2FGH | Genus

Total Genus 210

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	210
sequence length	729
structure length	721
Chain Sequence	VEHPEFLKAGKEPGLQIWRVEKFDLVPVPPNLYGDFFTGDAYVILKTVQLRNGILQYDLHYWLGNECSQDESGAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVVVQRLLQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIYQWCGSKSNRFERLKATQVSKGIRDNERSGRAQVSVFEEGAEPEAMLQVLGPKPTLPEATENRKLAKLYKVSNGAGPMVVSLVADENPFAQGALRSEDCFILDHGKDGKIFVWKGKQANMEERKAALKTASDFISKMDYPKQTQVSVLPEGGETPLFRQFFKNWRDPDQTEGLGLAYLSSHIAHVERVPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRVEGSNKVPVDPATYGQFYGGDSYIILYNYRHGSRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIVYKGGTSREGGQTAPASTRLFQVRASSSGATRAVEIIPKAGALNSNDAFVLKTPSAAYLWVGAGASEAEKTGAQELLRVLRAQPVQVAEGSEPDSFWEALGGKATYRTSPRLKDKKMDAHPPRLFACSNKIGRFVIEEVPGEFMQEDLATDDVMLLDTWDQVFVWVGKDSQDEEKTEALTSAKRYIDTDPAHRDRRTPITVVKQGFEPPSFVGWFLGWDDSYWSVDPLDRALAELAA

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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

publication title	The structure of gelsolin bound to ATP pubmed doi rcsb
molecule keywords	gelsolin
molecule tags	Contractile protein, structural protein
total genus	210
structure length	721
sequence length	729
chains with identical sequence	B
ec nomenclature
pdb deposition date	2005-12-22

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00626	Gelsolin	Gelsolin repeat

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA02
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA01
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA04
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA06
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA05
3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	2fghA03

4KEDA 5KYWB 1AK6A 1COFA 3EH1A 1KCQA 2NUPB 1X67A 4Z94G 5KYYA 1PD0A 2FH1A 4KEFA 2KVKA 4PKIG 3EGDA 1YVNG 1PD1A 1WM4A 1VKKA 1WFSA 1YAGG 2FGHA 1H1VG 1NLVG 1M2OA 2LJ8A 1CNUA 5HVKB 5KYNA 5KYWA 1ESVS 1T3YA 1HQZ1 1P8XA 3EG9B 1T3XA 1D4XG 5IVUA 5L6WC 1AK7A 1PCXA 1C0FS 1NPHA 5KYXA 2L72A 4PKGG 3EGXB 1RGIG 3FG7A 5HVKD 1F7SA 4CBXG 2VILA 4CBWG 3CIPG 1DEJS 5KYUB 3A5OS 4LIZA 3A5LS 2XF1A 1EQYS 4S10C 2HD7A 4CBUG 3A5NS 3CI5G 1Q8GA 3EH2A 3Q2BA 1P8ZG 3DAWB 2NUPA 2FF3A 2FH3A 4PKHB 1UDMA 4BEX1 1T44G 3EFOB 5KYUA 5DD2A 1V6FA 1WNJA 2LLFA 2FH2A 5KYYB 1TMWA 2MOTA 4JD2H 5A1MA 5FAEA 1SVRA 3EG9A 1D0NA 1VFQA 1M2VB 1TVJA 1QPVA 1M4JA 4KEEA 1J72A 3EGXA 2MV2A 1NM1G 3FFKA 3FG6A 1NMDG 1T2LA 2FH4A 2D8BA 2NUTB 3CJBG 3FFNA 5KYXB 1Q8XA 1JHWA 3CJCG 1SVYA 2FF6G 1M2VA 2QTVA 2VACA 1C0GS 2VIKA 2I2QA 2W0IA 3A5MS 2XFAA 3TU5B 3EGDB 2LXXA 1AHQA 1SVQA 3L50A 1CFYA 2NUTA 3EFOA 5FAFA 1MDUA 2MP4A
chains in the Genus database with same CATH superfamily

4KEDA 3DA7A 5KYWB 1AK6A 1COFA 3EH1A 1KCQA 2NUPB 1X67A 4Z94G 5KYYA 1PD0A 2FH1A 4KEFA 2KVKA 4PKIG 3EGDA 1YVNG 1PD1A 1WM4A 1VKKA 1WFSA 1YAGG 2FGHA 1H1VG 1NLVG 1M2OA 2LJ8A 1CNUA 5HVKB 5KYNA 5KYWA 1ESVS 1T3YA 1HQZ1 1P8XA 3EG9B 1T3XA 1D4XG 5IVUA 5L6WC 1AK7A 1PCXA 1C0FS 1NPHA 5KYXA 2L72A 4PKGG 3EGXB 1RGIG 3FG7A 5HVKD 1F7SA 4CBXG 2VILA 4CBWG 3CIPG 1DEJS 5KYUB 3A5OS 4LIZA 3A5LS 2XF1A 1EQYS 4S10C 2HD7A 4CBUG 3A5NS 3CI5G 1Q8GA 3EH2A 3Q2BA 1P8ZG 3DAWB 2NUPA 2FF3A 2FH3A 4PKHB 1UDMA 4BEX1 1T44G 3EFOB 5KYUA 5DD2A 1V6FA 1WNJA 2LLFA 2FH2A 5KYYB 1TMWA 2MOTA 4JD2H 5A1MA 5FAEA 1SVRA 3EG9A 1D0NA 1VFQA 1M2VB 1TVJA 1QPVA 1M4JA 4KEEA 1J72A 3EGXA 2MV2A 1NM1G 3FFKA 3FG6A 1NMDG 1T2LA 2FH4A 2D8BA 2NUTB 3CJBG 3FFNA 5KYXB 1Q8XA 1JHWA 3CJCG 1SVYA 2FF6G 1M2VA 2QTVA 2VACA 1C0GS 2VIKA 2I2QA 2W0IA 3A5MS 2XFAA 3TU5B 3EGDB 2LXXA 1AHQA 1SVQA 3L50A 1CFYA 2NUTA 3EFOA 5FAFA 1MDUA 2MP4A
chains in the Genus database with same CATH topology

#chains in the Genus database with same CATH superfamily
 4KED A;  5KYW B;  1AK6 A;  1COF A;  3EH1 A;  1KCQ A;  2NUP B;  1X67 A;  4Z94 G;  5KYY A;  1PD0 A;  2FH1 A;  4KEF A;  2KVK A;  4PKI G;  3EGD A;  1YVN G;  1PD1 A;  1WM4 A;  1VKK A;  1WFS A;  1YAG G;  2FGH A;  1H1V G;  1NLV G;  1M2O A;  2LJ8 A;  1CNU A;  5HVK B;  5KYN A;  5KYW A;  1ESV S;  1T3Y A;  1HQZ 1;  1P8X A;  3EG9 B;  1T3X A;  1D4X G;  5IVU A;  5L6W C;  1AK7 A;  1PCX A;  1C0F S;  1NPH A;  5KYX A;  2L72 A;  4PKG G;  3EGX B;  1RGI G;  3FG7 A;  5HVK D;  1F7S A;  4CBX G;  2VIL A;  4CBW G;  3CIP G;  1DEJ S;  5KYU B;  3A5O S;  4LIZ A;  3A5L S;  2XF1 A;  1EQY S;  4S10 C;  2HD7 A;  4CBU G;  3A5N S;  3CI5 G;  1Q8G A;  3EH2 A;  3Q2B A;  1P8Z G;  3DAW B;  2NUP A;  2FF3 A;  2FH3 A;  4PKH B;  1UDM A;  4BEX 1;  1T44 G;  3EFO B;  5KYU A;  5DD2 A;  1V6F A;  1WNJ A;  2LLF A;  2FH2 A;  5KYY B;  1TMW A;  2MOT A;  4JD2 H;  5A1M A;  5FAE A;  1SVR A;  3EG9 A;  1D0N A;  1VFQ A;  1M2V B;  1TVJ A;  1QPV A;  1M4J A;  4KEE A;  1J72 A;  3EGX A;  2MV2 A;  1NM1 G;  3FFK A;  3FG6 A;  1NMD G;  1T2L A;  2FH4 A;  2D8B A;  2NUT B;  3CJB G;  3FFN A;  5KYX B;  1Q8X A;  1JHW A;  3CJC G;  1SVY A;  2FF6 G;  1M2V A;  2QTV A;  2VAC A;  1C0G S;  2VIK A;  2I2Q A;  2W0I A;  3A5M S;  2XFA A;  3TU5 B;  3EGD B;  2LXX A;  1AHQ A;  1SVQ A;  3L50 A;  1CFY A;  2NUT A;  3EFO A;  5FAF A;  1MDU A;  2MP4 A; 
#chains in the Genus database with same CATH topology
 4KED A;  3DA7 A;  5KYW B;  1AK6 A;  1COF A;  3EH1 A;  1KCQ A;  2NUP B;  1X67 A;  4Z94 G;  5KYY A;  1PD0 A;  2FH1 A;  4KEF A;  2KVK A;  4PKI G;  3EGD A;  1YVN G;  1PD1 A;  1WM4 A;  1VKK A;  1WFS A;  1YAG G;  2FGH A;  1H1V G;  1NLV G;  1M2O A;  2LJ8 A;  1CNU A;  5HVK B;  5KYN A;  5KYW A;  1ESV S;  1T3Y A;  1HQZ 1;  1P8X A;  3EG9 B;  1T3X A;  1D4X G;  5IVU A;  5L6W C;  1AK7 A;  1PCX A;  1C0F S;  1NPH A;  5KYX A;  2L72 A;  4PKG G;  3EGX B;  1RGI G;  3FG7 A;  5HVK D;  1F7S A;  4CBX G;  2VIL A;  4CBW G;  3CIP G;  1DEJ S;  5KYU B;  3A5O S;  4LIZ A;  3A5L S;  2XF1 A;  1EQY S;  4S10 C;  2HD7 A;  4CBU G;  3A5N S;  3CI5 G;  1Q8G A;  3EH2 A;  3Q2B A;  1P8Z G;  3DAW B;  2NUP A;  2FF3 A;  2FH3 A;  4PKH B;  1UDM A;  4BEX 1;  1T44 G;  3EFO B;  5KYU A;  5DD2 A;  1V6F A;  1WNJ A;  2LLF A;  2FH2 A;  5KYY B;  1TMW A;  2MOT A;  4JD2 H;  5A1M A;  5FAE A;  1SVR A;  3EG9 A;  1D0N A;  1VFQ A;  1M2V B;  1TVJ A;  1QPV A;  1M4J A;  4KEE A;  1J72 A;  3EGX A;  2MV2 A;  1NM1 G;  3FFK A;  3FG6 A;  1NMD G;  1T2L A;  2FH4 A;  2D8B A;  2NUT B;  3CJB G;  3FFN A;  5KYX B;  1Q8X A;  1JHW A;  3CJC G;  1SVY A;  2FF6 G;  1M2V A;  2QTV A;  2VAC A;  1C0G S;  2VIK A;  2I2Q A;  2W0I A;  3A5M S;  2XFA A;  3TU5 B;  3EGD B;  2LXX A;  1AHQ A;  1SVQ A;  3L50 A;  1CFY A;  2NUT A;  3EFO A;  5FAF A;  1MDU A;  2MP4 A; 
#chains in the Genus database with same CATH homology
 4KED A;  3DA7 A;  5KYW B;  1AK6 A;  1COF A;  3EH1 A;  1KCQ A;  2NUP B;  1X67 A;  4Z94 G;  5KYY A;  1PD0 A;  2FH1 A;  4KEF A;  2KVK A;  4PKI G;  3EGD A;  1YVN G;  1PD1 A;  1WM4 A;  1VKK A;  1WFS A;  1YAG G;  2FGH A;  1H1V G;  1NLV G;  1M2O A;  2LJ8 A;  1CNU A;  5HVK B;  5KYN A;  5KYW A;  1ESV S;  1T3Y A;  1HQZ 1;  1P8X A;  3EG9 B;  1T3X A;  1D4X G;  5IVU A;  5L6W C;  1AK7 A;  1PCX A;  1C0F S;  1NPH A;  5KYX A;  2L72 A;  4PKG G;  3EGX B;  1RGI G;  3FG7 A;  5HVK D;  1F7S A;  4CBX G;  2VIL A;  4CBW G;  3CIP G;  1DEJ S;  5KYU B;  3A5O S;  4LIZ A;  3A5L S;  2XF1 A;  1EQY S;  4S10 C;  2HD7 A;  4CBU G;  3A5N S;  3CI5 G;  1Q8G A;  3EH2 A;  3Q2B A;  1P8Z G;  3DAW B;  2NUP A;  2FF3 A;  2FH3 A;  4PKH B;  1UDM A;  4BEX 1;  1T44 G;  3EFO B;  5KYU A;  5DD2 A;  1V6F A;  1WNJ A;  2LLF A;  2FH2 A;  5KYY B;  1TMW A;  2MOT A;  4JD2 H;  5A1M A;  5FAE A;  1SVR A;  3EG9 A;  1D0N A;  1VFQ A;  1M2V B;  1TVJ A;  1QPV A;  1M4J A;  4KEE A;  1J72 A;  3EGX A;  2MV2 A;  1NM1 G;  3FFK A;  3FG6 A;  1NMD G;  1T2L A;  2FH4 A;  2D8B A;  2NUT B;  3CJB G;  3FFN A;  5KYX B;  1Q8X A;  1JHW A;  3CJC G;  1SVY A;  2FF6 G;  1M2V A;  2QTV A;  2VAC A;  1C0G S;  2VIK A;  2I2Q A;  2W0I A;  3A5M S;  2XFA A;  3TU5 B;  3EGD B;  2LXX A;  1AHQ A;  1SVQ A;  3L50 A;  1CFY A;  2NUT A;  3EFO A;  5FAF A;  1MDU A;  2MP4 A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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#similar chains, but unknotted
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2FGHA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

pfam database annotations