2CLAA

Crystal structure of the asp-199-asn mutant of chloramphenicol acetyltransferase to 2.35 angstroms resolution. structural consequences of disruption of a buried salt-bridge
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
213
structure length
213
Chain Sequence
MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDDSAYKFYPVMIYLIAQAVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPYSSDIDQFMVNYLSVMERYKSDTKLFPQGVTPENHLNISALPWVNFDSFNLNVANFTDYFAPIITMAKYQQEGDRLLLPLSVQVHHAVCNGFHVARFINRLQELCNSKLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of the aspartic acid-199----asparagine mutant of chloramphenicol acetyltransferase to 2.35-A resolution: structural consequences of disruption of a buried salt bridge.
pubmed doi rcsb
molecule tags Transferase (acyltransferase)
source organism Escherichia coli
molecule keywords CHLORAMPHENICOL ACETYLTRANSFERASE
total genus 55
structure length 213
sequence length 213
ec nomenclature ec 2.3.1.28: Chloramphenicol O-acetyltransferase.
pdb deposition date 1990-04-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00302 CAT Chloramphenicol acetyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 2claA00
1C4TA 1EABA 5T3EA 3B2SA 3L60A 4HVMA 1DPBA 3U9BA 5FALA 4JN5A 1EAAA 5KJUA 2II4A 1PD5A 3MAEA 1EAFA 3FP0A 3FOTA 2BGHA 1Q23A 1QCAA 1EAEA 1XL8A 2IHWA 2RKVA 4G22A 3CLAA 4KE4A 2RKTA 4KECA 4N72A 1XL7A 2E1VA 1CIAA 1EADA 2II5A 5KJTA 5FANA 1SCZA 2E1UA 5KJWA 5KJVA 1DPCA 2ZBAA 2I9DA 5DU9A 3U9FA 1NOCB 2XR7A 1XMCA 1L5AA 1EACA 3B30A 2VSQA 4G0BA 5KJSA 2CLAA 2XHGA 2JGPA 4CLAA 5DUAA 2II3A 4G2MA 1XMDA 2E1TA 1DPDA 1E2OA 4JN3A 1CLAA 1Q9JA
chains in the Genus database with same CATH superfamily
1T7OA 5T3EA 2H3UA 1NDFA 5FALA 3FOTA 2BGHA 2IHWA 2II5A 2FY4A 2E1UA 3U9FA 1NM8A 4G0BA 5KJSA 2RCUA 1Q9JA 1EABA 2DEBA 3B2SA 3L60A 4JN5A 3CLAA 2FY5A 2RKTA 2H3WA 5FANA 2FY2A 2I9DA 5DU9A 1NOCB 1Q6XA 2XR7A 1XMCA 1EACA 2XHGA 4CLAA 5DUAA 2II3A 4G2MA 1XMDA 2E1TA 1DPDA 4JN3A 4N72A 2H4TA 1DPBA 1NDIA 1EAFA 3FP0A 1QCAA 1EAEA 1XL8A 2RKVA 4G22A 4KECA 2H3PA 2E1VA 1EADA 5KJTA 1SCZA 5KJWA 2ZBAA 1L5AA 2VSQA 2JGPA 4EP9A 1E2OA 1T7QA 1CLAA 1C4TA 4HVMA 3U9BA 1EAAA 1T1UA 5KJUA 2II4A 1PD5A 3MAEA 1Q23A 1S5OA 4KE4A 1XL7A 1CIAA 4EPHA 4EYWA 2FY3A 5KJVA 1NDBA 1DPCA 2FW3A 3B30A 2CLAA 2FYOA 1T7NA
chains in the Genus database with same CATH topology
1C4TA 1EABA 5T3EA 3B2SA 3L60A 4HVMA 1DPBA 3U9BA 5FALA 4JN5A 1EAAA 5KJUA 2II4A 1PD5A 3MAEA 1EAFA 3FP0A 3FOTA 2BGHA 1Q23A 1QCAA 1EAEA 1XL8A 2IHWA 2RKVA 4G22A 3CLAA 4KE4A 2RKTA 4KECA 4N72A 1XL7A 2E1VA 1CIAA 1EADA 2II5A 5KJTA 5FANA 1SCZA 2E1UA 5KJWA 5KJVA 1DPCA 2ZBAA 2I9DA 5DU9A 3U9FA 1NOCB 2XR7A 1XMCA 1L5AA 1EACA 3B30A 2VSQA 4G0BA 5KJSA 2CLAA 2XHGA 2JGPA 4CLAA 5DUAA 2II3A 4G2MA 1XMDA 2E1TA 1DPDA 1E2OA 4JN3A 1CLAA 1Q9JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C4T A;  1EAB A;  5T3E A;  3B2S A;  3L60 A;  4HVM A;  1DPB A;  3U9B A;  5FAL A;  4JN5 A;  1EAA A;  5KJU A;  2II4 A;  1PD5 A;  3MAE A;  1EAF A;  3FP0 A;  3FOT A;  2BGH A;  1Q23 A;  1QCA A;  1EAE A;  1XL8 A;  2IHW A;  2RKV A;  4G22 A;  3CLA A;  4KE4 A;  2RKT A;  4KEC A;  4N72 A;  1XL7 A;  2E1V A;  1CIA A;  1EAD A;  2II5 A;  5KJT A;  5FAN A;  1SCZ A;  2E1U A;  5KJW A;  5KJV A;  1DPC A;  2ZBA A;  2I9D A;  5DU9 A;  3U9F A;  1NOC B;  2XR7 A;  1XMC A;  1L5A A;  1EAC A;  3B30 A;  2VSQ A;  4G0B A;  5KJS A;  2CLA A;  2XHG A;  2JGP A;  4CLA A;  5DUA A;  2II3 A;  4G2M A;  1XMD A;  2E1T A;  1DPD A;  1E2O A;  4JN3 A;  1CLA A;  1Q9J A; 
#chains in the Genus database with same CATH topology
 1T7O A;  5T3E A;  2H3U A;  1NDF A;  5FAL A;  3FOT A;  2BGH A;  2IHW A;  2II5 A;  2FY4 A;  2E1U A;  3U9F A;  1NM8 A;  4G0B A;  5KJS A;  2RCU A;  1Q9J A;  1EAB A;  2DEB A;  3B2S A;  3L60 A;  4JN5 A;  3CLA A;  2FY5 A;  2RKT A;  2H3W A;  5FAN A;  2FY2 A;  2I9D A;  5DU9 A;  1NOC B;  1Q6X A;  2XR7 A;  1XMC A;  1EAC A;  2XHG A;  4CLA A;  5DUA A;  2II3 A;  4G2M A;  1XMD A;  2E1T A;  1DPD A;  4JN3 A;  4N72 A;  2H4T A;  1DPB A;  1NDI A;  1EAF A;  3FP0 A;  1QCA A;  1EAE A;  1XL8 A;  2RKV A;  4G22 A;  4KEC A;  2H3P A;  2E1V A;  1EAD A;  5KJT A;  1SCZ A;  5KJW A;  2ZBA A;  1L5A A;  2VSQ A;  2JGP A;  4EP9 A;  1E2O A;  1T7Q A;  1CLA A;  1C4T A;  4HVM A;  3U9B A;  1EAA A;  1T1U A;  5KJU A;  2II4 A;  1PD5 A;  3MAE A;  1Q23 A;  1S5O A;  4KE4 A;  1XL7 A;  1CIA A;  4EPH A;  4EYW A;  2FY3 A;  5KJV A;  1NDB A;  1DPC A;  2FW3 A;  3B30 A;  2CLA A;  2FYO A;  1T7N A; 
#chains in the Genus database with same CATH homology
 1C4T A;  1EAB A;  5T3E A;  3B2S A;  3L60 A;  4HVM A;  1DPB A;  3U9B A;  5FAL A;  4JN5 A;  1EAA A;  5KJU A;  2II4 A;  1PD5 A;  3MAE A;  1EAF A;  3FP0 A;  3FOT A;  2BGH A;  1Q23 A;  1QCA A;  1EAE A;  1XL8 A;  2IHW A;  2RKV A;  4G22 A;  3CLA A;  4KE4 A;  2RKT A;  4KEC A;  4N72 A;  1XL7 A;  2E1V A;  1CIA A;  1EAD A;  2II5 A;  5KJT A;  5FAN A;  1SCZ A;  2E1U A;  5KJW A;  5KJV A;  1DPC A;  2ZBA A;  2I9D A;  5DU9 A;  3U9F A;  1NOC B;  2XR7 A;  1XMC A;  1L5A A;  1EAC A;  3B30 A;  2VSQ A;  4G0B A;  5KJS A;  2CLA A;  2XHG A;  2JGP A;  4CLA A;  5DUA A;  2II3 A;  4G2M A;  1XMD A;  2E1T A;  1DPD A;  1E2O A;  4JN3 A;  1CLA A;  1Q9J A; 
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