1M4J | Genus

Total Genus 40

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	40
sequence length	133
structure length	133
Chain Sequence	IQASEDVKEIFARARNGKYRLLKISIENEQLVVGSCSPPSDSWEQDYDSFVLPLLEDKQPCYVLFRLDSQNAQGYEWIFIAWSPDHSHVRQKMLYAATRATLKKEFGGGHIKDEVFGTVKEDVSLHGYKKYLL

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

publication title	Structural Conservation Between the Actin Monomer-binding Sites of Twinfilin and Actin-depolymerizing Factor (ADF)/Cofilin pubmed doi rcsb
molecule keywords	A6 gene product
molecule tags	Structural protein
source organism	Mus musculus
total genus	40
structure length	133
sequence length	133
chains with identical sequence	B
ec nomenclature
pdb deposition date	2002-07-03

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00241	Cofilin_ADF	Cofilin/tropomyosin-type actin-binding protein

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	1m4jA00

3EH1A 1SVQA 5KYWB 1P8XA 2VACA 3A5LS 5L6WC 1NMDG 1F7SA 1J72A 3FG6A 2MOTA 1SVRA 1AK7A 1NM1G 2FF6G 1P8ZG 1EQYS 3L50A 1C0GS 5FAFA 2MV2A 3FG7A 5KYNA 2NUTB 2FGHA 1Q8GA 5A1MA 1WM4A 1V6FA 2NUPB 3CJCG 3EFOB 3EGXB 3TU5B 2L72A 4KEFA 3A5OS 2NUTA 1KCQA 4KEEA 3CI5G 1M2VA 1TMWA 3EFOA 4PKHB 3A5NS 1PCXA 5IVUA 2XFAA 2VILA 5KYWA 1D0NA 1CNUA 2QTVA 1T2LA 1C0FS 2FH1A 3CIPG 1NLVG 2LXXA 1T3YA 5HVKB 2I2QA 3FFNA 1Q8XA 1X67A 2FH4A 5FAEA 3DAWB 1ESVS 5KYUB 1M4JA 1T44G 2W0IA 3EG9B 1VFQA 2HD7A 2FF3A 2NUPA 1TVJA 1YAGG 2LJ8A 4CBXG 1D4XG 2XF1A 4JD2H 3EGXA 2FH2A 4Z94G 2FH3A 4PKIG 1AHQA 1JHWA 5KYYB 1T3XA 2VIKA 1PD0A 1HQZ1 1PD1A 2MP4A 1UDMA 4CBWG 2LLFA 1AK6A 3EH2A 5KYYA 1H1VG 4KEDA 3A5MS 3FFKA 1WNJA 5DD2A 3Q2BA 1CFYA 1M2OA 1MDUA 1COFA 1VKKA 2KVKA 1WFSA 4S10C 4CBUG 5KYXB 4LIZA 5KYUA 1SVYA 3EGDB 2D8BA 3EG9A 1NPHA 1DEJS 1QPVA 5KYXA 1M2VB 5HVKD 3CJBG 1RGIG 3EGDA 4PKGG 1YVNG 4BEX1
chains in the Genus database with same CATH superfamily

3EH1A 1SVQA 5KYWB 1P8XA 2VACA 3A5LS 5L6WC 1NMDG 1F7SA 1J72A 3FG6A 2MOTA 1SVRA 1AK7A 1NM1G 2FF6G 1P8ZG 1EQYS 3L50A 1C0GS 5FAFA 2MV2A 3FG7A 5KYNA 2NUTB 2FGHA 1Q8GA 5A1MA 1WM4A 1V6FA 2NUPB 3CJCG 3EFOB 3EGXB 3TU5B 2L72A 4KEFA 3A5OS 2NUTA 1KCQA 4KEEA 3CI5G 1M2VA 1TMWA 3EFOA 4PKHB 3A5NS 1PCXA 5IVUA 2XFAA 2VILA 5KYWA 1D0NA 1CNUA 2QTVA 1T2LA 1C0FS 2FH1A 3CIPG 1NLVG 2LXXA 1T3YA 5HVKB 2I2QA 3FFNA 1Q8XA 1X67A 2FH4A 5FAEA 3DAWB 1ESVS 5KYUB 1M4JA 1T44G 2W0IA 3EG9B 1VFQA 2HD7A 2FF3A 2NUPA 1TVJA 1YAGG 2LJ8A 4CBXG 1D4XG 2XF1A 4JD2H 3EGXA 2FH2A 4Z94G 2FH3A 4PKIG 1AHQA 1JHWA 5KYYB 1T3XA 2VIKA 3DA7A 1PD0A 1HQZ1 1PD1A 2MP4A 1UDMA 4CBWG 2LLFA 1AK6A 3EH2A 5KYYA 1H1VG 4KEDA 3A5MS 3FFKA 1WNJA 5DD2A 3Q2BA 1CFYA 1M2OA 1MDUA 1COFA 1VKKA 2KVKA 1WFSA 4S10C 4CBUG 5KYXB 4LIZA 5KYUA 1SVYA 3EGDB 2D8BA 3EG9A 1NPHA 1DEJS 1QPVA 5KYXA 1M2VB 5HVKD 3CJBG 1RGIG 3EGDA 4PKGG 1YVNG 4BEX1
chains in the Genus database with same CATH topology

3EH1A 1SVQA 5KYWB 1P8XA 2VACA 3A5LS 5L6WC 1NMDG 1F7SA 1J72A 3FG6A 2MOTA 1SVRA 1AK7A 1NM1G 2FF6G 1P8ZG 1EQYS 3L50A 1C0GS 5FAFA 2MV2A 3FG7A 5KYNA 2NUTB 2FGHA 1Q8GA 5A1MA 1WM4A 1V6FA 2NUPB 3CJCG 3EFOB 3EGXB 3TU5B 2L72A 4KEFA 3A5OS 2NUTA 1KCQA 4KEEA 3CI5G 1M2VA 1TMWA 3EFOA 4PKHB 3A5NS 1PCXA 5IVUA 2XFAA 2VILA 5KYWA 1D0NA 1CNUA 2QTVA 1T2LA 1C0FS 2FH1A 3CIPG 1NLVG 2LXXA 1T3YA 5HVKB 2I2QA 3FFNA 1Q8XA 1X67A 2FH4A 5FAEA 3DAWB 1ESVS 5KYUB 1M4JA 1T44G 2W0IA 3EG9B 1VFQA 2HD7A 2FF3A 2NUPA 1TVJA 1YAGG 2LJ8A 4CBXG 1D4XG 2XF1A 4JD2H 3EGXA 2FH2A 4Z94G 2FH3A 4PKIG 1AHQA 1JHWA 5KYYB 1T3XA 2VIKA 3DA7A 1PD0A 1HQZ1 1PD1A 2MP4A 1UDMA 4CBWG 2LLFA 1AK6A 3EH2A 5KYYA 1H1VG 4KEDA 3A5MS 3FFKA 1WNJA 5DD2A 3Q2BA 1CFYA 1M2OA 1MDUA 1COFA 1VKKA 2KVKA 1WFSA 4S10C 4CBUG 5KYXB 4LIZA 5KYUA 1SVYA 3EGDB 2D8BA 3EG9A 1NPHA 1DEJS 1QPVA 5KYXA 1M2VB 5HVKD 3CJBG 1RGIG 3EGDA 4PKGG 1YVNG 4BEX1
chains in the Genus database with same CATH homology

#chains in the Genus database with same CATH superfamily
 3EH1 A;  1SVQ A;  5KYW B;  1P8X A;  2VAC A;  3A5L S;  5L6W C;  1NMD G;  1F7S A;  1J72 A;  3FG6 A;  2MOT A;  1SVR A;  1AK7 A;  1NM1 G;  2FF6 G;  1P8Z G;  1EQY S;  3L50 A;  1C0G S;  5FAF A;  2MV2 A;  3FG7 A;  5KYN A;  2NUT B;  2FGH A;  1Q8G A;  5A1M A;  1WM4 A;  1V6F A;  2NUP B;  3CJC G;  3EFO B;  3EGX B;  3TU5 B;  2L72 A;  4KEF A;  3A5O S;  2NUT A;  1KCQ A;  4KEE A;  3CI5 G;  1M2V A;  1TMW A;  3EFO A;  4PKH B;  3A5N S;  1PCX A;  5IVU A;  2XFA A;  2VIL A;  5KYW A;  1D0N A;  1CNU A;  2QTV A;  1T2L A;  1C0F S;  2FH1 A;  3CIP G;  1NLV G;  2LXX A;  1T3Y A;  5HVK B;  2I2Q A;  3FFN A;  1Q8X A;  1X67 A;  2FH4 A;  5FAE A;  3DAW B;  1ESV S;  5KYU B;  1M4J A;  1T44 G;  2W0I A;  3EG9 B;  1VFQ A;  2HD7 A;  2FF3 A;  2NUP A;  1TVJ A;  1YAG G;  2LJ8 A;  4CBX G;  1D4X G;  2XF1 A;  4JD2 H;  3EGX A;  2FH2 A;  4Z94 G;  2FH3 A;  4PKI G;  1AHQ A;  1JHW A;  5KYY B;  1T3X A;  2VIK A;  1PD0 A;  1HQZ 1;  1PD1 A;  2MP4 A;  1UDM A;  4CBW G;  2LLF A;  1AK6 A;  3EH2 A;  5KYY A;  1H1V G;  4KED A;  3A5M S;  3FFK A;  1WNJ A;  5DD2 A;  3Q2B A;  1CFY A;  1M2O A;  1MDU A;  1COF A;  1VKK A;  2KVK A;  1WFS A;  4S10 C;  4CBU G;  5KYX B;  4LIZ A;  5KYU A;  1SVY A;  3EGD B;  2D8B A;  3EG9 A;  1NPH A;  1DEJ S;  1QPV A;  5KYX A;  1M2V B;  5HVK D;  3CJB G;  1RGI G;  3EGD A;  4PKG G;  1YVN G;  4BEX 1; 
#chains in the Genus database with same CATH topology
 3EH1 A;  1SVQ A;  5KYW B;  1P8X A;  2VAC A;  3A5L S;  5L6W C;  1NMD G;  1F7S A;  1J72 A;  3FG6 A;  2MOT A;  1SVR A;  1AK7 A;  1NM1 G;  2FF6 G;  1P8Z G;  1EQY S;  3L50 A;  1C0G S;  5FAF A;  2MV2 A;  3FG7 A;  5KYN A;  2NUT B;  2FGH A;  1Q8G A;  5A1M A;  1WM4 A;  1V6F A;  2NUP B;  3CJC G;  3EFO B;  3EGX B;  3TU5 B;  2L72 A;  4KEF A;  3A5O S;  2NUT A;  1KCQ A;  4KEE A;  3CI5 G;  1M2V A;  1TMW A;  3EFO A;  4PKH B;  3A5N S;  1PCX A;  5IVU A;  2XFA A;  2VIL A;  5KYW A;  1D0N A;  1CNU A;  2QTV A;  1T2L A;  1C0F S;  2FH1 A;  3CIP G;  1NLV G;  2LXX A;  1T3Y A;  5HVK B;  2I2Q A;  3FFN A;  1Q8X A;  1X67 A;  2FH4 A;  5FAE A;  3DAW B;  1ESV S;  5KYU B;  1M4J A;  1T44 G;  2W0I A;  3EG9 B;  1VFQ A;  2HD7 A;  2FF3 A;  2NUP A;  1TVJ A;  1YAG G;  2LJ8 A;  4CBX G;  1D4X G;  2XF1 A;  4JD2 H;  3EGX A;  2FH2 A;  4Z94 G;  2FH3 A;  4PKI G;  1AHQ A;  1JHW A;  5KYY B;  1T3X A;  2VIK A;  3DA7 A;  1PD0 A;  1HQZ 1;  1PD1 A;  2MP4 A;  1UDM A;  4CBW G;  2LLF A;  1AK6 A;  3EH2 A;  5KYY A;  1H1V G;  4KED A;  3A5M S;  3FFK A;  1WNJ A;  5DD2 A;  3Q2B A;  1CFY A;  1M2O A;  1MDU A;  1COF A;  1VKK A;  2KVK A;  1WFS A;  4S10 C;  4CBU G;  5KYX B;  4LIZ A;  5KYU A;  1SVY A;  3EGD B;  2D8B A;  3EG9 A;  1NPH A;  1DEJ S;  1QPV A;  5KYX A;  1M2V B;  5HVK D;  3CJB G;  1RGI G;  3EGD A;  4PKG G;  1YVN G;  4BEX 1; 
#chains in the Genus database with same CATH homology
 3EH1 A;  1SVQ A;  5KYW B;  1P8X A;  2VAC A;  3A5L S;  5L6W C;  1NMD G;  1F7S A;  1J72 A;  3FG6 A;  2MOT A;  1SVR A;  1AK7 A;  1NM1 G;  2FF6 G;  1P8Z G;  1EQY S;  3L50 A;  1C0G S;  5FAF A;  2MV2 A;  3FG7 A;  5KYN A;  2NUT B;  2FGH A;  1Q8G A;  5A1M A;  1WM4 A;  1V6F A;  2NUP B;  3CJC G;  3EFO B;  3EGX B;  3TU5 B;  2L72 A;  4KEF A;  3A5O S;  2NUT A;  1KCQ A;  4KEE A;  3CI5 G;  1M2V A;  1TMW A;  3EFO A;  4PKH B;  3A5N S;  1PCX A;  5IVU A;  2XFA A;  2VIL A;  5KYW A;  1D0N A;  1CNU A;  2QTV A;  1T2L A;  1C0F S;  2FH1 A;  3CIP G;  1NLV G;  2LXX A;  1T3Y A;  5HVK B;  2I2Q A;  3FFN A;  1Q8X A;  1X67 A;  2FH4 A;  5FAE A;  3DAW B;  1ESV S;  5KYU B;  1M4J A;  1T44 G;  2W0I A;  3EG9 B;  1VFQ A;  2HD7 A;  2FF3 A;  2NUP A;  1TVJ A;  1YAG G;  2LJ8 A;  4CBX G;  1D4X G;  2XF1 A;  4JD2 H;  3EGX A;  2FH2 A;  4Z94 G;  2FH3 A;  4PKI G;  1AHQ A;  1JHW A;  5KYY B;  1T3X A;  2VIK A;  3DA7 A;  1PD0 A;  1HQZ 1;  1PD1 A;  2MP4 A;  1UDM A;  4CBW G;  2LLF A;  1AK6 A;  3EH2 A;  5KYY A;  1H1V G;  4KED A;  3A5M S;  3FFK A;  1WNJ A;  5DD2 A;  3Q2B A;  1CFY A;  1M2O A;  1MDU A;  1COF A;  1VKK A;  2KVK A;  1WFS A;  4S10 C;  4CBU G;  5KYX B;  4LIZ A;  5KYU A;  1SVY A;  3EGD B;  2D8B A;  3EG9 A;  1NPH A;  1DEJ S;  1QPV A;  5KYX A;  1M2V B;  5HVK D;  3CJB G;  1RGI G;  3EGD A;  4PKG G;  1YVN G;  4BEX 1;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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1M4JA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations