3B9JC

Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
Total Genus 247
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
247
sequence length
758
structure length
758
Chain Sequence
DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCKPW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords xanthine oxidase
total genus 247
structure length 758
sequence length 758
chains with identical sequence K
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2007-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC05
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC03
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 3b9jC01
2W55B 3SR6C 1N5XA 4USAA 4C80A 1WYGA 3NS1C 1FFVB 4US9A 2E3TA 1DGJA 1FIQC 3HRDB 1VLBA 1SIJA 1ZXIB 3L4PA 3B9JC 4C7ZA 1N5WB 1N62B 3NVZC 1FFUB 4ZOHA 3AM9A 3EUB4 1SB3A 3NRZC 4C7YA 1RM6A 3AN1A 3AMZA 1V97A 1N61B 3ETRC 3HRDA 1FO4A 3NVVC 2W54B 1N63B 4US8A 3NVYC 2W3RB 2W3SB 1JRPB 3FC4A 1N60B 3NVWC 3FAHA 1VDVA 1JROB
chains in the Genus database with same CATH superfamily
2W55B 1S72H 3SR6C 4KWVA 3C2OA 4C80A 1WYGA 2OTJH 1VQ7H 3HRDB 1FMAE 5HL7J 4IOCJ 1W2BH 4WFBJ 2OMDA 1ZXIB 5MLCO 3G6EH 1Q82J 1YI2H 1YITH 1M1KJ 1YHQH 5GAHN 2QEXH 1VQPH 3CC4H 1YTEA 3PIOJ 2I14A 3CCLH 3CCEH 3CCUH 4GA6A 1FM0E 1KC8J 3CPWH 3AN1A 5HUPA 3G4SH 1QPRA 3CMAH 4EAFA 3CC2H 4UY8M 1KQSH 3CCMH 1Q7YJ 2DSJA 1N63B 1JRPB 3H5QA 5HUOA 1K8AJ 5HULA 1YTDA 1QAPA 1O4UA 3C2VA 3NS1C 1FFVB 1DGJA 1AZYA 3OW2H 2B7QA 5AYXA 3I55H 2JBMA 5JVGJ 4XR5A 2WK5A 1VQ4H 4WF9J 1QVFH 1FFUB 1VQ9H 3CF5J 1OTPA 3CXCH 1JJ2H 4C7YA 3CCSH 1RM6A 2OTLH 3CCJH 2QA4H 1FO4A 5AN9F 1YJ9H 5MPOC 1YTKA 4WCEJ 3I56H 2I1OA 1QPQA 1NVIE 5EP8A 1K73J 3PIPJ 3FC4A 1N60B 1VQNH 4GA5A 4IO9J 1JROB 2TPTA 1NVJA 3BIIE 4GA4A 4USAA 2B7NA 3PAJA 1Y69K 3J7ZM 4KWWA 2QIEA 3CC7H 1VLBA 1SIJA 1UOUA 1Q81J 3VMMA 3L4PA 2J0FA 1YIJH 3NVZC 2ZJQJ 1VQ5H 5AYYA 4YYYA 3DLLJ 3CCVH 3WO0A 4I9AA 3RPFA 1V97A 1N61B 3ETRC 3HRDA 1VQLH 4EADA 5H1SO 4X46A 1YJNH 2W54B 4US8A 3WO1A 3NVYC 2W3RB 1X1OA 1WKIA 5DM6J 3CCRH 1VQMH 4U67J 3G71H 3NVWC 4LHMA 5GADN 4IOAJ 1QPNA 5AYZA 1QVGH 1N5XA 4YEKA 3L0GA 2ZJRJ 1YJWH 4US9A 2E3TA 3C2FA 5GAGN 3CCQH 1FIQC 3C2RA 4AP8A 1T3QB 1BRWA 1QPOA 4WFAJ 3B9JC 4C7ZA 1N5WB 2WP4A 3CD6H 1N62B 4ZOHA 3AM9A 2PA2A 3TQVA 1Q86J 1VQ6H 5GAEN 1KD1J 3EUB4 3CMEH 1SB3A 3NRZC 3GNNA 3C2EA 5JVHJ 1N8RJ 5DM7J 3AMZA 5EY3A 1VQOH 1K9MJ 2WK6A 1VQ8H 1NJIJ 3NVVC 3WNZA 1VQKH 2Q5WE 2B7PA 4WFNJ 2ZJPJ 1M90J 2W3SB 3FAHA 1VDVA
chains in the Genus database with same CATH topology
2W55B 3SR6C 1N5XA 4USAA 4C80A 1WYGA 3NS1C 1FFVB 4US9A 2E3TA 1DGJA 1FIQC 3HRDB 1VLBA 1SIJA 1ZXIB 3L4PA 3B9JC 4C7ZA 1N5WB 1N62B 3NVZC 1FFUB 4ZOHA 3AM9A 3EUB4 1SB3A 3NRZC 4C7YA 1RM6A 3AN1A 3AMZA 1V97A 1N61B 3ETRC 3HRDA 1FO4A 3NVVC 2W54B 1N63B 4US8A 3NVYC 2W3RB 2W3SB 1JRPB 3FC4A 1N60B 3NVWC 3FAHA 1VDVA 1JROB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W55 B;  3SR6 C;  1N5X A;  4USA A;  4C80 A;  1WYG A;  3NS1 C;  1FFV B;  4US9 A;  2E3T A;  1DGJ A;  1FIQ C;  3HRD B;  1VLB A;  1SIJ A;  1ZXI B;  3L4P A;  3B9J C;  4C7Z A;  1N5W B;  1N62 B;  3NVZ C;  1FFU B;  4ZOH A;  3AM9 A;  3EUB 4;  1SB3 A;  3NRZ C;  4C7Y A;  1RM6 A;  3AN1 A;  3AMZ A;  1V97 A;  1N61 B;  3ETR C;  3HRD A;  1FO4 A;  3NVV C;  2W54 B;  1N63 B;  4US8 A;  3NVY C;  2W3R B;  2W3S B;  1JRP B;  3FC4 A;  1N60 B;  3NVW C;  3FAH A;  1VDV A;  1JRO B; 
#chains in the Genus database with same CATH topology
 2W55 B;  1S72 H;  3SR6 C;  4KWV A;  3C2O A;  4C80 A;  1WYG A;  2OTJ H;  1VQ7 H;  3HRD B;  1FMA E;  5HL7 J;  4IOC J;  1W2B H;  4WFB J;  2OMD A;  1ZXI B;  5MLC O;  3G6E H;  1Q82 J;  1YI2 H;  1YIT H;  1M1K J;  1YHQ H;  5GAH N;  2QEX H;  1VQP H;  3CC4 H;  1YTE A;  3PIO J;  2I14 A;  3CCL H;  3CCE H;  3CCU H;  4GA6 A;  1FM0 E;  1KC8 J;  3CPW H;  3AN1 A;  5HUP A;  3G4S H;  1QPR A;  3CMA H;  4EAF A;  3CC2 H;  4UY8 M;  1KQS H;  3CCM H;  1Q7Y J;  2DSJ A;  1N63 B;  1JRP B;  3H5Q A;  5HUO A;  1K8A J;  5HUL A;  1YTD A;  1QAP A;  1O4U A;  3C2V A;  3NS1 C;  1FFV B;  1DGJ A;  1AZY A;  3OW2 H;  2B7Q A;  5AYX A;  3I55 H;  2JBM A;  5JVG J;  4XR5 A;  2WK5 A;  1VQ4 H;  4WF9 J;  1QVF H;  1FFU B;  1VQ9 H;  3CF5 J;  1OTP A;  3CXC H;  1JJ2 H;  4C7Y A;  3CCS H;  1RM6 A;  2OTL H;  3CCJ H;  2QA4 H;  1FO4 A;  5AN9 F;  1YJ9 H;  5MPO C;  1YTK A;  4WCE J;  3I56 H;  2I1O A;  1QPQ A;  1NVI E;  5EP8 A;  1K73 J;  3PIP J;  3FC4 A;  1N60 B;  1VQN H;  4GA5 A;  4IO9 J;  1JRO B;  2TPT A;  1NVJ A;  3BII E;  4GA4 A;  4USA A;  2B7N A;  3PAJ A;  1Y69 K;  3J7Z M;  4KWW A;  2QIE A;  3CC7 H;  1VLB A;  1SIJ A;  1UOU A;  1Q81 J;  3VMM A;  3L4P A;  2J0F A;  1YIJ H;  3NVZ C;  2ZJQ J;  1VQ5 H;  5AYY A;  4YYY A;  3DLL J;  3CCV H;  3WO0 A;  4I9A A;  3RPF A;  1V97 A;  1N61 B;  3ETR C;  3HRD A;  1VQL H;  4EAD A;  5H1S O;  4X46 A;  1YJN H;  2W54 B;  4US8 A;  3WO1 A;  3NVY C;  2W3R B;  1X1O A;  1WKI A;  5DM6 J;  3CCR H;  1VQM H;  4U67 J;  3G71 H;  3NVW C;  4LHM A;  5GAD N;  4IOA J;  1QPN A;  5AYZ A;  1QVG H;  1N5X A;  4YEK A;  3L0G A;  2ZJR J;  1YJW H;  4US9 A;  2E3T A;  3C2F A;  5GAG N;  3CCQ H;  1FIQ C;  3C2R A;  4AP8 A;  1T3Q B;  1BRW A;  1QPO A;  4WFA J;  3B9J C;  4C7Z A;  1N5W B;  2WP4 A;  3CD6 H;  1N62 B;  4ZOH A;  3AM9 A;  2PA2 A;  3TQV A;  1Q86 J;  1VQ6 H;  5GAE N;  1KD1 J;  3EUB 4;  3CME H;  1SB3 A;  3NRZ C;  3GNN A;  3C2E A;  5JVH J;  1N8R J;  5DM7 J;  3AMZ A;  5EY3 A;  1VQO H;  1K9M J;  2WK6 A;  1VQ8 H;  1NJI J;  3NVV C;  3WNZ A;  1VQK H;  2Q5W E;  2B7P A;  4WFN J;  2ZJP J;  1M90 J;  2W3S B;  3FAH A;  1VDV A; 
#chains in the Genus database with same CATH homology
 2W55 B;  3SR6 C;  1N5X A;  4USA A;  4C80 A;  1WYG A;  3NS1 C;  1FFV B;  4US9 A;  2E3T A;  1DGJ A;  1FIQ C;  3HRD B;  1VLB A;  1SIJ A;  1ZXI B;  3L4P A;  3B9J C;  4C7Z A;  1N5W B;  1N62 B;  3NVZ C;  1FFU B;  4ZOH A;  3AM9 A;  3EUB 4;  1SB3 A;  3NRZ C;  4C7Y A;  1RM6 A;  3AN1 A;  3AMZ A;  1V97 A;  1N61 B;  3ETR C;  3HRD A;  1FO4 A;  3NVV C;  2W54 B;  1N63 B;  4US8 A;  3NVY C;  2W3R B;  2W3S B;  1JRP B;  3FC4 A;  1N60 B;  3NVW C;  3FAH A;  1VDV A;  1JRO B; 
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