1C0GS

Crystal structure of 1:1 complex between gelsolin segment 1 and a dictyostelium/tetrahymena chimera actin (mutant 228: q228k/t229a/a230y/e360h)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
127
structure length
127
Chain Sequence
MGSVVEHPEFLKAGKEPGLQIWRVEKFDLVPVPTCLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for the higher Ca(2+)-activation of the regulated actin-activated myosin ATPase observed with Dictyostelium/Tetrahymena actin chimeras.
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords PROTEIN (GELSOLIN SEGMENT 1)
total genus 39
structure length 127
sequence length 127
ec nomenclature
pdb deposition date 1999-07-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
S PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1c0gS00
1COFA 1D0NA 1NLVG 4KEDA 2FGHA 4CBUG 2W0IA 1YAGG 3EGXA 1RGIG 1CFYA 1H1VG 1PCXA 5KYUA 2NUTA 2FH1A 1M2OA 2LLFA 1TMWA 2XFAA 1J72A 1HQZ1 5KYXB 2NUPB 1PD0A 4CBWG 1F7SA 1DEJS 1QPVA 2FF3A 1AHQA 3EGXB 1M4JA 2L72A 1V6FA 1JHWA 1UDMA 4PKGG 1T3XA 3EG9A 2NUTB 2VILA 2QTVA 3FFKA 5L6WC 3TU5B 2LXXA 1P8ZG 4PKIG 4BEX1 3L50A 1EQYS 5HVKB 5HVKD 1TVJA 2VACA 1SVRA 1YVNG 3EGDA 1C0GS 2FH3A 4KEFA 3FG7A 3EG9B 1P8XA 2MOTA 5A1MA 1Q8XA 3FFNA 1M2VA 2MP4A 2VIKA 5IVUA 1KCQA 3CJBG 2LJ8A 1SVQA 3A5MS 2KVKA 5FAEA 1Q8GA 5KYWA 3EGDB 1WM4A 4JD2H 3A5NS 5DD2A 4S10C 1NMDG 1AK6A 1M2VB 1ESVS 2FH4A 1T2LA 2I2QA 4KEEA 1AK7A 3Q2BA 3EFOA 4PKHB 1VFQA 1CNUA 2FF6G 2MV2A 1SVYA 2FH2A 5KYWB 2HD7A 4LIZA 4CBXG 3A5LS 2D8BA 5KYYA 3CJCG 1MDUA 1NPHA 1WNJA 1X67A 2XF1A 3FG6A 1VKKA 1WFSA 3A5OS 1T3YA 1T44G 3EFOB 3CIPG 1D4XG 3DAWB 5FAFA 1PD1A 4Z94G 3EH2A 1C0FS 3CI5G 5KYXA 5KYNA 1NM1G 2NUPA 5KYYB 5KYUB 3EH1A
chains in the Genus database with same CATH superfamily
1COFA 1D0NA 1NLVG 4KEDA 2FGHA 4CBUG 2W0IA 1YAGG 3EGXA 1RGIG 1CFYA 1H1VG 1PCXA 5KYUA 2NUTA 2FH1A 1M2OA 2LLFA 1TMWA 2XFAA 1J72A 1HQZ1 5KYXB 2NUPB 1PD0A 4CBWG 1F7SA 1DEJS 1QPVA 2FF3A 1AHQA 3EGXB 1M4JA 2L72A 1V6FA 1JHWA 1UDMA 4PKGG 1T3XA 3EG9A 2NUTB 2VILA 2QTVA 3FFKA 5L6WC 3TU5B 2LXXA 1P8ZG 4PKIG 4BEX1 3L50A 1EQYS 5HVKB 5HVKD 1TVJA 2VACA 1SVRA 1YVNG 3EGDA 1C0GS 2FH3A 4KEFA 3FG7A 3EG9B 1P8XA 2MOTA 5A1MA 1Q8XA 3FFNA 1M2VA 2MP4A 2VIKA 5IVUA 1KCQA 3CJBG 2LJ8A 1SVQA 3A5MS 2KVKA 5FAEA 1Q8GA 5KYWA 3EGDB 1WM4A 4JD2H 3A5NS 5DD2A 4S10C 1NMDG 1AK6A 1M2VB 1ESVS 2FH4A 1T2LA 2I2QA 4KEEA 1AK7A 3Q2BA 3EFOA 4PKHB 1VFQA 1CNUA 2FF6G 2MV2A 1SVYA 2FH2A 5KYWB 2HD7A 4LIZA 4CBXG 3A5LS 2D8BA 5KYYA 3CJCG 1MDUA 1NPHA 1WNJA 1X67A 2XF1A 3FG6A 1VKKA 3DA7A 1WFSA 3A5OS 1T3YA 1T44G 3EFOB 3CIPG 1D4XG 3DAWB 5FAFA 1PD1A 4Z94G 3EH2A 1C0FS 3CI5G 5KYXA 5KYNA 1NM1G 2NUPA 5KYYB 5KYUB 3EH1A
chains in the Genus database with same CATH topology
1COFA 1D0NA 1NLVG 4KEDA 2FGHA 4CBUG 2W0IA 1YAGG 3EGXA 1RGIG 1CFYA 1H1VG 1PCXA 5KYUA 2NUTA 2FH1A 1M2OA 2LLFA 1TMWA 2XFAA 1J72A 1HQZ1 5KYXB 2NUPB 1PD0A 4CBWG 1F7SA 1DEJS 1QPVA 2FF3A 1AHQA 3EGXB 1M4JA 2L72A 1V6FA 1JHWA 1UDMA 4PKGG 1T3XA 3EG9A 2NUTB 2VILA 2QTVA 3FFKA 5L6WC 3TU5B 2LXXA 1P8ZG 4PKIG 4BEX1 3L50A 1EQYS 5HVKB 5HVKD 1TVJA 2VACA 1SVRA 1YVNG 3EGDA 1C0GS 2FH3A 4KEFA 3FG7A 3EG9B 1P8XA 2MOTA 5A1MA 1Q8XA 3FFNA 1M2VA 2MP4A 2VIKA 5IVUA 1KCQA 3CJBG 2LJ8A 1SVQA 3A5MS 2KVKA 5FAEA 1Q8GA 5KYWA 3EGDB 1WM4A 4JD2H 3A5NS 5DD2A 4S10C 1NMDG 1AK6A 1M2VB 1ESVS 2FH4A 1T2LA 2I2QA 4KEEA 1AK7A 3Q2BA 3EFOA 4PKHB 1VFQA 1CNUA 2FF6G 2MV2A 1SVYA 2FH2A 5KYWB 2HD7A 4LIZA 4CBXG 3A5LS 2D8BA 5KYYA 3CJCG 1MDUA 1NPHA 1WNJA 1X67A 2XF1A 3FG6A 1VKKA 3DA7A 1WFSA 3A5OS 1T3YA 1T44G 3EFOB 3CIPG 1D4XG 3DAWB 5FAFA 1PD1A 4Z94G 3EH2A 1C0FS 3CI5G 5KYXA 5KYNA 1NM1G 2NUPA 5KYYB 5KYUB 3EH1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1COF A;  1D0N A;  1NLV G;  4KED A;  2FGH A;  4CBU G;  2W0I A;  1YAG G;  3EGX A;  1RGI G;  1CFY A;  1H1V G;  1PCX A;  5KYU A;  2NUT A;  2FH1 A;  1M2O A;  2LLF A;  1TMW A;  2XFA A;  1J72 A;  1HQZ 1;  5KYX B;  2NUP B;  1PD0 A;  4CBW G;  1F7S A;  1DEJ S;  1QPV A;  2FF3 A;  1AHQ A;  3EGX B;  1M4J A;  2L72 A;  1V6F A;  1JHW A;  1UDM A;  4PKG G;  1T3X A;  3EG9 A;  2NUT B;  2VIL A;  2QTV A;  3FFK A;  5L6W C;  3TU5 B;  2LXX A;  1P8Z G;  4PKI G;  4BEX 1;  3L50 A;  1EQY S;  5HVK B;  5HVK D;  1TVJ A;  2VAC A;  1SVR A;  1YVN G;  3EGD A;  1C0G S;  2FH3 A;  4KEF A;  3FG7 A;  3EG9 B;  1P8X A;  2MOT A;  5A1M A;  1Q8X A;  3FFN A;  1M2V A;  2MP4 A;  2VIK A;  5IVU A;  1KCQ A;  3CJB G;  2LJ8 A;  1SVQ A;  3A5M S;  2KVK A;  5FAE A;  1Q8G A;  5KYW A;  3EGD B;  1WM4 A;  4JD2 H;  3A5N S;  5DD2 A;  4S10 C;  1NMD G;  1AK6 A;  1M2V B;  1ESV S;  2FH4 A;  1T2L A;  2I2Q A;  4KEE A;  1AK7 A;  3Q2B A;  3EFO A;  4PKH B;  1VFQ A;  1CNU A;  2FF6 G;  2MV2 A;  1SVY A;  2FH2 A;  5KYW B;  2HD7 A;  4LIZ A;  4CBX G;  3A5L S;  2D8B A;  5KYY A;  3CJC G;  1MDU A;  1NPH A;  1WNJ A;  1X67 A;  2XF1 A;  3FG6 A;  1VKK A;  1WFS A;  3A5O S;  1T3Y A;  1T44 G;  3EFO B;  3CIP G;  1D4X G;  3DAW B;  5FAF A;  1PD1 A;  4Z94 G;  3EH2 A;  1C0F S;  3CI5 G;  5KYX A;  5KYN A;  1NM1 G;  2NUP A;  5KYY B;  5KYU B;  3EH1 A; 
#chains in the Genus database with same CATH topology
 1COF A;  1D0N A;  1NLV G;  4KED A;  2FGH A;  4CBU G;  2W0I A;  1YAG G;  3EGX A;  1RGI G;  1CFY A;  1H1V G;  1PCX A;  5KYU A;  2NUT A;  2FH1 A;  1M2O A;  2LLF A;  1TMW A;  2XFA A;  1J72 A;  1HQZ 1;  5KYX B;  2NUP B;  1PD0 A;  4CBW G;  1F7S A;  1DEJ S;  1QPV A;  2FF3 A;  1AHQ A;  3EGX B;  1M4J A;  2L72 A;  1V6F A;  1JHW A;  1UDM A;  4PKG G;  1T3X A;  3EG9 A;  2NUT B;  2VIL A;  2QTV A;  3FFK A;  5L6W C;  3TU5 B;  2LXX A;  1P8Z G;  4PKI G;  4BEX 1;  3L50 A;  1EQY S;  5HVK B;  5HVK D;  1TVJ A;  2VAC A;  1SVR A;  1YVN G;  3EGD A;  1C0G S;  2FH3 A;  4KEF A;  3FG7 A;  3EG9 B;  1P8X A;  2MOT A;  5A1M A;  1Q8X A;  3FFN A;  1M2V A;  2MP4 A;  2VIK A;  5IVU A;  1KCQ A;  3CJB G;  2LJ8 A;  1SVQ A;  3A5M S;  2KVK A;  5FAE A;  1Q8G A;  5KYW A;  3EGD B;  1WM4 A;  4JD2 H;  3A5N S;  5DD2 A;  4S10 C;  1NMD G;  1AK6 A;  1M2V B;  1ESV S;  2FH4 A;  1T2L A;  2I2Q A;  4KEE A;  1AK7 A;  3Q2B A;  3EFO A;  4PKH B;  1VFQ A;  1CNU A;  2FF6 G;  2MV2 A;  1SVY A;  2FH2 A;  5KYW B;  2HD7 A;  4LIZ A;  4CBX G;  3A5L S;  2D8B A;  5KYY A;  3CJC G;  1MDU A;  1NPH A;  1WNJ A;  1X67 A;  2XF1 A;  3FG6 A;  1VKK A;  3DA7 A;  1WFS A;  3A5O S;  1T3Y A;  1T44 G;  3EFO B;  3CIP G;  1D4X G;  3DAW B;  5FAF A;  1PD1 A;  4Z94 G;  3EH2 A;  1C0F S;  3CI5 G;  5KYX A;  5KYN A;  1NM1 G;  2NUP A;  5KYY B;  5KYU B;  3EH1 A; 
#chains in the Genus database with same CATH homology
 1COF A;  1D0N A;  1NLV G;  4KED A;  2FGH A;  4CBU G;  2W0I A;  1YAG G;  3EGX A;  1RGI G;  1CFY A;  1H1V G;  1PCX A;  5KYU A;  2NUT A;  2FH1 A;  1M2O A;  2LLF A;  1TMW A;  2XFA A;  1J72 A;  1HQZ 1;  5KYX B;  2NUP B;  1PD0 A;  4CBW G;  1F7S A;  1DEJ S;  1QPV A;  2FF3 A;  1AHQ A;  3EGX B;  1M4J A;  2L72 A;  1V6F A;  1JHW A;  1UDM A;  4PKG G;  1T3X A;  3EG9 A;  2NUT B;  2VIL A;  2QTV A;  3FFK A;  5L6W C;  3TU5 B;  2LXX A;  1P8Z G;  4PKI G;  4BEX 1;  3L50 A;  1EQY S;  5HVK B;  5HVK D;  1TVJ A;  2VAC A;  1SVR A;  1YVN G;  3EGD A;  1C0G S;  2FH3 A;  4KEF A;  3FG7 A;  3EG9 B;  1P8X A;  2MOT A;  5A1M A;  1Q8X A;  3FFN A;  1M2V A;  2MP4 A;  2VIK A;  5IVU A;  1KCQ A;  3CJB G;  2LJ8 A;  1SVQ A;  3A5M S;  2KVK A;  5FAE A;  1Q8G A;  5KYW A;  3EGD B;  1WM4 A;  4JD2 H;  3A5N S;  5DD2 A;  4S10 C;  1NMD G;  1AK6 A;  1M2V B;  1ESV S;  2FH4 A;  1T2L A;  2I2Q A;  4KEE A;  1AK7 A;  3Q2B A;  3EFO A;  4PKH B;  1VFQ A;  1CNU A;  2FF6 G;  2MV2 A;  1SVY A;  2FH2 A;  5KYW B;  2HD7 A;  4LIZ A;  4CBX G;  3A5L S;  2D8B A;  5KYY A;  3CJC G;  1MDU A;  1NPH A;  1WNJ A;  1X67 A;  2XF1 A;  3FG6 A;  1VKK A;  3DA7 A;  1WFS A;  3A5O S;  1T3Y A;  1T44 G;  3EFO B;  3CIP G;  1D4X G;  3DAW B;  5FAF A;  1PD1 A;  4Z94 G;  3EH2 A;  1C0F S;  3CI5 G;  5KYX A;  5KYN A;  1NM1 G;  2NUP A;  5KYY B;  5KYU B;  3EH1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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