5DU9A

First condensation domain of the calcium-dependent antibiotic synthetase in complex with substrate analogue 2a
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
sequence length
444
structure length
427
Chain Sequence
SVRHGLTSAQHCVWLAQQLDPRGAHYRTGSCLEIDGPLDHAVLSRALRLTVAGTETLCSRFLTDEEGRPYRAYCPPAPVPYTPVLLRHIDLSGHEDPEGEAQRWMDRDRATPLPLDRPGLSSHALFTLGGGRHLYYLGVHHIVIDGTSMALFYERLAEVYRALRDGRAVPAAAFGDTDRMVAGEEAYRASARYERDRAYWTGLFTDRPEPVSLRALAPTVRSLGLPPERTEVLGRAAEATGAHWARVVIAGVAAFLHRTTGARDVVVSVPVTGRYGANARITPGMVSNRLPLRLAVRPGESFARVVETVSEAMSGLLAHSRFRGEDLDRELGGAGVSGPTVNVMPYIRPVDFGGPVGLMRSISSGPTTDLNIVLTGTPESGLRVDFEGNPQVYGGQDLTVLQERFVRFLAELAADPAATVDEVALLT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Chemical Probes Allow Structural Insight into the Condensation Reaction of Nonribosomal Peptide Synthetases.
pubmed doi rcsb
molecule tags Phosphopantetheine binding protein
source organism Streptomyces coelicolor (strain atcc baa-471 / a3(2) / m145)
molecule keywords CDA peptide synthetase I
total genus 142
structure length 427
sequence length 444
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-09-18
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.559.10 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol acetyltransferase-like domain 5du9A01
3.30.559.30 Alpha Beta 2-Layer Sandwich Chloramphenicol Acetyltransferase Chloramphenicol Acetyltransferase 5du9A02
1Q9JA 1XMCA 5T3EA 5FALA 4G0BA 4JN5A 4HVMA 1XMDA 1EADA 1Q23A 4KE4A 3U9BA 3FOTA 3MAEA 1EAAA 1XL7A 1DPCA 2E1TA 2II3A 5FANA 2ZBAA 1L5AA 4G22A 2XR7A 3CLAA 1C4TA 1NOCB 2BGHA 5DUAA 5KJWA 1DPDA 2E1UA 5DU9A 4KECA 2RKVA 1CLAA 1DPBA 5KJUA 1EAEA 3B2SA 2II4A 1EABA 3B30A 1PD5A 4G2MA 1XL8A 2RKTA 3FP0A 2CLAA 1SCZA 4N72A 2IHWA 2I9DA 1EACA 2VSQA 2JGPA 5KJTA 2E1VA 3L60A 2XHGA 4CLAA 4JN3A 3U9FA 5KJVA 1CIAA 1EAFA 5KJSA 1QCAA 2II5A 1E2OA
chains in the Genus database with same CATH superfamily
2FYOA 5FALA 2RCUA 4JN5A 1EADA 1Q23A 3U9BA 3MAEA 2E1TA 2FY3A 1DPCA 4G22A 2XR7A 3CLAA 1C4TA 1NOCB 1DPDA 2E1UA 1EAEA 3B2SA 1PD5A 2FY5A 1XL8A 2RKTA 3FP0A 2CLAA 2JGPA 1NDFA 2H3WA 1E2OA 2DEBA 2FW3A 1EAAA 5FANA 2H3PA 1DPBA 5KJUA 1NM8A 4N72A 2I9DA 1EACA 4CLAA 1EAFA 1S5OA 5KJSA 1T7OA 4EPHA 1Q9JA 1XMCA 5T3EA 4HVMA 3FOTA 1XL7A 1L5AA 5KJWA 2BGHA 1NDIA 4KECA 2II4A 1EABA 3B30A 1SCZA 1NDBA 2FY2A 2E1VA 2XHGA 4JN3A 4EYWA 1T7NA 1T7QA 4G0BA 1XMDA 4KE4A 2II3A 2ZBAA 2FY4A 1Q6XA 5DUAA 5DU9A 4EP9A 2H4TA 2RKVA 1CLAA 4G2MA 2IHWA 2VSQA 5KJTA 3L60A 1T1UA 3U9FA 5KJVA 1CIAA 2H3UA 1QCAA 2II5A
chains in the Genus database with same CATH topology
2FYOA 5FALA 2RCUA 4JN5A 1EADA 1Q23A 3U9BA 3MAEA 2E1TA 2FY3A 1DPCA 4G22A 2XR7A 3CLAA 1C4TA 1NOCB 1DPDA 2E1UA 1EAEA 3B2SA 1PD5A 2FY5A 1XL8A 2RKTA 3FP0A 2CLAA 2JGPA 1NDFA 2H3WA 1E2OA 2DEBA 2FW3A 1EAAA 5FANA 2H3PA 1DPBA 5KJUA 1NM8A 4N72A 2I9DA 1EACA 4CLAA 1EAFA 1S5OA 5KJSA 1T7OA 4EPHA 1Q9JA 1XMCA 5T3EA 4HVMA 3FOTA 1XL7A 1L5AA 5KJWA 2BGHA 1NDIA 4KECA 2II4A 1EABA 3B30A 1SCZA 1NDBA 2FY2A 2E1VA 2XHGA 4JN3A 4EYWA 1T7NA 1T7QA 4G0BA 1XMDA 4KE4A 2II3A 2ZBAA 2FY4A 1Q6XA 5DUAA 5DU9A 4EP9A 2H4TA 2RKVA 1CLAA 4G2MA 2IHWA 2VSQA 5KJTA 3L60A 1T1UA 3U9FA 5KJVA 1CIAA 2H3UA 1QCAA 2II5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Q9J A;  1XMC A;  5T3E A;  5FAL A;  4G0B A;  4JN5 A;  4HVM A;  1XMD A;  1EAD A;  1Q23 A;  4KE4 A;  3U9B A;  3FOT A;  3MAE A;  1EAA A;  1XL7 A;  1DPC A;  2E1T A;  2II3 A;  5FAN A;  2ZBA A;  1L5A A;  4G22 A;  2XR7 A;  3CLA A;  1C4T A;  1NOC B;  2BGH A;  5DUA A;  5KJW A;  1DPD A;  2E1U A;  5DU9 A;  4KEC A;  2RKV A;  1CLA A;  1DPB A;  5KJU A;  1EAE A;  3B2S A;  2II4 A;  1EAB A;  3B30 A;  1PD5 A;  4G2M A;  1XL8 A;  2RKT A;  3FP0 A;  2CLA A;  1SCZ A;  4N72 A;  2IHW A;  2I9D A;  1EAC A;  2VSQ A;  2JGP A;  5KJT A;  2E1V A;  3L60 A;  2XHG A;  4CLA A;  4JN3 A;  3U9F A;  5KJV A;  1CIA A;  1EAF A;  5KJS A;  1QCA A;  2II5 A;  1E2O A; 
#chains in the Genus database with same CATH topology
 2FYO A;  5FAL A;  2RCU A;  4JN5 A;  1EAD A;  1Q23 A;  3U9B A;  3MAE A;  2E1T A;  2FY3 A;  1DPC A;  4G22 A;  2XR7 A;  3CLA A;  1C4T A;  1NOC B;  1DPD A;  2E1U A;  1EAE A;  3B2S A;  1PD5 A;  2FY5 A;  1XL8 A;  2RKT A;  3FP0 A;  2CLA A;  2JGP A;  1NDF A;  2H3W A;  1E2O A;  2DEB A;  2FW3 A;  1EAA A;  5FAN A;  2H3P A;  1DPB A;  5KJU A;  1NM8 A;  4N72 A;  2I9D A;  1EAC A;  4CLA A;  1EAF A;  1S5O A;  5KJS A;  1T7O A;  4EPH A;  1Q9J A;  1XMC A;  5T3E A;  4HVM A;  3FOT A;  1XL7 A;  1L5A A;  5KJW A;  2BGH A;  1NDI A;  4KEC A;  2II4 A;  1EAB A;  3B30 A;  1SCZ A;  1NDB A;  2FY2 A;  2E1V A;  2XHG A;  4JN3 A;  4EYW A;  1T7N A;  1T7Q A;  4G0B A;  1XMD A;  4KE4 A;  2II3 A;  2ZBA A;  2FY4 A;  1Q6X A;  5DUA A;  5DU9 A;  4EP9 A;  2H4T A;  2RKV A;  1CLA A;  4G2M A;  2IHW A;  2VSQ A;  5KJT A;  3L60 A;  1T1U A;  3U9F A;  5KJV A;  1CIA A;  2H3U A;  1QCA A;  2II5 A; 
#chains in the Genus database with same CATH homology
 2FYO A;  5FAL A;  2RCU A;  4JN5 A;  1EAD A;  1Q23 A;  3U9B A;  3MAE A;  2E1T A;  2FY3 A;  1DPC A;  4G22 A;  2XR7 A;  3CLA A;  1C4T A;  1NOC B;  1DPD A;  2E1U A;  1EAE A;  3B2S A;  1PD5 A;  2FY5 A;  1XL8 A;  2RKT A;  3FP0 A;  2CLA A;  2JGP A;  1NDF A;  2H3W A;  1E2O A;  2DEB A;  2FW3 A;  1EAA A;  5FAN A;  2H3P A;  1DPB A;  5KJU A;  1NM8 A;  4N72 A;  2I9D A;  1EAC A;  4CLA A;  1EAF A;  1S5O A;  5KJS A;  1T7O A;  4EPH A;  1Q9J A;  1XMC A;  5T3E A;  4HVM A;  3FOT A;  1XL7 A;  1L5A A;  5KJW A;  2BGH A;  1NDI A;  4KEC A;  2II4 A;  1EAB A;  3B30 A;  1SCZ A;  1NDB A;  2FY2 A;  2E1V A;  2XHG A;  4JN3 A;  4EYW A;  1T7N A;  1T7Q A;  4G0B A;  1XMD A;  4KE4 A;  2II3 A;  2ZBA A;  2FY4 A;  1Q6X A;  5DUA A;  5DU9 A;  4EP9 A;  2H4T A;  2RKV A;  1CLA A;  4G2M A;  2IHW A;  2VSQ A;  5KJT A;  3L60 A;  1T1U A;  3U9F A;  5KJV A;  1CIA A;  2H3U A;  1QCA A;  2II5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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