2D8BA

Solution structure of the second tandem cofilin-domain of mouse twinfilin
Total Genus 24
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
24
sequence length
166
structure length
166
Chain Sequence
GSSGSSGEVQTDVSVDTKHQTLQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELRDLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGDELTADFLYDEVHSGPSSG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR solution structures of actin depolymerizing factor homology domains
pubmed doi rcsb
molecule tags Protein binding
source organism Mus musculus
molecule keywords Twinfilin-1
total genus 24
structure length 166
sequence length 166
ec nomenclature
pdb deposition date 2005-12-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2d8bA01
1MDUA 1TVJA 1SVRA 3EH1A 5IVUA 4PKHB 1PD1A 4KEEA 3A5MS 1SVQA 1V6FA 3EG9B 3L50A 1D4XG 2VACA 4BEX1 2HD7A 3EG9A 1NLVG 2FF3A 1PD0A 1Q8XA 1EQYS 5A1MA 1C0GS 1D0NA 1YVNG 2LXXA 4PKIG 1HQZ1 4PKGG 1UDMA 3EFOB 1AK7A 3EGDB 2FH2A 1P8ZG 3DAWB 2VILA 3EFOA 4KEFA 1X67A 3EGDA 3Q2BA 2FH4A 2W0IA 3EH2A 4KEDA 4CBWG 5FAFA 4Z94G 1WFSA 1T44G 1T3XA 5L6WC 5HVKD 1TMWA 2FH1A 5DD2A 1F7SA 2VIKA 1WM4A 3FFKA 3CI5G 2FF6G 1H1VG 4CBXG 3CIPG 1COFA 1YAGG 1M2VB 3CJCG 1AK6A 1T2LA 2LLFA 1M2VA 3A5NS 5KYWB 1NPHA 1T3YA 1CFYA 5KYWA 1C0FS 3EGXB 5FAEA 1SVYA 1NM1G 3EGXA 1J72A 4LIZA 5HVKB 1VKKA 2LJ8A 4CBUG 5KYYA 3FFNA 1WNJA 1JHWA 5KYXB 4S10C 2MV2A 1AHQA 5KYXA 5KYNA 2XFAA 4JD2H 2L72A 1M2OA 2D8BA 3TU5B 2NUTB 2XF1A 1ESVS 1Q8GA 3CJBG 2MP4A 2NUTA 2MOTA 2KVKA 1M4JA 3A5OS 2NUPB 3FG6A 1RGIG 2FGHA 2I2QA 1VFQA 1KCQA 2NUPA 5KYUB 5KYYB 2QTVA 5KYUA 3A5LS 2FH3A 1CNUA 1DEJS 1QPVA 3FG7A 1PCXA 1P8XA 1NMDG
chains in the Genus database with same CATH superfamily
1MDUA 1TVJA 1SVRA 3EH1A 5IVUA 4PKHB 1PD1A 4KEEA 3A5MS 1SVQA 1V6FA 3EG9B 3L50A 1D4XG 2VACA 4BEX1 2HD7A 3EG9A 1NLVG 2FF3A 1PD0A 1Q8XA 1EQYS 5A1MA 1C0GS 1D0NA 1YVNG 2LXXA 4PKIG 1HQZ1 4PKGG 1UDMA 3EFOB 1AK7A 3EGDB 2FH2A 1P8ZG 3DAWB 2VILA 3EFOA 4KEFA 1X67A 3EGDA 3Q2BA 2FH4A 2W0IA 3EH2A 4KEDA 4CBWG 5FAFA 4Z94G 1WFSA 1T44G 1T3XA 5L6WC 5HVKD 1TMWA 2FH1A 5DD2A 1F7SA 2VIKA 1WM4A 3FFKA 3CI5G 2FF6G 1H1VG 4CBXG 3CIPG 1COFA 1YAGG 1M2VB 3CJCG 1AK6A 1T2LA 2LLFA 1M2VA 3A5NS 5KYWB 1NPHA 1T3YA 1CFYA 5KYWA 1C0FS 3EGXB 5FAEA 1SVYA 1NM1G 3DA7A 3EGXA 1J72A 4LIZA 5HVKB 1VKKA 2LJ8A 4CBUG 5KYYA 3FFNA 1WNJA 1JHWA 5KYXB 4S10C 2MV2A 1AHQA 5KYXA 5KYNA 2XFAA 4JD2H 2L72A 1M2OA 2D8BA 3TU5B 2NUTB 2XF1A 1ESVS 1Q8GA 3CJBG 2MP4A 2NUTA 2MOTA 2KVKA 1M4JA 3A5OS 2NUPB 3FG6A 1RGIG 2FGHA 2I2QA 1VFQA 1KCQA 2NUPA 5KYUB 5KYYB 2QTVA 5KYUA 3A5LS 2FH3A 1CNUA 1DEJS 1QPVA 3FG7A 1PCXA 1P8XA 1NMDG
chains in the Genus database with same CATH topology
1MDUA 1TVJA 1SVRA 3EH1A 5IVUA 4PKHB 1PD1A 4KEEA 3A5MS 1SVQA 1V6FA 3EG9B 3L50A 1D4XG 2VACA 4BEX1 2HD7A 3EG9A 1NLVG 2FF3A 1PD0A 1Q8XA 1EQYS 5A1MA 1C0GS 1D0NA 1YVNG 2LXXA 4PKIG 1HQZ1 4PKGG 1UDMA 3EFOB 1AK7A 3EGDB 2FH2A 1P8ZG 3DAWB 2VILA 3EFOA 4KEFA 1X67A 3EGDA 3Q2BA 2FH4A 2W0IA 3EH2A 4KEDA 4CBWG 5FAFA 4Z94G 1WFSA 1T44G 1T3XA 5L6WC 5HVKD 1TMWA 2FH1A 5DD2A 1F7SA 2VIKA 1WM4A 3FFKA 3CI5G 2FF6G 1H1VG 4CBXG 3CIPG 1COFA 1YAGG 1M2VB 3CJCG 1AK6A 1T2LA 2LLFA 1M2VA 3A5NS 5KYWB 1NPHA 1T3YA 1CFYA 5KYWA 1C0FS 3EGXB 5FAEA 1SVYA 1NM1G 3DA7A 3EGXA 1J72A 4LIZA 5HVKB 1VKKA 2LJ8A 4CBUG 5KYYA 3FFNA 1WNJA 1JHWA 5KYXB 4S10C 2MV2A 1AHQA 5KYXA 5KYNA 2XFAA 4JD2H 2L72A 1M2OA 2D8BA 3TU5B 2NUTB 2XF1A 1ESVS 1Q8GA 3CJBG 2MP4A 2NUTA 2MOTA 2KVKA 1M4JA 3A5OS 2NUPB 3FG6A 1RGIG 2FGHA 2I2QA 1VFQA 1KCQA 2NUPA 5KYUB 5KYYB 2QTVA 5KYUA 3A5LS 2FH3A 1CNUA 1DEJS 1QPVA 3FG7A 1PCXA 1P8XA 1NMDG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MDU A;  1TVJ A;  1SVR A;  3EH1 A;  5IVU A;  4PKH B;  1PD1 A;  4KEE A;  3A5M S;  1SVQ A;  1V6F A;  3EG9 B;  3L50 A;  1D4X G;  2VAC A;  4BEX 1;  2HD7 A;  3EG9 A;  1NLV G;  2FF3 A;  1PD0 A;  1Q8X A;  1EQY S;  5A1M A;  1C0G S;  1D0N A;  1YVN G;  2LXX A;  4PKI G;  1HQZ 1;  4PKG G;  1UDM A;  3EFO B;  1AK7 A;  3EGD B;  2FH2 A;  1P8Z G;  3DAW B;  2VIL A;  3EFO A;  4KEF A;  1X67 A;  3EGD A;  3Q2B A;  2FH4 A;  2W0I A;  3EH2 A;  4KED A;  4CBW G;  5FAF A;  4Z94 G;  1WFS A;  1T44 G;  1T3X A;  5L6W C;  5HVK D;  1TMW A;  2FH1 A;  5DD2 A;  1F7S A;  2VIK A;  1WM4 A;  3FFK A;  3CI5 G;  2FF6 G;  1H1V G;  4CBX G;  3CIP G;  1COF A;  1YAG G;  1M2V B;  3CJC G;  1AK6 A;  1T2L A;  2LLF A;  1M2V A;  3A5N S;  5KYW B;  1NPH A;  1T3Y A;  1CFY A;  5KYW A;  1C0F S;  3EGX B;  5FAE A;  1SVY A;  1NM1 G;  3EGX A;  1J72 A;  4LIZ A;  5HVK B;  1VKK A;  2LJ8 A;  4CBU G;  5KYY A;  3FFN A;  1WNJ A;  1JHW A;  5KYX B;  4S10 C;  2MV2 A;  1AHQ A;  5KYX A;  5KYN A;  2XFA A;  4JD2 H;  2L72 A;  1M2O A;  2D8B A;  3TU5 B;  2NUT B;  2XF1 A;  1ESV S;  1Q8G A;  3CJB G;  2MP4 A;  2NUT A;  2MOT A;  2KVK A;  1M4J A;  3A5O S;  2NUP B;  3FG6 A;  1RGI G;  2FGH A;  2I2Q A;  1VFQ A;  1KCQ A;  2NUP A;  5KYU B;  5KYY B;  2QTV A;  5KYU A;  3A5L S;  2FH3 A;  1CNU A;  1DEJ S;  1QPV A;  3FG7 A;  1PCX A;  1P8X A;  1NMD G; 
#chains in the Genus database with same CATH topology
 1MDU A;  1TVJ A;  1SVR A;  3EH1 A;  5IVU A;  4PKH B;  1PD1 A;  4KEE A;  3A5M S;  1SVQ A;  1V6F A;  3EG9 B;  3L50 A;  1D4X G;  2VAC A;  4BEX 1;  2HD7 A;  3EG9 A;  1NLV G;  2FF3 A;  1PD0 A;  1Q8X A;  1EQY S;  5A1M A;  1C0G S;  1D0N A;  1YVN G;  2LXX A;  4PKI G;  1HQZ 1;  4PKG G;  1UDM A;  3EFO B;  1AK7 A;  3EGD B;  2FH2 A;  1P8Z G;  3DAW B;  2VIL A;  3EFO A;  4KEF A;  1X67 A;  3EGD A;  3Q2B A;  2FH4 A;  2W0I A;  3EH2 A;  4KED A;  4CBW G;  5FAF A;  4Z94 G;  1WFS A;  1T44 G;  1T3X A;  5L6W C;  5HVK D;  1TMW A;  2FH1 A;  5DD2 A;  1F7S A;  2VIK A;  1WM4 A;  3FFK A;  3CI5 G;  2FF6 G;  1H1V G;  4CBX G;  3CIP G;  1COF A;  1YAG G;  1M2V B;  3CJC G;  1AK6 A;  1T2L A;  2LLF A;  1M2V A;  3A5N S;  5KYW B;  1NPH A;  1T3Y A;  1CFY A;  5KYW A;  1C0F S;  3EGX B;  5FAE A;  1SVY A;  1NM1 G;  3DA7 A;  3EGX A;  1J72 A;  4LIZ A;  5HVK B;  1VKK A;  2LJ8 A;  4CBU G;  5KYY A;  3FFN A;  1WNJ A;  1JHW A;  5KYX B;  4S10 C;  2MV2 A;  1AHQ A;  5KYX A;  5KYN A;  2XFA A;  4JD2 H;  2L72 A;  1M2O A;  2D8B A;  3TU5 B;  2NUT B;  2XF1 A;  1ESV S;  1Q8G A;  3CJB G;  2MP4 A;  2NUT A;  2MOT A;  2KVK A;  1M4J A;  3A5O S;  2NUP B;  3FG6 A;  1RGI G;  2FGH A;  2I2Q A;  1VFQ A;  1KCQ A;  2NUP A;  5KYU B;  5KYY B;  2QTV A;  5KYU A;  3A5L S;  2FH3 A;  1CNU A;  1DEJ S;  1QPV A;  3FG7 A;  1PCX A;  1P8X A;  1NMD G; 
#chains in the Genus database with same CATH homology
 1MDU A;  1TVJ A;  1SVR A;  3EH1 A;  5IVU A;  4PKH B;  1PD1 A;  4KEE A;  3A5M S;  1SVQ A;  1V6F A;  3EG9 B;  3L50 A;  1D4X G;  2VAC A;  4BEX 1;  2HD7 A;  3EG9 A;  1NLV G;  2FF3 A;  1PD0 A;  1Q8X A;  1EQY S;  5A1M A;  1C0G S;  1D0N A;  1YVN G;  2LXX A;  4PKI G;  1HQZ 1;  4PKG G;  1UDM A;  3EFO B;  1AK7 A;  3EGD B;  2FH2 A;  1P8Z G;  3DAW B;  2VIL A;  3EFO A;  4KEF A;  1X67 A;  3EGD A;  3Q2B A;  2FH4 A;  2W0I A;  3EH2 A;  4KED A;  4CBW G;  5FAF A;  4Z94 G;  1WFS A;  1T44 G;  1T3X A;  5L6W C;  5HVK D;  1TMW A;  2FH1 A;  5DD2 A;  1F7S A;  2VIK A;  1WM4 A;  3FFK A;  3CI5 G;  2FF6 G;  1H1V G;  4CBX G;  3CIP G;  1COF A;  1YAG G;  1M2V B;  3CJC G;  1AK6 A;  1T2L A;  2LLF A;  1M2V A;  3A5N S;  5KYW B;  1NPH A;  1T3Y A;  1CFY A;  5KYW A;  1C0F S;  3EGX B;  5FAE A;  1SVY A;  1NM1 G;  3DA7 A;  3EGX A;  1J72 A;  4LIZ A;  5HVK B;  1VKK A;  2LJ8 A;  4CBU G;  5KYY A;  3FFN A;  1WNJ A;  1JHW A;  5KYX B;  4S10 C;  2MV2 A;  1AHQ A;  5KYX A;  5KYN A;  2XFA A;  4JD2 H;  2L72 A;  1M2O A;  2D8B A;  3TU5 B;  2NUT B;  2XF1 A;  1ESV S;  1Q8G A;  3CJB G;  2MP4 A;  2NUT A;  2MOT A;  2KVK A;  1M4J A;  3A5O S;  2NUP B;  3FG6 A;  1RGI G;  2FGH A;  2I2Q A;  1VFQ A;  1KCQ A;  2NUP A;  5KYU B;  5KYY B;  2QTV A;  5KYU A;  3A5L S;  2FH3 A;  1CNU A;  1DEJ S;  1QPV A;  3FG7 A;  1PCX A;  1P8X A;  1NMD G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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