3DH3A

Crystal structure of rluf in complex with a 22 nucleotide rna substrate
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
240
structure length
240
Chain Sequence
DSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITEEFIRGMSAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
pubmed doi rcsb
molecule tags Isomerase/rna
source organism Escherichia coli
molecule keywords Ribosomal large subunit pseudouridine synthase F
total genus 60
structure length 240
sequence length 240
chains with identical sequence B, C, D
ec nomenclature ec 5.4.99.21: 23S rRNA pseudouridine(2604) synthase.
pdb deposition date 2008-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00849 PseudoU_synth_2 RNA pseudouridylate synthase
A PF01479 S4 S4 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.290.10 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A RNA-binding S4 domain 3dh3A01
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 3dh3A02
1J5ED 5LMUD 2VQED 1V9KA 1FKAD 4LFBD 4LF7D 1ZE1A 2ISTA 2ZM6D 4DV3D 1HNZD 1V9FA 4DR6D 4LF5D 1KSVA 2E5LD 2UUCD 4B3MD 3T1HD 4JI5D 4DV4D 2UUAD 4DUZD 5BR8D 1XNRD 1N34D 1DM9A 4DV2D 3UAIA 2HHHD 4GKKD 2UXDD 4JI3D 1N33D 4B3SD 4DR7D 4JI8D 3LWRA 4X64D 3HP7A 3LWQA 2JANA 4JI0D 1XMOD 1IBMD 4LF6D 2APOA 4OUDA 4LGTA 4DUYD 4NXMD 2EY4A 4YY3D 4KHPD 3DH3A 1IBLD 1N36D 3HJYA 3LWVA 4LABA 1C06A 1HR0D 4X66D 1ZL3A 2HVYA 4DR2D 3LWOA 4LFCD 4LF9D 4DR4D 4GKJD 1R3EA 2UXCD 1H3EA 1FJGD 2UUBD 4LFAD 1VIOA 4X65D 4JI6D 1P9KA 2UU9D 4DV6D 4YHHD 1H3FA 1N32D 3HJWA 2RFKA 4OX9D 2VQFD 1R3FA 1PRZA 3KBGA 4JI7D 3MQKA 4DV0D 1XMQD 1HNWD 4NXND 1IBKD 3OTOD 4JI1D 5IWAD 4DR5D 2I82A 2UXBD 4AQYD 1KSKA 1ZE2A 1JH3A 4JI4D 4JV5D 2AB4A 4LF4D 1SGVA 1QYUA 3T1YD 1KSLA 4DR3D 4JI2D 1XNQD 4JYAD 4X62D 4B3RD 5LMND 2AUSA 4B3TD 2F4VD 4DV7D 3HAXA 4DR1D 3LWPA 4K0KD 2KTLA 1XPIA 3U28A 1K8WA 1HNXD 4LF8D 1C05A 2K6PA 4DV5D 1I94D 4DV1D
chains in the Genus database with same CATH superfamily
1J5ED 5LMUD 2VQED 1V9KA 1FKAD 4LFBD 4LF7D 1ZE1A 3J81E 2ISTA 2ZM6D 4DV3D 1HNZD 1V9FA 4DR6D 4II2A 4LF5D 1KSVA 2E5LD 2UUCD 1Z2ZA 4B3MD 3T1HD 4JI5D 4DV4D 5FQ2B 2UUAD 4DUZD 3J7AF 5BR8D 1XNRD 1N34D 1DM9A 1Y8XB 4DV2D 3UAIA 2HHHD 4GKKD 2UXDD 5A2QE 4JI3D 1N33D 1SB7A 2NVUB 4B3SD 4DR7D 4JI8D 3LWRA 4X64D 3HP7A 3LWQA 2JANA 4JI0D 1XMOD 1IBMD 4LF6D 2LQ7A 2APOA 4OUDA 4LGTA 5LL6S 5IT9E 4DUYD 1Y8RB 4NXMD 2EY4A 4YY3D 4KHPD 3DH3A 1IBLD 1N36D 3HJYA 3LWVA 5FLXE 4LABA 1C06A 3JAME 1HR0D 4X66D 1ZL3A 2HVYA 4DR2D 3LWOA 4LFCD 4LF9D 4DR4D 4GKJD 2I1SA 1Y8QB 1R3EA 2UXCD 1H3EA 1FJGD 2UUBD 4LFAD 3CMMA 1VIOA 4X65D 4JI6D 1P9KA 3ONHA 4NNJA 4DV6D 2UU9D 4YHHD 1H3FA 1SZWA 1N32D 3HJWA 2RFKA 4OX9D 2VQFD 1R3FA 1PRZA 3KBGA 4JI7D 3MQKA 4DV0D 1XMQD 5KNLA 1HNWD 4NXND 1IBKD 3OTOD 4JI1D 3FN1A 5IWAD 4DR5D 4W5VB 2I82A 2UXBD 4AQYD 1KSKA 1ZE2A 1JH3A 3J80E 4JI4D 4JV5D 2AB4A 4LF4D 1SI7A 1SGVA 1QYUA 3T1YD 3KYDB 1KSLA 4DR3D 4JI2D 1XNQD 4JYAD 4X62D 4B3RD 5LMND 3ONGA 2AUSA 4B3TD 2F4VD 4DV7D 3HAXA 4DR1D 3LWPA 4K0KD 2KTLA 1XPIA 3KYCB 3U28A 4II3A 2ZTBA 1K8WA 1HNXD 4LF8D 1C05A 2K6PA 4DV5D 1I94D 4DV1D
chains in the Genus database with same CATH topology
1J5ED 5LMUD 2VQED 1V9KA 1FKAD 4LFBD 4LF7D 1ZE1A 2ISTA 2ZM6D 4DV3D 1HNZD 1V9FA 4DR6D 4LF5D 1KSVA 2E5LD 2UUCD 1Z2ZA 4B3MD 3T1HD 4JI5D 4DV4D 2UUAD 4DUZD 5BR8D 1XNRD 1N34D 1DM9A 4DV2D 3UAIA 2HHHD 4GKKD 2UXDD 4JI3D 1N33D 1SB7A 4B3SD 4DR7D 4JI8D 3LWRA 4X64D 3HP7A 3LWQA 2JANA 4JI0D 1XMOD 1IBMD 4LF6D 2APOA 4OUDA 4LGTA 4DUYD 4NXMD 2EY4A 4YY3D 4KHPD 3DH3A 1IBLD 1N36D 3HJYA 3LWVA 4LABA 1C06A 1HR0D 4X66D 1ZL3A 2HVYA 4DR2D 3LWOA 4LFCD 4LF9D 4DR4D 4GKJD 1R3EA 2UXCD 1H3EA 1FJGD 2UUBD 4LFAD 1VIOA 4X65D 4JI6D 1P9KA 2UU9D 4DV6D 4YHHD 1H3FA 1SZWA 1N32D 3HJWA 2RFKA 4OX9D 2VQFD 1R3FA 1PRZA 3KBGA 4JI7D 3MQKA 4DV0D 1XMQD 1HNWD 4NXND 1IBKD 3OTOD 4JI1D 5IWAD 4DR5D 2I82A 2UXBD 4AQYD 1KSKA 1ZE2A 1JH3A 4JI4D 4JV5D 2AB4A 4LF4D 1SI7A 1SGVA 1QYUA 3T1YD 1KSLA 4DR3D 4JI2D 1XNQD 4JYAD 4X62D 4B3RD 5LMND 2AUSA 4B3TD 2F4VD 4DV7D 3HAXA 4DR1D 3LWPA 4K0KD 2KTLA 1XPIA 3U28A 1K8WA 1HNXD 4LF8D 1C05A 2K6PA 4DV5D 1I94D 4DV1D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1J5E D;  5LMU D;  2VQE D;  1V9K A;  1FKA D;  4LFB D;  4LF7 D;  1ZE1 A;  2IST A;  2ZM6 D;  4DV3 D;  1HNZ D;  1V9F A;  4DR6 D;  4LF5 D;  1KSV A;  2E5L D;  2UUC D;  4B3M D;  3T1H D;  4JI5 D;  4DV4 D;  2UUA D;  4DUZ D;  5BR8 D;  1XNR D;  1N34 D;  1DM9 A;  4DV2 D;  3UAI A;  2HHH D;  4GKK D;  2UXD D;  4JI3 D;  1N33 D;  4B3S D;  4DR7 D;  4JI8 D;  3LWR A;  4X64 D;  3HP7 A;  3LWQ A;  2JAN A;  4JI0 D;  1XMO D;  1IBM D;  4LF6 D;  2APO A;  4OUD A;  4LGT A;  4DUY D;  4NXM D;  2EY4 A;  4YY3 D;  4KHP D;  3DH3 A;  1IBL D;  1N36 D;  3HJY A;  3LWV A;  4LAB A;  1C06 A;  1HR0 D;  4X66 D;  1ZL3 A;  2HVY A;  4DR2 D;  3LWO A;  4LFC D;  4LF9 D;  4DR4 D;  4GKJ D;  1R3E A;  2UXC D;  1H3E A;  1FJG D;  2UUB D;  4LFA D;  1VIO A;  4X65 D;  4JI6 D;  1P9K A;  2UU9 D;  4DV6 D;  4YHH D;  1H3F A;  1N32 D;  3HJW A;  2RFK A;  4OX9 D;  2VQF D;  1R3F A;  1PRZ A;  3KBG A;  4JI7 D;  3MQK A;  4DV0 D;  1XMQ D;  1HNW D;  4NXN D;  1IBK D;  3OTO D;  4JI1 D;  5IWA D;  4DR5 D;  2I82 A;  2UXB D;  4AQY D;  1KSK A;  1ZE2 A;  1JH3 A;  4JI4 D;  4JV5 D;  2AB4 A;  4LF4 D;  1SGV A;  1QYU A;  3T1Y D;  1KSL A;  4DR3 D;  4JI2 D;  1XNQ D;  4JYA D;  4X62 D;  4B3R D;  5LMN D;  2AUS A;  4B3T D;  2F4V D;  4DV7 D;  3HAX A;  4DR1 D;  3LWP A;  4K0K D;  2KTL A;  1XPI A;  3U28 A;  1K8W A;  1HNX D;  4LF8 D;  1C05 A;  2K6P A;  4DV5 D;  1I94 D;  4DV1 D; 
#chains in the Genus database with same CATH topology
 1J5E D;  5LMU D;  2VQE D;  1V9K A;  1FKA D;  4LFB D;  4LF7 D;  1ZE1 A;  3J81 E;  2IST A;  2ZM6 D;  4DV3 D;  1HNZ D;  1V9F A;  4DR6 D;  4II2 A;  4LF5 D;  1KSV A;  2E5L D;  2UUC D;  1Z2Z A;  4B3M D;  3T1H D;  4JI5 D;  4DV4 D;  5FQ2 B;  2UUA D;  4DUZ D;  3J7A F;  5BR8 D;  1XNR D;  1N34 D;  1DM9 A;  1Y8X B;  4DV2 D;  3UAI A;  2HHH D;  4GKK D;  2UXD D;  5A2Q E;  4JI3 D;  1N33 D;  1SB7 A;  2NVU B;  4B3S D;  4DR7 D;  4JI8 D;  3LWR A;  4X64 D;  3HP7 A;  3LWQ A;  2JAN A;  4JI0 D;  1XMO D;  1IBM D;  4LF6 D;  2LQ7 A;  2APO A;  4OUD A;  4LGT A;  5LL6 S;  5IT9 E;  4DUY D;  1Y8R B;  4NXM D;  2EY4 A;  4YY3 D;  4KHP D;  3DH3 A;  1IBL D;  1N36 D;  3HJY A;  3LWV A;  5FLX E;  4LAB A;  1C06 A;  3JAM E;  1HR0 D;  4X66 D;  1ZL3 A;  2HVY A;  4DR2 D;  3LWO A;  4LFC D;  4LF9 D;  4DR4 D;  4GKJ D;  2I1S A;  1Y8Q B;  1R3E A;  2UXC D;  1H3E A;  1FJG D;  2UUB D;  4LFA D;  3CMM A;  1VIO A;  4X65 D;  4JI6 D;  1P9K A;  3ONH A;  4NNJ A;  4DV6 D;  2UU9 D;  4YHH D;  1H3F A;  1SZW A;  1N32 D;  3HJW A;  2RFK A;  4OX9 D;  2VQF D;  1R3F A;  1PRZ A;  3KBG A;  4JI7 D;  3MQK A;  4DV0 D;  1XMQ D;  5KNL A;  1HNW D;  4NXN D;  1IBK D;  3OTO D;  4JI1 D;  3FN1 A;  5IWA D;  4DR5 D;  4W5V B;  2I82 A;  2UXB D;  4AQY D;  1KSK A;  1ZE2 A;  1JH3 A;  3J80 E;  4JI4 D;  4JV5 D;  2AB4 A;  4LF4 D;  1SI7 A;  1SGV A;  1QYU A;  3T1Y D;  3KYD B;  1KSL A;  4DR3 D;  4JI2 D;  1XNQ D;  4JYA D;  4X62 D;  4B3R D;  5LMN D;  3ONG A;  2AUS A;  4B3T D;  2F4V D;  4DV7 D;  3HAX A;  4DR1 D;  3LWP A;  4K0K D;  2KTL A;  1XPI A;  3KYC B;  3U28 A;  4II3 A;  2ZTB A;  1K8W A;  1HNX D;  4LF8 D;  1C05 A;  2K6P A;  4DV5 D;  1I94 D;  4DV1 D; 
#chains in the Genus database with same CATH homology
 1J5E D;  5LMU D;  2VQE D;  1V9K A;  1FKA D;  4LFB D;  4LF7 D;  1ZE1 A;  2IST A;  2ZM6 D;  4DV3 D;  1HNZ D;  1V9F A;  4DR6 D;  4LF5 D;  1KSV A;  2E5L D;  2UUC D;  1Z2Z A;  4B3M D;  3T1H D;  4JI5 D;  4DV4 D;  2UUA D;  4DUZ D;  5BR8 D;  1XNR D;  1N34 D;  1DM9 A;  4DV2 D;  3UAI A;  2HHH D;  4GKK D;  2UXD D;  4JI3 D;  1N33 D;  1SB7 A;  4B3S D;  4DR7 D;  4JI8 D;  3LWR A;  4X64 D;  3HP7 A;  3LWQ A;  2JAN A;  4JI0 D;  1XMO D;  1IBM D;  4LF6 D;  2APO A;  4OUD A;  4LGT A;  4DUY D;  4NXM D;  2EY4 A;  4YY3 D;  4KHP D;  3DH3 A;  1IBL D;  1N36 D;  3HJY A;  3LWV A;  4LAB A;  1C06 A;  1HR0 D;  4X66 D;  1ZL3 A;  2HVY A;  4DR2 D;  3LWO A;  4LFC D;  4LF9 D;  4DR4 D;  4GKJ D;  1R3E A;  2UXC D;  1H3E A;  1FJG D;  2UUB D;  4LFA D;  1VIO A;  4X65 D;  4JI6 D;  1P9K A;  2UU9 D;  4DV6 D;  4YHH D;  1H3F A;  1SZW A;  1N32 D;  3HJW A;  2RFK A;  4OX9 D;  2VQF D;  1R3F A;  1PRZ A;  3KBG A;  4JI7 D;  3MQK A;  4DV0 D;  1XMQ D;  1HNW D;  4NXN D;  1IBK D;  3OTO D;  4JI1 D;  5IWA D;  4DR5 D;  2I82 A;  2UXB D;  4AQY D;  1KSK A;  1ZE2 A;  1JH3 A;  4JI4 D;  4JV5 D;  2AB4 A;  4LF4 D;  1SI7 A;  1SGV A;  1QYU A;  3T1Y D;  1KSL A;  4DR3 D;  4JI2 D;  1XNQ D;  4JYA D;  4X62 D;  4B3R D;  5LMN D;  2AUS A;  4B3T D;  2F4V D;  4DV7 D;  3HAX A;  4DR1 D;  3LWP A;  4K0K D;  2KTL A;  1XPI A;  3U28 A;  1K8W A;  1HNX D;  4LF8 D;  1C05 A;  2K6P A;  4DV5 D;  1I94 D;  4DV1 D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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