3DH3A

Crystal structure of rluf in complex with a 22 nucleotide rna substrate
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
240
structure length
240
Chain Sequence
DSSVRLNKYISESGICSRREADRYIEQGNVFLNGKRATIGDQVKPGDVVKVNGQLIEPREAEDLVLIALNKPVGIVSTTEDGERDNIVDFVNHSKRVFPIGRLDKDSQGLIFLTNHGDLVNKILRAGNDHEKEYLVTVDKPITEEFIRGMSAGVPILGTVTKKCKVKKEAPFVFRITLVQGLNRQIRRMCEHFGYEVKKLERTRIMNVSLSGIPLGEWRDLTDDELIDLFKLIENSSSEV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome.
pubmed doi rcsb
molecule tags Isomerase/rna
source organism Escherichia coli
molecule keywords Ribosomal large subunit pseudouridine synthase F
total genus 60
structure length 240
sequence length 240
chains with identical sequence B, C, D
ec nomenclature ec 5.4.99.21: 23S rRNA pseudouridine(2604) synthase.
pdb deposition date 2008-06-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00849 PseudoU_synth_2 RNA pseudouridylate synthase
A PF01479 S4 S4 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.290.10 Alpha Beta Roll Structural Genomics Hypothetical 15.5 Kd Protein In mrcA-pckA Intergenic Region; Chain A RNA-binding S4 domain 3dh3A01
3.30.2350.10 Alpha Beta 2-Layer Sandwich Pseudouridine synthase Pseudouridine synthase 3dh3A02
5LMND 1C06A 1KSKA 4DV5D 4X66D 4X64D 4JI6D 2JANA 1ZE2A 4DV0D 2AUSA 4JI7D 1R3EA 5LMUD 4DUZD 1N34D 3LWRA 2UXCD 4DV1D 1ZL3A 1HNWD 4JV5D 4LFBD 2EY4A 4GKKD 4LFCD 3LWQA 4DR4D 1P9KA 1J5ED 2APOA 4X65D 3HJWA 2UUCD 4NXND 1HR0D 1R3FA 3HJYA 1QYUA 5BR8D 1XPIA 4JI2D 4KHPD 3HP7A 4JI3D 4JI0D 4K0KD 1HNXD 4DR2D 3U28A 2HHHD 3LWOA 4LF7D 4YY3D 1N33D 1ZE1A 1XMOD 4LF9D 2K6PA 1IBKD 4GKJD 1XNRD 4DR3D 4NXMD 1DM9A 3T1YD 5IWAD 4DR6D 3OTOD 4DV6D 4OX9D 2RFKA 4DV3D 3UAIA 3HAXA 3MQKA 1XMQD 4LFAD 4YHHD 4JI1D 3T1HD 4B3SD 4B3TD 4OUDA 1IBMD 1V9KA 2F4VD 4DV4D 4DR5D 1PRZA 1IBLD 4LF6D 1V9FA 1FJGD 1SGVA 4DV2D 2HVYA 4X62D 1K8WA 2UUAD 4LF5D 2UUBD 4DR7D 2ZM6D 4JI4D 4LF8D 3DH3A 1KSVA 2ISTA 1JH3A 1XNQD 1VIOA 1HNZD 4JI5D 3KBGA 4B3RD 1N36D 2UXBD 4B3MD 2AB4A 1FKAD 1H3EA 1C05A 2E5LD 4JI8D 2VQFD 4DV7D 3LWVA 2VQED 4AQYD 4LGTA 2I82A 4LABA 2KTLA 4DR1D 3LWPA 4JYAD 1KSLA 2UU9D 1N32D 2UXDD 1H3FA 4DUYD 1I94D 4LF4D
chains in the Genus database with same CATH superfamily
5LMND 3ONGA 1KSKA 4DV5D 1C06A 4X66D 3FN1A 2I1SA 4X64D 4JI6D 2JANA 4NNJA 1ZE2A 4DV0D 2AUSA 4JI7D 1R3EA 5LMUD 4DUZD 1SZWA 1N34D 3ONHA 3LWRA 2UXCD 3KYCB 1Y8XB 2ZTBA 4DV1D 1HNWD 1ZL3A 4JV5D 4LFBD 4W5VB 2EY4A 4GKKD 4LFCD 3LWQA 4DR4D 1P9KA 1J5ED 2APOA 4X65D 4II2A 5A2QE 3HJWA 1Y8QB 2UUCD 4NXND 1HR0D 1R3FA 3HJYA 1QYUA 5BR8D 1XPIA 4JI2D 4KHPD 3HP7A 4JI3D 4JI0D 4K0KD 1HNXD 4DR2D 3KYDB 3U28A 2HHHD 3LWOA 3J80E 4LF7D 4YY3D 1N33D 1ZE1A 1XMOD 4LF9D 2K6PA 1IBKD 4GKJD 1XNRD 3J7AF 4DR3D 4NXMD 1DM9A 3T1YD 5IWAD 5FLXE 4DR6D 3OTOD 4DV6D 4OX9D 2RFKA 4DV3D 3UAIA 3HAXA 3MQKA 1XMQD 1SB7A 5LL6S 4LFAD 4II3A 4YHHD 4JI1D 3T1HD 4B3SD 4B3TD 4OUDA 3CMMA 1IBMD 1V9KA 3J81E 2F4VD 4DV4D 4DR5D 1PRZA 1IBLD 4LF6D 5FQ2B 5KNLA 1V9FA 5IT9E 2LQ7A 1FJGD 1SGVA 4DV2D 2NVUB 4X62D 2HVYA 1K8WA 2UUAD 4LF5D 2UUBD 4DR7D 2ZM6D 4JI4D 4LF8D 1SI7A 3DH3A 3JAME 1KSVA 2ISTA 1JH3A 1XNQD 1VIOA 1HNZD 4JI5D 3KBGA 4B3RD 1N36D 2UXBD 4B3MD 2AB4A 1FKAD 1H3EA 1C05A 2E5LD 4JI8D 2VQFD 4DV7D 3LWVA 2VQED 4AQYD 4LGTA 2I82A 4LABA 2KTLA 4DR1D 1Z2ZA 3LWPA 4JYAD 1KSLA 2UU9D 1N32D 2UXDD 1Y8RB 1H3FA 4DUYD 1I94D 4LF4D
chains in the Genus database with same CATH topology
5LMND 1C06A 1KSKA 4DV5D 4X66D 4X64D 4JI6D 2JANA 1ZE2A 4DV0D 2AUSA 4JI7D 1R3EA 5LMUD 4DUZD 1SZWA 1N34D 3LWRA 2UXCD 4DV1D 1ZL3A 1HNWD 4JV5D 4LFBD 2EY4A 4GKKD 4LFCD 3LWQA 4DR4D 1P9KA 1J5ED 2APOA 4X65D 3HJWA 2UUCD 4NXND 1HR0D 1R3FA 3HJYA 1QYUA 5BR8D 1XPIA 4JI2D 4KHPD 3HP7A 4JI3D 4JI0D 4K0KD 1HNXD 4DR2D 3U28A 2HHHD 3LWOA 4LF7D 4YY3D 1N33D 1ZE1A 1XMOD 4LF9D 2K6PA 1IBKD 4GKJD 1XNRD 4DR3D 4NXMD 1DM9A 3T1YD 5IWAD 4DR6D 3OTOD 4DV6D 4OX9D 2RFKA 4DV3D 3UAIA 3HAXA 3MQKA 1XMQD 1SB7A 4LFAD 4YHHD 4JI1D 3T1HD 4B3SD 4B3TD 4OUDA 1IBMD 1V9KA 2F4VD 4DV4D 4DR5D 1PRZA 1IBLD 4LF6D 1V9FA 1FJGD 1SGVA 4DV2D 2HVYA 4X62D 1K8WA 2UUAD 4LF5D 2UUBD 4DR7D 2ZM6D 4JI4D 4LF8D 1SI7A 3DH3A 1KSVA 2ISTA 1JH3A 1XNQD 1VIOA 1HNZD 4JI5D 3KBGA 4B3RD 1N36D 2UXBD 4B3MD 2AB4A 1FKAD 1H3EA 1C05A 2E5LD 4JI8D 2VQFD 4DV7D 3LWVA 2VQED 4AQYD 4LGTA 2I82A 4LABA 2KTLA 4DR1D 1Z2ZA 3LWPA 4JYAD 1KSLA 2UU9D 1N32D 2UXDD 1H3FA 4DUYD 1I94D 4LF4D
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LMN D;  1C06 A;  1KSK A;  4DV5 D;  4X66 D;  4X64 D;  4JI6 D;  2JAN A;  1ZE2 A;  4DV0 D;  2AUS A;  4JI7 D;  1R3E A;  5LMU D;  4DUZ D;  1N34 D;  3LWR A;  2UXC D;  4DV1 D;  1ZL3 A;  1HNW D;  4JV5 D;  4LFB D;  2EY4 A;  4GKK D;  4LFC D;  3LWQ A;  4DR4 D;  1P9K A;  1J5E D;  2APO A;  4X65 D;  3HJW A;  2UUC D;  4NXN D;  1HR0 D;  1R3F A;  3HJY A;  1QYU A;  5BR8 D;  1XPI A;  4JI2 D;  4KHP D;  3HP7 A;  4JI3 D;  4JI0 D;  4K0K D;  1HNX D;  4DR2 D;  3U28 A;  2HHH D;  3LWO A;  4LF7 D;  4YY3 D;  1N33 D;  1ZE1 A;  1XMO D;  4LF9 D;  2K6P A;  1IBK D;  4GKJ D;  1XNR D;  4DR3 D;  4NXM D;  1DM9 A;  3T1Y D;  5IWA D;  4DR6 D;  3OTO D;  4DV6 D;  4OX9 D;  2RFK A;  4DV3 D;  3UAI A;  3HAX A;  3MQK A;  1XMQ D;  4LFA D;  4YHH D;  4JI1 D;  3T1H D;  4B3S D;  4B3T D;  4OUD A;  1IBM D;  1V9K A;  2F4V D;  4DV4 D;  4DR5 D;  1PRZ A;  1IBL D;  4LF6 D;  1V9F A;  1FJG D;  1SGV A;  4DV2 D;  2HVY A;  4X62 D;  1K8W A;  2UUA D;  4LF5 D;  2UUB D;  4DR7 D;  2ZM6 D;  4JI4 D;  4LF8 D;  3DH3 A;  1KSV A;  2IST A;  1JH3 A;  1XNQ D;  1VIO A;  1HNZ D;  4JI5 D;  3KBG A;  4B3R D;  1N36 D;  2UXB D;  4B3M D;  2AB4 A;  1FKA D;  1H3E A;  1C05 A;  2E5L D;  4JI8 D;  2VQF D;  4DV7 D;  3LWV A;  2VQE D;  4AQY D;  4LGT A;  2I82 A;  4LAB A;  2KTL A;  4DR1 D;  3LWP A;  4JYA D;  1KSL A;  2UU9 D;  1N32 D;  2UXD D;  1H3F A;  4DUY D;  1I94 D;  4LF4 D; 
#chains in the Genus database with same CATH topology
 5LMN D;  3ONG A;  1KSK A;  4DV5 D;  1C06 A;  4X66 D;  3FN1 A;  2I1S A;  4X64 D;  4JI6 D;  2JAN A;  4NNJ A;  1ZE2 A;  4DV0 D;  2AUS A;  4JI7 D;  1R3E A;  5LMU D;  4DUZ D;  1SZW A;  1N34 D;  3ONH A;  3LWR A;  2UXC D;  3KYC B;  1Y8X B;  2ZTB A;  4DV1 D;  1HNW D;  1ZL3 A;  4JV5 D;  4LFB D;  4W5V B;  2EY4 A;  4GKK D;  4LFC D;  3LWQ A;  4DR4 D;  1P9K A;  1J5E D;  2APO A;  4X65 D;  4II2 A;  5A2Q E;  3HJW A;  1Y8Q B;  2UUC D;  4NXN D;  1HR0 D;  1R3F A;  3HJY A;  1QYU A;  5BR8 D;  1XPI A;  4JI2 D;  4KHP D;  3HP7 A;  4JI3 D;  4JI0 D;  4K0K D;  1HNX D;  4DR2 D;  3KYD B;  3U28 A;  2HHH D;  3LWO A;  3J80 E;  4LF7 D;  4YY3 D;  1N33 D;  1ZE1 A;  1XMO D;  4LF9 D;  2K6P A;  1IBK D;  4GKJ D;  1XNR D;  3J7A F;  4DR3 D;  4NXM D;  1DM9 A;  3T1Y D;  5IWA D;  5FLX E;  4DR6 D;  3OTO D;  4DV6 D;  4OX9 D;  2RFK A;  4DV3 D;  3UAI A;  3HAX A;  3MQK A;  1XMQ D;  1SB7 A;  5LL6 S;  4LFA D;  4II3 A;  4YHH D;  4JI1 D;  3T1H D;  4B3S D;  4B3T D;  4OUD A;  3CMM A;  1IBM D;  1V9K A;  3J81 E;  2F4V D;  4DV4 D;  4DR5 D;  1PRZ A;  1IBL D;  4LF6 D;  5FQ2 B;  5KNL A;  1V9F A;  5IT9 E;  2LQ7 A;  1FJG D;  1SGV A;  4DV2 D;  2NVU B;  4X62 D;  2HVY A;  1K8W A;  2UUA D;  4LF5 D;  2UUB D;  4DR7 D;  2ZM6 D;  4JI4 D;  4LF8 D;  1SI7 A;  3DH3 A;  3JAM E;  1KSV A;  2IST A;  1JH3 A;  1XNQ D;  1VIO A;  1HNZ D;  4JI5 D;  3KBG A;  4B3R D;  1N36 D;  2UXB D;  4B3M D;  2AB4 A;  1FKA D;  1H3E A;  1C05 A;  2E5L D;  4JI8 D;  2VQF D;  4DV7 D;  3LWV A;  2VQE D;  4AQY D;  4LGT A;  2I82 A;  4LAB A;  2KTL A;  4DR1 D;  1Z2Z A;  3LWP A;  4JYA D;  1KSL A;  2UU9 D;  1N32 D;  2UXD D;  1Y8R B;  1H3F A;  4DUY D;  1I94 D;  4LF4 D; 
#chains in the Genus database with same CATH homology
 5LMN D;  1C06 A;  1KSK A;  4DV5 D;  4X66 D;  4X64 D;  4JI6 D;  2JAN A;  1ZE2 A;  4DV0 D;  2AUS A;  4JI7 D;  1R3E A;  5LMU D;  4DUZ D;  1SZW A;  1N34 D;  3LWR A;  2UXC D;  4DV1 D;  1ZL3 A;  1HNW D;  4JV5 D;  4LFB D;  2EY4 A;  4GKK D;  4LFC D;  3LWQ A;  4DR4 D;  1P9K A;  1J5E D;  2APO A;  4X65 D;  3HJW A;  2UUC D;  4NXN D;  1HR0 D;  1R3F A;  3HJY A;  1QYU A;  5BR8 D;  1XPI A;  4JI2 D;  4KHP D;  3HP7 A;  4JI3 D;  4JI0 D;  4K0K D;  1HNX D;  4DR2 D;  3U28 A;  2HHH D;  3LWO A;  4LF7 D;  4YY3 D;  1N33 D;  1ZE1 A;  1XMO D;  4LF9 D;  2K6P A;  1IBK D;  4GKJ D;  1XNR D;  4DR3 D;  4NXM D;  1DM9 A;  3T1Y D;  5IWA D;  4DR6 D;  3OTO D;  4DV6 D;  4OX9 D;  2RFK A;  4DV3 D;  3UAI A;  3HAX A;  3MQK A;  1XMQ D;  1SB7 A;  4LFA D;  4YHH D;  4JI1 D;  3T1H D;  4B3S D;  4B3T D;  4OUD A;  1IBM D;  1V9K A;  2F4V D;  4DV4 D;  4DR5 D;  1PRZ A;  1IBL D;  4LF6 D;  1V9F A;  1FJG D;  1SGV A;  4DV2 D;  2HVY A;  4X62 D;  1K8W A;  2UUA D;  4LF5 D;  2UUB D;  4DR7 D;  2ZM6 D;  4JI4 D;  4LF8 D;  1SI7 A;  3DH3 A;  1KSV A;  2IST A;  1JH3 A;  1XNQ D;  1VIO A;  1HNZ D;  4JI5 D;  3KBG A;  4B3R D;  1N36 D;  2UXB D;  4B3M D;  2AB4 A;  1FKA D;  1H3E A;  1C05 A;  2E5L D;  4JI8 D;  2VQF D;  4DV7 D;  3LWV A;  2VQE D;  4AQY D;  4LGT A;  2I82 A;  4LAB A;  2KTL A;  4DR1 D;  1Z2Z A;  3LWP A;  4JYA D;  1KSL A;  2UU9 D;  1N32 D;  2UXD D;  1H3F A;  4DUY D;  1I94 D;  4LF4 D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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