The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
92
|
sequence length |
289
|
structure length |
289
|
Chain Sequence |
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
publication title |
Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis
pubmed doi rcsb |
molecule tags |
Transferase
|
source organism |
Homo sapiens
|
molecule keywords |
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
|
total genus |
92
|
structure length |
289
|
sequence length |
289
|
chains with identical sequence |
B, C, D, E, F, G, H, I, J, K, L
|
ec nomenclature |
ec
2.4.2.19: Nicotinate-nucleotide diphosphorylase (carboxylating). |
pdb deposition date | 2015-09-14 |
chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
---|---|---|---|
A | PF01729 | QRPTase_C | Quinolinate phosphoribosyl transferase, C-terminal domain |
A | PF02749 | QRPTase_N | Quinolinate phosphoribosyl transferase, N-terminal domain |
cath code
| Class | Architecture | Topology | Homology | Domain |
---|---|---|---|---|---|
Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | ||
Alpha Beta | Alpha-Beta Complex | Aldehyde Oxidoreductase; domain 3 | Quinolinate phosphoribosyl transferase, N-terminal domain |