2W0IA

Structure of c-terminal actin depolymerizing factor homology (adf-h) domain of human twinfilin-2
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
135
structure length
135
Chain Sequence
SMPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLDDEVH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of C-Terminal Actin Depolymerizing Factor Homology (Adf-H) Domain of Human Twinfilin- 2
rcsb
source organism Homo sapiens
molecule tags Transferase
molecule keywords TWINFILIN-2
total genus 41
structure length 135
sequence length 135
ec nomenclature
pdb deposition date 2008-08-18

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2w0iA00
1WM4A 1M2VA 3FG6A 5FAEA 1SVRA 5KYWA 5A1MA 2FGHA 1D0NA 1HQZ1 1VFQA 2HD7A 1PD0A 1M2OA 2VILA 2L72A 1M2VB 3A5NS 4JD2H 5KYUB 2LJ8A 5KYUA 1JHWA 1COFA 4PKHB 4BEX1 1PD1A 1H1VG 4LIZA 1NLVG 1CNUA 2I2QA 1C0GS 2XF1A 3Q2BA 1CFYA 1D4XG 1MDUA 2W0IA 2NUTA 1Q8XA 1AK6A 4S10C 1M4JA 1P8XA 3A5MS 3EGXB 4PKIG 5KYWB 2MOTA 1PCXA 3EH2A 4KEFA 3EFOB 3A5LS 1NPHA 1TMWA 1TVJA 2NUTB 3EH1A 3TU5B 3CJCG 3CJBG 3CIPG 1V6FA 2FH1A 3CI5G 1ESVS 2LXXA 2MP4A 2MV2A 3EG9B 1P8ZG 5KYXA 1C0FS 1QPVA 5KYYB 2VACA 3L50A 2FH4A 5L6WC 4CBUG 1AHQA 1NMDG 5HVKB 2NUPB 2FH3A 3EFOA 5DD2A 4CBXG 1SVYA 1VKKA 1NM1G 4Z94G 3FFKA 5KYYA 2VIKA 1EQYS 3EGXA 5KYNA 3FG7A 3EGDA 3A5OS 1YAGG 3FFNA 4KEEA 2LLFA 2FF6G 2KVKA 3DAWB 4PKGG 2XFAA 5KYXB 4CBWG 1YVNG 2QTVA 1T2LA 1AK7A 5FAFA 2FH2A 1WNJA 1X67A 1T3YA 2FF3A 2NUPA 1WFSA 3EG9A 1DEJS 1J72A 1UDMA 1T3XA 4KEDA 1SVQA 5HVKD 3EGDB 5IVUA 1Q8GA 1RGIG 1T44G 1KCQA 2D8BA 1F7SA
chains in the Genus database with same CATH superfamily
1WM4A 1M2VA 3FG6A 5FAEA 1SVRA 5KYWA 5A1MA 2FGHA 1D0NA 1HQZ1 1VFQA 2HD7A 1PD0A 1M2OA 2VILA 2L72A 1M2VB 3A5NS 4JD2H 5KYUB 2LJ8A 5KYUA 1JHWA 1COFA 4PKHB 4BEX1 1PD1A 1H1VG 4LIZA 1NLVG 1CNUA 2I2QA 1C0GS 2XF1A 3Q2BA 1CFYA 1D4XG 1MDUA 2W0IA 2NUTA 1Q8XA 1AK6A 4S10C 1M4JA 1P8XA 3A5MS 3EGXB 4PKIG 5KYWB 3DA7A 2MOTA 1PCXA 3EH2A 4KEFA 3EFOB 3A5LS 1NPHA 1TMWA 1TVJA 2NUTB 3EH1A 3TU5B 3CJCG 3CJBG 3CIPG 1V6FA 2FH1A 3CI5G 1ESVS 2LXXA 2MP4A 2MV2A 3EG9B 1P8ZG 5KYXA 1C0FS 1QPVA 5KYYB 2VACA 3L50A 2FH4A 5L6WC 4CBUG 1AHQA 1NMDG 5HVKB 2NUPB 2FH3A 3EFOA 5DD2A 4CBXG 1SVYA 1VKKA 1NM1G 4Z94G 3FFKA 5KYYA 2VIKA 1EQYS 3EGXA 5KYNA 3FG7A 3EGDA 3A5OS 1YAGG 3FFNA 4KEEA 2LLFA 2FF6G 2KVKA 3DAWB 4PKGG 2XFAA 5KYXB 4CBWG 1YVNG 2QTVA 1T2LA 1AK7A 5FAFA 2FH2A 1WNJA 1X67A 1T3YA 2FF3A 2NUPA 1WFSA 3EG9A 1DEJS 1J72A 1UDMA 1T3XA 4KEDA 1SVQA 5HVKD 3EGDB 5IVUA 1Q8GA 1RGIG 1T44G 1KCQA 2D8BA 1F7SA
chains in the Genus database with same CATH topology
1WM4A 1M2VA 3FG6A 5FAEA 1SVRA 5KYWA 5A1MA 2FGHA 1D0NA 1HQZ1 1VFQA 2HD7A 1PD0A 1M2OA 2VILA 2L72A 1M2VB 3A5NS 4JD2H 5KYUB 2LJ8A 5KYUA 1JHWA 1COFA 4PKHB 4BEX1 1PD1A 1H1VG 4LIZA 1NLVG 1CNUA 2I2QA 1C0GS 2XF1A 3Q2BA 1CFYA 1D4XG 1MDUA 2W0IA 2NUTA 1Q8XA 1AK6A 4S10C 1M4JA 1P8XA 3A5MS 3EGXB 4PKIG 5KYWB 3DA7A 2MOTA 1PCXA 3EH2A 4KEFA 3EFOB 3A5LS 1NPHA 1TMWA 1TVJA 2NUTB 3EH1A 3TU5B 3CJCG 3CJBG 3CIPG 1V6FA 2FH1A 3CI5G 1ESVS 2LXXA 2MP4A 2MV2A 3EG9B 1P8ZG 5KYXA 1C0FS 1QPVA 5KYYB 2VACA 3L50A 2FH4A 5L6WC 4CBUG 1AHQA 1NMDG 5HVKB 2NUPB 2FH3A 3EFOA 5DD2A 4CBXG 1SVYA 1VKKA 1NM1G 4Z94G 3FFKA 5KYYA 2VIKA 1EQYS 3EGXA 5KYNA 3FG7A 3EGDA 3A5OS 1YAGG 3FFNA 4KEEA 2LLFA 2FF6G 2KVKA 3DAWB 4PKGG 2XFAA 5KYXB 4CBWG 1YVNG 2QTVA 1T2LA 1AK7A 5FAFA 2FH2A 1WNJA 1X67A 1T3YA 2FF3A 2NUPA 1WFSA 3EG9A 1DEJS 1J72A 1UDMA 1T3XA 4KEDA 1SVQA 5HVKD 3EGDB 5IVUA 1Q8GA 1RGIG 1T44G 1KCQA 2D8BA 1F7SA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WM4 A;  1M2V A;  3FG6 A;  5FAE A;  1SVR A;  5KYW A;  5A1M A;  2FGH A;  1D0N A;  1HQZ 1;  1VFQ A;  2HD7 A;  1PD0 A;  1M2O A;  2VIL A;  2L72 A;  1M2V B;  3A5N S;  4JD2 H;  5KYU B;  2LJ8 A;  5KYU A;  1JHW A;  1COF A;  4PKH B;  4BEX 1;  1PD1 A;  1H1V G;  4LIZ A;  1NLV G;  1CNU A;  2I2Q A;  1C0G S;  2XF1 A;  3Q2B A;  1CFY A;  1D4X G;  1MDU A;  2W0I A;  2NUT A;  1Q8X A;  1AK6 A;  4S10 C;  1M4J A;  1P8X A;  3A5M S;  3EGX B;  4PKI G;  5KYW B;  2MOT A;  1PCX A;  3EH2 A;  4KEF A;  3EFO B;  3A5L S;  1NPH A;  1TMW A;  1TVJ A;  2NUT B;  3EH1 A;  3TU5 B;  3CJC G;  3CJB G;  3CIP G;  1V6F A;  2FH1 A;  3CI5 G;  1ESV S;  2LXX A;  2MP4 A;  2MV2 A;  3EG9 B;  1P8Z G;  5KYX A;  1C0F S;  1QPV A;  5KYY B;  2VAC A;  3L50 A;  2FH4 A;  5L6W C;  4CBU G;  1AHQ A;  1NMD G;  5HVK B;  2NUP B;  2FH3 A;  3EFO A;  5DD2 A;  4CBX G;  1SVY A;  1VKK A;  1NM1 G;  4Z94 G;  3FFK A;  5KYY A;  2VIK A;  1EQY S;  3EGX A;  5KYN A;  3FG7 A;  3EGD A;  3A5O S;  1YAG G;  3FFN A;  4KEE A;  2LLF A;  2FF6 G;  2KVK A;  3DAW B;  4PKG G;  2XFA A;  5KYX B;  4CBW G;  1YVN G;  2QTV A;  1T2L A;  1AK7 A;  5FAF A;  2FH2 A;  1WNJ A;  1X67 A;  1T3Y A;  2FF3 A;  2NUP A;  1WFS A;  3EG9 A;  1DEJ S;  1J72 A;  1UDM A;  1T3X A;  4KED A;  1SVQ A;  5HVK D;  3EGD B;  5IVU A;  1Q8G A;  1RGI G;  1T44 G;  1KCQ A;  2D8B A;  1F7S A; 
#chains in the Genus database with same CATH topology
 1WM4 A;  1M2V A;  3FG6 A;  5FAE A;  1SVR A;  5KYW A;  5A1M A;  2FGH A;  1D0N A;  1HQZ 1;  1VFQ A;  2HD7 A;  1PD0 A;  1M2O A;  2VIL A;  2L72 A;  1M2V B;  3A5N S;  4JD2 H;  5KYU B;  2LJ8 A;  5KYU A;  1JHW A;  1COF A;  4PKH B;  4BEX 1;  1PD1 A;  1H1V G;  4LIZ A;  1NLV G;  1CNU A;  2I2Q A;  1C0G S;  2XF1 A;  3Q2B A;  1CFY A;  1D4X G;  1MDU A;  2W0I A;  2NUT A;  1Q8X A;  1AK6 A;  4S10 C;  1M4J A;  1P8X A;  3A5M S;  3EGX B;  4PKI G;  5KYW B;  3DA7 A;  2MOT A;  1PCX A;  3EH2 A;  4KEF A;  3EFO B;  3A5L S;  1NPH A;  1TMW A;  1TVJ A;  2NUT B;  3EH1 A;  3TU5 B;  3CJC G;  3CJB G;  3CIP G;  1V6F A;  2FH1 A;  3CI5 G;  1ESV S;  2LXX A;  2MP4 A;  2MV2 A;  3EG9 B;  1P8Z G;  5KYX A;  1C0F S;  1QPV A;  5KYY B;  2VAC A;  3L50 A;  2FH4 A;  5L6W C;  4CBU G;  1AHQ A;  1NMD G;  5HVK B;  2NUP B;  2FH3 A;  3EFO A;  5DD2 A;  4CBX G;  1SVY A;  1VKK A;  1NM1 G;  4Z94 G;  3FFK A;  5KYY A;  2VIK A;  1EQY S;  3EGX A;  5KYN A;  3FG7 A;  3EGD A;  3A5O S;  1YAG G;  3FFN A;  4KEE A;  2LLF A;  2FF6 G;  2KVK A;  3DAW B;  4PKG G;  2XFA A;  5KYX B;  4CBW G;  1YVN G;  2QTV A;  1T2L A;  1AK7 A;  5FAF A;  2FH2 A;  1WNJ A;  1X67 A;  1T3Y A;  2FF3 A;  2NUP A;  1WFS A;  3EG9 A;  1DEJ S;  1J72 A;  1UDM A;  1T3X A;  4KED A;  1SVQ A;  5HVK D;  3EGD B;  5IVU A;  1Q8G A;  1RGI G;  1T44 G;  1KCQ A;  2D8B A;  1F7S A; 
#chains in the Genus database with same CATH homology
 1WM4 A;  1M2V A;  3FG6 A;  5FAE A;  1SVR A;  5KYW A;  5A1M A;  2FGH A;  1D0N A;  1HQZ 1;  1VFQ A;  2HD7 A;  1PD0 A;  1M2O A;  2VIL A;  2L72 A;  1M2V B;  3A5N S;  4JD2 H;  5KYU B;  2LJ8 A;  5KYU A;  1JHW A;  1COF A;  4PKH B;  4BEX 1;  1PD1 A;  1H1V G;  4LIZ A;  1NLV G;  1CNU A;  2I2Q A;  1C0G S;  2XF1 A;  3Q2B A;  1CFY A;  1D4X G;  1MDU A;  2W0I A;  2NUT A;  1Q8X A;  1AK6 A;  4S10 C;  1M4J A;  1P8X A;  3A5M S;  3EGX B;  4PKI G;  5KYW B;  3DA7 A;  2MOT A;  1PCX A;  3EH2 A;  4KEF A;  3EFO B;  3A5L S;  1NPH A;  1TMW A;  1TVJ A;  2NUT B;  3EH1 A;  3TU5 B;  3CJC G;  3CJB G;  3CIP G;  1V6F A;  2FH1 A;  3CI5 G;  1ESV S;  2LXX A;  2MP4 A;  2MV2 A;  3EG9 B;  1P8Z G;  5KYX A;  1C0F S;  1QPV A;  5KYY B;  2VAC A;  3L50 A;  2FH4 A;  5L6W C;  4CBU G;  1AHQ A;  1NMD G;  5HVK B;  2NUP B;  2FH3 A;  3EFO A;  5DD2 A;  4CBX G;  1SVY A;  1VKK A;  1NM1 G;  4Z94 G;  3FFK A;  5KYY A;  2VIK A;  1EQY S;  3EGX A;  5KYN A;  3FG7 A;  3EGD A;  3A5O S;  1YAG G;  3FFN A;  4KEE A;  2LLF A;  2FF6 G;  2KVK A;  3DAW B;  4PKG G;  2XFA A;  5KYX B;  4CBW G;  1YVN G;  2QTV A;  1T2L A;  1AK7 A;  5FAF A;  2FH2 A;  1WNJ A;  1X67 A;  1T3Y A;  2FF3 A;  2NUP A;  1WFS A;  3EG9 A;  1DEJ S;  1J72 A;  1UDM A;  1T3X A;  4KED A;  1SVQ A;  5HVK D;  3EGD B;  5IVU A;  1Q8G A;  1RGI G;  1T44 G;  1KCQ A;  2D8B A;  1F7S A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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