3ETRC

Crystal structure of xanthine oxidase in complex with lumazine
Total Genus 247
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
247
sequence length
755
structure length
755
Chain Sequence
DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Xanthine dehydrogenase/oxidase
total genus 247
structure length 755
sequence length 755
chains with identical sequence N
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2008-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC05
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC03
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 3etrC01
1FO4A 1SB3A 2W55B 3AM9A 1N5WB 3NRZC 3AN1A 3HRDA 1FFUB 1FIQC 3NVZC 4C7ZA 3HRDB 1VLBA 3EUB4 3L4PA 1N62B 3NVVC 1RM6A 1N63B 1N5XA 2E3TA 1JRPB 1ZXIB 3B9JC 4US8A 1DGJA 4USAA 3NVYC 3AMZA 3NVWC 3ETRC 4ZOHA 2W3SB 4C7YA 4C80A 1JROB 1N61B 1FFVB 3NS1C 1VDVA 2W54B 3FAHA 2W3RB 4US9A 3SR6C 1SIJA 1N60B 3FC4A 1WYGA 1V97A
chains in the Genus database with same CATH superfamily
1SB3A 2QA4H 5AYXA 4WFAJ 1N5WB 5AN9F 1AZYA 4LHMA 4AP8A 1S72H 1W2BH 4EADA 5H1SO 3NVZC 4C7ZA 3HRDB 5HUPA 3WO0A 5GAGN 1FMAE 1YJ9H 5JVGJ 3OW2H 1Q7YJ 5GAEN 4KWVA 1VQ5H 1KC8J 1RM6A 3BIIE 1N5XA 2E3TA 1QPQA 1YTEA 1QPNA 4USAA 1QVFH 3NVYC 3AMZA 3NVWC 1OTPA 2WK6A 3ETRC 2W3SB 4WFBJ 2QEXH 1YJNH 5HL7J 1N61B 3NS1C 2OMDA 1VDVA 2WP4A 5JVHJ 3FAHA 3SR6C 2W3RB 1NVIE 1M1KJ 1YTDA 2I1OA 1N60B 3FC4A 3CCEH 1VQMH 2I14A 1QPRA 1YJWH 1FO4A 3CCSH 2W55B 4GA5A 1QVGH 5EY3A 1K9MJ 1VQ8H 1FFUB 3CC2H 1VLBA 3EUB4 2TPTA 3PIOJ 1N62B 2B7NA 1BRWA 1VQNH 3CMEH 3PAJA 1VQOH 1KD1J 1JRPB 1ZXIB 1QPOA 4IOCJ 4GA6A 1DGJA 1Y69K 2B7QA 3J7ZM 4IOAJ 1Q82J 1NJIJ 2ZJRJ 1QAPA 2DSJA 3VMMA 5MLCO 1VQ9H 1VQ6H 4EAFA 4WCEJ 4UY8M 1YTKA 2B7PA 3CCMH 1VQLH 3AM9A 3CC4H 5AYZA 2OTLH 1UOUA 3CCUH 4I9AA 2WK5A 2PA2A 1FM0E 2JBMA 3CCQH 3CC7H 1K8AJ 4IO9J 1N63B 4GA4A 4WFNJ 1Q86J 3B9JC 3CXCH 1VQKH 1YI2H 3G71H 2OTJH 4ZOHA 4C80A 2J0FA 3TQVA 1M90J 1JROB 4YEKA 3C2RA 3GNNA 3WO1A 3C2VA 4US9A 5HUOA 2ZJPJ 1SIJA 3CF5J 1KQSH 4XR5A 3I56H 3CCRH 3CCVH 1WYGA 5HULA 5DM7J 3C2EA 4YYYA 3NRZC 5MPOC 3AN1A 4X46A 1T3QB 3HRDA 1FIQC 2ZJQJ 1VQ7H 3RPFA 4WF9J 1N8RJ 5EP8A 1VQ4H 3DLLJ 5GADN 3L4PA 5AYYA 1YIJH 4KWWA 3NVVC 3G4SH 1NVJA 3C2OA 3CPWH 2Q5WE 3PIPJ 3G6EH 1O4UA 1Q81J 4US8A 1K73J 1VQPH 4C7YA 3L0GA 5DM6J 1JJ2H 1FFVB 3CD6H 2QIEA 3I55H 2W54B 3WNZA 1YITH 3C2FA 1WKIA 3CCLH 1YHQH 4U67J 3H5QA 3CMAH 1V97A 5GAHN 1X1OA 3CCJH
chains in the Genus database with same CATH topology
1FO4A 1SB3A 2W55B 3AM9A 1N5WB 3NRZC 3AN1A 3HRDA 1FFUB 1FIQC 3NVZC 4C7ZA 3HRDB 1VLBA 3EUB4 3L4PA 1N62B 3NVVC 1RM6A 1N63B 1N5XA 2E3TA 1JRPB 1ZXIB 3B9JC 4US8A 1DGJA 4USAA 3NVYC 3AMZA 3NVWC 3ETRC 4ZOHA 2W3SB 4C7YA 4C80A 1JROB 1N61B 1FFVB 3NS1C 1VDVA 2W54B 3FAHA 2W3RB 4US9A 3SR6C 1SIJA 1N60B 3FC4A 1WYGA 1V97A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1FO4 A;  1SB3 A;  2W55 B;  3AM9 A;  1N5W B;  3NRZ C;  3AN1 A;  3HRD A;  1FFU B;  1FIQ C;  3NVZ C;  4C7Z A;  3HRD B;  1VLB A;  3EUB 4;  3L4P A;  1N62 B;  3NVV C;  1RM6 A;  1N63 B;  1N5X A;  2E3T A;  1JRP B;  1ZXI B;  3B9J C;  4US8 A;  1DGJ A;  4USA A;  3NVY C;  3AMZ A;  3NVW C;  3ETR C;  4ZOH A;  2W3S B;  4C7Y A;  4C80 A;  1JRO B;  1N61 B;  1FFV B;  3NS1 C;  1VDV A;  2W54 B;  3FAH A;  2W3R B;  4US9 A;  3SR6 C;  1SIJ A;  1N60 B;  3FC4 A;  1WYG A;  1V97 A; 
#chains in the Genus database with same CATH topology
 1SB3 A;  2QA4 H;  5AYX A;  4WFA J;  1N5W B;  5AN9 F;  1AZY A;  4LHM A;  4AP8 A;  1S72 H;  1W2B H;  4EAD A;  5H1S O;  3NVZ C;  4C7Z A;  3HRD B;  5HUP A;  3WO0 A;  5GAG N;  1FMA E;  1YJ9 H;  5JVG J;  3OW2 H;  1Q7Y J;  5GAE N;  4KWV A;  1VQ5 H;  1KC8 J;  1RM6 A;  3BII E;  1N5X A;  2E3T A;  1QPQ A;  1YTE A;  1QPN A;  4USA A;  1QVF H;  3NVY C;  3AMZ A;  3NVW C;  1OTP A;  2WK6 A;  3ETR C;  2W3S B;  4WFB J;  2QEX H;  1YJN H;  5HL7 J;  1N61 B;  3NS1 C;  2OMD A;  1VDV A;  2WP4 A;  5JVH J;  3FAH A;  3SR6 C;  2W3R B;  1NVI E;  1M1K J;  1YTD A;  2I1O A;  1N60 B;  3FC4 A;  3CCE H;  1VQM H;  2I14 A;  1QPR A;  1YJW H;  1FO4 A;  3CCS H;  2W55 B;  4GA5 A;  1QVG H;  5EY3 A;  1K9M J;  1VQ8 H;  1FFU B;  3CC2 H;  1VLB A;  3EUB 4;  2TPT A;  3PIO J;  1N62 B;  2B7N A;  1BRW A;  1VQN H;  3CME H;  3PAJ A;  1VQO H;  1KD1 J;  1JRP B;  1ZXI B;  1QPO A;  4IOC J;  4GA6 A;  1DGJ A;  1Y69 K;  2B7Q A;  3J7Z M;  4IOA J;  1Q82 J;  1NJI J;  2ZJR J;  1QAP A;  2DSJ A;  3VMM A;  5MLC O;  1VQ9 H;  1VQ6 H;  4EAF A;  4WCE J;  4UY8 M;  1YTK A;  2B7P A;  3CCM H;  1VQL H;  3AM9 A;  3CC4 H;  5AYZ A;  2OTL H;  1UOU A;  3CCU H;  4I9A A;  2WK5 A;  2PA2 A;  1FM0 E;  2JBM A;  3CCQ H;  3CC7 H;  1K8A J;  4IO9 J;  1N63 B;  4GA4 A;  4WFN J;  1Q86 J;  3B9J C;  3CXC H;  1VQK H;  1YI2 H;  3G71 H;  2OTJ H;  4ZOH A;  4C80 A;  2J0F A;  3TQV A;  1M90 J;  1JRO B;  4YEK A;  3C2R A;  3GNN A;  3WO1 A;  3C2V A;  4US9 A;  5HUO A;  2ZJP J;  1SIJ A;  3CF5 J;  1KQS H;  4XR5 A;  3I56 H;  3CCR H;  3CCV H;  1WYG A;  5HUL A;  5DM7 J;  3C2E A;  4YYY A;  3NRZ C;  5MPO C;  3AN1 A;  4X46 A;  1T3Q B;  3HRD A;  1FIQ C;  2ZJQ J;  1VQ7 H;  3RPF A;  4WF9 J;  1N8R J;  5EP8 A;  1VQ4 H;  3DLL J;  5GAD N;  3L4P A;  5AYY A;  1YIJ H;  4KWW A;  3NVV C;  3G4S H;  1NVJ A;  3C2O A;  3CPW H;  2Q5W E;  3PIP J;  3G6E H;  1O4U A;  1Q81 J;  4US8 A;  1K73 J;  1VQP H;  4C7Y A;  3L0G A;  5DM6 J;  1JJ2 H;  1FFV B;  3CD6 H;  2QIE A;  3I55 H;  2W54 B;  3WNZ A;  1YIT H;  3C2F A;  1WKI A;  3CCL H;  1YHQ H;  4U67 J;  3H5Q A;  3CMA H;  1V97 A;  5GAH N;  1X1O A;  3CCJ H; 
#chains in the Genus database with same CATH homology
 1FO4 A;  1SB3 A;  2W55 B;  3AM9 A;  1N5W B;  3NRZ C;  3AN1 A;  3HRD A;  1FFU B;  1FIQ C;  3NVZ C;  4C7Z A;  3HRD B;  1VLB A;  3EUB 4;  3L4P A;  1N62 B;  3NVV C;  1RM6 A;  1N63 B;  1N5X A;  2E3T A;  1JRP B;  1ZXI B;  3B9J C;  4US8 A;  1DGJ A;  4USA A;  3NVY C;  3AMZ A;  3NVW C;  3ETR C;  4ZOH A;  2W3S B;  4C7Y A;  4C80 A;  1JRO B;  1N61 B;  1FFV B;  3NS1 C;  1VDV A;  2W54 B;  3FAH A;  2W3R B;  4US9 A;  3SR6 C;  1SIJ A;  1N60 B;  3FC4 A;  1WYG A;  1V97 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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