1T44G

Structural basis of actin sequestration by thymosin-b4: implications for arp2/3 activation
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
144
structure length
144
Chain Sequence
EHPEFLKAGKEPGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVETQEKNPLPSKETIEQEKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins.
pubmed doi rcsb
molecule tags Structural protein
source organism Homo sapiens
molecule keywords Chimera of Gelsolin domain 1 and C-Terminal domain of thymos
total genus 41
structure length 144
sequence length 144
ec nomenclature
pdb deposition date 2004-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1t44G00
5KYNA 3CJBG 1EQYS 1SVRA 1WNJA 5HVKD 5FAEA 3A5LS 1WFSA 2VACA 3EGXB 4PKIG 2XF1A 1PD1A 3DAWB 3EGDB 1Q8GA 1T3YA 1M2VB 1RGIG 1M2OA 2L72A 5DD2A 1PCXA 5A1MA 4LIZA 1P8XA 1TVJA 1T3XA 1D4XG 4PKGG 5KYXB 1COFA 2NUTA 1H1VG 2QTVA 4CBWG 1NPHA 1NLVG 1X67A 3EFOA 3EH1A 3EH2A 1PD0A 4CBUG 2FGHA 1QPVA 1UDMA 1SVYA 1T2LA 3FFKA 5KYUA 3CI5G 1SVQA 3CIPG 1CNUA 1YAGG 1AHQA 3TU5B 2VIKA 1Q8XA 1D0NA 3EG9A 2KVKA 3FFNA 1HQZ1 2W0IA 1P8ZG 2FH4A 3A5MS 4KEFA 5KYWB 2LJ8A 2NUPA 5L6WC 4KEDA 1M4JA 5KYYA 1J72A 1C0FS 4JD2H 1DEJS 2MP4A 1C0GS 2FH1A 3FG7A 4KEEA 1T44G 2XFAA 5FAFA 3EGXA 1NM1G 2VILA 2FH2A 2FF3A 1WM4A 2HD7A 3EGDA 4PKHB 1M2VA 4BEX1 1CFYA 3L50A 2LLFA 3CJCG 2NUTB 5KYXA 2I2QA 1AK6A 1V6FA 2MOTA 3EFOB 3A5OS 4Z94G 1F7SA 5IVUA 1ESVS 2FH3A 1VKKA 1MDUA 3Q2BA 1JHWA 5KYUB 1AK7A 2D8BA 4CBXG 3A5NS 1NMDG 3EG9B 3FG6A 5HVKB 1YVNG 1VFQA 1TMWA 2FF6G 1KCQA 2LXXA 2NUPB 4S10C 5KYWA 5KYYB 2MV2A
chains in the Genus database with same CATH superfamily
5KYNA 3CJBG 1EQYS 1SVRA 1WNJA 5HVKD 5FAEA 3A5LS 1WFSA 2VACA 3EGXB 4PKIG 2XF1A 1PD1A 3DAWB 3EGDB 1Q8GA 1T3YA 1M2VB 1RGIG 1M2OA 2L72A 5DD2A 1PCXA 5A1MA 4LIZA 1P8XA 1TVJA 1T3XA 1D4XG 4PKGG 5KYXB 1COFA 2NUTA 1H1VG 2QTVA 4CBWG 1NPHA 1NLVG 1X67A 3EFOA 3EH1A 3EH2A 1PD0A 4CBUG 2FGHA 1QPVA 1UDMA 1SVYA 1T2LA 3FFKA 5KYUA 3CI5G 1SVQA 3CIPG 1CNUA 1YAGG 1AHQA 3TU5B 2VIKA 1Q8XA 1D0NA 3EG9A 2KVKA 3FFNA 1HQZ1 2W0IA 1P8ZG 2FH4A 3A5MS 4KEFA 5KYWB 2LJ8A 2NUPA 5L6WC 4KEDA 1M4JA 5KYYA 1J72A 1C0FS 4JD2H 1DEJS 2MP4A 1C0GS 2FH1A 3FG7A 4KEEA 1T44G 2XFAA 5FAFA 3EGXA 1NM1G 2VILA 2FH2A 2FF3A 1WM4A 2HD7A 3EGDA 4PKHB 1M2VA 4BEX1 1CFYA 3L50A 2LLFA 3CJCG 2NUTB 5KYXA 2I2QA 1AK6A 1V6FA 2MOTA 3EFOB 3A5OS 4Z94G 1F7SA 5IVUA 1ESVS 2FH3A 1VKKA 1MDUA 3DA7A 3Q2BA 1JHWA 5KYUB 1AK7A 2D8BA 4CBXG 3A5NS 1NMDG 3EG9B 3FG6A 5HVKB 1YVNG 1VFQA 1TMWA 2FF6G 1KCQA 2LXXA 2NUPB 4S10C 5KYWA 5KYYB 2MV2A
chains in the Genus database with same CATH topology
5KYNA 3CJBG 1EQYS 1SVRA 1WNJA 5HVKD 5FAEA 3A5LS 1WFSA 2VACA 3EGXB 4PKIG 2XF1A 1PD1A 3DAWB 3EGDB 1Q8GA 1T3YA 1M2VB 1RGIG 1M2OA 2L72A 5DD2A 1PCXA 5A1MA 4LIZA 1P8XA 1TVJA 1T3XA 1D4XG 4PKGG 5KYXB 1COFA 2NUTA 1H1VG 2QTVA 4CBWG 1NPHA 1NLVG 1X67A 3EFOA 3EH1A 3EH2A 1PD0A 4CBUG 2FGHA 1QPVA 1UDMA 1SVYA 1T2LA 3FFKA 5KYUA 3CI5G 1SVQA 3CIPG 1CNUA 1YAGG 1AHQA 3TU5B 2VIKA 1Q8XA 1D0NA 3EG9A 2KVKA 3FFNA 1HQZ1 2W0IA 1P8ZG 2FH4A 3A5MS 4KEFA 5KYWB 2LJ8A 2NUPA 5L6WC 4KEDA 1M4JA 5KYYA 1J72A 1C0FS 4JD2H 1DEJS 2MP4A 1C0GS 2FH1A 3FG7A 4KEEA 1T44G 2XFAA 5FAFA 3EGXA 1NM1G 2VILA 2FH2A 2FF3A 1WM4A 2HD7A 3EGDA 4PKHB 1M2VA 4BEX1 1CFYA 3L50A 2LLFA 3CJCG 2NUTB 5KYXA 2I2QA 1AK6A 1V6FA 2MOTA 3EFOB 3A5OS 4Z94G 1F7SA 5IVUA 1ESVS 2FH3A 1VKKA 1MDUA 3DA7A 3Q2BA 1JHWA 5KYUB 1AK7A 2D8BA 4CBXG 3A5NS 1NMDG 3EG9B 3FG6A 5HVKB 1YVNG 1VFQA 1TMWA 2FF6G 1KCQA 2LXXA 2NUPB 4S10C 5KYWA 5KYYB 2MV2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5KYN A;  3CJB G;  1EQY S;  1SVR A;  1WNJ A;  5HVK D;  5FAE A;  3A5L S;  1WFS A;  2VAC A;  3EGX B;  4PKI G;  2XF1 A;  1PD1 A;  3DAW B;  3EGD B;  1Q8G A;  1T3Y A;  1M2V B;  1RGI G;  1M2O A;  2L72 A;  5DD2 A;  1PCX A;  5A1M A;  4LIZ A;  1P8X A;  1TVJ A;  1T3X A;  1D4X G;  4PKG G;  5KYX B;  1COF A;  2NUT A;  1H1V G;  2QTV A;  4CBW G;  1NPH A;  1NLV G;  1X67 A;  3EFO A;  3EH1 A;  3EH2 A;  1PD0 A;  4CBU G;  2FGH A;  1QPV A;  1UDM A;  1SVY A;  1T2L A;  3FFK A;  5KYU A;  3CI5 G;  1SVQ A;  3CIP G;  1CNU A;  1YAG G;  1AHQ A;  3TU5 B;  2VIK A;  1Q8X A;  1D0N A;  3EG9 A;  2KVK A;  3FFN A;  1HQZ 1;  2W0I A;  1P8Z G;  2FH4 A;  3A5M S;  4KEF A;  5KYW B;  2LJ8 A;  2NUP A;  5L6W C;  4KED A;  1M4J A;  5KYY A;  1J72 A;  1C0F S;  4JD2 H;  1DEJ S;  2MP4 A;  1C0G S;  2FH1 A;  3FG7 A;  4KEE A;  1T44 G;  2XFA A;  5FAF A;  3EGX A;  1NM1 G;  2VIL A;  2FH2 A;  2FF3 A;  1WM4 A;  2HD7 A;  3EGD A;  4PKH B;  1M2V A;  4BEX 1;  1CFY A;  3L50 A;  2LLF A;  3CJC G;  2NUT B;  5KYX A;  2I2Q A;  1AK6 A;  1V6F A;  2MOT A;  3EFO B;  3A5O S;  4Z94 G;  1F7S A;  5IVU A;  1ESV S;  2FH3 A;  1VKK A;  1MDU A;  3Q2B A;  1JHW A;  5KYU B;  1AK7 A;  2D8B A;  4CBX G;  3A5N S;  1NMD G;  3EG9 B;  3FG6 A;  5HVK B;  1YVN G;  1VFQ A;  1TMW A;  2FF6 G;  1KCQ A;  2LXX A;  2NUP B;  4S10 C;  5KYW A;  5KYY B;  2MV2 A; 
#chains in the Genus database with same CATH topology
 5KYN A;  3CJB G;  1EQY S;  1SVR A;  1WNJ A;  5HVK D;  5FAE A;  3A5L S;  1WFS A;  2VAC A;  3EGX B;  4PKI G;  2XF1 A;  1PD1 A;  3DAW B;  3EGD B;  1Q8G A;  1T3Y A;  1M2V B;  1RGI G;  1M2O A;  2L72 A;  5DD2 A;  1PCX A;  5A1M A;  4LIZ A;  1P8X A;  1TVJ A;  1T3X A;  1D4X G;  4PKG G;  5KYX B;  1COF A;  2NUT A;  1H1V G;  2QTV A;  4CBW G;  1NPH A;  1NLV G;  1X67 A;  3EFO A;  3EH1 A;  3EH2 A;  1PD0 A;  4CBU G;  2FGH A;  1QPV A;  1UDM A;  1SVY A;  1T2L A;  3FFK A;  5KYU A;  3CI5 G;  1SVQ A;  3CIP G;  1CNU A;  1YAG G;  1AHQ A;  3TU5 B;  2VIK A;  1Q8X A;  1D0N A;  3EG9 A;  2KVK A;  3FFN A;  1HQZ 1;  2W0I A;  1P8Z G;  2FH4 A;  3A5M S;  4KEF A;  5KYW B;  2LJ8 A;  2NUP A;  5L6W C;  4KED A;  1M4J A;  5KYY A;  1J72 A;  1C0F S;  4JD2 H;  1DEJ S;  2MP4 A;  1C0G S;  2FH1 A;  3FG7 A;  4KEE A;  1T44 G;  2XFA A;  5FAF A;  3EGX A;  1NM1 G;  2VIL A;  2FH2 A;  2FF3 A;  1WM4 A;  2HD7 A;  3EGD A;  4PKH B;  1M2V A;  4BEX 1;  1CFY A;  3L50 A;  2LLF A;  3CJC G;  2NUT B;  5KYX A;  2I2Q A;  1AK6 A;  1V6F A;  2MOT A;  3EFO B;  3A5O S;  4Z94 G;  1F7S A;  5IVU A;  1ESV S;  2FH3 A;  1VKK A;  1MDU A;  3DA7 A;  3Q2B A;  1JHW A;  5KYU B;  1AK7 A;  2D8B A;  4CBX G;  3A5N S;  1NMD G;  3EG9 B;  3FG6 A;  5HVK B;  1YVN G;  1VFQ A;  1TMW A;  2FF6 G;  1KCQ A;  2LXX A;  2NUP B;  4S10 C;  5KYW A;  5KYY B;  2MV2 A; 
#chains in the Genus database with same CATH homology
 5KYN A;  3CJB G;  1EQY S;  1SVR A;  1WNJ A;  5HVK D;  5FAE A;  3A5L S;  1WFS A;  2VAC A;  3EGX B;  4PKI G;  2XF1 A;  1PD1 A;  3DAW B;  3EGD B;  1Q8G A;  1T3Y A;  1M2V B;  1RGI G;  1M2O A;  2L72 A;  5DD2 A;  1PCX A;  5A1M A;  4LIZ A;  1P8X A;  1TVJ A;  1T3X A;  1D4X G;  4PKG G;  5KYX B;  1COF A;  2NUT A;  1H1V G;  2QTV A;  4CBW G;  1NPH A;  1NLV G;  1X67 A;  3EFO A;  3EH1 A;  3EH2 A;  1PD0 A;  4CBU G;  2FGH A;  1QPV A;  1UDM A;  1SVY A;  1T2L A;  3FFK A;  5KYU A;  3CI5 G;  1SVQ A;  3CIP G;  1CNU A;  1YAG G;  1AHQ A;  3TU5 B;  2VIK A;  1Q8X A;  1D0N A;  3EG9 A;  2KVK A;  3FFN A;  1HQZ 1;  2W0I A;  1P8Z G;  2FH4 A;  3A5M S;  4KEF A;  5KYW B;  2LJ8 A;  2NUP A;  5L6W C;  4KED A;  1M4J A;  5KYY A;  1J72 A;  1C0F S;  4JD2 H;  1DEJ S;  2MP4 A;  1C0G S;  2FH1 A;  3FG7 A;  4KEE A;  1T44 G;  2XFA A;  5FAF A;  3EGX A;  1NM1 G;  2VIL A;  2FH2 A;  2FF3 A;  1WM4 A;  2HD7 A;  3EGD A;  4PKH B;  1M2V A;  4BEX 1;  1CFY A;  3L50 A;  2LLF A;  3CJC G;  2NUT B;  5KYX A;  2I2Q A;  1AK6 A;  1V6F A;  2MOT A;  3EFO B;  3A5O S;  4Z94 G;  1F7S A;  5IVU A;  1ESV S;  2FH3 A;  1VKK A;  1MDU A;  3DA7 A;  3Q2B A;  1JHW A;  5KYU B;  1AK7 A;  2D8B A;  4CBX G;  3A5N S;  1NMD G;  3EG9 B;  3FG6 A;  5HVK B;  1YVN G;  1VFQ A;  1TMW A;  2FF6 G;  1KCQ A;  2LXX A;  2NUP B;  4S10 C;  5KYW A;  5KYY B;  2MV2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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