2II5A

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (e2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (bckdc), isobutyryl-coenzyme a-bound form
Total Genus 65
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
234
structure length
234
Chain Sequence
GKDRTEPVKGFHKAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPIAFARGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQIRSIFEIATELNRLQKLGSAGQLSTNDLIGGTFTLSNIGSIGGTYAKPVILPPEVAIGALGTIKALPRFNEKGEVCKAQIMNVSWSADHRIIDGATVSRFSNLWKSYLENPAFMLLDLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.
pubmed doi rcsb
molecule tags Transferase
source organism Bos taurus
molecule keywords Lipoamide acyltransferase component of branched-chain alpha-
total genus 65
structure length 234
sequence length 234
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 2.3.1.168: Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase.
pdb deposition date 2006-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 2ii5A01
2VSQA 1XL8A 1EAAA 5FALA 5KJWA 1DPBA 2CLAA 2IHWA 3B30A 4JN5A 4KE4A 2BGHA 2E1TA 2JGPA 3B2SA 4G2MA 2E1UA 5DUAA 2RKTA 5DU9A 1SCZA 1XMDA 1EACA 5KJVA 2RKVA 1PD5A 1EAEA 3U9BA 4HVMA 3FOTA 3MAEA 1EABA 2I9DA 1EAFA 3FP0A 4G0BA 3L60A 1C4TA 2II5A 1L5AA 1CIAA 2XHGA 5FANA 3U9FA 1Q9JA 1CLAA 4CLAA 5T3EA 5KJTA 1DPCA 1E2OA 1QCAA 4N72A 4G22A 1XMCA 1DPDA 2II3A 1XL7A 2II4A 1EADA 4KECA 5KJSA 4JN3A 2ZBAA 1Q23A 5KJUA 2XR7A 1NOCB 3CLAA 2E1VA
chains in the Genus database with same CATH superfamily
1XL8A 1EAAA 5KJWA 3B30A 2CLAA 2BGHA 2JGPA 1SCZA 1XMDA 4HVMA 2FY4A 5FANA 4CLAA 4EP9A 1E2OA 4G22A 1XL7A 5KJSA 1Q23A 1NDBA 1NOCB 2E1VA 2FYOA 4G2MA 2E1UA 1T1UA 1EACA 1PD5A 1EAEA 1EABA 2FY5A 1NDFA 2FY3A 3L60A 1C4TA 1NM8A 1CLAA 1DPCA 2FY2A 1DPDA 1T7QA 2II4A 1EADA 4KECA 4EYWA 2RCUA 1T7NA 1DPBA 2IHWA 4JN5A 4KE4A 2E1TA 2H4TA 3FOTA 3MAEA 1EAFA 4G0BA 1L5AA 2II5A 2XHGA 1Q9JA 2DEBA 1Q6XA 2II3A 1T7OA 4JN3A 2ZBAA 5KJUA 2XR7A 2VSQA 5FALA 3B2SA 5DUAA 2RKTA 5DU9A 5KJVA 2RKVA 3U9BA 2I9DA 3FP0A 4EPHA 1CIAA 3U9FA 5KJTA 5T3EA 2FW3A 1QCAA 4N72A 1XMCA 2H3PA 2H3UA 1S5OA 2H3WA 3CLAA 1NDIA
chains in the Genus database with same CATH topology
2VSQA 1XL8A 1EAAA 5FALA 5KJWA 1DPBA 2CLAA 2IHWA 3B30A 4JN5A 4KE4A 2BGHA 2E1TA 2JGPA 3B2SA 4G2MA 2E1UA 5DUAA 2RKTA 5DU9A 1SCZA 1XMDA 1EACA 5KJVA 2RKVA 1PD5A 1EAEA 3U9BA 4HVMA 3FOTA 3MAEA 1EABA 2I9DA 1EAFA 3FP0A 4G0BA 3L60A 1C4TA 2II5A 1L5AA 1CIAA 2XHGA 5FANA 3U9FA 1Q9JA 1CLAA 4CLAA 5T3EA 5KJTA 1DPCA 1E2OA 1QCAA 4N72A 4G22A 1XMCA 1DPDA 2II3A 1XL7A 2II4A 1EADA 4KECA 5KJSA 4JN3A 2ZBAA 1Q23A 5KJUA 2XR7A 1NOCB 3CLAA 2E1VA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2VSQ A;  1XL8 A;  1EAA A;  5FAL A;  5KJW A;  1DPB A;  2CLA A;  2IHW A;  3B30 A;  4JN5 A;  4KE4 A;  2BGH A;  2E1T A;  2JGP A;  3B2S A;  4G2M A;  2E1U A;  5DUA A;  2RKT A;  5DU9 A;  1SCZ A;  1XMD A;  1EAC A;  5KJV A;  2RKV A;  1PD5 A;  1EAE A;  3U9B A;  4HVM A;  3FOT A;  3MAE A;  1EAB A;  2I9D A;  1EAF A;  3FP0 A;  4G0B A;  3L60 A;  1C4T A;  2II5 A;  1L5A A;  1CIA A;  2XHG A;  5FAN A;  3U9F A;  1Q9J A;  1CLA A;  4CLA A;  5T3E A;  5KJT A;  1DPC A;  1E2O A;  1QCA A;  4N72 A;  4G22 A;  1XMC A;  1DPD A;  2II3 A;  1XL7 A;  2II4 A;  1EAD A;  4KEC A;  5KJS A;  4JN3 A;  2ZBA A;  1Q23 A;  5KJU A;  2XR7 A;  1NOC B;  3CLA A;  2E1V A; 
#chains in the Genus database with same CATH topology
 1XL8 A;  1EAA A;  5KJW A;  3B30 A;  2CLA A;  2BGH A;  2JGP A;  1SCZ A;  1XMD A;  4HVM A;  2FY4 A;  5FAN A;  4CLA A;  4EP9 A;  1E2O A;  4G22 A;  1XL7 A;  5KJS A;  1Q23 A;  1NDB A;  1NOC B;  2E1V A;  2FYO A;  4G2M A;  2E1U A;  1T1U A;  1EAC A;  1PD5 A;  1EAE A;  1EAB A;  2FY5 A;  1NDF A;  2FY3 A;  3L60 A;  1C4T A;  1NM8 A;  1CLA A;  1DPC A;  2FY2 A;  1DPD A;  1T7Q A;  2II4 A;  1EAD A;  4KEC A;  4EYW A;  2RCU A;  1T7N A;  1DPB A;  2IHW A;  4JN5 A;  4KE4 A;  2E1T A;  2H4T A;  3FOT A;  3MAE A;  1EAF A;  4G0B A;  1L5A A;  2II5 A;  2XHG A;  1Q9J A;  2DEB A;  1Q6X A;  2II3 A;  1T7O A;  4JN3 A;  2ZBA A;  5KJU A;  2XR7 A;  2VSQ A;  5FAL A;  3B2S A;  5DUA A;  2RKT A;  5DU9 A;  5KJV A;  2RKV A;  3U9B A;  2I9D A;  3FP0 A;  4EPH A;  1CIA A;  3U9F A;  5KJT A;  5T3E A;  2FW3 A;  1QCA A;  4N72 A;  1XMC A;  2H3P A;  2H3U A;  1S5O A;  2H3W A;  3CLA A;  1NDI A; 
#chains in the Genus database with same CATH homology
 2VSQ A;  1XL8 A;  1EAA A;  5FAL A;  5KJW A;  1DPB A;  2CLA A;  2IHW A;  3B30 A;  4JN5 A;  4KE4 A;  2BGH A;  2E1T A;  2JGP A;  3B2S A;  4G2M A;  2E1U A;  5DUA A;  2RKT A;  5DU9 A;  1SCZ A;  1XMD A;  1EAC A;  5KJV A;  2RKV A;  1PD5 A;  1EAE A;  3U9B A;  4HVM A;  3FOT A;  3MAE A;  1EAB A;  2I9D A;  1EAF A;  3FP0 A;  4G0B A;  3L60 A;  1C4T A;  2II5 A;  1L5A A;  1CIA A;  2XHG A;  5FAN A;  3U9F A;  1Q9J A;  1CLA A;  4CLA A;  5T3E A;  5KJT A;  1DPC A;  1E2O A;  1QCA A;  4N72 A;  4G22 A;  1XMC A;  1DPD A;  2II3 A;  1XL7 A;  2II4 A;  1EAD A;  4KEC A;  5KJS A;  4JN3 A;  2ZBA A;  1Q23 A;  5KJU A;  2XR7 A;  1NOC B;  3CLA A;  2E1V A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...