2FY2A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 228
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
228
sequence length
597
structure length
585
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTGQPLCMKQYYGLFSSYRLPGHTQDTLVAQMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Choline O-acetyltransferase
total genus 228
structure length 585
sequence length 597
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy2A02
1Q6XA 1T7NA 2FY3A 2H3WA 4EP9A 1NDIA 2RCUA 2FY2A 4EPHA 2H4TA 1S5OA 2FY5A 1NDFA 1T7OA 1T7QA 2FW3A 1NM8A 2FYOA 1NDBA 4EYWA 2DEBA 1T1UA 2H3PA 2FY4A 2H3UA
chains in the Genus database with same CATH superfamily
2FY3A 4G0BA 1EAEA 5T3EA 2RCUA 3L60A 4G22A 2H4TA 1S5OA 2BGHA 2E1VA 2FY5A 1QCAA 1E2OA 5KJWA 5DUAA 1NOCB 1EAAA 2E1TA 5FANA 1EABA 1NDBA 1CIAA 2II5A 3MAEA 2II3A 4KECA 1DPDA 1C4TA 1Q9JA 2FY4A 1XMCA 5KJVA 1T7NA 1Q23A 3FOTA 1XMDA 4EP9A 1L5AA 5KJSA 1DPBA 1T7OA 1T7QA 3B2SA 4HVMA 5FALA 2DEBA 1T1UA 5DU9A 2IHWA 1Q6XA 1EACA 3U9FA 2JGPA 2E1UA 5KJTA 3FP0A 2ZBAA 1NDIA 2FY2A 5KJUA 4JN3A 4CLAA 4N72A 1EAFA 1NDFA 1XL8A 4JN5A 2FW3A 4EYWA 2I9DA 1EADA 2RKTA 3B30A 4KE4A 3U9BA 4G2MA 2H3WA 2XR7A 2VSQA 2CLAA 4EPHA 1CLAA 1DPCA 2RKVA 1PD5A 1NM8A 2FYOA 1XL7A 1SCZA 2II4A 2H3PA 3CLAA 2XHGA 2H3UA
chains in the Genus database with same CATH topology
1Q6XA 1T7NA 2FY3A 2JGPA 2XHGA 2H3WA 5T3EA 3FOTA 4EP9A 1L5AA 3FP0A 1NDIA 2RCUA 2VSQA 2FY2A 4EPHA 2H4TA 1S5OA 2FY5A 4JN3A 1NDFA 5DUAA 4JN5A 1T7OA 1T7QA 2FW3A 1NM8A 2FYOA 1NDBA 4EYWA 4HVMA 2DEBA 1T1UA 1Q9JA 2H3PA 2FY4A 2H3UA 5DU9A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q6X A;  1T7N A;  2FY3 A;  2H3W A;  4EP9 A;  1NDI A;  2RCU A;  2FY2 A;  4EPH A;  2H4T A;  1S5O A;  2FY5 A;  1NDF A;  1T7O A;  1T7Q A;  2FW3 A;  1NM8 A;  2FYO A;  1NDB A;  4EYW A;  2DEB A;  1T1U A;  2H3P A;  2FY4 A;  2H3U A; 
#chains in the Genus database with same CATH topology
 2FY3 A;  4G0B A;  1EAE A;  5T3E A;  2RCU A;  3L60 A;  4G22 A;  2H4T A;  1S5O A;  2BGH A;  2E1V A;  2FY5 A;  1QCA A;  1E2O A;  5KJW A;  5DUA A;  1NOC B;  1EAA A;  2E1T A;  5FAN A;  1EAB A;  1NDB A;  1CIA A;  2II5 A;  3MAE A;  2II3 A;  4KEC A;  1DPD A;  1C4T A;  1Q9J A;  2FY4 A;  1XMC A;  5KJV A;  1T7N A;  1Q23 A;  3FOT A;  1XMD A;  4EP9 A;  1L5A A;  5KJS A;  1DPB A;  1T7O A;  1T7Q A;  3B2S A;  4HVM A;  5FAL A;  2DEB A;  1T1U A;  5DU9 A;  2IHW A;  1Q6X A;  1EAC A;  3U9F A;  2JGP A;  2E1U A;  5KJT A;  3FP0 A;  2ZBA A;  1NDI A;  2FY2 A;  5KJU A;  4JN3 A;  4CLA A;  4N72 A;  1EAF A;  1NDF A;  1XL8 A;  4JN5 A;  2FW3 A;  4EYW A;  2I9D A;  1EAD A;  2RKT A;  3B30 A;  4KE4 A;  3U9B A;  4G2M A;  2H3W A;  2XR7 A;  2VSQ A;  2CLA A;  4EPH A;  1CLA A;  1DPC A;  2RKV A;  1PD5 A;  1NM8 A;  2FYO A;  1XL7 A;  1SCZ A;  2II4 A;  2H3P A;  3CLA A;  2XHG A;  2H3U A; 
#chains in the Genus database with same CATH homology
 1Q6X A;  1T7N A;  2FY3 A;  2JGP A;  2XHG A;  2H3W A;  5T3E A;  3FOT A;  4EP9 A;  1L5A A;  3FP0 A;  1NDI A;  2RCU A;  2VSQ A;  2FY2 A;  4EPH A;  2H4T A;  1S5O A;  2FY5 A;  4JN3 A;  1NDF A;  5DUA A;  4JN5 A;  1T7O A;  1T7Q A;  2FW3 A;  1NM8 A;  2FYO A;  1NDB A;  4EYW A;  4HVM A;  2DEB A;  1T1U A;  1Q9J A;  2H3P A;  2FY4 A;  2H3U A;  5DU9 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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