1P8XA

The calcium-activated c-terminal half of gelsolin
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
330
structure length
316
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDNRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Gelsolin precursor, plasma
total genus 96
structure length 316
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2003-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA02
2NUPA 1NMDG 1SVYA 2D8BA 3EH2A 1M2OA 3DAWB 3EG9A 5KYUA 1AK7A 3EFOB 1F7SA 3A5LS 2W0IA 3CIPG 5KYWA 1MDUA 1JHWA 2VILA 2VIKA 4Z94G 3EFOA 1T44G 1PD1A 1M2VA 2FH3A 4JD2H 2HD7A 1M4JA 2VACA 1P8ZG 1COFA 4LIZA 1QPVA 1T3YA 3EGDA 1NPHA 1V6FA 1D4XG 5KYYA 3FG6A 1PCXA 1P8XA 1VKKA 1TMWA 1HQZ1 1AHQA 5KYXB 3EH1A 5A1MA 2FF3A 2FF6G 4KEFA 5IVUA 5HVKD 4S10C 3EGXB 3TU5B 2LXXA 1Q8XA 1WM4A 4PKGG 5FAFA 1TVJA 1CNUA 2QTVA 5L6WC 5KYNA 2FH4A 1ESVS 1X67A 3FFKA 4KEEA 2LJ8A 3A5NS 4PKIG 1RGIG 1T3XA 1DEJS 1VFQA 3FFNA 3A5OS 2FH2A 1NLVG 1AK6A 1CFYA 1WNJA 2NUPB 2LLFA 1YAGG 5FAEA 4CBWG 1H1VG 1YVNG 2L72A 4KEDA 1SVRA 3EG9B 2MV2A 5KYXA 3CJCG 1SVQA 3L50A 2MP4A 3A5MS 1C0GS 1T2LA 1PD0A 4BEX1 1Q8GA 5KYWB 4PKHB 3EGXA 1UDMA 3CJBG 1NM1G 1M2VB 1C0FS 1WFSA 5DD2A 2MOTA 2KVKA 3CI5G 2XF1A 3Q2BA 2FH1A 2NUTB 4CBXG 1KCQA 2I2QA 3EGDB 1D0NA 2FGHA 2XFAA 1EQYS 4CBUG 5HVKB 5KYYB 2NUTA 5KYUB 1J72A 3FG7A
chains in the Genus database with same CATH superfamily
2NUPA 1NMDG 1SVYA 2D8BA 3EH2A 1M2OA 3DAWB 3EG9A 5KYUA 1AK7A 3EFOB 1F7SA 3A5LS 2W0IA 3CIPG 5KYWA 1MDUA 1JHWA 2VILA 2VIKA 4Z94G 3EFOA 1T44G 1PD1A 1M2VA 2FH3A 4JD2H 2HD7A 1M4JA 2VACA 1P8ZG 1COFA 4LIZA 1QPVA 1T3YA 3EGDA 1NPHA 1V6FA 1D4XG 5KYYA 3FG6A 1PCXA 1P8XA 1VKKA 1TMWA 1HQZ1 1AHQA 5KYXB 3EH1A 5A1MA 2FF3A 2FF6G 4KEFA 5IVUA 5HVKD 4S10C 3EGXB 3TU5B 2LXXA 1Q8XA 1WM4A 4PKGG 5FAFA 1TVJA 1CNUA 2QTVA 5L6WC 5KYNA 2FH4A 1ESVS 1X67A 3FFKA 4KEEA 2LJ8A 3A5NS 4PKIG 1RGIG 1T3XA 1DEJS 1VFQA 3FFNA 3DA7A 3A5OS 2FH2A 1NLVG 1AK6A 1CFYA 1WNJA 2NUPB 2LLFA 1YAGG 5FAEA 4CBWG 1H1VG 1YVNG 2L72A 4KEDA 1SVRA 3EG9B 2MV2A 5KYXA 3CJCG 1SVQA 3L50A 2MP4A 3A5MS 1C0GS 1T2LA 1PD0A 4BEX1 1Q8GA 5KYWB 4PKHB 3EGXA 1UDMA 3CJBG 1NM1G 1M2VB 1C0FS 1WFSA 5DD2A 2MOTA 2KVKA 3CI5G 2XF1A 3Q2BA 2FH1A 2NUTB 4CBXG 1KCQA 2I2QA 3EGDB 1D0NA 2FGHA 2XFAA 1EQYS 4CBUG 5HVKB 5KYYB 2NUTA 5KYUB 1J72A 3FG7A
chains in the Genus database with same CATH topology
2NUPA 1NMDG 1SVYA 2D8BA 3EH2A 1M2OA 3DAWB 3EG9A 5KYUA 1AK7A 3EFOB 1F7SA 3A5LS 2W0IA 3CIPG 5KYWA 1MDUA 1JHWA 2VILA 2VIKA 4Z94G 3EFOA 1T44G 1PD1A 1M2VA 2FH3A 4JD2H 2HD7A 1M4JA 2VACA 1P8ZG 1COFA 4LIZA 1QPVA 1T3YA 3EGDA 1NPHA 1V6FA 1D4XG 5KYYA 3FG6A 1PCXA 1P8XA 1VKKA 1TMWA 1HQZ1 1AHQA 5KYXB 3EH1A 5A1MA 2FF3A 2FF6G 4KEFA 5IVUA 5HVKD 4S10C 3EGXB 3TU5B 2LXXA 1Q8XA 1WM4A 4PKGG 5FAFA 1TVJA 1CNUA 2QTVA 5L6WC 5KYNA 2FH4A 1ESVS 1X67A 3FFKA 4KEEA 2LJ8A 3A5NS 4PKIG 1RGIG 1T3XA 1DEJS 1VFQA 3FFNA 3DA7A 3A5OS 2FH2A 1NLVG 1AK6A 1CFYA 1WNJA 2NUPB 2LLFA 1YAGG 5FAEA 4CBWG 1H1VG 1YVNG 2L72A 4KEDA 1SVRA 3EG9B 2MV2A 5KYXA 3CJCG 1SVQA 3L50A 2MP4A 3A5MS 1C0GS 1T2LA 1PD0A 4BEX1 1Q8GA 5KYWB 4PKHB 3EGXA 1UDMA 3CJBG 1NM1G 1M2VB 1C0FS 1WFSA 5DD2A 2MOTA 2KVKA 3CI5G 2XF1A 3Q2BA 2FH1A 2NUTB 4CBXG 1KCQA 2I2QA 3EGDB 1D0NA 2FGHA 2XFAA 1EQYS 4CBUG 5HVKB 5KYYB 2NUTA 5KYUB 1J72A 3FG7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NUP A;  1NMD G;  1SVY A;  2D8B A;  3EH2 A;  1M2O A;  3DAW B;  3EG9 A;  5KYU A;  1AK7 A;  3EFO B;  1F7S A;  3A5L S;  2W0I A;  3CIP G;  5KYW A;  1MDU A;  1JHW A;  2VIL A;  2VIK A;  4Z94 G;  3EFO A;  1T44 G;  1PD1 A;  1M2V A;  2FH3 A;  4JD2 H;  2HD7 A;  1M4J A;  2VAC A;  1P8Z G;  1COF A;  4LIZ A;  1QPV A;  1T3Y A;  3EGD A;  1NPH A;  1V6F A;  1D4X G;  5KYY A;  3FG6 A;  1PCX A;  1P8X A;  1VKK A;  1TMW A;  1HQZ 1;  1AHQ A;  5KYX B;  3EH1 A;  5A1M A;  2FF3 A;  2FF6 G;  4KEF A;  5IVU A;  5HVK D;  4S10 C;  3EGX B;  3TU5 B;  2LXX A;  1Q8X A;  1WM4 A;  4PKG G;  5FAF A;  1TVJ A;  1CNU A;  2QTV A;  5L6W C;  5KYN A;  2FH4 A;  1ESV S;  1X67 A;  3FFK A;  4KEE A;  2LJ8 A;  3A5N S;  4PKI G;  1RGI G;  1T3X A;  1DEJ S;  1VFQ A;  3FFN A;  3A5O S;  2FH2 A;  1NLV G;  1AK6 A;  1CFY A;  1WNJ A;  2NUP B;  2LLF A;  1YAG G;  5FAE A;  4CBW G;  1H1V G;  1YVN G;  2L72 A;  4KED A;  1SVR A;  3EG9 B;  2MV2 A;  5KYX A;  3CJC G;  1SVQ A;  3L50 A;  2MP4 A;  3A5M S;  1C0G S;  1T2L A;  1PD0 A;  4BEX 1;  1Q8G A;  5KYW B;  4PKH B;  3EGX A;  1UDM A;  3CJB G;  1NM1 G;  1M2V B;  1C0F S;  1WFS A;  5DD2 A;  2MOT A;  2KVK A;  3CI5 G;  2XF1 A;  3Q2B A;  2FH1 A;  2NUT B;  4CBX G;  1KCQ A;  2I2Q A;  3EGD B;  1D0N A;  2FGH A;  2XFA A;  1EQY S;  4CBU G;  5HVK B;  5KYY B;  2NUT A;  5KYU B;  1J72 A;  3FG7 A; 
#chains in the Genus database with same CATH topology
 2NUP A;  1NMD G;  1SVY A;  2D8B A;  3EH2 A;  1M2O A;  3DAW B;  3EG9 A;  5KYU A;  1AK7 A;  3EFO B;  1F7S A;  3A5L S;  2W0I A;  3CIP G;  5KYW A;  1MDU A;  1JHW A;  2VIL A;  2VIK A;  4Z94 G;  3EFO A;  1T44 G;  1PD1 A;  1M2V A;  2FH3 A;  4JD2 H;  2HD7 A;  1M4J A;  2VAC A;  1P8Z G;  1COF A;  4LIZ A;  1QPV A;  1T3Y A;  3EGD A;  1NPH A;  1V6F A;  1D4X G;  5KYY A;  3FG6 A;  1PCX A;  1P8X A;  1VKK A;  1TMW A;  1HQZ 1;  1AHQ A;  5KYX B;  3EH1 A;  5A1M A;  2FF3 A;  2FF6 G;  4KEF A;  5IVU A;  5HVK D;  4S10 C;  3EGX B;  3TU5 B;  2LXX A;  1Q8X A;  1WM4 A;  4PKG G;  5FAF A;  1TVJ A;  1CNU A;  2QTV A;  5L6W C;  5KYN A;  2FH4 A;  1ESV S;  1X67 A;  3FFK A;  4KEE A;  2LJ8 A;  3A5N S;  4PKI G;  1RGI G;  1T3X A;  1DEJ S;  1VFQ A;  3FFN A;  3DA7 A;  3A5O S;  2FH2 A;  1NLV G;  1AK6 A;  1CFY A;  1WNJ A;  2NUP B;  2LLF A;  1YAG G;  5FAE A;  4CBW G;  1H1V G;  1YVN G;  2L72 A;  4KED A;  1SVR A;  3EG9 B;  2MV2 A;  5KYX A;  3CJC G;  1SVQ A;  3L50 A;  2MP4 A;  3A5M S;  1C0G S;  1T2L A;  1PD0 A;  4BEX 1;  1Q8G A;  5KYW B;  4PKH B;  3EGX A;  1UDM A;  3CJB G;  1NM1 G;  1M2V B;  1C0F S;  1WFS A;  5DD2 A;  2MOT A;  2KVK A;  3CI5 G;  2XF1 A;  3Q2B A;  2FH1 A;  2NUT B;  4CBX G;  1KCQ A;  2I2Q A;  3EGD B;  1D0N A;  2FGH A;  2XFA A;  1EQY S;  4CBU G;  5HVK B;  5KYY B;  2NUT A;  5KYU B;  1J72 A;  3FG7 A; 
#chains in the Genus database with same CATH homology
 2NUP A;  1NMD G;  1SVY A;  2D8B A;  3EH2 A;  1M2O A;  3DAW B;  3EG9 A;  5KYU A;  1AK7 A;  3EFO B;  1F7S A;  3A5L S;  2W0I A;  3CIP G;  5KYW A;  1MDU A;  1JHW A;  2VIL A;  2VIK A;  4Z94 G;  3EFO A;  1T44 G;  1PD1 A;  1M2V A;  2FH3 A;  4JD2 H;  2HD7 A;  1M4J A;  2VAC A;  1P8Z G;  1COF A;  4LIZ A;  1QPV A;  1T3Y A;  3EGD A;  1NPH A;  1V6F A;  1D4X G;  5KYY A;  3FG6 A;  1PCX A;  1P8X A;  1VKK A;  1TMW A;  1HQZ 1;  1AHQ A;  5KYX B;  3EH1 A;  5A1M A;  2FF3 A;  2FF6 G;  4KEF A;  5IVU A;  5HVK D;  4S10 C;  3EGX B;  3TU5 B;  2LXX A;  1Q8X A;  1WM4 A;  4PKG G;  5FAF A;  1TVJ A;  1CNU A;  2QTV A;  5L6W C;  5KYN A;  2FH4 A;  1ESV S;  1X67 A;  3FFK A;  4KEE A;  2LJ8 A;  3A5N S;  4PKI G;  1RGI G;  1T3X A;  1DEJ S;  1VFQ A;  3FFN A;  3DA7 A;  3A5O S;  2FH2 A;  1NLV G;  1AK6 A;  1CFY A;  1WNJ A;  2NUP B;  2LLF A;  1YAG G;  5FAE A;  4CBW G;  1H1V G;  1YVN G;  2L72 A;  4KED A;  1SVR A;  3EG9 B;  2MV2 A;  5KYX A;  3CJC G;  1SVQ A;  3L50 A;  2MP4 A;  3A5M S;  1C0G S;  1T2L A;  1PD0 A;  4BEX 1;  1Q8G A;  5KYW B;  4PKH B;  3EGX A;  1UDM A;  3CJB G;  1NM1 G;  1M2V B;  1C0F S;  1WFS A;  5DD2 A;  2MOT A;  2KVK A;  3CI5 G;  2XF1 A;  3Q2B A;  2FH1 A;  2NUT B;  4CBX G;  1KCQ A;  2I2Q A;  3EGD B;  1D0N A;  2FGH A;  2XFA A;  1EQY S;  4CBU G;  5HVK B;  5KYY B;  2NUT A;  5KYU B;  1J72 A;  3FG7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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