5HVKD

Crystal structure of limk1 mutant d460n in complex with full-length cofilin-1
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
164
structure length
164
Chain Sequence
ASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDVGQTVDDPYTTFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords LIM domain kinase 1
total genus 30
structure length 164
sequence length 164
ec nomenclature
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 5hvkD00
1VKKA 3FG7A 1C0GS 1DEJS 5IVUA 5KYYA 2LJ8A 5FAEA 3CIPG 1AHQA 1SVQA 1SVYA 3EG9A 3L50A 1PD0A 3EFOB 1T3YA 1ESVS 2L72A 1PD1A 1KCQA 1NM1G 3FG6A 1PCXA 1T3XA 1HQZ1 2W0IA 3FFNA 1D4XG 1JHWA 2MP4A 4KEEA 1SVRA 3FFKA 1NLVG 1COFA 1P8ZG 2I2QA 4CBWG 1T2LA 1H1VG 2FH1A 1C0FS 1Q8GA 3EFOA 4Z94G 4KEFA 3DAWB 1YVNG 1VFQA 1T44G 1NMDG 1M2VB 1WM4A 1P8XA 5KYUB 1D0NA 1X67A 3EGDB 2FH2A 2FF6G 2D8BA 1QPVA 4KEDA 5KYXB 3CJCG 2NUTB 4PKHB 1EQYS 2FF3A 3EH1A 3A5LS 5L6WC 1Q8XA 1TMWA 2XF1A 1J72A 5DD2A 2VILA 5A1MA 1WNJA 5KYWB 3Q2BA 1M4JA 2KVKA 1M2VA 3A5NS 3EGXB 2FH3A 1CFYA 1WFSA 4JD2H 5KYNA 2LXXA 5KYUA 1MDUA 2QTVA 2VIKA 3EGDA 4CBXG 4LIZA 1TVJA 4PKIG 1AK6A 1UDMA 5KYXA 2NUPA 2NUTA 3CJBG 1RGIG 4BEX1 2NUPB 1CNUA 2FGHA 4CBUG 2MV2A 4S10C 2XFAA 5FAFA 5KYWA 1F7SA 5KYYB 5HVKB 1M2OA 3CI5G 2VACA 3EGXA 1V6FA 3EG9B 3EH2A 3TU5B 3A5OS 2FH4A 4PKGG 3A5MS 2HD7A 2MOTA 1NPHA 1AK7A 1YAGG 2LLFA 5HVKD
chains in the Genus database with same CATH superfamily
1VKKA 3FG7A 1C0GS 1DEJS 5IVUA 5KYYA 2LJ8A 5FAEA 3CIPG 1AHQA 1SVQA 1SVYA 3EG9A 3L50A 1PD0A 3EFOB 1T3YA 1ESVS 2L72A 1PD1A 1KCQA 1NM1G 3FG6A 1PCXA 1T3XA 1HQZ1 2W0IA 3FFNA 1D4XG 1JHWA 2MP4A 4KEEA 1SVRA 3FFKA 1NLVG 1COFA 1P8ZG 2I2QA 4CBWG 1T2LA 1H1VG 2FH1A 1C0FS 1Q8GA 3EFOA 4Z94G 4KEFA 3DAWB 1YVNG 1VFQA 1T44G 1NMDG 1M2VB 1WM4A 1P8XA 5KYUB 1D0NA 1X67A 3EGDB 2FH2A 2FF6G 2D8BA 1QPVA 4KEDA 5KYXB 3CJCG 2NUTB 4PKHB 1EQYS 2FF3A 3EH1A 3A5LS 5L6WC 1Q8XA 1TMWA 2XF1A 1J72A 5DD2A 2VILA 5A1MA 1WNJA 5KYWB 3Q2BA 1M4JA 2KVKA 3DA7A 1M2VA 3A5NS 3EGXB 2FH3A 1CFYA 1WFSA 4JD2H 5KYNA 2LXXA 5KYUA 1MDUA 2QTVA 2VIKA 3EGDA 4CBXG 4LIZA 1TVJA 4PKIG 1AK6A 1UDMA 5KYXA 2NUPA 2NUTA 3CJBG 1RGIG 4BEX1 2NUPB 1CNUA 2FGHA 4CBUG 2MV2A 4S10C 2XFAA 5FAFA 5KYWA 1F7SA 5KYYB 5HVKB 1M2OA 3CI5G 2VACA 3EGXA 1V6FA 3EG9B 3EH2A 3TU5B 3A5OS 2FH4A 4PKGG 3A5MS 2HD7A 2MOTA 1NPHA 1AK7A 1YAGG 2LLFA 5HVKD
chains in the Genus database with same CATH topology
1VKKA 3FG7A 1C0GS 1DEJS 5IVUA 5KYYA 2LJ8A 5FAEA 3CIPG 1AHQA 1SVQA 1SVYA 3EG9A 3L50A 1PD0A 3EFOB 1T3YA 1ESVS 2L72A 1PD1A 1KCQA 1NM1G 3FG6A 1PCXA 1T3XA 1HQZ1 2W0IA 3FFNA 1D4XG 1JHWA 2MP4A 4KEEA 1SVRA 3FFKA 1NLVG 1COFA 1P8ZG 2I2QA 4CBWG 1T2LA 1H1VG 2FH1A 1C0FS 1Q8GA 3EFOA 4Z94G 4KEFA 3DAWB 1YVNG 1VFQA 1T44G 1NMDG 1M2VB 1WM4A 1P8XA 5KYUB 1D0NA 1X67A 3EGDB 2FH2A 2FF6G 2D8BA 1QPVA 4KEDA 5KYXB 3CJCG 2NUTB 4PKHB 1EQYS 2FF3A 3EH1A 3A5LS 5L6WC 1Q8XA 1TMWA 2XF1A 1J72A 5DD2A 2VILA 5A1MA 1WNJA 5KYWB 3Q2BA 1M4JA 2KVKA 3DA7A 1M2VA 3A5NS 3EGXB 2FH3A 1CFYA 1WFSA 4JD2H 5KYNA 2LXXA 5KYUA 1MDUA 2QTVA 2VIKA 3EGDA 4CBXG 4LIZA 1TVJA 4PKIG 1AK6A 1UDMA 5KYXA 2NUPA 2NUTA 3CJBG 1RGIG 4BEX1 2NUPB 1CNUA 2FGHA 4CBUG 2MV2A 4S10C 2XFAA 5FAFA 5KYWA 1F7SA 5KYYB 5HVKB 1M2OA 3CI5G 2VACA 3EGXA 1V6FA 3EG9B 3EH2A 3TU5B 3A5OS 2FH4A 4PKGG 3A5MS 2HD7A 2MOTA 1NPHA 1AK7A 1YAGG 2LLFA 5HVKD
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1VKK A;  3FG7 A;  1C0G S;  1DEJ S;  5IVU A;  5KYY A;  2LJ8 A;  5FAE A;  3CIP G;  1AHQ A;  1SVQ A;  1SVY A;  3EG9 A;  3L50 A;  1PD0 A;  3EFO B;  1T3Y A;  1ESV S;  2L72 A;  1PD1 A;  1KCQ A;  1NM1 G;  3FG6 A;  1PCX A;  1T3X A;  1HQZ 1;  2W0I A;  3FFN A;  1D4X G;  1JHW A;  2MP4 A;  4KEE A;  1SVR A;  3FFK A;  1NLV G;  1COF A;  1P8Z G;  2I2Q A;  4CBW G;  1T2L A;  1H1V G;  2FH1 A;  1C0F S;  1Q8G A;  3EFO A;  4Z94 G;  4KEF A;  3DAW B;  1YVN G;  1VFQ A;  1T44 G;  1NMD G;  1M2V B;  1WM4 A;  1P8X A;  5KYU B;  1D0N A;  1X67 A;  3EGD B;  2FH2 A;  2FF6 G;  2D8B A;  1QPV A;  4KED A;  5KYX B;  3CJC G;  2NUT B;  4PKH B;  1EQY S;  2FF3 A;  3EH1 A;  3A5L S;  5L6W C;  1Q8X A;  1TMW A;  2XF1 A;  1J72 A;  5DD2 A;  2VIL A;  5A1M A;  1WNJ A;  5KYW B;  3Q2B A;  1M4J A;  2KVK A;  1M2V A;  3A5N S;  3EGX B;  2FH3 A;  1CFY A;  1WFS A;  4JD2 H;  5KYN A;  2LXX A;  5KYU A;  1MDU A;  2QTV A;  2VIK A;  3EGD A;  4CBX G;  4LIZ A;  1TVJ A;  4PKI G;  1AK6 A;  1UDM A;  5KYX A;  2NUP A;  2NUT A;  3CJB G;  1RGI G;  4BEX 1;  2NUP B;  1CNU A;  2FGH A;  4CBU G;  2MV2 A;  4S10 C;  2XFA A;  5FAF A;  5KYW A;  1F7S A;  5KYY B;  5HVK B;  1M2O A;  3CI5 G;  2VAC A;  3EGX A;  1V6F A;  3EG9 B;  3EH2 A;  3TU5 B;  3A5O S;  2FH4 A;  4PKG G;  3A5M S;  2HD7 A;  2MOT A;  1NPH A;  1AK7 A;  1YAG G;  2LLF A;  5HVK D; 
#chains in the Genus database with same CATH topology
 1VKK A;  3FG7 A;  1C0G S;  1DEJ S;  5IVU A;  5KYY A;  2LJ8 A;  5FAE A;  3CIP G;  1AHQ A;  1SVQ A;  1SVY A;  3EG9 A;  3L50 A;  1PD0 A;  3EFO B;  1T3Y A;  1ESV S;  2L72 A;  1PD1 A;  1KCQ A;  1NM1 G;  3FG6 A;  1PCX A;  1T3X A;  1HQZ 1;  2W0I A;  3FFN A;  1D4X G;  1JHW A;  2MP4 A;  4KEE A;  1SVR A;  3FFK A;  1NLV G;  1COF A;  1P8Z G;  2I2Q A;  4CBW G;  1T2L A;  1H1V G;  2FH1 A;  1C0F S;  1Q8G A;  3EFO A;  4Z94 G;  4KEF A;  3DAW B;  1YVN G;  1VFQ A;  1T44 G;  1NMD G;  1M2V B;  1WM4 A;  1P8X A;  5KYU B;  1D0N A;  1X67 A;  3EGD B;  2FH2 A;  2FF6 G;  2D8B A;  1QPV A;  4KED A;  5KYX B;  3CJC G;  2NUT B;  4PKH B;  1EQY S;  2FF3 A;  3EH1 A;  3A5L S;  5L6W C;  1Q8X A;  1TMW A;  2XF1 A;  1J72 A;  5DD2 A;  2VIL A;  5A1M A;  1WNJ A;  5KYW B;  3Q2B A;  1M4J A;  2KVK A;  3DA7 A;  1M2V A;  3A5N S;  3EGX B;  2FH3 A;  1CFY A;  1WFS A;  4JD2 H;  5KYN A;  2LXX A;  5KYU A;  1MDU A;  2QTV A;  2VIK A;  3EGD A;  4CBX G;  4LIZ A;  1TVJ A;  4PKI G;  1AK6 A;  1UDM A;  5KYX A;  2NUP A;  2NUT A;  3CJB G;  1RGI G;  4BEX 1;  2NUP B;  1CNU A;  2FGH A;  4CBU G;  2MV2 A;  4S10 C;  2XFA A;  5FAF A;  5KYW A;  1F7S A;  5KYY B;  5HVK B;  1M2O A;  3CI5 G;  2VAC A;  3EGX A;  1V6F A;  3EG9 B;  3EH2 A;  3TU5 B;  3A5O S;  2FH4 A;  4PKG G;  3A5M S;  2HD7 A;  2MOT A;  1NPH A;  1AK7 A;  1YAG G;  2LLF A;  5HVK D; 
#chains in the Genus database with same CATH homology
 1VKK A;  3FG7 A;  1C0G S;  1DEJ S;  5IVU A;  5KYY A;  2LJ8 A;  5FAE A;  3CIP G;  1AHQ A;  1SVQ A;  1SVY A;  3EG9 A;  3L50 A;  1PD0 A;  3EFO B;  1T3Y A;  1ESV S;  2L72 A;  1PD1 A;  1KCQ A;  1NM1 G;  3FG6 A;  1PCX A;  1T3X A;  1HQZ 1;  2W0I A;  3FFN A;  1D4X G;  1JHW A;  2MP4 A;  4KEE A;  1SVR A;  3FFK A;  1NLV G;  1COF A;  1P8Z G;  2I2Q A;  4CBW G;  1T2L A;  1H1V G;  2FH1 A;  1C0F S;  1Q8G A;  3EFO A;  4Z94 G;  4KEF A;  3DAW B;  1YVN G;  1VFQ A;  1T44 G;  1NMD G;  1M2V B;  1WM4 A;  1P8X A;  5KYU B;  1D0N A;  1X67 A;  3EGD B;  2FH2 A;  2FF6 G;  2D8B A;  1QPV A;  4KED A;  5KYX B;  3CJC G;  2NUT B;  4PKH B;  1EQY S;  2FF3 A;  3EH1 A;  3A5L S;  5L6W C;  1Q8X A;  1TMW A;  2XF1 A;  1J72 A;  5DD2 A;  2VIL A;  5A1M A;  1WNJ A;  5KYW B;  3Q2B A;  1M4J A;  2KVK A;  3DA7 A;  1M2V A;  3A5N S;  3EGX B;  2FH3 A;  1CFY A;  1WFS A;  4JD2 H;  5KYN A;  2LXX A;  5KYU A;  1MDU A;  2QTV A;  2VIK A;  3EGD A;  4CBX G;  4LIZ A;  1TVJ A;  4PKI G;  1AK6 A;  1UDM A;  5KYX A;  2NUP A;  2NUT A;  3CJB G;  1RGI G;  4BEX 1;  2NUP B;  1CNU A;  2FGH A;  4CBU G;  2MV2 A;  4S10 C;  2XFA A;  5FAF A;  5KYW A;  1F7S A;  5KYY B;  5HVK B;  1M2O A;  3CI5 G;  2VAC A;  3EGX A;  1V6F A;  3EG9 B;  3EH2 A;  3TU5 B;  3A5O S;  2FH4 A;  4PKG G;  3A5M S;  2HD7 A;  2MOT A;  1NPH A;  1AK7 A;  1YAG G;  2LLF A;  5HVK D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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