1T44G

Structural basis of actin sequestration by thymosin-b4: implications for arp2/3 activation
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
144
structure length
144
Chain Sequence
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVETQEKNPLPSKETIEQEKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Chimera of Gelsolin domain 1 and C-Terminal domain of thymos
total genus 41
structure length 144
sequence length 144
ec nomenclature
pdb deposition date 2004-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1t44G00
1JHWA 1AK6A 1NMDG 3A5MS 1COFA 3CJBG 3EGDA 4CBWG 1KCQA 1RGIG 5KYXA 1Q8GA 1T3XA 2FH4A 3TU5B 2FH1A 5HVKD 3EG9B 5KYYB 1WFSA 1TMWA 2FGHA 5KYNA 5KYWA 1ESVS 2LJ8A 1NM1G 3EGXB 3EFOA 1AK7A 2L72A 1T2LA 4JD2H 1PCXA 5KYXB 1T44G 2NUTA 1NPHA 2HD7A 2W0IA 1P8ZG 5KYWB 3A5NS 3EGXA 1SVQA 3FG7A 1WNJA 3EFOB 1J72A 1V6FA 5IVUA 2D8BA 4PKGG 2NUTB 1H1VG 4KEDA 2KVKA 1QPVA 2VACA 1CNUA 2FH2A 3FFKA 1C0GS 1UDMA 1MDUA 2I2QA 3FFNA 1D0NA 4LIZA 2VIKA 4CBXG 1Q8XA 1PD1A 2MP4A 5HVKB 1M2OA 1D4XG 5KYUA 1T3YA 1X67A 2FF6G 3Q2BA 2MV2A 2QTVA 3EH2A 4KEFA 5A1MA 1TVJA 1P8XA 2FH3A 1DEJS 3EH1A 4PKIG 1M2VB 3CIPG 1VFQA 2LXXA 5KYUB 1NLVG 1YVNG 2NUPB 4Z94G 3A5OS 3FG6A 3L50A 4S10C 3CI5G 1PD0A 1HQZ1 4BEX1 1CFYA 4PKHB 2MOTA 5DD2A 1M2VA 5FAEA 3CJCG 5FAFA 1M4JA 4KEEA 2NUPA 2LLFA 1SVRA 1EQYS 1YAGG 4CBUG 3EGDB 1F7SA 1AHQA 2XF1A 1SVYA 1VKKA 3EG9A 5KYYA 3DAWB 2FF3A 2VILA 1WM4A 2XFAA 3A5LS 1C0FS 5L6WC
chains in the Genus database with same CATH superfamily
1JHWA 1AK6A 1NMDG 3A5MS 1COFA 3CJBG 3EGDA 4CBWG 1KCQA 1RGIG 5KYXA 1Q8GA 1T3XA 2FH4A 3TU5B 2FH1A 5HVKD 3EG9B 5KYYB 1WFSA 1TMWA 2FGHA 5KYNA 5KYWA 1ESVS 2LJ8A 1NM1G 3EGXB 3EFOA 1AK7A 2L72A 1T2LA 4JD2H 1PCXA 5KYXB 1T44G 2NUTA 1NPHA 2HD7A 2W0IA 1P8ZG 5KYWB 3A5NS 3EGXA 1SVQA 3FG7A 1WNJA 3EFOB 1J72A 1V6FA 5IVUA 2D8BA 4PKGG 2NUTB 1H1VG 4KEDA 2KVKA 1QPVA 2VACA 1CNUA 2FH2A 3FFKA 1C0GS 1UDMA 1MDUA 2I2QA 3FFNA 1D0NA 4LIZA 2VIKA 4CBXG 1Q8XA 1PD1A 2MP4A 5HVKB 1M2OA 1D4XG 5KYUA 1T3YA 1X67A 2FF6G 3Q2BA 2MV2A 2QTVA 3EH2A 4KEFA 5A1MA 3DA7A 1TVJA 1P8XA 2FH3A 1DEJS 3EH1A 4PKIG 1M2VB 3CIPG 1VFQA 2LXXA 5KYUB 1NLVG 1YVNG 2NUPB 4Z94G 3A5OS 3FG6A 3L50A 4S10C 3CI5G 1PD0A 1HQZ1 4BEX1 1CFYA 4PKHB 2MOTA 5DD2A 1M2VA 5FAEA 3CJCG 5FAFA 1M4JA 4KEEA 2NUPA 2LLFA 1SVRA 1EQYS 1YAGG 4CBUG 3EGDB 1F7SA 1AHQA 2XF1A 1SVYA 1VKKA 3EG9A 5KYYA 3DAWB 2FF3A 2VILA 1WM4A 2XFAA 3A5LS 1C0FS 5L6WC
chains in the Genus database with same CATH topology
1JHWA 1AK6A 1NMDG 3A5MS 1COFA 3CJBG 3EGDA 4CBWG 1KCQA 1RGIG 5KYXA 1Q8GA 1T3XA 2FH4A 3TU5B 2FH1A 5HVKD 3EG9B 5KYYB 1WFSA 1TMWA 2FGHA 5KYNA 5KYWA 1ESVS 2LJ8A 1NM1G 3EGXB 3EFOA 1AK7A 2L72A 1T2LA 4JD2H 1PCXA 5KYXB 1T44G 2NUTA 1NPHA 2HD7A 2W0IA 1P8ZG 5KYWB 3A5NS 3EGXA 1SVQA 3FG7A 1WNJA 3EFOB 1J72A 1V6FA 5IVUA 2D8BA 4PKGG 2NUTB 1H1VG 4KEDA 2KVKA 1QPVA 2VACA 1CNUA 2FH2A 3FFKA 1C0GS 1UDMA 1MDUA 2I2QA 3FFNA 1D0NA 4LIZA 2VIKA 4CBXG 1Q8XA 1PD1A 2MP4A 5HVKB 1M2OA 1D4XG 5KYUA 1T3YA 1X67A 2FF6G 3Q2BA 2MV2A 2QTVA 3EH2A 4KEFA 5A1MA 3DA7A 1TVJA 1P8XA 2FH3A 1DEJS 3EH1A 4PKIG 1M2VB 3CIPG 1VFQA 2LXXA 5KYUB 1NLVG 1YVNG 2NUPB 4Z94G 3A5OS 3FG6A 3L50A 4S10C 3CI5G 1PD0A 1HQZ1 4BEX1 1CFYA 4PKHB 2MOTA 5DD2A 1M2VA 5FAEA 3CJCG 5FAFA 1M4JA 4KEEA 2NUPA 2LLFA 1SVRA 1EQYS 1YAGG 4CBUG 3EGDB 1F7SA 1AHQA 2XF1A 1SVYA 1VKKA 3EG9A 5KYYA 3DAWB 2FF3A 2VILA 1WM4A 2XFAA 3A5LS 1C0FS 5L6WC
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1JHW A;  1AK6 A;  1NMD G;  3A5M S;  1COF A;  3CJB G;  3EGD A;  4CBW G;  1KCQ A;  1RGI G;  5KYX A;  1Q8G A;  1T3X A;  2FH4 A;  3TU5 B;  2FH1 A;  5HVK D;  3EG9 B;  5KYY B;  1WFS A;  1TMW A;  2FGH A;  5KYN A;  5KYW A;  1ESV S;  2LJ8 A;  1NM1 G;  3EGX B;  3EFO A;  1AK7 A;  2L72 A;  1T2L A;  4JD2 H;  1PCX A;  5KYX B;  1T44 G;  2NUT A;  1NPH A;  2HD7 A;  2W0I A;  1P8Z G;  5KYW B;  3A5N S;  3EGX A;  1SVQ A;  3FG7 A;  1WNJ A;  3EFO B;  1J72 A;  1V6F A;  5IVU A;  2D8B A;  4PKG G;  2NUT B;  1H1V G;  4KED A;  2KVK A;  1QPV A;  2VAC A;  1CNU A;  2FH2 A;  3FFK A;  1C0G S;  1UDM A;  1MDU A;  2I2Q A;  3FFN A;  1D0N A;  4LIZ A;  2VIK A;  4CBX G;  1Q8X A;  1PD1 A;  2MP4 A;  5HVK B;  1M2O A;  1D4X G;  5KYU A;  1T3Y A;  1X67 A;  2FF6 G;  3Q2B A;  2MV2 A;  2QTV A;  3EH2 A;  4KEF A;  5A1M A;  1TVJ A;  1P8X A;  2FH3 A;  1DEJ S;  3EH1 A;  4PKI G;  1M2V B;  3CIP G;  1VFQ A;  2LXX A;  5KYU B;  1NLV G;  1YVN G;  2NUP B;  4Z94 G;  3A5O S;  3FG6 A;  3L50 A;  4S10 C;  3CI5 G;  1PD0 A;  1HQZ 1;  4BEX 1;  1CFY A;  4PKH B;  2MOT A;  5DD2 A;  1M2V A;  5FAE A;  3CJC G;  5FAF A;  1M4J A;  4KEE A;  2NUP A;  2LLF A;  1SVR A;  1EQY S;  1YAG G;  4CBU G;  3EGD B;  1F7S A;  1AHQ A;  2XF1 A;  1SVY A;  1VKK A;  3EG9 A;  5KYY A;  3DAW B;  2FF3 A;  2VIL A;  1WM4 A;  2XFA A;  3A5L S;  1C0F S;  5L6W C; 
#chains in the Genus database with same CATH topology
 1JHW A;  1AK6 A;  1NMD G;  3A5M S;  1COF A;  3CJB G;  3EGD A;  4CBW G;  1KCQ A;  1RGI G;  5KYX A;  1Q8G A;  1T3X A;  2FH4 A;  3TU5 B;  2FH1 A;  5HVK D;  3EG9 B;  5KYY B;  1WFS A;  1TMW A;  2FGH A;  5KYN A;  5KYW A;  1ESV S;  2LJ8 A;  1NM1 G;  3EGX B;  3EFO A;  1AK7 A;  2L72 A;  1T2L A;  4JD2 H;  1PCX A;  5KYX B;  1T44 G;  2NUT A;  1NPH A;  2HD7 A;  2W0I A;  1P8Z G;  5KYW B;  3A5N S;  3EGX A;  1SVQ A;  3FG7 A;  1WNJ A;  3EFO B;  1J72 A;  1V6F A;  5IVU A;  2D8B A;  4PKG G;  2NUT B;  1H1V G;  4KED A;  2KVK A;  1QPV A;  2VAC A;  1CNU A;  2FH2 A;  3FFK A;  1C0G S;  1UDM A;  1MDU A;  2I2Q A;  3FFN A;  1D0N A;  4LIZ A;  2VIK A;  4CBX G;  1Q8X A;  1PD1 A;  2MP4 A;  5HVK B;  1M2O A;  1D4X G;  5KYU A;  1T3Y A;  1X67 A;  2FF6 G;  3Q2B A;  2MV2 A;  2QTV A;  3EH2 A;  4KEF A;  5A1M A;  3DA7 A;  1TVJ A;  1P8X A;  2FH3 A;  1DEJ S;  3EH1 A;  4PKI G;  1M2V B;  3CIP G;  1VFQ A;  2LXX A;  5KYU B;  1NLV G;  1YVN G;  2NUP B;  4Z94 G;  3A5O S;  3FG6 A;  3L50 A;  4S10 C;  3CI5 G;  1PD0 A;  1HQZ 1;  4BEX 1;  1CFY A;  4PKH B;  2MOT A;  5DD2 A;  1M2V A;  5FAE A;  3CJC G;  5FAF A;  1M4J A;  4KEE A;  2NUP A;  2LLF A;  1SVR A;  1EQY S;  1YAG G;  4CBU G;  3EGD B;  1F7S A;  1AHQ A;  2XF1 A;  1SVY A;  1VKK A;  3EG9 A;  5KYY A;  3DAW B;  2FF3 A;  2VIL A;  1WM4 A;  2XFA A;  3A5L S;  1C0F S;  5L6W C; 
#chains in the Genus database with same CATH homology
 1JHW A;  1AK6 A;  1NMD G;  3A5M S;  1COF A;  3CJB G;  3EGD A;  4CBW G;  1KCQ A;  1RGI G;  5KYX A;  1Q8G A;  1T3X A;  2FH4 A;  3TU5 B;  2FH1 A;  5HVK D;  3EG9 B;  5KYY B;  1WFS A;  1TMW A;  2FGH A;  5KYN A;  5KYW A;  1ESV S;  2LJ8 A;  1NM1 G;  3EGX B;  3EFO A;  1AK7 A;  2L72 A;  1T2L A;  4JD2 H;  1PCX A;  5KYX B;  1T44 G;  2NUT A;  1NPH A;  2HD7 A;  2W0I A;  1P8Z G;  5KYW B;  3A5N S;  3EGX A;  1SVQ A;  3FG7 A;  1WNJ A;  3EFO B;  1J72 A;  1V6F A;  5IVU A;  2D8B A;  4PKG G;  2NUT B;  1H1V G;  4KED A;  2KVK A;  1QPV A;  2VAC A;  1CNU A;  2FH2 A;  3FFK A;  1C0G S;  1UDM A;  1MDU A;  2I2Q A;  3FFN A;  1D0N A;  4LIZ A;  2VIK A;  4CBX G;  1Q8X A;  1PD1 A;  2MP4 A;  5HVK B;  1M2O A;  1D4X G;  5KYU A;  1T3Y A;  1X67 A;  2FF6 G;  3Q2B A;  2MV2 A;  2QTV A;  3EH2 A;  4KEF A;  5A1M A;  3DA7 A;  1TVJ A;  1P8X A;  2FH3 A;  1DEJ S;  3EH1 A;  4PKI G;  1M2V B;  3CIP G;  1VFQ A;  2LXX A;  5KYU B;  1NLV G;  1YVN G;  2NUP B;  4Z94 G;  3A5O S;  3FG6 A;  3L50 A;  4S10 C;  3CI5 G;  1PD0 A;  1HQZ 1;  4BEX 1;  1CFY A;  4PKH B;  2MOT A;  5DD2 A;  1M2V A;  5FAE A;  3CJC G;  5FAF A;  1M4J A;  4KEE A;  2NUP A;  2LLF A;  1SVR A;  1EQY S;  1YAG G;  4CBU G;  3EGD B;  1F7S A;  1AHQ A;  2XF1 A;  1SVY A;  1VKK A;  3EG9 A;  5KYY A;  3DAW B;  2FF3 A;  2VIL A;  1WM4 A;  2XFA A;  3A5L S;  1C0F S;  5L6W C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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