2FY5A

Structures of ligand bound human choline acetyltransferase provide insight into regulation of acetylcholine synthesis
Total Genus 218
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
218
Knots found
sequence length
594
structure length
577
Chain Sequence
SGLPKLPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGLGETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVNSSPAVIFARQHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDCAKGQLSGQPLCMKQYYGLFSSYRLPGHTQDTLVMPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNAAARLPPIGLLTSDGRSEWAEARTVLVKDSTNRDSLDMIERCICLVCLDAPGGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIVLVQCTEHLLKHMPLPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKCSPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAAVPASEKLLLLKDAIRAQTAYTVMAITGMAIDNHLLALRELARAMCAALPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETILFCISSFHSCAATSSSKFAKAVEESLIDMRDLCSLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Substrate binding and catalytic mechanism of human choline acetyltransferase.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Choline O-acetyltransferase
total genus 218
structure length 577
sequence length 594
other databases KnotProt 2.0: Artifct K -31 -31 -
ec nomenclature ec 2.3.1.6: Choline O-acetyltransferase.
pdb deposition date 2006-02-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00755 Carn_acyltransf Choline/Carnitine o-acyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.40 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy5A01
3.30.559.70 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 2fy5A02
2H3WA 2H4TA 4EYWA 2H3UA 1NDBA 1Q6XA 2FY2A 4EPHA 2FY3A 2FY5A 1T7OA 2RCUA 2FY4A 2DEBA 4EP9A 1NDIA 1T7QA 1NDFA 2FYOA 1S5OA 1NM8A 1T1UA 2FW3A 1T7NA 2H3PA
chains in the Genus database with same CATH superfamily
2H3WA 3U9FA 1SCZA 1CLAA 1Q23A 1Q6XA 1XMDA 4G22A 2FY5A 4G2MA 2IHWA 2RCUA 2FY4A 3U9BA 1EABA 1T7QA 2II3A 5DUAA 4JN5A 1DPBA 1NM8A 1T7NA 1PD5A 2E1VA 1EACA 2II4A 1Q9JA 3B2SA 2ZBAA 4KECA 4EYWA 3B30A 1QCAA 2VSQA 3FP0A 1T7OA 4HVMA 1CIAA 5KJUA 1C4TA 2DEBA 1EAFA 2II5A 1NDFA 3L60A 4G0BA 1S5OA 2XHGA 3FOTA 1DPCA 1EADA 2XR7A 2E1TA 2H3PA 2JGPA 5KJSA 4KE4A 5DU9A 5KJWA 2FY2A 5KJTA 1XMCA 1NDIA 1EAEA 5FANA 4N72A 2I9DA 1EAAA 1T1UA 3MAEA 2RKTA 5T3EA 2RKVA 1L5AA 2H4TA 2H3UA 1NDBA 1DPDA 4EPHA 2FY3A 1XL7A 2CLAA 2E1UA 2BGHA 1E2OA 4CLAA 4EP9A 3CLAA 5KJVA 1NOCB 5FALA 2FYOA 2FW3A 1XL8A 4JN3A
chains in the Genus database with same CATH topology
5T3EA 2H3WA 2JGPA 1Q9JA 1L5AA 2H4TA 5DU9A 4EYWA 2H3UA 1NDBA 1Q6XA 2FY2A 4JN3A 4EPHA 2FY3A 2FY5A 2VSQA 3FP0A 1T7OA 4HVMA 2RCUA 2FY4A 2DEBA 4EP9A 1NDIA 1T7QA 1NDFA 5DUAA 4JN5A 2FYOA 1S5OA 2XHGA 3FOTA 1NM8A 1T1UA 2FW3A 1T7NA 2H3PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2H3W A;  2H4T A;  4EYW A;  2H3U A;  1NDB A;  1Q6X A;  2FY2 A;  4EPH A;  2FY3 A;  2FY5 A;  1T7O A;  2RCU A;  2FY4 A;  2DEB A;  4EP9 A;  1NDI A;  1T7Q A;  1NDF A;  2FYO A;  1S5O A;  1NM8 A;  1T1U A;  2FW3 A;  1T7N A;  2H3P A; 
#chains in the Genus database with same CATH topology
 2H3W A;  3U9F A;  1SCZ A;  1CLA A;  1Q23 A;  1Q6X A;  1XMD A;  4G22 A;  2FY5 A;  4G2M A;  2IHW A;  2RCU A;  2FY4 A;  3U9B A;  1EAB A;  1T7Q A;  2II3 A;  5DUA A;  4JN5 A;  1DPB A;  1NM8 A;  1T7N A;  1PD5 A;  2E1V A;  1EAC A;  2II4 A;  1Q9J A;  3B2S A;  2ZBA A;  4KEC A;  4EYW A;  3B30 A;  1QCA A;  2VSQ A;  3FP0 A;  1T7O A;  4HVM A;  1CIA A;  5KJU A;  1C4T A;  2DEB A;  1EAF A;  2II5 A;  1NDF A;  3L60 A;  4G0B A;  1S5O A;  2XHG A;  3FOT A;  1DPC A;  1EAD A;  2XR7 A;  2E1T A;  2H3P A;  2JGP A;  5KJS A;  4KE4 A;  5DU9 A;  5KJW A;  2FY2 A;  5KJT A;  1XMC A;  1NDI A;  1EAE A;  5FAN A;  4N72 A;  2I9D A;  1EAA A;  1T1U A;  3MAE A;  2RKT A;  5T3E A;  2RKV A;  1L5A A;  2H4T A;  2H3U A;  1NDB A;  1DPD A;  4EPH A;  2FY3 A;  1XL7 A;  2CLA A;  2E1U A;  2BGH A;  1E2O A;  4CLA A;  4EP9 A;  3CLA A;  5KJV A;  1NOC B;  5FAL A;  2FYO A;  2FW3 A;  1XL8 A;  4JN3 A; 
#chains in the Genus database with same CATH homology
 5T3E A;  2H3W A;  2JGP A;  1Q9J A;  1L5A A;  2H4T A;  5DU9 A;  4EYW A;  2H3U A;  1NDB A;  1Q6X A;  2FY2 A;  4JN3 A;  4EPH A;  2FY3 A;  2FY5 A;  2VSQ A;  3FP0 A;  1T7O A;  4HVM A;  2RCU A;  2FY4 A;  2DEB A;  4EP9 A;  1NDI A;  1T7Q A;  1NDF A;  5DUA A;  4JN5 A;  2FYO A;  1S5O A;  2XHG A;  3FOT A;  1NM8 A;  1T1U A;  2FW3 A;  1T7N A;  2H3P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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