2FY3A

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
Total Genus 235
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
235
sequence length
599
structure length
595
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Choline O-acetyltransferase
total genus 235
structure length 595
sequence length 599
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A02
1S5OA 2H3UA 1T1UA 2H3WA 2FY2A 2RCUA 1NDFA 2DEBA 2H3PA 4EP9A 2FYOA 4EPHA 1NDBA 2FY4A 1T7QA 1T7OA 2FY5A 1NDIA 2H4TA 4EYWA 2FY3A 1NM8A 2FW3A 1T7NA 1Q6XA
chains in the Genus database with same CATH superfamily
5DU9A 1CLAA 2XHGA 1DPCA 4HVMA 1XMDA 2II3A 1XMCA 1DPBA 4EP9A 1DPDA 4EPHA 5DUAA 1EAFA 5KJWA 2VSQA 4G0BA 2FY4A 2FY5A 1Q23A 1XL7A 2H4TA 2E1UA 4EYWA 2E1TA 4JN3A 1S5OA 2H3UA 1EACA 2II4A 2H3WA 1NDFA 1C4TA 2FYOA 1Q9JA 2E1VA 2ZBAA 3MAEA 3FP0A 5KJUA 1EAEA 2I9DA 2XR7A 2BGHA 1SCZA 5KJVA 3B2SA 1T7NA 4KECA 2IHWA 5FALA 4KE4A 5KJTA 1EAAA 1T1UA 2FY2A 2RCUA 5T3EA 3B30A 3CLAA 4G22A 3U9BA 1XL8A 1NOCB 1T7QA 1T7OA 1EADA 3FOTA 2FY3A 1L5AA 2RKVA 2JGPA 2FW3A 1E2OA 1Q6XA 4G2MA 2RKTA 3L60A 2CLAA 2DEBA 2H3PA 5KJSA 1CIAA 5FANA 1NDBA 4JN5A 4N72A 1PD5A 2II5A 1QCAA 1NDIA 3U9FA 1EABA 1NM8A 4CLAA
chains in the Genus database with same CATH topology
1S5OA 5DU9A 2H3UA 2XHGA 4HVMA 1T1UA 2FY2A 2H3WA 2RCUA 5T3EA 1NDFA 2DEBA 2H3PA 4EP9A 2FYOA 4EPHA 5DUAA 1Q9JA 2VSQA 3FP0A 1NDBA 2FY4A 4JN5A 1T7QA 1T7OA 2FY5A 1NDIA 2H4TA 4EYWA 3FOTA 2FY3A 1L5AA 1NM8A 2JGPA 2FW3A 1T7NA 4JN3A 1Q6XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1S5O A;  2H3U A;  1T1U A;  2H3W A;  2FY2 A;  2RCU A;  1NDF A;  2DEB A;  2H3P A;  4EP9 A;  2FYO A;  4EPH A;  1NDB A;  2FY4 A;  1T7Q A;  1T7O A;  2FY5 A;  1NDI A;  2H4T A;  4EYW A;  2FY3 A;  1NM8 A;  2FW3 A;  1T7N A;  1Q6X A; 
#chains in the Genus database with same CATH topology
 5DU9 A;  1CLA A;  2XHG A;  1DPC A;  4HVM A;  1XMD A;  2II3 A;  1XMC A;  1DPB A;  4EP9 A;  1DPD A;  4EPH A;  5DUA A;  1EAF A;  5KJW A;  2VSQ A;  4G0B A;  2FY4 A;  2FY5 A;  1Q23 A;  1XL7 A;  2H4T A;  2E1U A;  4EYW A;  2E1T A;  4JN3 A;  1S5O A;  2H3U A;  1EAC A;  2II4 A;  2H3W A;  1NDF A;  1C4T A;  2FYO A;  1Q9J A;  2E1V A;  2ZBA A;  3MAE A;  3FP0 A;  5KJU A;  1EAE A;  2I9D A;  2XR7 A;  2BGH A;  1SCZ A;  5KJV A;  3B2S A;  1T7N A;  4KEC A;  2IHW A;  5FAL A;  4KE4 A;  5KJT A;  1EAA A;  1T1U A;  2FY2 A;  2RCU A;  5T3E A;  3B30 A;  3CLA A;  4G22 A;  3U9B A;  1XL8 A;  1NOC B;  1T7Q A;  1T7O A;  1EAD A;  3FOT A;  2FY3 A;  1L5A A;  2RKV A;  2JGP A;  2FW3 A;  1E2O A;  1Q6X A;  4G2M A;  2RKT A;  3L60 A;  2CLA A;  2DEB A;  2H3P A;  5KJS A;  1CIA A;  5FAN A;  1NDB A;  4JN5 A;  4N72 A;  1PD5 A;  2II5 A;  1QCA A;  1NDI A;  3U9F A;  1EAB A;  1NM8 A;  4CLA A; 
#chains in the Genus database with same CATH homology
 1S5O A;  5DU9 A;  2H3U A;  2XHG A;  4HVM A;  1T1U A;  2FY2 A;  2H3W A;  2RCU A;  5T3E A;  1NDF A;  2DEB A;  2H3P A;  4EP9 A;  2FYO A;  4EPH A;  5DUA A;  1Q9J A;  2VSQ A;  3FP0 A;  1NDB A;  2FY4 A;  4JN5 A;  1T7Q A;  1T7O A;  2FY5 A;  1NDI A;  2H4T A;  4EYW A;  3FOT A;  2FY3 A;  1L5A A;  1NM8 A;  2JGP A;  2FW3 A;  1T7N A;  4JN3 A;  1Q6X A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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