2FY3A

Structures of ligand bound human choline acetyltransferase provides insight into regulation of acetylcholine synthesis
Total Genus 235
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
235
sequence length
599
structure length
595
Chain Sequence
SEESGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQPLCMKQYYGLFSSYRLPGHTQDTLVAQNSSIMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMTQPELVRSPMVPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLLPP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Choline O-acetyltransferase
total genus 235
structure length 595
sequence length 599
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy3A02
1NDBA 1T7NA 1NDIA 2FY4A 4EPHA 2FY2A 2FY5A 2FW3A 2H4TA 1NM8A 2FY3A 2H3UA 1T7OA 4EP9A 1T7QA 2H3WA 4EYWA 1T1UA 2DEBA 2RCUA 2FYOA 1S5OA 2H3PA 1NDFA 1Q6XA
chains in the Genus database with same CATH superfamily
1CLAA 2RKTA 1EAAA 4EPHA 4N72A 2FY5A 3CLAA 2FW3A 2H4TA 5KJSA 2E1TA 2XR7A 4EP9A 5T3EA 2H3WA 1XL7A 2XHGA 3B30A 2ZBAA 1EADA 1NOCB 4KE4A 4G22A 1DPBA 1DPDA 2E1VA 1T7NA 4G0BA 1E2OA 4KECA 2FY4A 1QCAA 2FY2A 1EAFA 1CIAA 2H3UA 1XMCA 5KJVA 4HVMA 2DEBA 5FALA 2RCUA 1EAEA 2VSQA 1Q23A 4G2MA 2IHWA 1NDBA 5DUAA 3FOTA 1PD5A 2II5A 3B2SA 1Q9JA 4CLAA 1DPCA 1C4TA 5KJWA 1EACA 3FP0A 4JN3A 5KJUA 4EYWA 2I9DA 1T1UA 2E1UA 1S5OA 2II3A 1SCZA 2H3PA 1EABA 1NDIA 4JN5A 3U9FA 1XL8A 2BGHA 5KJTA 5FANA 1NM8A 2FY3A 3L60A 1T7OA 1T7QA 3U9BA 3MAEA 2FYOA 2II4A 2CLAA 1XMDA 1L5AA 1NDFA 1Q6XA 5DU9A 2RKVA 2JGPA
chains in the Genus database with same CATH topology
1NDBA 1T7NA 1NDIA 4JN5A 2FY4A 4EPHA 5DUAA 2FY2A 2FY5A 3FOTA 1Q9JA 2FW3A 2H4TA 1NM8A 2FY3A 2H3UA 1T7OA 3FP0A 4EP9A 4JN3A 1T7QA 5T3EA 2H3WA 4EYWA 4HVMA 1T1UA 2DEBA 2RCUA 2FYOA 2XHGA 1S5OA 2H3PA 1L5AA 1NDFA 1Q6XA 2VSQA 5DU9A 2JGPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1NDB A;  1T7N A;  1NDI A;  2FY4 A;  4EPH A;  2FY2 A;  2FY5 A;  2FW3 A;  2H4T A;  1NM8 A;  2FY3 A;  2H3U A;  1T7O A;  4EP9 A;  1T7Q A;  2H3W A;  4EYW A;  1T1U A;  2DEB A;  2RCU A;  2FYO A;  1S5O A;  2H3P A;  1NDF A;  1Q6X A; 
#chains in the Genus database with same CATH topology
 1CLA A;  2RKT A;  1EAA A;  4EPH A;  4N72 A;  2FY5 A;  3CLA A;  2FW3 A;  2H4T A;  5KJS A;  2E1T A;  2XR7 A;  4EP9 A;  5T3E A;  2H3W A;  1XL7 A;  2XHG A;  3B30 A;  2ZBA A;  1EAD A;  1NOC B;  4KE4 A;  4G22 A;  1DPB A;  1DPD A;  2E1V A;  1T7N A;  4G0B A;  1E2O A;  4KEC A;  2FY4 A;  1QCA A;  2FY2 A;  1EAF A;  1CIA A;  2H3U A;  1XMC A;  5KJV A;  4HVM A;  2DEB A;  5FAL A;  2RCU A;  1EAE A;  2VSQ A;  1Q23 A;  4G2M A;  2IHW A;  1NDB A;  5DUA A;  3FOT A;  1PD5 A;  2II5 A;  3B2S A;  1Q9J A;  4CLA A;  1DPC A;  1C4T A;  5KJW A;  1EAC A;  3FP0 A;  4JN3 A;  5KJU A;  4EYW A;  2I9D A;  1T1U A;  2E1U A;  1S5O A;  2II3 A;  1SCZ A;  2H3P A;  1EAB A;  1NDI A;  4JN5 A;  3U9F A;  1XL8 A;  2BGH A;  5KJT A;  5FAN A;  1NM8 A;  2FY3 A;  3L60 A;  1T7O A;  1T7Q A;  3U9B A;  3MAE A;  2FYO A;  2II4 A;  2CLA A;  1XMD A;  1L5A A;  1NDF A;  1Q6X A;  5DU9 A;  2RKV A;  2JGP A; 
#chains in the Genus database with same CATH homology
 1NDB A;  1T7N A;  1NDI A;  4JN5 A;  2FY4 A;  4EPH A;  5DUA A;  2FY2 A;  2FY5 A;  3FOT A;  1Q9J A;  2FW3 A;  2H4T A;  1NM8 A;  2FY3 A;  2H3U A;  1T7O A;  3FP0 A;  4EP9 A;  4JN3 A;  1T7Q A;  5T3E A;  2H3W A;  4EYW A;  4HVM A;  1T1U A;  2DEB A;  2RCU A;  2FYO A;  2XHG A;  1S5O A;  2H3P A;  1L5A A;  1NDF A;  1Q6X A;  2VSQ A;  5DU9 A;  2JGP A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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