A;  5KJW A;  3FP0 A;  1XMC A;  5KJS A;  2II5 A;  3B2S A;  5KJV A;  4G22 A;  1DPC A;  1EAB A;  3CLA A;  4N72 A;  2I9D A;  5FAN A;  2II3 A;  2II4 A;  3U9F A;  1EAE A;  4JN3 A;  2RKT A;  1E2O A;  1EAC A;  1Q23 A;  1XL7 A;  4KEC A;  4HVM A;  2CLA A;  1XMD A;  3U9B A;  2ZBA A;  2VSQ A;  2E1U A;  2E1T A;  3B30 A;  2RKV A;  1EAF A;  1QCA A;  3L60 A;  5DU9 A;  1XL8 A;  1NOC B;  4KE4 A;  2E1V A;  1Q9J A;  5T3E A;  1SCZ A;  2BGH A;  4G2M A;  4CLA A;  1EAA A;  5DUA A;  1PD5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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