3B9JC

Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
Total Genus 247
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
247
sequence length
758
structure length
758
Chain Sequence
DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCKPW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate orientation in xanthine oxidase: crystal structure of enzyme in reaction with 2-hydroxy-6-methylpurine.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords xanthine oxidase
total genus 247
structure length 758
sequence length 758
chains with identical sequence K
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2007-11-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC05
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3b9jC03
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 3b9jC01
1JRPB 3EUB4 1SIJA 4ZOHA 1N60B 4US8A 1N63B 1N62B 3AN1A 3FAHA 2E3TA 1RM6A 1DGJA 4C7ZA 3NVYC 3HRDA 1WYGA 2W3RB 3HRDB 1SB3A 2W3SB 3NVWC 1V97A 3AM9A 1FFVB 1JROB 1FO4A 4C80A 2W54B 3B9JC 2W55B 3L4PA 1VLBA 4US9A 1VDVA 3NRZC 4C7YA 1FIQC 1N5XA 1ZXIB 1N61B 3NS1C 3FC4A 3AMZA 3NVVC 3ETRC 3SR6C 4USAA 3NVZC 1N5WB 1FFUB
chains in the Genus database with same CATH superfamily
2B7PA 1SIJA 5AYZA 3CC4H 5JVHJ 1N62B 2QIEA 1OTPA 4YYYA 3H5QA 1QVFH 3FAHA 2I1OA 1VQ7H 1DGJA 2WK5A 2QEXH 1UOUA 1W2BH 3L0GA 1X1OA 1VQOH 4WFAJ 2TPTA 3J7ZM 5HL7J 1Q7YJ 1O4UA 1YITH 3AM9A 1YJ9H 1FFVB 1NVJA 3C2EA 1VLBA 2WP4A 3DLLJ 4C7YA 4LHMA 3I55H 1NVIE 3AMZA 3C2VA 3SR6C 4WFBJ 3WO0A 5GAHN 3CC2H 3CCLH 1FFUB 3CCUH 3EUB4 4ZOHA 2JBMA 1Q86J 1N60B 3C2OA 3VMMA 2OTJH 3CPWH 5JVGJ 3PIOJ 2DSJA 3RPFA 4EAFA 2OTLH 3CD6H 1VQKH 3WO1A 2W3RB 3G4SH 1S72H 1QVGH 1YI2H 2QA4H 4GA5A 1M90J 5H1SO 1KC8J 5EY3A 1V97A 2ZJQJ 3CXCH 1KQSH 3G6EH 1QPRA 3CF5J 4KWWA 3B9JC 5GAGN 2W55B 3L4PA 4U67J 3NRZC 5AYXA 1N8RJ 3WNZA 4IOAJ 1ZXIB 1VQ6H 5GAEN 3FC4A 3CMAH 3ETRC 1QPNA 4AP8A 4IO9J 3NVZC 1N5WB 3C2FA 1JJ2H 1JRPB 1VQ9H 5DM7J 1QAPA 4US8A 3PAJA 1Q82J 1M1KJ 3PIPJ 1NJIJ 2WK6A 5GADN 1VQ5H 1KD1J 2E3TA 1AZYA 3NVYC 1WYGA 3HRDB 3CCEH 1T3QB 2B7QA 1VQLH 2W3SB 3NVWC 4IOCJ 3TQVA 3CCSH 1YHQH 5AN9F 2J0FA 2ZJRJ 1YTDA 1YIJH 4US9A 1VDVA 3CCJH 4GA6A 1N5XA 1VQNH 1Q81J 5EP8A 3NS1C 4XR5A 1VQMH 3GNNA 1K73J 4GA4A 5MPOC 1FMAE 1QPOA 3I56H 1N63B 3CCVH 1VQPH 1YTEA 3AN1A 1VQ4H 4C7ZA 1RM6A 1BRWA 2ZJPJ 3HRDA 3G71H 1VQ8H 5HUPA 5DM6J 2I14A 3CC7H 4EADA 1SB3A 3BIIE 4WFNJ 3CMEH 4KWVA 2PA2A 4YEKA 2B7NA 3CCRH 1Y69K 5MLCO 4UY8M 1JROB 1YJNH 1QPQA 1FO4A 3CCMH 3CCQH 4C80A 1K9MJ 2W54B 1K8AJ 2Q5WE 5HULA 2OMDA 5HUOA 4WCEJ 1YJWH 1FIQC 4WF9J 1WKIA 4X46A 1YTKA 1N61B 5AYYA 3C2RA 3NVVC 4USAA 1FM0E 4I9AA 3OW2H
chains in the Genus database with same CATH topology
1JRPB 3EUB4 1SIJA 4ZOHA 1N60B 4US8A 1N63B 1N62B 3AN1A 3FAHA 2E3TA 1RM6A 1DGJA 4C7ZA 3NVYC 3HRDA 1WYGA 2W3RB 3HRDB 1SB3A 2W3SB 3NVWC 1V97A 3AM9A 1FFVB 1JROB 1FO4A 4C80A 2W54B 3B9JC 2W55B 3L4PA 1VLBA 4US9A 1VDVA 3NRZC 4C7YA 1FIQC 1N5XA 1ZXIB 1N61B 3NS1C 3FC4A 3AMZA 3NVVC 3ETRC 3SR6C 4USAA 3NVZC 1N5WB 1FFUB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JRP B;  3EUB 4;  1SIJ A;  4ZOH A;  1N60 B;  4US8 A;  1N63 B;  1N62 B;  3AN1 A;  3FAH A;  2E3T A;  1RM6 A;  1DGJ A;  4C7Z A;  3NVY C;  3HRD A;  1WYG A;  2W3R B;  3HRD B;  1SB3 A;  2W3S B;  3NVW C;  1V97 A;  3AM9 A;  1FFV B;  1JRO B;  1FO4 A;  4C80 A;  2W54 B;  3B9J C;  2W55 B;  3L4P A;  1VLB A;  4US9 A;  1VDV A;  3NRZ C;  4C7Y A;  1FIQ C;  1N5X A;  1ZXI B;  1N61 B;  3NS1 C;  3FC4 A;  3AMZ A;  3NVV C;  3ETR C;  3SR6 C;  4USA A;  3NVZ C;  1N5W B;  1FFU B; 
#chains in the Genus database with same CATH topology
 2B7P A;  1SIJ A;  5AYZ A;  3CC4 H;  5JVH J;  1N62 B;  2QIE A;  1OTP A;  4YYY A;  3H5Q A;  1QVF H;  3FAH A;  2I1O A;  1VQ7 H;  1DGJ A;  2WK5 A;  2QEX H;  1UOU A;  1W2B H;  3L0G A;  1X1O A;  1VQO H;  4WFA J;  2TPT A;  3J7Z M;  5HL7 J;  1Q7Y J;  1O4U A;  1YIT H;  3AM9 A;  1YJ9 H;  1FFV B;  1NVJ A;  3C2E A;  1VLB A;  2WP4 A;  3DLL J;  4C7Y A;  4LHM A;  3I55 H;  1NVI E;  3AMZ A;  3C2V A;  3SR6 C;  4WFB J;  3WO0 A;  5GAH N;  3CC2 H;  3CCL H;  1FFU B;  3CCU H;  3EUB 4;  4ZOH A;  2JBM A;  1Q86 J;  1N60 B;  3C2O A;  3VMM A;  2OTJ H;  3CPW H;  5JVG J;  3PIO J;  2DSJ A;  3RPF A;  4EAF A;  2OTL H;  3CD6 H;  1VQK H;  3WO1 A;  2W3R B;  3G4S H;  1S72 H;  1QVG H;  1YI2 H;  2QA4 H;  4GA5 A;  1M90 J;  5H1S O;  1KC8 J;  5EY3 A;  1V97 A;  2ZJQ J;  3CXC H;  1KQS H;  3G6E H;  1QPR A;  3CF5 J;  4KWW A;  3B9J C;  5GAG N;  2W55 B;  3L4P A;  4U67 J;  3NRZ C;  5AYX A;  1N8R J;  3WNZ A;  4IOA J;  1ZXI B;  1VQ6 H;  5GAE N;  3FC4 A;  3CMA H;  3ETR C;  1QPN A;  4AP8 A;  4IO9 J;  3NVZ C;  1N5W B;  3C2F A;  1JJ2 H;  1JRP B;  1VQ9 H;  5DM7 J;  1QAP A;  4US8 A;  3PAJ A;  1Q82 J;  1M1K J;  3PIP J;  1NJI J;  2WK6 A;  5GAD N;  1VQ5 H;  1KD1 J;  2E3T A;  1AZY A;  3NVY C;  1WYG A;  3HRD B;  3CCE H;  1T3Q B;  2B7Q A;  1VQL H;  2W3S B;  3NVW C;  4IOC J;  3TQV A;  3CCS H;  1YHQ H;  5AN9 F;  2J0F A;  2ZJR J;  1YTD A;  1YIJ H;  4US9 A;  1VDV A;  3CCJ H;  4GA6 A;  1N5X A;  1VQN H;  1Q81 J;  5EP8 A;  3NS1 C;  4XR5 A;  1VQM H;  3GNN A;  1K73 J;  4GA4 A;  5MPO C;  1FMA E;  1QPO A;  3I56 H;  1N63 B;  3CCV H;  1VQP H;  1YTE A;  3AN1 A;  1VQ4 H;  4C7Z A;  1RM6 A;  1BRW A;  2ZJP J;  3HRD A;  3G71 H;  1VQ8 H;  5HUP A;  5DM6 J;  2I14 A;  3CC7 H;  4EAD A;  1SB3 A;  3BII E;  4WFN J;  3CME H;  4KWV A;  2PA2 A;  4YEK A;  2B7N A;  3CCR H;  1Y69 K;  5MLC O;  4UY8 M;  1JRO B;  1YJN H;  1QPQ A;  1FO4 A;  3CCM H;  3CCQ H;  4C80 A;  1K9M J;  2W54 B;  1K8A J;  2Q5W E;  5HUL A;  2OMD A;  5HUO A;  4WCE J;  1YJW H;  1FIQ C;  4WF9 J;  1WKI A;  4X46 A;  1YTK A;  1N61 B;  5AYY A;  3C2R A;  3NVV C;  4USA A;  1FM0 E;  4I9A A;  3OW2 H; 
#chains in the Genus database with same CATH homology
 1JRP B;  3EUB 4;  1SIJ A;  4ZOH A;  1N60 B;  4US8 A;  1N63 B;  1N62 B;  3AN1 A;  3FAH A;  2E3T A;  1RM6 A;  1DGJ A;  4C7Z A;  3NVY C;  3HRD A;  1WYG A;  2W3R B;  3HRD B;  1SB3 A;  2W3S B;  3NVW C;  1V97 A;  3AM9 A;  1FFV B;  1JRO B;  1FO4 A;  4C80 A;  2W54 B;  3B9J C;  2W55 B;  3L4P A;  1VLB A;  4US9 A;  1VDV A;  3NRZ C;  4C7Y A;  1FIQ C;  1N5X A;  1ZXI B;  1N61 B;  3NS1 C;  3FC4 A;  3AMZ A;  3NVV C;  3ETR C;  3SR6 C;  4USA A;  3NVZ C;  1N5W B;  1FFU B; 
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similar chains in the pdb database (?% sequence similarity)

 
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