1C0GS

Crystal structure of 1:1 complex between gelsolin segment 1 and a dictyostelium/tetrahymena chimera actin (mutant 228: q228k/t229a/a230y/e360h)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
127
structure length
127
Chain Sequence
MGSVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTCLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords PROTEIN (GELSOLIN SEGMENT 1)
total genus 39
structure length 127
sequence length 127
ec nomenclature
pdb deposition date 1999-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1c0gS00
4CBXG 3A5OS 5A1MA 1VKKA 4CBWG 3A5LS 2KVKA 4KEDA 1Q8GA 1KCQA 3DAWB 2LXXA 3CJBG 1P8ZG 3FFKA 1NM1G 1CNUA 4KEFA 1T3XA 2FGHA 1T2LA 5KYYB 5KYWA 4KEEA 2MP4A 1WM4A 1PD0A 5KYXA 5KYYA 2MOTA 5KYUA 1M4JA 4S10C 1PD1A 1D4XG 1UDMA 4JD2H 5HVKD 5KYWB 1MDUA 2LLFA 1WFSA 1EQYS 1JHWA 1TMWA 2FH2A 3EH1A 4BEX1 3TU5B 5IVUA 1HQZ1 3EG9A 5DD2A 1M2OA 5KYXB 2XF1A 5KYUB 1M2VA 1SVQA 1VFQA 3FG7A 2FH3A 1F7SA 1SVRA 3CIPG 1YVNG 3EFOB 1D0NA 1X67A 2VILA 1P8XA 3FFNA 1H1VG 3EG9B 4Z94G 1Q8XA 1PCXA 1SVYA 1QPVA 3CI5G 1M2VB 3EFOA 3A5NS 2HD7A 4PKHB 5KYNA 1AK7A 2QTVA 1CFYA 3A5MS 4LIZA 2NUPA 1V6FA 5FAFA 4PKGG 2XFAA 1T44G 3Q2BA 5HVKB 4CBUG 1C0FS 2FF3A 2NUTA 2D8BA 1ESVS 2FH4A 2FF6G 2LJ8A 3FG6A 2W0IA 3EGDB 2VACA 1AHQA 2NUPB 1YAGG 1RGIG 1J72A 1DEJS 1NPHA 3CJCG 1WNJA 3EGXA 2FH1A 1COFA 1C0GS 2VIKA 2NUTB 3EGDA 2I2QA 1T3YA 1AK6A 3L50A 1TVJA 4PKIG 3EH2A 5L6WC 2L72A 1NLVG 1NMDG 3EGXB 5FAEA 2MV2A
chains in the Genus database with same CATH superfamily
4CBXG 3A5OS 5A1MA 1VKKA 4CBWG 3A5LS 2KVKA 4KEDA 1Q8GA 1KCQA 3DAWB 2LXXA 3CJBG 1P8ZG 3FFKA 1NM1G 1CNUA 4KEFA 1T3XA 2FGHA 1T2LA 5KYYB 5KYWA 4KEEA 2MP4A 1WM4A 1PD0A 5KYXA 5KYYA 2MOTA 5KYUA 1M4JA 4S10C 1PD1A 1D4XG 1UDMA 4JD2H 5HVKD 5KYWB 1MDUA 2LLFA 1WFSA 1EQYS 1JHWA 1TMWA 2FH2A 3EH1A 4BEX1 3TU5B 5IVUA 1HQZ1 3EG9A 5DD2A 1M2OA 5KYXB 2XF1A 5KYUB 1M2VA 1SVQA 1VFQA 3FG7A 2FH3A 1F7SA 1SVRA 3CIPG 1YVNG 3EFOB 1D0NA 1X67A 2VILA 1P8XA 3DA7A 3FFNA 1H1VG 3EG9B 4Z94G 1Q8XA 1PCXA 1SVYA 1QPVA 3CI5G 1M2VB 3EFOA 3A5NS 2HD7A 4PKHB 5KYNA 1AK7A 2QTVA 1CFYA 3A5MS 4LIZA 2NUPA 1V6FA 5FAFA 4PKGG 2XFAA 1T44G 3Q2BA 5HVKB 4CBUG 1C0FS 2FF3A 2NUTA 2D8BA 1ESVS 2FH4A 2FF6G 2LJ8A 3FG6A 2W0IA 3EGDB 2VACA 1AHQA 2NUPB 1YAGG 1RGIG 1J72A 1DEJS 1NPHA 3CJCG 1WNJA 3EGXA 2FH1A 1COFA 1C0GS 2VIKA 2NUTB 3EGDA 2I2QA 1T3YA 1AK6A 3L50A 1TVJA 4PKIG 3EH2A 5L6WC 2L72A 1NLVG 1NMDG 3EGXB 5FAEA 2MV2A
chains in the Genus database with same CATH topology
4CBXG 3A5OS 5A1MA 1VKKA 4CBWG 3A5LS 2KVKA 4KEDA 1Q8GA 1KCQA 3DAWB 2LXXA 3CJBG 1P8ZG 3FFKA 1NM1G 1CNUA 4KEFA 1T3XA 2FGHA 1T2LA 5KYYB 5KYWA 4KEEA 2MP4A 1WM4A 1PD0A 5KYXA 5KYYA 2MOTA 5KYUA 1M4JA 4S10C 1PD1A 1D4XG 1UDMA 4JD2H 5HVKD 5KYWB 1MDUA 2LLFA 1WFSA 1EQYS 1JHWA 1TMWA 2FH2A 3EH1A 4BEX1 3TU5B 5IVUA 1HQZ1 3EG9A 5DD2A 1M2OA 5KYXB 2XF1A 5KYUB 1M2VA 1SVQA 1VFQA 3FG7A 2FH3A 1F7SA 1SVRA 3CIPG 1YVNG 3EFOB 1D0NA 1X67A 2VILA 1P8XA 3DA7A 3FFNA 1H1VG 3EG9B 4Z94G 1Q8XA 1PCXA 1SVYA 1QPVA 3CI5G 1M2VB 3EFOA 3A5NS 2HD7A 4PKHB 5KYNA 1AK7A 2QTVA 1CFYA 3A5MS 4LIZA 2NUPA 1V6FA 5FAFA 4PKGG 2XFAA 1T44G 3Q2BA 5HVKB 4CBUG 1C0FS 2FF3A 2NUTA 2D8BA 1ESVS 2FH4A 2FF6G 2LJ8A 3FG6A 2W0IA 3EGDB 2VACA 1AHQA 2NUPB 1YAGG 1RGIG 1J72A 1DEJS 1NPHA 3CJCG 1WNJA 3EGXA 2FH1A 1COFA 1C0GS 2VIKA 2NUTB 3EGDA 2I2QA 1T3YA 1AK6A 3L50A 1TVJA 4PKIG 3EH2A 5L6WC 2L72A 1NLVG 1NMDG 3EGXB 5FAEA 2MV2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4CBX G;  3A5O S;  5A1M A;  1VKK A;  4CBW G;  3A5L S;  2KVK A;  4KED A;  1Q8G A;  1KCQ A;  3DAW B;  2LXX A;  3CJB G;  1P8Z G;  3FFK A;  1NM1 G;  1CNU A;  4KEF A;  1T3X A;  2FGH A;  1T2L A;  5KYY B;  5KYW A;  4KEE A;  2MP4 A;  1WM4 A;  1PD0 A;  5KYX A;  5KYY A;  2MOT A;  5KYU A;  1M4J A;  4S10 C;  1PD1 A;  1D4X G;  1UDM A;  4JD2 H;  5HVK D;  5KYW B;  1MDU A;  2LLF A;  1WFS A;  1EQY S;  1JHW A;  1TMW A;  2FH2 A;  3EH1 A;  4BEX 1;  3TU5 B;  5IVU A;  1HQZ 1;  3EG9 A;  5DD2 A;  1M2O A;  5KYX B;  2XF1 A;  5KYU B;  1M2V A;  1SVQ A;  1VFQ A;  3FG7 A;  2FH3 A;  1F7S A;  1SVR A;  3CIP G;  1YVN G;  3EFO B;  1D0N A;  1X67 A;  2VIL A;  1P8X A;  3FFN A;  1H1V G;  3EG9 B;  4Z94 G;  1Q8X A;  1PCX A;  1SVY A;  1QPV A;  3CI5 G;  1M2V B;  3EFO A;  3A5N S;  2HD7 A;  4PKH B;  5KYN A;  1AK7 A;  2QTV A;  1CFY A;  3A5M S;  4LIZ A;  2NUP A;  1V6F A;  5FAF A;  4PKG G;  2XFA A;  1T44 G;  3Q2B A;  5HVK B;  4CBU G;  1C0F S;  2FF3 A;  2NUT A;  2D8B A;  1ESV S;  2FH4 A;  2FF6 G;  2LJ8 A;  3FG6 A;  2W0I A;  3EGD B;  2VAC A;  1AHQ A;  2NUP B;  1YAG G;  1RGI G;  1J72 A;  1DEJ S;  1NPH A;  3CJC G;  1WNJ A;  3EGX A;  2FH1 A;  1COF A;  1C0G S;  2VIK A;  2NUT B;  3EGD A;  2I2Q A;  1T3Y A;  1AK6 A;  3L50 A;  1TVJ A;  4PKI G;  3EH2 A;  5L6W C;  2L72 A;  1NLV G;  1NMD G;  3EGX B;  5FAE A;  2MV2 A; 
#chains in the Genus database with same CATH topology
 4CBX G;  3A5O S;  5A1M A;  1VKK A;  4CBW G;  3A5L S;  2KVK A;  4KED A;  1Q8G A;  1KCQ A;  3DAW B;  2LXX A;  3CJB G;  1P8Z G;  3FFK A;  1NM1 G;  1CNU A;  4KEF A;  1T3X A;  2FGH A;  1T2L A;  5KYY B;  5KYW A;  4KEE A;  2MP4 A;  1WM4 A;  1PD0 A;  5KYX A;  5KYY A;  2MOT A;  5KYU A;  1M4J A;  4S10 C;  1PD1 A;  1D4X G;  1UDM A;  4JD2 H;  5HVK D;  5KYW B;  1MDU A;  2LLF A;  1WFS A;  1EQY S;  1JHW A;  1TMW A;  2FH2 A;  3EH1 A;  4BEX 1;  3TU5 B;  5IVU A;  1HQZ 1;  3EG9 A;  5DD2 A;  1M2O A;  5KYX B;  2XF1 A;  5KYU B;  1M2V A;  1SVQ A;  1VFQ A;  3FG7 A;  2FH3 A;  1F7S A;  1SVR A;  3CIP G;  1YVN G;  3EFO B;  1D0N A;  1X67 A;  2VIL A;  1P8X A;  3DA7 A;  3FFN A;  1H1V G;  3EG9 B;  4Z94 G;  1Q8X A;  1PCX A;  1SVY A;  1QPV A;  3CI5 G;  1M2V B;  3EFO A;  3A5N S;  2HD7 A;  4PKH B;  5KYN A;  1AK7 A;  2QTV A;  1CFY A;  3A5M S;  4LIZ A;  2NUP A;  1V6F A;  5FAF A;  4PKG G;  2XFA A;  1T44 G;  3Q2B A;  5HVK B;  4CBU G;  1C0F S;  2FF3 A;  2NUT A;  2D8B A;  1ESV S;  2FH4 A;  2FF6 G;  2LJ8 A;  3FG6 A;  2W0I A;  3EGD B;  2VAC A;  1AHQ A;  2NUP B;  1YAG G;  1RGI G;  1J72 A;  1DEJ S;  1NPH A;  3CJC G;  1WNJ A;  3EGX A;  2FH1 A;  1COF A;  1C0G S;  2VIK A;  2NUT B;  3EGD A;  2I2Q A;  1T3Y A;  1AK6 A;  3L50 A;  1TVJ A;  4PKI G;  3EH2 A;  5L6W C;  2L72 A;  1NLV G;  1NMD G;  3EGX B;  5FAE A;  2MV2 A; 
#chains in the Genus database with same CATH homology
 4CBX G;  3A5O S;  5A1M A;  1VKK A;  4CBW G;  3A5L S;  2KVK A;  4KED A;  1Q8G A;  1KCQ A;  3DAW B;  2LXX A;  3CJB G;  1P8Z G;  3FFK A;  1NM1 G;  1CNU A;  4KEF A;  1T3X A;  2FGH A;  1T2L A;  5KYY B;  5KYW A;  4KEE A;  2MP4 A;  1WM4 A;  1PD0 A;  5KYX A;  5KYY A;  2MOT A;  5KYU A;  1M4J A;  4S10 C;  1PD1 A;  1D4X G;  1UDM A;  4JD2 H;  5HVK D;  5KYW B;  1MDU A;  2LLF A;  1WFS A;  1EQY S;  1JHW A;  1TMW A;  2FH2 A;  3EH1 A;  4BEX 1;  3TU5 B;  5IVU A;  1HQZ 1;  3EG9 A;  5DD2 A;  1M2O A;  5KYX B;  2XF1 A;  5KYU B;  1M2V A;  1SVQ A;  1VFQ A;  3FG7 A;  2FH3 A;  1F7S A;  1SVR A;  3CIP G;  1YVN G;  3EFO B;  1D0N A;  1X67 A;  2VIL A;  1P8X A;  3DA7 A;  3FFN A;  1H1V G;  3EG9 B;  4Z94 G;  1Q8X A;  1PCX A;  1SVY A;  1QPV A;  3CI5 G;  1M2V B;  3EFO A;  3A5N S;  2HD7 A;  4PKH B;  5KYN A;  1AK7 A;  2QTV A;  1CFY A;  3A5M S;  4LIZ A;  2NUP A;  1V6F A;  5FAF A;  4PKG G;  2XFA A;  1T44 G;  3Q2B A;  5HVK B;  4CBU G;  1C0F S;  2FF3 A;  2NUT A;  2D8B A;  1ESV S;  2FH4 A;  2FF6 G;  2LJ8 A;  3FG6 A;  2W0I A;  3EGD B;  2VAC A;  1AHQ A;  2NUP B;  1YAG G;  1RGI G;  1J72 A;  1DEJ S;  1NPH A;  3CJC G;  1WNJ A;  3EGX A;  2FH1 A;  1COF A;  1C0G S;  2VIK A;  2NUT B;  3EGD A;  2I2Q A;  1T3Y A;  1AK6 A;  3L50 A;  1TVJ A;  4PKI G;  3EH2 A;  5L6W C;  2L72 A;  1NLV G;  1NMD G;  3EGX B;  5FAE A;  2MV2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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