2II5A

Crystal structure of a cubic core of the dihydrolipoamide acyltransferase (e2b) component in the branched-chain alpha-ketoacid dehydrogenase complex (bckdc), isobutyryl-coenzyme a-bound form
Total Genus 65
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
65
sequence length
234
structure length
234
Chain Sequence
GKDRTEPVKGFHKAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPIAFARGIKLSFMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQIRSIFEIATELNRLQKLGSAGQLSTNDLIGGTFTLSNIGSIGGTYAKPVILPPEVAIGALGTIKALPRFNEKGEVCKAQIMNVSWSADHRIIDGATVSRFSNLWKSYLENPAFMLLDLK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.
pubmed doi rcsb
molecule tags Transferase
source organism Bos taurus
molecule keywords Lipoamide acyltransferase component of branched-chain alpha-
total genus 65
structure length 234
sequence length 234
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature ec 2.3.1.168: Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase.
pdb deposition date 2006-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00198 2-oxoacid_dh 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 2ii5A01
5FALA 3U9BA 1XL7A 2I9DA 3U9FA 1SCZA 4JN3A 1XMDA 2II4A 3FOTA 5KJUA 2XR7A 1EABA 2E1TA 2IHWA 1Q9JA 2JGPA 3L60A 5KJWA 4JN5A 4HVMA 1EAFA 2BGHA 2RKVA 1EAAA 1Q23A 1C4TA 4KE4A 2XHGA 1DPBA 3B30A 4CLAA 1DPDA 3B2SA 1EAEA 1CIAA 2RKTA 3FP0A 4G0BA 5T3EA 5KJVA 2II3A 1QCAA 2II5A 2VSQA 1EADA 4G22A 4G2MA 1L5AA 5KJSA 1PD5A 5KJTA 2ZBAA 2E1VA 5FANA 1NOCB 3MAEA 4N72A 1EACA 4KECA 1CLAA 3CLAA 5DU9A 5DUAA 1DPCA 2E1UA 1E2OA 2CLAA 1XL8A 1XMCA
chains in the Genus database with same CATH superfamily
3U9BA 2I9DA 1SCZA 5KJUA 2H3UA 2DEBA 1Q23A 4KE4A 1EAEA 1T7OA 2II3A 1QCAA 4G2MA 2FW3A 5KJTA 5FANA 2E1VA 3MAEA 4EPHA 5DU9A 3CLAA 1NDFA 2E1UA 2H3PA 1T1UA 3U9FA 1T7QA 1XMDA 2II4A 2RKVA 1C4TA 3B30A 3FP0A 5KJSA 2VSQA 2FY4A 2ZBAA 4EP9A 4KECA 1CLAA 1DPCA 4JN5A 2FY3A 1XMCA 2CLAA 5FALA 1NDIA 4JN3A 2XR7A 1NDBA 2JGPA 2IHWA 1Q9JA 5KJWA 4HVMA 1EAAA 1T7NA 2XHGA 4CLAA 5KJVA 1CIAA 2FYOA 4G22A 1EADA 1PD5A 1EACA 5DUAA 1E2OA 1XL8A 2FY5A 1Q6XA 1XL7A 2RCUA 2FY2A 3FOTA 1EABA 2E1TA 3L60A 1EAFA 1DPBA 1DPDA 2H3WA 2RKTA 3B2SA 5T3EA 4G0BA 2II5A 1L5AA 4EYWA 1S5OA 1NOCB 2H4TA 4N72A 1NM8A 2BGHA
chains in the Genus database with same CATH topology
5FALA 3U9BA 1XL7A 2I9DA 3U9FA 1SCZA 4JN3A 1XMDA 2II4A 3FOTA 5KJUA 2XR7A 1EABA 2E1TA 2IHWA 1Q9JA 2JGPA 3L60A 5KJWA 4JN5A 4HVMA 1EAFA 2BGHA 2RKVA 1EAAA 1Q23A 1C4TA 4KE4A 2XHGA 1DPBA 3B30A 4CLAA 1DPDA 3B2SA 1EAEA 1CIAA 2RKTA 3FP0A 4G0BA 5T3EA 5KJVA 2II3A 1QCAA 2II5A 2VSQA 1EADA 4G22A 4G2MA 1L5AA 5KJSA 1PD5A 5KJTA 2ZBAA 2E1VA 5FANA 1NOCB 3MAEA 4N72A 1EACA 4KECA 1CLAA 3CLAA 5DU9A 5DUAA 1DPCA 2E1UA 1E2OA 2CLAA 1XL8A 1XMCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FAL A;  3U9B A;  1XL7 A;  2I9D A;  3U9F A;  1SCZ A;  4JN3 A;  1XMD A;  2II4 A;  3FOT A;  5KJU A;  2XR7 A;  1EAB A;  2E1T A;  2IHW A;  1Q9J A;  2JGP A;  3L60 A;  5KJW A;  4JN5 A;  4HVM A;  1EAF A;  2BGH A;  2RKV A;  1EAA A;  1Q23 A;  1C4T A;  4KE4 A;  2XHG A;  1DPB A;  3B30 A;  4CLA A;  1DPD A;  3B2S A;  1EAE A;  1CIA A;  2RKT A;  3FP0 A;  4G0B A;  5T3E A;  5KJV A;  2II3 A;  1QCA A;  2II5 A;  2VSQ A;  1EAD A;  4G22 A;  4G2M A;  1L5A A;  5KJS A;  1PD5 A;  5KJT A;  2ZBA A;  2E1V A;  5FAN A;  1NOC B;  3MAE A;  4N72 A;  1EAC A;  4KEC A;  1CLA A;  3CLA A;  5DU9 A;  5DUA A;  1DPC A;  2E1U A;  1E2O A;  2CLA A;  1XL8 A;  1XMC A; 
#chains in the Genus database with same CATH topology
 3U9B A;  2I9D A;  1SCZ A;  5KJU A;  2H3U A;  2DEB A;  1Q23 A;  4KE4 A;  1EAE A;  1T7O A;  2II3 A;  1QCA A;  4G2M A;  2FW3 A;  5KJT A;  5FAN A;  2E1V A;  3MAE A;  4EPH A;  5DU9 A;  3CLA A;  1NDF A;  2E1U A;  2H3P A;  1T1U A;  3U9F A;  1T7Q A;  1XMD A;  2II4 A;  2RKV A;  1C4T A;  3B30 A;  3FP0 A;  5KJS A;  2VSQ A;  2FY4 A;  2ZBA A;  4EP9 A;  4KEC A;  1CLA A;  1DPC A;  4JN5 A;  2FY3 A;  1XMC A;  2CLA A;  5FAL A;  1NDI A;  4JN3 A;  2XR7 A;  1NDB A;  2JGP A;  2IHW A;  1Q9J A;  5KJW A;  4HVM A;  1EAA A;  1T7N A;  2XHG A;  4CLA A;  5KJV A;  1CIA A;  2FYO A;  4G22 A;  1EAD A;  1PD5 A;  1EAC A;  5DUA A;  1E2O A;  1XL8 A;  2FY5 A;  1Q6X A;  1XL7 A;  2RCU A;  2FY2 A;  3FOT A;  1EAB A;  2E1T A;  3L60 A;  1EAF A;  1DPB A;  1DPD A;  2H3W A;  2RKT A;  3B2S A;  5T3E A;  4G0B A;  2II5 A;  1L5A A;  4EYW A;  1S5O A;  1NOC B;  2H4T A;  4N72 A;  1NM8 A;  2BGH A; 
#chains in the Genus database with same CATH homology
 5FAL A;  3U9B A;  1XL7 A;  2I9D A;  3U9F A;  1SCZ A;  4JN3 A;  1XMD A;  2II4 A;  3FOT A;  5KJU A;  2XR7 A;  1EAB A;  2E1T A;  2IHW A;  1Q9J A;  2JGP A;  3L60 A;  5KJW A;  4JN5 A;  4HVM A;  1EAF A;  2BGH A;  2RKV A;  1EAA A;  1Q23 A;  1C4T A;  4KE4 A;  2XHG A;  1DPB A;  3B30 A;  4CLA A;  1DPD A;  3B2S A;  1EAE A;  1CIA A;  2RKT A;  3FP0 A;  4G0B A;  5T3E A;  5KJV A;  2II3 A;  1QCA A;  2II5 A;  2VSQ A;  1EAD A;  4G22 A;  4G2M A;  1L5A A;  5KJS A;  1PD5 A;  5KJT A;  2ZBA A;  2E1V A;  5FAN A;  1NOC B;  3MAE A;  4N72 A;  1EAC A;  4KEC A;  1CLA A;  3CLA A;  5DU9 A;  5DUA A;  1DPC A;  2E1U A;  1E2O A;  2CLA A;  1XL8 A;  1XMC A; 
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