2FY2A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
597
structure length
585
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Choline O-acetyltransferase
total genus 228
structure length 585
sequence length 597
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A02
1T7QA 2H3UA 1T1UA 2FY2A 4EYWA 1S5OA 2H3PA 2DEBA 1NM8A 2FY3A 1NDFA 1T7OA 2FY5A 4EP9A 2FYOA 2FW3A 1NDIA 2FY4A 1Q6XA 1NDBA 2RCUA 4EPHA 2H3WA 1T7NA 2H4TA
chains in the Genus database with same CATH superfamily
1T7QA 5DU9A 1PD5A 3L60A 1XMDA 2H3PA 1EABA 2FY3A 1NDFA 1T7OA 4G2MA 1CIAA 2FW3A 2FY4A 1Q6XA 2E1TA 2XR7A 4EPHA 1Q23A 2ZBAA 5T3EA 1QCAA 1SCZA 5KJTA 1T1UA 1CLAA 2FY2A 4EYWA 3FOTA 4HVMA 2DEBA 2BGHA 3CLAA 4CLAA 2FYOA 2RKTA 5KJWA 4N72A 1C4TA 4JN3A 5FANA 5DUAA 1NDBA 4KE4A 2II3A 5KJUA 2RKVA 1DPBA 2I9DA 4G22A 5KJSA 1E2OA 1S5OA 1NOCB 1NM8A 4G0BA 3B30A 3U9FA 2FY5A 1Q9JA 2E1VA 1NDIA 4KECA 2VSQA 2IHWA 1EAFA 2JGPA 2H3WA 2II4A 1EACA 5FALA 2II5A 2H4TA 4JN5A 2H3UA 1EAEA 1EADA 3B2SA 3MAEA 1DPCA 4EP9A 1L5AA 3U9BA 2XHGA 1XL7A 2RCUA 1EAAA 2E1UA 5KJVA 1DPDA 3FP0A 1T7NA 1XMCA 2CLAA 1XL8A
chains in the Genus database with same CATH topology
1T7QA 4JN5A 2H3UA 1T1UA 5DU9A 2FY2A 4EYWA 1S5OA 3FOTA 2H3PA 4HVMA 2DEBA 1NM8A 2FY3A 1NDFA 1T7OA 2FY5A 1Q9JA 1L5AA 4EP9A 2FYOA 2FW3A 2XHGA 1NDIA 2FY4A 4JN3A 1Q6XA 2VSQA 5DUAA 1NDBA 2RCUA 4EPHA 3FP0A 2JGPA 2H3WA 1T7NA 5T3EA 2H4TA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T7Q A;  2H3U A;  1T1U A;  2FY2 A;  4EYW A;  1S5O A;  2H3P A;  2DEB A;  1NM8 A;  2FY3 A;  1NDF A;  1T7O A;  2FY5 A;  4EP9 A;  2FYO A;  2FW3 A;  1NDI A;  2FY4 A;  1Q6X A;  1NDB A;  2RCU A;  4EPH A;  2H3W A;  1T7N A;  2H4T A; 
#chains in the Genus database with same CATH topology
 1T7Q A;  5DU9 A;  1PD5 A;  3L60 A;  1XMD A;  2H3P A;  1EAB A;  2FY3 A;  1NDF A;  1T7O A;  4G2M A;  1CIA A;  2FW3 A;  2FY4 A;  1Q6X A;  2E1T A;  2XR7 A;  4EPH A;  1Q23 A;  2ZBA A;  5T3E A;  1QCA A;  1SCZ A;  5KJT A;  1T1U A;  1CLA A;  2FY2 A;  4EYW A;  3FOT A;  4HVM A;  2DEB A;  2BGH A;  3CLA A;  4CLA A;  2FYO A;  2RKT A;  5KJW A;  4N72 A;  1C4T A;  4JN3 A;  5FAN A;  5DUA A;  1NDB A;  4KE4 A;  2II3 A;  5KJU A;  2RKV A;  1DPB A;  2I9D A;  4G22 A;  5KJS A;  1E2O A;  1S5O A;  1NOC B;  1NM8 A;  4G0B A;  3B30 A;  3U9F A;  2FY5 A;  1Q9J A;  2E1V A;  1NDI A;  4KEC A;  2VSQ A;  2IHW A;  1EAF A;  2JGP A;  2H3W A;  2II4 A;  1EAC A;  5FAL A;  2II5 A;  2H4T A;  4JN5 A;  2H3U A;  1EAE A;  1EAD A;  3B2S A;  3MAE A;  1DPC A;  4EP9 A;  1L5A A;  3U9B A;  2XHG A;  1XL7 A;  2RCU A;  1EAA A;  2E1U A;  5KJV A;  1DPD A;  3FP0 A;  1T7N A;  1XMC A;  2CLA A;  1XL8 A; 
#chains in the Genus database with same CATH homology
 1T7Q A;  4JN5 A;  2H3U A;  1T1U A;  5DU9 A;  2FY2 A;  4EYW A;  1S5O A;  3FOT A;  2H3P A;  4HVM A;  2DEB A;  1NM8 A;  2FY3 A;  1NDF A;  1T7O A;  2FY5 A;  1Q9J A;  1L5A A;  4EP9 A;  2FYO A;  2FW3 A;  2XHG A;  1NDI A;  2FY4 A;  4JN3 A;  1Q6X A;  2VSQ A;  5DUA A;  1NDB A;  2RCU A;  4EPH A;  3FP0 A;  2JGP A;  2H3W A;  1T7N A;  5T3E A;  2H4T A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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