1FIQC

Crystal structure of xanthine oxidase from bovine milk
Total Genus 241
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
241
sequence length
745
structure length
745
Chain Sequence
DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords XANTHINE OXIDASE
total genus 241
structure length 745
sequence length 745
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2000-08-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 1fiqC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 1fiqC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 1fiqC03
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 1fiqC05
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 1fiqC01
1FFUB 1N5XA 1FIQC 3EUB4 4USAA 1N62B 1V97A 4ZOHA 1ZXIB 3NVZC 2W55B 1WYGA 3AN1A 3AM9A 3NRZC 4US8A 2W54B 1N61B 1SIJA 1FFVB 3ETRC 3NVWC 1RM6A 1SB3A 3L4PA 1N63B 2E3TA 3HRDA 2W3RB 2W3SB 1FO4A 4C80A 3NVVC 1JRPB 1VDVA 4C7ZA 4C7YA 1N5WB 1DGJA 3FC4A 3NVYC 1N60B 3SR6C 4US9A 1JROB 3AMZA 3FAHA 1VLBA 3B9JC 3NS1C 3HRDB
chains in the Genus database with same CATH superfamily
3RPFA 4WFAJ 2ZJPJ 1QAPA 1YI2H 2QIEA 4IOAJ 2I14A 2ZJQJ 1WYGA 3L0GA 2WK5A 5DM7J 1VQKH 5AYZA 3VMMA 3PIOJ 1KD1J 4EADA 3H5QA 4XR5A 1N61B 2J0FA 1M90J 3GNNA 1RM6A 3WNZA 4WF9J 1YHQH 4IOCJ 3CCJH 2DSJA 5HUOA 3CF5J 3CC2H 1WKIA 4C80A 3BIIE 4YEKA 1Q82J 1X1OA 1YIJH 3FC4A 1QPOA 1T3QB 1N60B 4US9A 3AMZA 3FAHA 3C2VA 3WO0A 5GAHN 1FMAE 3WO1A 3CCUH 5JVHJ 1YJ9H 4U67J 1KC8J 1K9MJ 3EUB4 4AP8A 3I55H 1V97A 2OTLH 2QEXH 3AN1A 3CXCH 2WK6A 3DLLJ 3CPWH 5H1SO 1JJ2H 1W2BH 3PAJA 1SIJA 1AZYA 1VQ4H 1FM0E 1QPNA 4WFBJ 3ETRC 5AYYA 1UOUA 3L4PA 5GAEN 1QPQA 2OMDA 3CCSH 5JVGJ 1YITH 3CC7H 1VQNH 2W3RB 5EP8A 1DGJA 3PIPJ 1Q86J 1Q81J 4EAFA 1VQ8H 4UY8M 3SR6C 5EY3A 1S72H 1VQLH 1Q7YJ 1SB3A 1VLBA 3CMEH 3J7ZM 1YJNH 3HRDB 4WCEJ 1FFUB 1N5XA 1FIQC 3C2RA 1N62B 4ZOHA 2ZJRJ 4WFNJ 1VQOH 4GA5A 3CCLH 2B7QA 3CCEH 3AM9A 3NRZC 5HULA 3I56H 1VQ9H 3C2FA 2QA4H 4KWWA 4KWVA 1VQ5H 1FFVB 4LHMA 5HL7J 3OW2H 3C2EA 1N8RJ 5MPOC 2E3TA 5MLCO 3HRDA 3G4SH 1OTPA 1YTKA 1FO4A 3NVVC 2B7PA 4C7YA 5HUPA 1QVFH 1VQ7H 2I1OA 1Y69K 5GADN 3CCQH 1VQMH 3CMAH 4GA4A 5AN9F 1M1KJ 2JBMA 1KQSH 4USAA 5AYXA 1YTEA 3CCMH 3CCRH 2Q5WE 1K73J 1ZXIB 3NVZC 3CC4H 1YJWH 2W55B 2TPTA 5DM6J 1NVJA 5GAGN 1YTDA 4US8A 2W54B 4X46A 2PA2A 1BRWA 1NJIJ 3CD6H 1VQPH 1O4UA 4YYYA 3NVWC 1QVGH 2B7NA 1N63B 3G6EH 1VQ6H 3TQVA 2W3SB 1JRPB 1VDVA 4C7ZA 1N5WB 2WP4A 1NVIE 3CCVH 3C2OA 4GA6A 3G71H 3NVYC 1JROB 1K8AJ 4I9AA 2OTJH 4IO9J 3B9JC 3NS1C 1QPRA
chains in the Genus database with same CATH topology
1FFUB 1N5XA 1FIQC 3EUB4 4USAA 1N62B 1V97A 4ZOHA 1ZXIB 3NVZC 2W55B 1WYGA 3AN1A 3AM9A 3NRZC 4US8A 2W54B 1N61B 1SIJA 1FFVB 3ETRC 3NVWC 1RM6A 1SB3A 3L4PA 1N63B 2E3TA 3HRDA 2W3RB 2W3SB 1FO4A 4C80A 3NVVC 1JRPB 1VDVA 4C7ZA 4C7YA 1N5WB 1DGJA 3FC4A 3NVYC 1N60B 3SR6C 4US9A 1JROB 3AMZA 3FAHA 1VLBA 3B9JC 3NS1C 3HRDB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FFU B;  1N5X A;  1FIQ C;  3EUB 4;  4USA A;  1N62 B;  1V97 A;  4ZOH A;  1ZXI B;  3NVZ C;  2W55 B;  1WYG A;  3AN1 A;  3AM9 A;  3NRZ C;  4US8 A;  2W54 B;  1N61 B;  1SIJ A;  1FFV B;  3ETR C;  3NVW C;  1RM6 A;  1SB3 A;  3L4P A;  1N63 B;  2E3T A;  3HRD A;  2W3R B;  2W3S B;  1FO4 A;  4C80 A;  3NVV C;  1JRP B;  1VDV A;  4C7Z A;  4C7Y A;  1N5W B;  1DGJ A;  3FC4 A;  3NVY C;  1N60 B;  3SR6 C;  4US9 A;  1JRO B;  3AMZ A;  3FAH A;  1VLB A;  3B9J C;  3NS1 C;  3HRD B; 
#chains in the Genus database with same CATH topology
 3RPF A;  4WFA J;  2ZJP J;  1QAP A;  1YI2 H;  2QIE A;  4IOA J;  2I14 A;  2ZJQ J;  1WYG A;  3L0G A;  2WK5 A;  5DM7 J;  1VQK H;  5AYZ A;  3VMM A;  3PIO J;  1KD1 J;  4EAD A;  3H5Q A;  4XR5 A;  1N61 B;  2J0F A;  1M90 J;  3GNN A;  1RM6 A;  3WNZ A;  4WF9 J;  1YHQ H;  4IOC J;  3CCJ H;  2DSJ A;  5HUO A;  3CF5 J;  3CC2 H;  1WKI A;  4C80 A;  3BII E;  4YEK A;  1Q82 J;  1X1O A;  1YIJ H;  3FC4 A;  1QPO A;  1T3Q B;  1N60 B;  4US9 A;  3AMZ A;  3FAH A;  3C2V A;  3WO0 A;  5GAH N;  1FMA E;  3WO1 A;  3CCU H;  5JVH J;  1YJ9 H;  4U67 J;  1KC8 J;  1K9M J;  3EUB 4;  4AP8 A;  3I55 H;  1V97 A;  2OTL H;  2QEX H;  3AN1 A;  3CXC H;  2WK6 A;  3DLL J;  3CPW H;  5H1S O;  1JJ2 H;  1W2B H;  3PAJ A;  1SIJ A;  1AZY A;  1VQ4 H;  1FM0 E;  1QPN A;  4WFB J;  3ETR C;  5AYY A;  1UOU A;  3L4P A;  5GAE N;  1QPQ A;  2OMD A;  3CCS H;  5JVG J;  1YIT H;  3CC7 H;  1VQN H;  2W3R B;  5EP8 A;  1DGJ A;  3PIP J;  1Q86 J;  1Q81 J;  4EAF A;  1VQ8 H;  4UY8 M;  3SR6 C;  5EY3 A;  1S72 H;  1VQL H;  1Q7Y J;  1SB3 A;  1VLB A;  3CME H;  3J7Z M;  1YJN H;  3HRD B;  4WCE J;  1FFU B;  1N5X A;  1FIQ C;  3C2R A;  1N62 B;  4ZOH A;  2ZJR J;  4WFN J;  1VQO H;  4GA5 A;  3CCL H;  2B7Q A;  3CCE H;  3AM9 A;  3NRZ C;  5HUL A;  3I56 H;  1VQ9 H;  3C2F A;  2QA4 H;  4KWW A;  4KWV A;  1VQ5 H;  1FFV B;  4LHM A;  5HL7 J;  3OW2 H;  3C2E A;  1N8R J;  5MPO C;  2E3T A;  5MLC O;  3HRD A;  3G4S H;  1OTP A;  1YTK A;  1FO4 A;  3NVV C;  2B7P A;  4C7Y A;  5HUP A;  1QVF H;  1VQ7 H;  2I1O A;  1Y69 K;  5GAD N;  3CCQ H;  1VQM H;  3CMA H;  4GA4 A;  5AN9 F;  1M1K J;  2JBM A;  1KQS H;  4USA A;  5AYX A;  1YTE A;  3CCM H;  3CCR H;  2Q5W E;  1K73 J;  1ZXI B;  3NVZ C;  3CC4 H;  1YJW H;  2W55 B;  2TPT A;  5DM6 J;  1NVJ A;  5GAG N;  1YTD A;  4US8 A;  2W54 B;  4X46 A;  2PA2 A;  1BRW A;  1NJI J;  3CD6 H;  1VQP H;  1O4U A;  4YYY A;  3NVW C;  1QVG H;  2B7N A;  1N63 B;  3G6E H;  1VQ6 H;  3TQV A;  2W3S B;  1JRP B;  1VDV A;  4C7Z A;  1N5W B;  2WP4 A;  1NVI E;  3CCV H;  3C2O A;  4GA6 A;  3G71 H;  3NVY C;  1JRO B;  1K8A J;  4I9A A;  2OTJ H;  4IO9 J;  3B9J C;  3NS1 C;  1QPR A; 
#chains in the Genus database with same CATH homology
 1FFU B;  1N5X A;  1FIQ C;  3EUB 4;  4USA A;  1N62 B;  1V97 A;  4ZOH A;  1ZXI B;  3NVZ C;  2W55 B;  1WYG A;  3AN1 A;  3AM9 A;  3NRZ C;  4US8 A;  2W54 B;  1N61 B;  1SIJ A;  1FFV B;  3ETR C;  3NVW C;  1RM6 A;  1SB3 A;  3L4P A;  1N63 B;  2E3T A;  3HRD A;  2W3R B;  2W3S B;  1FO4 A;  4C80 A;  3NVV C;  1JRP B;  1VDV A;  4C7Z A;  4C7Y A;  1N5W B;  1DGJ A;  3FC4 A;  3NVY C;  1N60 B;  3SR6 C;  4US9 A;  1JRO B;  3AMZ A;  3FAH A;  1VLB A;  3B9J C;  3NS1 C;  3HRD B; 
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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