4CLAA

Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and x-ray crystallography of chloramphenicol acetyltransferase
Total Genus 58
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
213
structure length
213
Chain Sequence
MNYTKFDVKNWVRREHFEFYRHRLPCGFSLTSKIDITTLKKSLDDSAYKFYPVMIYLIAQAVNQFDELRMAIKDDELIVWDSVDPQFTVFHQETETFSALSCPYSSDIDQFMVNYLSVMERYKSDTKLFPQGVTPENHLNISALPWVNFDSFNFNVANFTDYFAPIITMAKYQQEGDRLLLPLSVQVHHAVCDGFHVARFINRLQELCNSKLK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Alternative binding modes for chloramphenicol and 1-substituted chloramphenicol analogues revealed by site-directed mutagenesis and X-ray crystallography of chloramphenicol acetyltransferase.
pubmed doi rcsb
molecule keywords TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE
molecule tags Transferase (acyltransferase)
source organism Escherichia coli
total genus 58
structure length 213
sequence length 213
ec nomenclature ec 2.3.1.28: Chloramphenicol O-acetyltransferase.
pdb deposition date 1990-10-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00302 CAT Chloramphenicol acetyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 4claA00
4G0BA 1EAEA 1C4TA 2II5A 1EAFA 2BGHA 4G22A 1EACA 5DU9A 3U9BA 2XHGA 4KE4A 4G2MA 5KJVA 5FANA 3B30A 2CLAA 5T3EA 3U9FA 2RKVA 4HVMA 3MAEA 2E1TA 1DPDA 2I9DA 1DPBA 2JGPA 1XL8A 1L5AA 1XMCA 4JN5A 1DPCA 1Q23A 3CLAA 3FP0A 4KECA 5KJSA 4N72A 2ZBAA 3B2SA 1PD5A 3L60A 5DUAA 1Q9JA 2E1VA 1SCZA 1XL7A 2XR7A 1NOCB 1QCAA 5KJTA 5KJWA 2II3A 5KJUA 1CLAA 1EAAA 2IHWA 4CLAA 2VSQA 5FALA 1E2OA 1CIAA 4JN3A 3FOTA 2E1UA 2RKTA 2II4A 1EADA 1XMDA 1EABA
chains in the Genus database with same CATH superfamily
2H4TA 1EAEA 2II5A 3B30A 2CLAA 3U9FA 2E1TA 1S5OA 1T7QA 4KECA 4EYWA 3L60A 2FYOA 2E1VA 1XL7A 2XR7A 1CLAA 4CLAA 2H3UA 2E1UA 2II4A 1DPBA 1NDIA 4G2MA 5T3EA 3MAEA 2I9DA 2FY3A 1L5AA 1XMCA 1DPCA 3FP0A 1NM8A 1T1UA 5DUAA 2H3WA 1NOCB 1QCAA 1T7NA 3FOTA 1EADA 1XMDA 1EABA 1C4TA 1EAFA 2BGHA 2RCUA 1EACA 2XHGA 2FY4A 4KE4A 5KJVA 5FANA 1DPDA 1NDBA 1XL8A 1Q23A 2ZBAA 1PD5A 1SCZA 4EPHA 5KJTA 5KJUA 2II3A 2VSQA 5FALA 4EP9A 4G0BA 1T7OA 4G22A 2DEBA 5DU9A 3U9BA 2RKVA 4HVMA 2FW3A 2JGPA 5KJSA 4JN5A 3CLAA 4N72A 3B2SA 1NDFA 1Q9JA 2FY5A 2FY2A 5KJWA 1EAAA 2IHWA 1Q6XA 1E2OA 1CIAA 4JN3A 2RKTA 2H3PA
chains in the Genus database with same CATH topology
4G0BA 1EAEA 1C4TA 2II5A 1EAFA 2BGHA 4G22A 1EACA 5DU9A 3U9BA 2XHGA 4KE4A 4G2MA 5KJVA 5FANA 3B30A 2CLAA 5T3EA 3U9FA 2RKVA 4HVMA 3MAEA 2E1TA 1DPDA 2I9DA 1DPBA 2JGPA 1XL8A 1L5AA 1XMCA 4JN5A 1DPCA 1Q23A 3CLAA 3FP0A 4KECA 5KJSA 4N72A 2ZBAA 3B2SA 1PD5A 3L60A 5DUAA 1Q9JA 2E1VA 1SCZA 1XL7A 2XR7A 1NOCB 1QCAA 5KJTA 5KJWA 2II3A 5KJUA 1CLAA 1EAAA 2IHWA 4CLAA 2VSQA 5FALA 1E2OA 1CIAA 4JN3A 3FOTA 2E1UA 2RKTA 2II4A 1EADA 1XMDA 1EABA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4G0B A;  1EAE A;  1C4T A;  2II5 A;  1EAF A;  2BGH A;  4G22 A;  1EAC A;  5DU9 A;  3U9B A;  2XHG A;  4KE4 A;  4G2M A;  5KJV A;  5FAN A;  3B30 A;  2CLA A;  5T3E A;  3U9F A;  2RKV A;  4HVM A;  3MAE A;  2E1T A;  1DPD A;  2I9D A;  1DPB A;  2JGP A;  1XL8 A;  1L5A A;  1XMC A;  4JN5 A;  1DPC A;  1Q23 A;  3CLA A;  3FP0 A;  4KEC A;  5KJS A;  4N72 A;  2ZBA A;  3B2S A;  1PD5 A;  3L60 A;  5DUA A;  1Q9J A;  2E1V A;  1SCZ A;  1XL7 A;  2XR7 A;  1NOC B;  1QCA A;  5KJT A;  5KJW A;  2II3 A;  5KJU A;  1CLA A;  1EAA A;  2IHW A;  4CLA A;  2VSQ A;  5FAL A;  1E2O A;  1CIA A;  4JN3 A;  3FOT A;  2E1U A;  2RKT A;  2II4 A;  1EAD A;  1XMD A;  1EAB A; 
#chains in the Genus database with same CATH topology
 2H4T A;  1EAE A;  2II5 A;  3B30 A;  2CLA A;  3U9F A;  2E1T A;  1S5O A;  1T7Q A;  4KEC A;  4EYW A;  3L60 A;  2FYO A;  2E1V A;  1XL7 A;  2XR7 A;  1CLA A;  4CLA A;  2H3U A;  2E1U A;  2II4 A;  1DPB A;  1NDI A;  4G2M A;  5T3E A;  3MAE A;  2I9D A;  2FY3 A;  1L5A A;  1XMC A;  1DPC A;  3FP0 A;  1NM8 A;  1T1U A;  5DUA A;  2H3W A;  1NOC B;  1QCA A;  1T7N A;  3FOT A;  1EAD A;  1XMD A;  1EAB A;  1C4T A;  1EAF A;  2BGH A;  2RCU A;  1EAC A;  2XHG A;  2FY4 A;  4KE4 A;  5KJV A;  5FAN A;  1DPD A;  1NDB A;  1XL8 A;  1Q23 A;  2ZBA A;  1PD5 A;  1SCZ A;  4EPH A;  5KJT A;  5KJU A;  2II3 A;  2VSQ A;  5FAL A;  4EP9 A;  4G0B A;  1T7O A;  4G22 A;  2DEB A;  5DU9 A;  3U9B A;  2RKV A;  4HVM A;  2FW3 A;  2JGP A;  5KJS A;  4JN5 A;  3CLA A;  4N72 A;  3B2S A;  1NDF A;  1Q9J A;  2FY5 A;  2FY2 A;  5KJW A;  1EAA A;  2IHW A;  1Q6X A;  1E2O A;  1CIA A;  4JN3 A;  2RKT A;  2H3P A; 
#chains in the Genus database with same CATH homology
 4G0B A;  1EAE A;  1C4T A;  2II5 A;  1EAF A;  2BGH A;  4G22 A;  1EAC A;  5DU9 A;  3U9B A;  2XHG A;  4KE4 A;  4G2M A;  5KJV A;  5FAN A;  3B30 A;  2CLA A;  5T3E A;  3U9F A;  2RKV A;  4HVM A;  3MAE A;  2E1T A;  1DPD A;  2I9D A;  1DPB A;  2JGP A;  1XL8 A;  1L5A A;  1XMC A;  4JN5 A;  1DPC A;  1Q23 A;  3CLA A;  3FP0 A;  4KEC A;  5KJS A;  4N72 A;  2ZBA A;  3B2S A;  1PD5 A;  3L60 A;  5DUA A;  1Q9J A;  2E1V A;  1SCZ A;  1XL7 A;  2XR7 A;  1NOC B;  1QCA A;  5KJT A;  5KJW A;  2II3 A;  5KJU A;  1CLA A;  1EAA A;  2IHW A;  4CLA A;  2VSQ A;  5FAL A;  1E2O A;  1CIA A;  4JN3 A;  3FOT A;  2E1U A;  2RKT A;  2II4 A;  1EAD A;  1XMD A;  1EAB A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...