3ETRC

Crystal structure of xanthine oxidase in complex with lumazine
Total Genus 247
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
247
sequence length
755
structure length
755
Chain Sequence
DTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substrate Orientation and Catalysis at the Molybdenum Site in Xanthine Oxidase: CRYSTAL STRUCTURES IN COMPLEX WITH XANTHINE AND LUMAZINE.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Xanthine dehydrogenase/oxidase
total genus 247
structure length 755
sequence length 755
chains with identical sequence N
ec nomenclature ec 1.17.1.4: Xanthine dehydrogenase.
pdb deposition date 2008-10-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01315 Ald_Xan_dh_C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
C PF02738 Ald_Xan_dh_C2 Molybdopterin-binding domain of aldehyde dehydrogenase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC02
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC05
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC04
3.30.365.10 Alpha Beta 2-Layer Sandwich Aldehyde Oxidoreductase; domain 4 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 3etrC03
3.90.1170.50 Alpha Beta Alpha-Beta Complex Aldehyde Oxidoreductase; domain 3 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead 3etrC01
4USAA 1RM6A 2W55B 1JRPB 3NVZC 3ETRC 3HRDA 3EUB4 3NS1C 1N5XA 3FC4A 1FFVB 3AMZA 2W3RB 3AN1A 4US9A 1SB3A 1VLBA 4US8A 1FIQC 1N63B 4C7ZA 1DGJA 1N60B 4C7YA 1N5WB 3AM9A 3NVYC 1WYGA 3NVVC 3NVWC 3FAHA 1SIJA 4ZOHA 1FO4A 1ZXIB 2W3SB 3NRZC 3SR6C 1N62B 3HRDB 1JROB 2W54B 1FFUB 1VDVA 1V97A 1N61B 2E3TA 3B9JC 4C80A 3L4PA
chains in the Genus database with same CATH superfamily
5AYYA 4YYYA 3CC7H 1JRPB 3CCLH 1VQ7H 1YTDA 1QVGH 2QIEA 3NS1C 1FM0E 5HUPA 3J7ZM 3CCEH 3PIOJ 3FC4A 3I55H 4I9AA 3AN1A 3G4SH 5EY3A 1VLBA 4KWVA 1FIQC 1KQSH 1OTPA 1DGJA 2ZJPJ 3OW2H 4IOCJ 3CF5J 1KD1J 1VQKH 1Q82J 4ZOHA 2W3SB 4WFBJ 4WFAJ 4XR5A 3CXCH 3SR6C 2B7PA 4KWWA 5MLCO 5HL7J 1W2BH 1NJIJ 1QPQA 3H5QA 3I56H 2I14A 5HULA 1AZYA 1QPRA 1N61B 4C80A 1KC8J 3PIPJ 2QA4H 3C2EA 3CCSH 1YTKA 5JVHJ 3ETRC 5AYXA 5DM7J 2DSJA 2OMDA 3CC2H 5AYZA 5H1SO 1VQ9H 4US9A 1SB3A 1N8RJ 3C2VA 5MPOC 1N5WB 5EP8A 5AN9F 4AP8A 3AM9A 5GADN 3NVYC 1SIJA 3NRZC 4WF9J 1S72H 2B7NA 1N62B 1NVIE 4GA5A 1YJ9H 1YI2H 1K8AJ 3CCUH 2E3TA 3B9JC 2WP4A 1X1OA 3L4PA 2TPTA 4USAA 1RM6A 1M90J 1VQ4H 1O4UA 1FMAE 2B7QA 2WK6A 3GNNA 3EUB4 4WFNJ 1N5XA 3G71H 5GAGN 1FFVB 2Q5WE 3WO0A 4WCEJ 2W3RB 3RPFA 2ZJQJ 3WO1A 4IO9J 1NVJA 4C7ZA 4C7YA 1N60B 3PAJA 1K9MJ 1WYGA 2QEXH 1QPOA 3CD6H 2OTLH 1ZXIB 2OTJH 3L0GA 3VMMA 3DLLJ 1JJ2H 1JROB 1VQPH 1T3QB 1VQMH 3CC4H 3CCVH 4UY8M 1Y69K 3G6EH 3C2RA 3BIIE 1Q7YJ 1YIJH 2PA2A 1QAPA 2W55B 1YHQH 2ZJRJ 4LHMA 3NVZC 2JBMA 4EAFA 3HRDA 5JVGJ 4U67J 1BRWA 1VQLH 1Q86J 4GA4A 1M1KJ 4X46A 3AMZA 3TQVA 3CCRH 1VQOH 1WKIA 1Q81J 3CPWH 2I1OA 1QVFH 1YTEA 4EADA 3C2FA 3WNZA 4US8A 5HUOA 1N63B 1VQ8H 4IOAJ 1YJWH 3NVVC 5GAEN 1FO4A 3NVWC 3FAHA 4YEKA 1YITH 3CCJH 1VQ6H 3CMAH 5GAHN 1K73J 3CMEH 3C2OA 2J0FA 5DM6J 1VQ5H 1QPNA 3HRDB 3CCMH 2W54B 1FFUB 2WK5A 1VDVA 1V97A 3CCQH 1YJNH 1UOUA 1VQNH 4GA6A
chains in the Genus database with same CATH topology
4USAA 1RM6A 2W55B 1JRPB 3NVZC 3ETRC 3HRDA 3EUB4 3NS1C 1N5XA 3FC4A 1FFVB 3AMZA 2W3RB 3AN1A 4US9A 1SB3A 1VLBA 4US8A 1FIQC 1N63B 4C7ZA 1DGJA 1N60B 4C7YA 1N5WB 3AM9A 3NVYC 1WYGA 3NVVC 3NVWC 3FAHA 1SIJA 4ZOHA 1FO4A 1ZXIB 2W3SB 3NRZC 3SR6C 1N62B 3HRDB 1JROB 2W54B 1FFUB 1VDVA 1V97A 1N61B 2E3TA 3B9JC 4C80A 3L4PA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4USA A;  1RM6 A;  2W55 B;  1JRP B;  3NVZ C;  3ETR C;  3HRD A;  3EUB 4;  3NS1 C;  1N5X A;  3FC4 A;  1FFV B;  3AMZ A;  2W3R B;  3AN1 A;  4US9 A;  1SB3 A;  1VLB A;  4US8 A;  1FIQ C;  1N63 B;  4C7Z A;  1DGJ A;  1N60 B;  4C7Y A;  1N5W B;  3AM9 A;  3NVY C;  1WYG A;  3NVV C;  3NVW C;  3FAH A;  1SIJ A;  4ZOH A;  1FO4 A;  1ZXI B;  2W3S B;  3NRZ C;  3SR6 C;  1N62 B;  3HRD B;  1JRO B;  2W54 B;  1FFU B;  1VDV A;  1V97 A;  1N61 B;  2E3T A;  3B9J C;  4C80 A;  3L4P A; 
#chains in the Genus database with same CATH topology
 5AYY A;  4YYY A;  3CC7 H;  1JRP B;  3CCL H;  1VQ7 H;  1YTD A;  1QVG H;  2QIE A;  3NS1 C;  1FM0 E;  5HUP A;  3J7Z M;  3CCE H;  3PIO J;  3FC4 A;  3I55 H;  4I9A A;  3AN1 A;  3G4S H;  5EY3 A;  1VLB A;  4KWV A;  1FIQ C;  1KQS H;  1OTP A;  1DGJ A;  2ZJP J;  3OW2 H;  4IOC J;  3CF5 J;  1KD1 J;  1VQK H;  1Q82 J;  4ZOH A;  2W3S B;  4WFB J;  4WFA J;  4XR5 A;  3CXC H;  3SR6 C;  2B7P A;  4KWW A;  5MLC O;  5HL7 J;  1W2B H;  1NJI J;  1QPQ A;  3H5Q A;  3I56 H;  2I14 A;  5HUL A;  1AZY A;  1QPR A;  1N61 B;  4C80 A;  1KC8 J;  3PIP J;  2QA4 H;  3C2E A;  3CCS H;  1YTK A;  5JVH J;  3ETR C;  5AYX A;  5DM7 J;  2DSJ A;  2OMD A;  3CC2 H;  5AYZ A;  5H1S O;  1VQ9 H;  4US9 A;  1SB3 A;  1N8R J;  3C2V A;  5MPO C;  1N5W B;  5EP8 A;  5AN9 F;  4AP8 A;  3AM9 A;  5GAD N;  3NVY C;  1SIJ A;  3NRZ C;  4WF9 J;  1S72 H;  2B7N A;  1N62 B;  1NVI E;  4GA5 A;  1YJ9 H;  1YI2 H;  1K8A J;  3CCU H;  2E3T A;  3B9J C;  2WP4 A;  1X1O A;  3L4P A;  2TPT A;  4USA A;  1RM6 A;  1M90 J;  1VQ4 H;  1O4U A;  1FMA E;  2B7Q A;  2WK6 A;  3GNN A;  3EUB 4;  4WFN J;  1N5X A;  3G71 H;  5GAG N;  1FFV B;  2Q5W E;  3WO0 A;  4WCE J;  2W3R B;  3RPF A;  2ZJQ J;  3WO1 A;  4IO9 J;  1NVJ A;  4C7Z A;  4C7Y A;  1N60 B;  3PAJ A;  1K9M J;  1WYG A;  2QEX H;  1QPO A;  3CD6 H;  2OTL H;  1ZXI B;  2OTJ H;  3L0G A;  3VMM A;  3DLL J;  1JJ2 H;  1JRO B;  1VQP H;  1T3Q B;  1VQM H;  3CC4 H;  3CCV H;  4UY8 M;  1Y69 K;  3G6E H;  3C2R A;  3BII E;  1Q7Y J;  1YIJ H;  2PA2 A;  1QAP A;  2W55 B;  1YHQ H;  2ZJR J;  4LHM A;  3NVZ C;  2JBM A;  4EAF A;  3HRD A;  5JVG J;  4U67 J;  1BRW A;  1VQL H;  1Q86 J;  4GA4 A;  1M1K J;  4X46 A;  3AMZ A;  3TQV A;  3CCR H;  1VQO H;  1WKI A;  1Q81 J;  3CPW H;  2I1O A;  1QVF H;  1YTE A;  4EAD A;  3C2F A;  3WNZ A;  4US8 A;  5HUO A;  1N63 B;  1VQ8 H;  4IOA J;  1YJW H;  3NVV C;  5GAE N;  1FO4 A;  3NVW C;  3FAH A;  4YEK A;  1YIT H;  3CCJ H;  1VQ6 H;  3CMA H;  5GAH N;  1K73 J;  3CME H;  3C2O A;  2J0F A;  5DM6 J;  1VQ5 H;  1QPN A;  3HRD B;  3CCM H;  2W54 B;  1FFU B;  2WK5 A;  1VDV A;  1V97 A;  3CCQ H;  1YJN H;  1UOU A;  1VQN H;  4GA6 A; 
#chains in the Genus database with same CATH homology
 4USA A;  1RM6 A;  2W55 B;  1JRP B;  3NVZ C;  3ETR C;  3HRD A;  3EUB 4;  3NS1 C;  1N5X A;  3FC4 A;  1FFV B;  3AMZ A;  2W3R B;  3AN1 A;  4US9 A;  1SB3 A;  1VLB A;  4US8 A;  1FIQ C;  1N63 B;  4C7Z A;  1DGJ A;  1N60 B;  4C7Y A;  1N5W B;  3AM9 A;  3NVY C;  1WYG A;  3NVV C;  3NVW C;  3FAH A;  1SIJ A;  4ZOH A;  1FO4 A;  1ZXI B;  2W3S B;  3NRZ C;  3SR6 C;  1N62 B;  3HRD B;  1JRO B;  2W54 B;  1FFU B;  1VDV A;  1V97 A;  1N61 B;  2E3T A;  3B9J C;  4C80 A;  3L4P A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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