1P8XA

The calcium-activated c-terminal half of gelsolin
Total Genus 96
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
96
sequence length
330
structure length
316
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDNRDRRTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Activation in isolation: Exposure of the actin-binding site in the C-terminal half of gelsolin does not require actin
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Gelsolin precursor, plasma
total genus 96
structure length 316
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2003-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1p8xA02
1AK7A 1P8XA 2L72A 2LLFA 3A5OS 5FAFA 5KYWA 1T3XA 4KEDA 1JHWA 1WFSA 4KEEA 3EH1A 2LXXA 3DAWB 3FFNA 1Q8XA 2MOTA 3A5NS 1NPHA 4PKIG 2VIKA 2XF1A 2QTVA 3EFOA 3EGDA 1PD0A 2MV2A 4Z94G 1M2VA 5KYUA 4PKHB 3EH2A 1WM4A 2FGHA 3A5LS 1VKKA 2FH3A 1AHQA 2XFAA 1COFA 3TU5B 2I2QA 1H1VG 1QPVA 2FH1A 1YAGG 1TMWA 1CFYA 2FH2A 5KYNA 1NMDG 5HVKD 1AK6A 3EGXB 2NUTA 1C0GS 2W0IA 4KEFA 5KYYA 1ESVS 5KYUB 1M2VB 5HVKB 1TVJA 3EG9A 4CBXG 3CJBG 1F7SA 3CI5G 1T3YA 4S10C 5FAEA 5KYWB 1SVYA 3CJCG 3A5MS 4PKGG 3FFKA 1P8ZG 2HD7A 2FF3A 2FH4A 1PD1A 2VILA 2KVKA 1CNUA 1T2LA 1KCQA 1D0NA 1V6FA 2VACA 1VFQA 1M2OA 2NUTB 3Q2BA 5L6WC 2NUPA 1M4JA 3EFOB 3EG9B 1C0FS 3EGDB 3FG7A 1SVRA 4BEX1 2LJ8A 5KYXA 2D8BA 1NLVG 1DEJS 3L50A 1PCXA 3CIPG 1YVNG 2FF6G 1Q8GA 1J72A 1MDUA 1EQYS 1T44G 1D4XG 1SVQA 1WNJA 1HQZ1 4JD2H 4CBWG 4LIZA 5DD2A 5A1MA 2MP4A 1RGIG 2NUPB 1X67A 3EGXA 3FG6A 4CBUG 5KYYB 1NM1G 5IVUA 1UDMA 5KYXB
chains in the Genus database with same CATH superfamily
1AK7A 1P8XA 2L72A 2LLFA 3A5OS 5FAFA 5KYWA 3DA7A 1T3XA 4KEDA 1JHWA 1WFSA 4KEEA 3EH1A 2LXXA 3DAWB 3FFNA 1Q8XA 2MOTA 3A5NS 1NPHA 4PKIG 2VIKA 2XF1A 2QTVA 3EFOA 3EGDA 1PD0A 2MV2A 4Z94G 1M2VA 5KYUA 4PKHB 3EH2A 1WM4A 2FGHA 3A5LS 1VKKA 2FH3A 1AHQA 2XFAA 1COFA 3TU5B 2I2QA 1H1VG 1QPVA 2FH1A 1YAGG 1TMWA 1CFYA 2FH2A 5KYNA 1NMDG 5HVKD 1AK6A 3EGXB 2NUTA 1C0GS 2W0IA 4KEFA 5KYYA 1ESVS 5KYUB 1M2VB 5HVKB 1TVJA 3EG9A 4CBXG 3CJBG 1F7SA 3CI5G 1T3YA 4S10C 5FAEA 5KYWB 1SVYA 3CJCG 3A5MS 4PKGG 3FFKA 1P8ZG 2HD7A 2FF3A 2FH4A 1PD1A 2VILA 2KVKA 1CNUA 1T2LA 1KCQA 1D0NA 1V6FA 2VACA 1VFQA 1M2OA 2NUTB 3Q2BA 5L6WC 2NUPA 1M4JA 3EFOB 3EG9B 1C0FS 3EGDB 3FG7A 1SVRA 4BEX1 2LJ8A 5KYXA 2D8BA 1NLVG 1DEJS 3L50A 1PCXA 3CIPG 1YVNG 2FF6G 1Q8GA 1J72A 1MDUA 1EQYS 1T44G 1D4XG 1SVQA 1WNJA 1HQZ1 4JD2H 4CBWG 4LIZA 5DD2A 5A1MA 2MP4A 1RGIG 2NUPB 1X67A 3EGXA 3FG6A 4CBUG 5KYYB 1NM1G 5IVUA 1UDMA 5KYXB
chains in the Genus database with same CATH topology
1AK7A 1P8XA 2L72A 2LLFA 3A5OS 5FAFA 5KYWA 3DA7A 1T3XA 4KEDA 1JHWA 1WFSA 4KEEA 3EH1A 2LXXA 3DAWB 3FFNA 1Q8XA 2MOTA 3A5NS 1NPHA 4PKIG 2VIKA 2XF1A 2QTVA 3EFOA 3EGDA 1PD0A 2MV2A 4Z94G 1M2VA 5KYUA 4PKHB 3EH2A 1WM4A 2FGHA 3A5LS 1VKKA 2FH3A 1AHQA 2XFAA 1COFA 3TU5B 2I2QA 1H1VG 1QPVA 2FH1A 1YAGG 1TMWA 1CFYA 2FH2A 5KYNA 1NMDG 5HVKD 1AK6A 3EGXB 2NUTA 1C0GS 2W0IA 4KEFA 5KYYA 1ESVS 5KYUB 1M2VB 5HVKB 1TVJA 3EG9A 4CBXG 3CJBG 1F7SA 3CI5G 1T3YA 4S10C 5FAEA 5KYWB 1SVYA 3CJCG 3A5MS 4PKGG 3FFKA 1P8ZG 2HD7A 2FF3A 2FH4A 1PD1A 2VILA 2KVKA 1CNUA 1T2LA 1KCQA 1D0NA 1V6FA 2VACA 1VFQA 1M2OA 2NUTB 3Q2BA 5L6WC 2NUPA 1M4JA 3EFOB 3EG9B 1C0FS 3EGDB 3FG7A 1SVRA 4BEX1 2LJ8A 5KYXA 2D8BA 1NLVG 1DEJS 3L50A 1PCXA 3CIPG 1YVNG 2FF6G 1Q8GA 1J72A 1MDUA 1EQYS 1T44G 1D4XG 1SVQA 1WNJA 1HQZ1 4JD2H 4CBWG 4LIZA 5DD2A 5A1MA 2MP4A 1RGIG 2NUPB 1X67A 3EGXA 3FG6A 4CBUG 5KYYB 1NM1G 5IVUA 1UDMA 5KYXB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AK7 A;  1P8X A;  2L72 A;  2LLF A;  3A5O S;  5FAF A;  5KYW A;  1T3X A;  4KED A;  1JHW A;  1WFS A;  4KEE A;  3EH1 A;  2LXX A;  3DAW B;  3FFN A;  1Q8X A;  2MOT A;  3A5N S;  1NPH A;  4PKI G;  2VIK A;  2XF1 A;  2QTV A;  3EFO A;  3EGD A;  1PD0 A;  2MV2 A;  4Z94 G;  1M2V A;  5KYU A;  4PKH B;  3EH2 A;  1WM4 A;  2FGH A;  3A5L S;  1VKK A;  2FH3 A;  1AHQ A;  2XFA A;  1COF A;  3TU5 B;  2I2Q A;  1H1V G;  1QPV A;  2FH1 A;  1YAG G;  1TMW A;  1CFY A;  2FH2 A;  5KYN A;  1NMD G;  5HVK D;  1AK6 A;  3EGX B;  2NUT A;  1C0G S;  2W0I A;  4KEF A;  5KYY A;  1ESV S;  5KYU B;  1M2V B;  5HVK B;  1TVJ A;  3EG9 A;  4CBX G;  3CJB G;  1F7S A;  3CI5 G;  1T3Y A;  4S10 C;  5FAE A;  5KYW B;  1SVY A;  3CJC G;  3A5M S;  4PKG G;  3FFK A;  1P8Z G;  2HD7 A;  2FF3 A;  2FH4 A;  1PD1 A;  2VIL A;  2KVK A;  1CNU A;  1T2L A;  1KCQ A;  1D0N A;  1V6F A;  2VAC A;  1VFQ A;  1M2O A;  2NUT B;  3Q2B A;  5L6W C;  2NUP A;  1M4J A;  3EFO B;  3EG9 B;  1C0F S;  3EGD B;  3FG7 A;  1SVR A;  4BEX 1;  2LJ8 A;  5KYX A;  2D8B A;  1NLV G;  1DEJ S;  3L50 A;  1PCX A;  3CIP G;  1YVN G;  2FF6 G;  1Q8G A;  1J72 A;  1MDU A;  1EQY S;  1T44 G;  1D4X G;  1SVQ A;  1WNJ A;  1HQZ 1;  4JD2 H;  4CBW G;  4LIZ A;  5DD2 A;  5A1M A;  2MP4 A;  1RGI G;  2NUP B;  1X67 A;  3EGX A;  3FG6 A;  4CBU G;  5KYY B;  1NM1 G;  5IVU A;  1UDM A;  5KYX B; 
#chains in the Genus database with same CATH topology
 1AK7 A;  1P8X A;  2L72 A;  2LLF A;  3A5O S;  5FAF A;  5KYW A;  3DA7 A;  1T3X A;  4KED A;  1JHW A;  1WFS A;  4KEE A;  3EH1 A;  2LXX A;  3DAW B;  3FFN A;  1Q8X A;  2MOT A;  3A5N S;  1NPH A;  4PKI G;  2VIK A;  2XF1 A;  2QTV A;  3EFO A;  3EGD A;  1PD0 A;  2MV2 A;  4Z94 G;  1M2V A;  5KYU A;  4PKH B;  3EH2 A;  1WM4 A;  2FGH A;  3A5L S;  1VKK A;  2FH3 A;  1AHQ A;  2XFA A;  1COF A;  3TU5 B;  2I2Q A;  1H1V G;  1QPV A;  2FH1 A;  1YAG G;  1TMW A;  1CFY A;  2FH2 A;  5KYN A;  1NMD G;  5HVK D;  1AK6 A;  3EGX B;  2NUT A;  1C0G S;  2W0I A;  4KEF A;  5KYY A;  1ESV S;  5KYU B;  1M2V B;  5HVK B;  1TVJ A;  3EG9 A;  4CBX G;  3CJB G;  1F7S A;  3CI5 G;  1T3Y A;  4S10 C;  5FAE A;  5KYW B;  1SVY A;  3CJC G;  3A5M S;  4PKG G;  3FFK A;  1P8Z G;  2HD7 A;  2FF3 A;  2FH4 A;  1PD1 A;  2VIL A;  2KVK A;  1CNU A;  1T2L A;  1KCQ A;  1D0N A;  1V6F A;  2VAC A;  1VFQ A;  1M2O A;  2NUT B;  3Q2B A;  5L6W C;  2NUP A;  1M4J A;  3EFO B;  3EG9 B;  1C0F S;  3EGD B;  3FG7 A;  1SVR A;  4BEX 1;  2LJ8 A;  5KYX A;  2D8B A;  1NLV G;  1DEJ S;  3L50 A;  1PCX A;  3CIP G;  1YVN G;  2FF6 G;  1Q8G A;  1J72 A;  1MDU A;  1EQY S;  1T44 G;  1D4X G;  1SVQ A;  1WNJ A;  1HQZ 1;  4JD2 H;  4CBW G;  4LIZ A;  5DD2 A;  5A1M A;  2MP4 A;  1RGI G;  2NUP B;  1X67 A;  3EGX A;  3FG6 A;  4CBU G;  5KYY B;  1NM1 G;  5IVU A;  1UDM A;  5KYX B; 
#chains in the Genus database with same CATH homology
 1AK7 A;  1P8X A;  2L72 A;  2LLF A;  3A5O S;  5FAF A;  5KYW A;  3DA7 A;  1T3X A;  4KED A;  1JHW A;  1WFS A;  4KEE A;  3EH1 A;  2LXX A;  3DAW B;  3FFN A;  1Q8X A;  2MOT A;  3A5N S;  1NPH A;  4PKI G;  2VIK A;  2XF1 A;  2QTV A;  3EFO A;  3EGD A;  1PD0 A;  2MV2 A;  4Z94 G;  1M2V A;  5KYU A;  4PKH B;  3EH2 A;  1WM4 A;  2FGH A;  3A5L S;  1VKK A;  2FH3 A;  1AHQ A;  2XFA A;  1COF A;  3TU5 B;  2I2Q A;  1H1V G;  1QPV A;  2FH1 A;  1YAG G;  1TMW A;  1CFY A;  2FH2 A;  5KYN A;  1NMD G;  5HVK D;  1AK6 A;  3EGX B;  2NUT A;  1C0G S;  2W0I A;  4KEF A;  5KYY A;  1ESV S;  5KYU B;  1M2V B;  5HVK B;  1TVJ A;  3EG9 A;  4CBX G;  3CJB G;  1F7S A;  3CI5 G;  1T3Y A;  4S10 C;  5FAE A;  5KYW B;  1SVY A;  3CJC G;  3A5M S;  4PKG G;  3FFK A;  1P8Z G;  2HD7 A;  2FF3 A;  2FH4 A;  1PD1 A;  2VIL A;  2KVK A;  1CNU A;  1T2L A;  1KCQ A;  1D0N A;  1V6F A;  2VAC A;  1VFQ A;  1M2O A;  2NUT B;  3Q2B A;  5L6W C;  2NUP A;  1M4J A;  3EFO B;  3EG9 B;  1C0F S;  3EGD B;  3FG7 A;  1SVR A;  4BEX 1;  2LJ8 A;  5KYX A;  2D8B A;  1NLV G;  1DEJ S;  3L50 A;  1PCX A;  3CIP G;  1YVN G;  2FF6 G;  1Q8G A;  1J72 A;  1MDU A;  1EQY S;  1T44 G;  1D4X G;  1SVQ A;  1WNJ A;  1HQZ 1;  4JD2 H;  4CBW G;  4LIZ A;  5DD2 A;  5A1M A;  2MP4 A;  1RGI G;  2NUP B;  1X67 A;  3EGX A;  3FG6 A;  4CBU G;  5KYY B;  1NM1 G;  5IVU A;  1UDM A;  5KYX B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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