1T1UA

Structural insights and functional implications of choline acetyltransferase
Total Genus 221
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
221
sequence length
597
structure length
597
Chain Sequence
ELDLPKLPVPPLQQTLATYLQCMQHLVPEEQFRKSQAIVKRFGAPGGLGETLQEKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFQDTNDQLRFAACLISGVLSYKTLLDSHSLPTDWAKGQLSGQPLCMKQYYRLFSSYRLPGHTQDTLVAQKSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAKARTVLLKDSTNRDSLDMIERCICLVCLDGPGTGELSDTHRALQLLHGGGCSLNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMMTSNKKLVRADSVSELPAPRRLRWKCSPETQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKYSPDGFIQVALQLAYYRLYQRLVPTYESASIRRFQEGRVDNIRSATPEALAFVQAMTDHKAAMPASEKLQLLQTAMQAQTEYTVMAITGMAIDNHLLALRELARDLCKEPPEMFMDETYLMSNRFVLSTSQVPTTMEMFCCYGPVVPNGYGACYNPQPEAITFCISSFHSCKETSSVEFAEAVGASLVDMRDLCSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural insights and functional implications of choline acetyltransferase
pubmed doi rcsb
molecule tags Transferase
source organism Rattus norvegicus
molecule keywords Choline O-acetyltransferase
total genus 221
structure length 597
sequence length 597
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2004-04-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 1t1uA01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 1t1uA02
1S5OA 2H3WA 2FW3A 1NDFA 2FY3A 2H3PA 4EYWA 2FY4A 1Q6XA 1T1UA 4EP9A 1NDBA 2H3UA 2DEBA 2H4TA 2FYOA 2FY2A 1NDIA 1T7OA 1T7NA 1T7QA 2RCUA 1NM8A 4EPHA 2FY5A
chains in the Genus database with same CATH superfamily
5KJWA 5DU9A 4G0BA 3FP0A 1NDBA 2H3UA 3FOTA 1DPBA 1SCZA 2RKVA 1CLAA 2E1TA 2RCUA 5KJSA 1EAFA 4JN3A 5FANA 1Q23A 2XHGA 1E2OA 5DUAA 1PD5A 1L5AA 1XL7A 5KJVA 4KE4A 2IHWA 1EABA 5T3EA 1Q6XA 5KJTA 4HVMA 2RKTA 3U9BA 1T7OA 2CLAA 2JGPA 1NM8A 5KJUA 2I9DA 2II5A 1XMCA 1Q9JA 2E1UA 2ZBAA 1XMDA 2FW3A 3MAEA 1NDFA 4JN5A 2H3PA 4EYWA 2FY4A 2BGHA 2II3A 2DEBA 4G22A 1EAEA 1NDIA 1QCAA 1DPDA 1T7NA 1T7QA 3CLAA 2II4A 2E1VA 1C4TA 4EPHA 3L60A 2FY5A 1S5OA 1NOCB 2H3WA 2FY3A 2XR7A 3U9FA 1EACA 1XL8A 3B2SA 1T1UA 4EP9A 1CIAA 2H4TA 2FYOA 2FY2A 1EADA 4KECA 4G2MA 4CLAA 5FALA 1DPCA 1EAAA 3B30A 4N72A 2VSQA
chains in the Genus database with same CATH topology
1S5OA 2XHGA 2H3WA 5DUAA 2FW3A 1NDFA 2FY3A 1L5AA 4JN5A 2H3PA 5DU9A 4EYWA 5T3EA 2FY4A 1Q6XA 1T1UA 3FP0A 4EP9A 1NDBA 2H3UA 2DEBA 3FOTA 2H4TA 4HVMA 2FYOA 2FY2A 1NDIA 1T7OA 1T7NA 2JGPA 1T7QA 2RCUA 1NM8A 1Q9JA 4JN3A 4EPHA 2FY5A 2VSQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S5O A;  2H3W A;  2FW3 A;  1NDF A;  2FY3 A;  2H3P A;  4EYW A;  2FY4 A;  1Q6X A;  1T1U A;  4EP9 A;  1NDB A;  2H3U A;  2DEB A;  2H4T A;  2FYO A;  2FY2 A;  1NDI A;  1T7O A;  1T7N A;  1T7Q A;  2RCU A;  1NM8 A;  4EPH A;  2FY5 A; 
#chains in the Genus database with same CATH topology
 5KJW A;  5DU9 A;  4G0B A;  3FP0 A;  1NDB A;  2H3U A;  3FOT A;  1DPB A;  1SCZ A;  2RKV A;  1CLA A;  2E1T A;  2RCU A;  5KJS A;  1EAF A;  4JN3 A;  5FAN A;  1Q23 A;  2XHG A;  1E2O A;  5DUA A;  1PD5 A;  1L5A A;  1XL7 A;  5KJV A;  4KE4 A;  2IHW A;  1EAB A;  5T3E A;  1Q6X A;  5KJT A;  4HVM A;  2RKT A;  3U9B A;  1T7O A;  2CLA A;  2JGP A;  1NM8 A;  5KJU A;  2I9D A;  2II5 A;  1XMC A;  1Q9J A;  2E1U A;  2ZBA A;  1XMD A;  2FW3 A;  3MAE A;  1NDF A;  4JN5 A;  2H3P A;  4EYW A;  2FY4 A;  2BGH A;  2II3 A;  2DEB A;  4G22 A;  1EAE A;  1NDI A;  1QCA A;  1DPD A;  1T7N A;  1T7Q A;  3CLA A;  2II4 A;  2E1V A;  1C4T A;  4EPH A;  3L60 A;  2FY5 A;  1S5O A;  1NOC B;  2H3W A;  2FY3 A;  2XR7 A;  3U9F A;  1EAC A;  1XL8 A;  3B2S A;  1T1U A;  4EP9 A;  1CIA A;  2H4T A;  2FYO A;  2FY2 A;  1EAD A;  4KEC A;  4G2M A;  4CLA A;  5FAL A;  1DPC A;  1EAA A;  3B30 A;  4N72 A;  2VSQ A; 
#chains in the Genus database with same CATH homology
 1S5O A;  2XHG A;  2H3W A;  5DUA A;  2FW3 A;  1NDF A;  2FY3 A;  1L5A A;  4JN5 A;  2H3P A;  5DU9 A;  4EYW A;  5T3E A;  2FY4 A;  1Q6X A;  1T1U A;  3FP0 A;  4EP9 A;  1NDB A;  2H3U A;  2DEB A;  3FOT A;  2H4T A;  4HVM A;  2FYO A;  2FY2 A;  1NDI A;  1T7O A;  1T7N A;  2JGP A;  1T7Q A;  2RCU A;  1NM8 A;  1Q9J A;  4JN3 A;  4EPH A;  2FY5 A;  2VSQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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