1X67A

Solution structure of the cofilin homology domain of hip-55 (drebrin-like protein)
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
146
structure length
146
Chain Sequence
GSSGSSGMAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVASGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR solution structures of actin depolymerizing factor homology domains.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Drebrin-like protein
total genus 21
structure length 146
sequence length 146
ec nomenclature
pdb deposition date 2005-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 1x67A01
4Z94G 2MV2A 1YVNG 3FG7A 1NM1G 1ESVS 1VKKA 2VILA 1P8ZG 1SVQA 1J72A 1EQYS 1H1VG 1UDMA 5FAFA 5KYUA 5A1MA 2HD7A 2FH3A 3EH2A 4PKHB 2FH1A 1WFSA 3L50A 1NMDG 2FF6G 4PKGG 1AK7A 1SVYA 4S10C 2VIKA 5KYNA 1F7SA 5HVKB 1JHWA 1C0FS 2VACA 3EFOA 1X67A 3A5NS 3CIPG 1T44G 1M2OA 2XFAA 3TU5B 3CI5G 3EGXA 1M2VA 3A5OS 2FH4A 1AK6A 2NUTA 5FAEA 1T3YA 3EG9A 1WM4A 1M2VB 1D4XG 3A5LS 2NUPA 4KEDA 1D0NA 5KYUB 5KYYA 1COFA 2NUPB 1SVRA 2FGHA 2FF3A 1AHQA 2LXXA 3EGDA 2MOTA 1T2LA 5KYWA 1PD1A 3EFOB 1NPHA 1DEJS 1RGIG 5L6WC 2KVKA 3CJBG 5KYWB 1CFYA 5DD2A 2MP4A 1P8XA 3EGXB 4CBWG 4JD2H 3CJCG 2QTVA 1CNUA 2NUTB 3FFKA 1TVJA 1Q8XA 5IVUA 2FH2A 4LIZA 2W0IA 3EG9B 5KYXA 3EH1A 1T3XA 1C0GS 1HQZ1 4KEEA 5KYYB 5KYXB 1VFQA 1PCXA 1M4JA 4BEX1 2LLFA 4CBUG 1PD0A 2D8BA 3EGDB 1Q8GA 4CBXG 2LJ8A 3FFNA 3A5MS 1KCQA 3FG6A 2L72A 5HVKD 1QPVA 3Q2BA 3DAWB 2XF1A 1YAGG 4PKIG 1V6FA 1TMWA 1NLVG 4KEFA 1MDUA 2I2QA 1WNJA
chains in the Genus database with same CATH superfamily
4Z94G 2MV2A 1YVNG 3FG7A 1NM1G 1ESVS 1VKKA 2VILA 1P8ZG 1SVQA 1J72A 1EQYS 1H1VG 1UDMA 5FAFA 5KYUA 5A1MA 2HD7A 2FH3A 3EH2A 4PKHB 2FH1A 1WFSA 3L50A 1NMDG 2FF6G 4PKGG 1AK7A 1SVYA 4S10C 2VIKA 5KYNA 1F7SA 5HVKB 1JHWA 1C0FS 2VACA 3EFOA 1X67A 3A5NS 3CIPG 1T44G 1M2OA 2XFAA 3TU5B 3CI5G 3EGXA 1M2VA 3A5OS 2FH4A 1AK6A 2NUTA 3DA7A 5FAEA 1T3YA 3EG9A 1WM4A 1M2VB 1D4XG 3A5LS 2NUPA 4KEDA 1D0NA 5KYUB 5KYYA 1COFA 2NUPB 1SVRA 2FGHA 2FF3A 1AHQA 2LXXA 3EGDA 2MOTA 1T2LA 5KYWA 1PD1A 3EFOB 1NPHA 1DEJS 1RGIG 5L6WC 2KVKA 3CJBG 5KYWB 1CFYA 5DD2A 2MP4A 1P8XA 3EGXB 4CBWG 4JD2H 3CJCG 2QTVA 1CNUA 2NUTB 3FFKA 1TVJA 1Q8XA 5IVUA 2FH2A 4LIZA 2W0IA 3EG9B 5KYXA 3EH1A 1T3XA 1C0GS 1HQZ1 4KEEA 5KYYB 5KYXB 1VFQA 1PCXA 1M4JA 4BEX1 2LLFA 4CBUG 1PD0A 2D8BA 3EGDB 1Q8GA 4CBXG 2LJ8A 3FFNA 3A5MS 1KCQA 3FG6A 2L72A 5HVKD 1QPVA 3Q2BA 3DAWB 2XF1A 1YAGG 4PKIG 1V6FA 1TMWA 1NLVG 4KEFA 1MDUA 2I2QA 1WNJA
chains in the Genus database with same CATH topology
4Z94G 2MV2A 1YVNG 3FG7A 1NM1G 1ESVS 1VKKA 2VILA 1P8ZG 1SVQA 1J72A 1EQYS 1H1VG 1UDMA 5FAFA 5KYUA 5A1MA 2HD7A 2FH3A 3EH2A 4PKHB 2FH1A 1WFSA 3L50A 1NMDG 2FF6G 4PKGG 1AK7A 1SVYA 4S10C 2VIKA 5KYNA 1F7SA 5HVKB 1JHWA 1C0FS 2VACA 3EFOA 1X67A 3A5NS 3CIPG 1T44G 1M2OA 2XFAA 3TU5B 3CI5G 3EGXA 1M2VA 3A5OS 2FH4A 1AK6A 2NUTA 3DA7A 5FAEA 1T3YA 3EG9A 1WM4A 1M2VB 1D4XG 3A5LS 2NUPA 4KEDA 1D0NA 5KYUB 5KYYA 1COFA 2NUPB 1SVRA 2FGHA 2FF3A 1AHQA 2LXXA 3EGDA 2MOTA 1T2LA 5KYWA 1PD1A 3EFOB 1NPHA 1DEJS 1RGIG 5L6WC 2KVKA 3CJBG 5KYWB 1CFYA 5DD2A 2MP4A 1P8XA 3EGXB 4CBWG 4JD2H 3CJCG 2QTVA 1CNUA 2NUTB 3FFKA 1TVJA 1Q8XA 5IVUA 2FH2A 4LIZA 2W0IA 3EG9B 5KYXA 3EH1A 1T3XA 1C0GS 1HQZ1 4KEEA 5KYYB 5KYXB 1VFQA 1PCXA 1M4JA 4BEX1 2LLFA 4CBUG 1PD0A 2D8BA 3EGDB 1Q8GA 4CBXG 2LJ8A 3FFNA 3A5MS 1KCQA 3FG6A 2L72A 5HVKD 1QPVA 3Q2BA 3DAWB 2XF1A 1YAGG 4PKIG 1V6FA 1TMWA 1NLVG 4KEFA 1MDUA 2I2QA 1WNJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z94 G;  2MV2 A;  1YVN G;  3FG7 A;  1NM1 G;  1ESV S;  1VKK A;  2VIL A;  1P8Z G;  1SVQ A;  1J72 A;  1EQY S;  1H1V G;  1UDM A;  5FAF A;  5KYU A;  5A1M A;  2HD7 A;  2FH3 A;  3EH2 A;  4PKH B;  2FH1 A;  1WFS A;  3L50 A;  1NMD G;  2FF6 G;  4PKG G;  1AK7 A;  1SVY A;  4S10 C;  2VIK A;  5KYN A;  1F7S A;  5HVK B;  1JHW A;  1C0F S;  2VAC A;  3EFO A;  1X67 A;  3A5N S;  3CIP G;  1T44 G;  1M2O A;  2XFA A;  3TU5 B;  3CI5 G;  3EGX A;  1M2V A;  3A5O S;  2FH4 A;  1AK6 A;  2NUT A;  5FAE A;  1T3Y A;  3EG9 A;  1WM4 A;  1M2V B;  1D4X G;  3A5L S;  2NUP A;  4KED A;  1D0N A;  5KYU B;  5KYY A;  1COF A;  2NUP B;  1SVR A;  2FGH A;  2FF3 A;  1AHQ A;  2LXX A;  3EGD A;  2MOT A;  1T2L A;  5KYW A;  1PD1 A;  3EFO B;  1NPH A;  1DEJ S;  1RGI G;  5L6W C;  2KVK A;  3CJB G;  5KYW B;  1CFY A;  5DD2 A;  2MP4 A;  1P8X A;  3EGX B;  4CBW G;  4JD2 H;  3CJC G;  2QTV A;  1CNU A;  2NUT B;  3FFK A;  1TVJ A;  1Q8X A;  5IVU A;  2FH2 A;  4LIZ A;  2W0I A;  3EG9 B;  5KYX A;  3EH1 A;  1T3X A;  1C0G S;  1HQZ 1;  4KEE A;  5KYY B;  5KYX B;  1VFQ A;  1PCX A;  1M4J A;  4BEX 1;  2LLF A;  4CBU G;  1PD0 A;  2D8B A;  3EGD B;  1Q8G A;  4CBX G;  2LJ8 A;  3FFN A;  3A5M S;  1KCQ A;  3FG6 A;  2L72 A;  5HVK D;  1QPV A;  3Q2B A;  3DAW B;  2XF1 A;  1YAG G;  4PKI G;  1V6F A;  1TMW A;  1NLV G;  4KEF A;  1MDU A;  2I2Q A;  1WNJ A; 
#chains in the Genus database with same CATH topology
 4Z94 G;  2MV2 A;  1YVN G;  3FG7 A;  1NM1 G;  1ESV S;  1VKK A;  2VIL A;  1P8Z G;  1SVQ A;  1J72 A;  1EQY S;  1H1V G;  1UDM A;  5FAF A;  5KYU A;  5A1M A;  2HD7 A;  2FH3 A;  3EH2 A;  4PKH B;  2FH1 A;  1WFS A;  3L50 A;  1NMD G;  2FF6 G;  4PKG G;  1AK7 A;  1SVY A;  4S10 C;  2VIK A;  5KYN A;  1F7S A;  5HVK B;  1JHW A;  1C0F S;  2VAC A;  3EFO A;  1X67 A;  3A5N S;  3CIP G;  1T44 G;  1M2O A;  2XFA A;  3TU5 B;  3CI5 G;  3EGX A;  1M2V A;  3A5O S;  2FH4 A;  1AK6 A;  2NUT A;  3DA7 A;  5FAE A;  1T3Y A;  3EG9 A;  1WM4 A;  1M2V B;  1D4X G;  3A5L S;  2NUP A;  4KED A;  1D0N A;  5KYU B;  5KYY A;  1COF A;  2NUP B;  1SVR A;  2FGH A;  2FF3 A;  1AHQ A;  2LXX A;  3EGD A;  2MOT A;  1T2L A;  5KYW A;  1PD1 A;  3EFO B;  1NPH A;  1DEJ S;  1RGI G;  5L6W C;  2KVK A;  3CJB G;  5KYW B;  1CFY A;  5DD2 A;  2MP4 A;  1P8X A;  3EGX B;  4CBW G;  4JD2 H;  3CJC G;  2QTV A;  1CNU A;  2NUT B;  3FFK A;  1TVJ A;  1Q8X A;  5IVU A;  2FH2 A;  4LIZ A;  2W0I A;  3EG9 B;  5KYX A;  3EH1 A;  1T3X A;  1C0G S;  1HQZ 1;  4KEE A;  5KYY B;  5KYX B;  1VFQ A;  1PCX A;  1M4J A;  4BEX 1;  2LLF A;  4CBU G;  1PD0 A;  2D8B A;  3EGD B;  1Q8G A;  4CBX G;  2LJ8 A;  3FFN A;  3A5M S;  1KCQ A;  3FG6 A;  2L72 A;  5HVK D;  1QPV A;  3Q2B A;  3DAW B;  2XF1 A;  1YAG G;  4PKI G;  1V6F A;  1TMW A;  1NLV G;  4KEF A;  1MDU A;  2I2Q A;  1WNJ A; 
#chains in the Genus database with same CATH homology
 4Z94 G;  2MV2 A;  1YVN G;  3FG7 A;  1NM1 G;  1ESV S;  1VKK A;  2VIL A;  1P8Z G;  1SVQ A;  1J72 A;  1EQY S;  1H1V G;  1UDM A;  5FAF A;  5KYU A;  5A1M A;  2HD7 A;  2FH3 A;  3EH2 A;  4PKH B;  2FH1 A;  1WFS A;  3L50 A;  1NMD G;  2FF6 G;  4PKG G;  1AK7 A;  1SVY A;  4S10 C;  2VIK A;  5KYN A;  1F7S A;  5HVK B;  1JHW A;  1C0F S;  2VAC A;  3EFO A;  1X67 A;  3A5N S;  3CIP G;  1T44 G;  1M2O A;  2XFA A;  3TU5 B;  3CI5 G;  3EGX A;  1M2V A;  3A5O S;  2FH4 A;  1AK6 A;  2NUT A;  3DA7 A;  5FAE A;  1T3Y A;  3EG9 A;  1WM4 A;  1M2V B;  1D4X G;  3A5L S;  2NUP A;  4KED A;  1D0N A;  5KYU B;  5KYY A;  1COF A;  2NUP B;  1SVR A;  2FGH A;  2FF3 A;  1AHQ A;  2LXX A;  3EGD A;  2MOT A;  1T2L A;  5KYW A;  1PD1 A;  3EFO B;  1NPH A;  1DEJ S;  1RGI G;  5L6W C;  2KVK A;  3CJB G;  5KYW B;  1CFY A;  5DD2 A;  2MP4 A;  1P8X A;  3EGX B;  4CBW G;  4JD2 H;  3CJC G;  2QTV A;  1CNU A;  2NUT B;  3FFK A;  1TVJ A;  1Q8X A;  5IVU A;  2FH2 A;  4LIZ A;  2W0I A;  3EG9 B;  5KYX A;  3EH1 A;  1T3X A;  1C0G S;  1HQZ 1;  4KEE A;  5KYY B;  5KYX B;  1VFQ A;  1PCX A;  1M4J A;  4BEX 1;  2LLF A;  4CBU G;  1PD0 A;  2D8B A;  3EGD B;  1Q8G A;  4CBX G;  2LJ8 A;  3FFN A;  3A5M S;  1KCQ A;  3FG6 A;  2L72 A;  5HVK D;  1QPV A;  3Q2B A;  3DAW B;  2XF1 A;  1YAG G;  4PKI G;  1V6F A;  1TMW A;  1NLV G;  4KEF A;  1MDU A;  2I2Q A;  1WNJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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