1M4JA

Crystal structure of the n-terminal adf-h domain of mouse twinfilin isoform-1
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
133
structure length
133
Chain Sequence
IQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Conservation Between the Actin Monomer-binding Sites of Twinfilin and Actin-depolymerizing Factor (ADF)/Cofilin
pubmed doi rcsb
molecule tags Structural protein
source organism Mus musculus
molecule keywords A6 gene product
total genus 40
structure length 133
sequence length 133
chains with identical sequence B
ec nomenclature
pdb deposition date 2002-07-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1m4jA00
1C0FS 1SVRA 3EGDA 5FAEA 1M2VA 1TVJA 2W0IA 5HVKD 2KVKA 3TU5B 5IVUA 3A5OS 2FH2A 2NUPB 2VACA 4KEFA 4PKGG 3FFKA 1PD1A 3A5MS 2NUPA 4KEDA 1AHQA 1F7SA 1M4JA 1P8XA 5KYXA 1VKKA 1NM1G 3EGXB 2FH1A 2XFAA 4LIZA 2LXXA 1NMDG 1C0GS 2FF6G 1D4XG 3EG9A 2I2QA 5KYYA 1D0NA 1P8ZG 1VFQA 1T2LA 1NPHA 1DEJS 2HD7A 2L72A 2D8BA 2MV2A 4KEEA 3EH2A 3L50A 1MDUA 5KYXB 2FGHA 3Q2BA 1HQZ1 3FFNA 4CBXG 1KCQA 1QPVA 3CIPG 1YAGG 5DD2A 1AK6A 2QTVA 3CI5G 3EG9B 3CJCG 1T3XA 3A5LS 5KYYB 3FG6A 5KYWB 1T3YA 2VIKA 4Z94G 1JHWA 1J72A 5KYWA 1WNJA 2LJ8A 4JD2H 4S10C 1M2OA 2NUTA 1COFA 1CFYA 1RGIG 1YVNG 2LLFA 4PKIG 1H1VG 1V6FA 2FH3A 3FG7A 2VILA 2XF1A 5KYNA 1NLVG 3CJBG 2MP4A 1ESVS 1TMWA 4CBWG 2FF3A 4CBUG 3EFOA 4PKHB 1EQYS 5KYUB 3EH1A 2MOTA 1Q8XA 3A5NS 5KYUA 2NUTB 1T44G 1AK7A 5HVKB 5FAFA 1CNUA 1SVQA 1WFSA 1PD0A 3EFOB 5A1MA 5L6WC 1Q8GA 3DAWB 2FH4A 1PCXA 3EGDB 1SVYA 4BEX1 1X67A 1M2VB 3EGXA 1WM4A 1UDMA
chains in the Genus database with same CATH superfamily
1C0FS 1SVRA 3EGDA 5FAEA 1M2VA 1TVJA 2W0IA 5HVKD 2KVKA 3TU5B 5IVUA 3A5OS 2FH2A 2NUPB 2VACA 4KEFA 4PKGG 3FFKA 1PD1A 3A5MS 2NUPA 4KEDA 1AHQA 1F7SA 1M4JA 1P8XA 5KYXA 1VKKA 1NM1G 3EGXB 2FH1A 2XFAA 4LIZA 2LXXA 1NMDG 1C0GS 2FF6G 1D4XG 3EG9A 2I2QA 5KYYA 1D0NA 1P8ZG 1VFQA 1T2LA 1NPHA 1DEJS 2HD7A 2L72A 2D8BA 2MV2A 4KEEA 3EH2A 3L50A 1MDUA 5KYXB 2FGHA 3Q2BA 1HQZ1 3FFNA 4CBXG 1KCQA 1QPVA 3CIPG 1YAGG 5DD2A 1AK6A 2QTVA 3CI5G 3EG9B 3CJCG 1T3XA 3A5LS 5KYYB 3FG6A 5KYWB 1T3YA 2VIKA 4Z94G 1JHWA 1J72A 5KYWA 3DA7A 1WNJA 2LJ8A 4JD2H 4S10C 1M2OA 2NUTA 1COFA 1CFYA 1RGIG 1YVNG 2LLFA 4PKIG 1H1VG 1V6FA 2FH3A 3FG7A 2VILA 2XF1A 5KYNA 1NLVG 3CJBG 2MP4A 1ESVS 1TMWA 4CBWG 2FF3A 4CBUG 3EFOA 4PKHB 1EQYS 5KYUB 3EH1A 2MOTA 1Q8XA 3A5NS 5KYUA 2NUTB 1T44G 1AK7A 5HVKB 5FAFA 1CNUA 1SVQA 1WFSA 1PD0A 3EFOB 5A1MA 5L6WC 1Q8GA 3DAWB 2FH4A 1PCXA 3EGDB 1SVYA 4BEX1 1X67A 1M2VB 3EGXA 1WM4A 1UDMA
chains in the Genus database with same CATH topology
1C0FS 1SVRA 3EGDA 5FAEA 1M2VA 1TVJA 2W0IA 5HVKD 2KVKA 3TU5B 5IVUA 3A5OS 2FH2A 2NUPB 2VACA 4KEFA 4PKGG 3FFKA 1PD1A 3A5MS 2NUPA 4KEDA 1AHQA 1F7SA 1M4JA 1P8XA 5KYXA 1VKKA 1NM1G 3EGXB 2FH1A 2XFAA 4LIZA 2LXXA 1NMDG 1C0GS 2FF6G 1D4XG 3EG9A 2I2QA 5KYYA 1D0NA 1P8ZG 1VFQA 1T2LA 1NPHA 1DEJS 2HD7A 2L72A 2D8BA 2MV2A 4KEEA 3EH2A 3L50A 1MDUA 5KYXB 2FGHA 3Q2BA 1HQZ1 3FFNA 4CBXG 1KCQA 1QPVA 3CIPG 1YAGG 5DD2A 1AK6A 2QTVA 3CI5G 3EG9B 3CJCG 1T3XA 3A5LS 5KYYB 3FG6A 5KYWB 1T3YA 2VIKA 4Z94G 1JHWA 1J72A 5KYWA 3DA7A 1WNJA 2LJ8A 4JD2H 4S10C 1M2OA 2NUTA 1COFA 1CFYA 1RGIG 1YVNG 2LLFA 4PKIG 1H1VG 1V6FA 2FH3A 3FG7A 2VILA 2XF1A 5KYNA 1NLVG 3CJBG 2MP4A 1ESVS 1TMWA 4CBWG 2FF3A 4CBUG 3EFOA 4PKHB 1EQYS 5KYUB 3EH1A 2MOTA 1Q8XA 3A5NS 5KYUA 2NUTB 1T44G 1AK7A 5HVKB 5FAFA 1CNUA 1SVQA 1WFSA 1PD0A 3EFOB 5A1MA 5L6WC 1Q8GA 3DAWB 2FH4A 1PCXA 3EGDB 1SVYA 4BEX1 1X67A 1M2VB 3EGXA 1WM4A 1UDMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C0F S;  1SVR A;  3EGD A;  5FAE A;  1M2V A;  1TVJ A;  2W0I A;  5HVK D;  2KVK A;  3TU5 B;  5IVU A;  3A5O S;  2FH2 A;  2NUP B;  2VAC A;  4KEF A;  4PKG G;  3FFK A;  1PD1 A;  3A5M S;  2NUP A;  4KED A;  1AHQ A;  1F7S A;  1M4J A;  1P8X A;  5KYX A;  1VKK A;  1NM1 G;  3EGX B;  2FH1 A;  2XFA A;  4LIZ A;  2LXX A;  1NMD G;  1C0G S;  2FF6 G;  1D4X G;  3EG9 A;  2I2Q A;  5KYY A;  1D0N A;  1P8Z G;  1VFQ A;  1T2L A;  1NPH A;  1DEJ S;  2HD7 A;  2L72 A;  2D8B A;  2MV2 A;  4KEE A;  3EH2 A;  3L50 A;  1MDU A;  5KYX B;  2FGH A;  3Q2B A;  1HQZ 1;  3FFN A;  4CBX G;  1KCQ A;  1QPV A;  3CIP G;  1YAG G;  5DD2 A;  1AK6 A;  2QTV A;  3CI5 G;  3EG9 B;  3CJC G;  1T3X A;  3A5L S;  5KYY B;  3FG6 A;  5KYW B;  1T3Y A;  2VIK A;  4Z94 G;  1JHW A;  1J72 A;  5KYW A;  1WNJ A;  2LJ8 A;  4JD2 H;  4S10 C;  1M2O A;  2NUT A;  1COF A;  1CFY A;  1RGI G;  1YVN G;  2LLF A;  4PKI G;  1H1V G;  1V6F A;  2FH3 A;  3FG7 A;  2VIL A;  2XF1 A;  5KYN A;  1NLV G;  3CJB G;  2MP4 A;  1ESV S;  1TMW A;  4CBW G;  2FF3 A;  4CBU G;  3EFO A;  4PKH B;  1EQY S;  5KYU B;  3EH1 A;  2MOT A;  1Q8X A;  3A5N S;  5KYU A;  2NUT B;  1T44 G;  1AK7 A;  5HVK B;  5FAF A;  1CNU A;  1SVQ A;  1WFS A;  1PD0 A;  3EFO B;  5A1M A;  5L6W C;  1Q8G A;  3DAW B;  2FH4 A;  1PCX A;  3EGD B;  1SVY A;  4BEX 1;  1X67 A;  1M2V B;  3EGX A;  1WM4 A;  1UDM A; 
#chains in the Genus database with same CATH topology
 1C0F S;  1SVR A;  3EGD A;  5FAE A;  1M2V A;  1TVJ A;  2W0I A;  5HVK D;  2KVK A;  3TU5 B;  5IVU A;  3A5O S;  2FH2 A;  2NUP B;  2VAC A;  4KEF A;  4PKG G;  3FFK A;  1PD1 A;  3A5M S;  2NUP A;  4KED A;  1AHQ A;  1F7S A;  1M4J A;  1P8X A;  5KYX A;  1VKK A;  1NM1 G;  3EGX B;  2FH1 A;  2XFA A;  4LIZ A;  2LXX A;  1NMD G;  1C0G S;  2FF6 G;  1D4X G;  3EG9 A;  2I2Q A;  5KYY A;  1D0N A;  1P8Z G;  1VFQ A;  1T2L A;  1NPH A;  1DEJ S;  2HD7 A;  2L72 A;  2D8B A;  2MV2 A;  4KEE A;  3EH2 A;  3L50 A;  1MDU A;  5KYX B;  2FGH A;  3Q2B A;  1HQZ 1;  3FFN A;  4CBX G;  1KCQ A;  1QPV A;  3CIP G;  1YAG G;  5DD2 A;  1AK6 A;  2QTV A;  3CI5 G;  3EG9 B;  3CJC G;  1T3X A;  3A5L S;  5KYY B;  3FG6 A;  5KYW B;  1T3Y A;  2VIK A;  4Z94 G;  1JHW A;  1J72 A;  5KYW A;  3DA7 A;  1WNJ A;  2LJ8 A;  4JD2 H;  4S10 C;  1M2O A;  2NUT A;  1COF A;  1CFY A;  1RGI G;  1YVN G;  2LLF A;  4PKI G;  1H1V G;  1V6F A;  2FH3 A;  3FG7 A;  2VIL A;  2XF1 A;  5KYN A;  1NLV G;  3CJB G;  2MP4 A;  1ESV S;  1TMW A;  4CBW G;  2FF3 A;  4CBU G;  3EFO A;  4PKH B;  1EQY S;  5KYU B;  3EH1 A;  2MOT A;  1Q8X A;  3A5N S;  5KYU A;  2NUT B;  1T44 G;  1AK7 A;  5HVK B;  5FAF A;  1CNU A;  1SVQ A;  1WFS A;  1PD0 A;  3EFO B;  5A1M A;  5L6W C;  1Q8G A;  3DAW B;  2FH4 A;  1PCX A;  3EGD B;  1SVY A;  4BEX 1;  1X67 A;  1M2V B;  3EGX A;  1WM4 A;  1UDM A; 
#chains in the Genus database with same CATH homology
 1C0F S;  1SVR A;  3EGD A;  5FAE A;  1M2V A;  1TVJ A;  2W0I A;  5HVK D;  2KVK A;  3TU5 B;  5IVU A;  3A5O S;  2FH2 A;  2NUP B;  2VAC A;  4KEF A;  4PKG G;  3FFK A;  1PD1 A;  3A5M S;  2NUP A;  4KED A;  1AHQ A;  1F7S A;  1M4J A;  1P8X A;  5KYX A;  1VKK A;  1NM1 G;  3EGX B;  2FH1 A;  2XFA A;  4LIZ A;  2LXX A;  1NMD G;  1C0G S;  2FF6 G;  1D4X G;  3EG9 A;  2I2Q A;  5KYY A;  1D0N A;  1P8Z G;  1VFQ A;  1T2L A;  1NPH A;  1DEJ S;  2HD7 A;  2L72 A;  2D8B A;  2MV2 A;  4KEE A;  3EH2 A;  3L50 A;  1MDU A;  5KYX B;  2FGH A;  3Q2B A;  1HQZ 1;  3FFN A;  4CBX G;  1KCQ A;  1QPV A;  3CIP G;  1YAG G;  5DD2 A;  1AK6 A;  2QTV A;  3CI5 G;  3EG9 B;  3CJC G;  1T3X A;  3A5L S;  5KYY B;  3FG6 A;  5KYW B;  1T3Y A;  2VIK A;  4Z94 G;  1JHW A;  1J72 A;  5KYW A;  3DA7 A;  1WNJ A;  2LJ8 A;  4JD2 H;  4S10 C;  1M2O A;  2NUT A;  1COF A;  1CFY A;  1RGI G;  1YVN G;  2LLF A;  4PKI G;  1H1V G;  1V6F A;  2FH3 A;  3FG7 A;  2VIL A;  2XF1 A;  5KYN A;  1NLV G;  3CJB G;  2MP4 A;  1ESV S;  1TMW A;  4CBW G;  2FF3 A;  4CBU G;  3EFO A;  4PKH B;  1EQY S;  5KYU B;  3EH1 A;  2MOT A;  1Q8X A;  3A5N S;  5KYU A;  2NUT B;  1T44 G;  1AK7 A;  5HVK B;  5FAF A;  1CNU A;  1SVQ A;  1WFS A;  1PD0 A;  3EFO B;  5A1M A;  5L6W C;  1Q8G A;  3DAW B;  2FH4 A;  1PCX A;  3EGD B;  1SVY A;  4BEX 1;  1X67 A;  1M2V B;  3EGX A;  1WM4 A;  1UDM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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