2FH2A

C-terminal half of gelsolin soaked in egta at ph 4.5
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
330
structure length
321
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Calcium ion exchange in crystalline gelsolin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Gelsolin
total genus 94
structure length 321
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2005-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A02
1M2VB 2L72A 4S10C 4KEDA 1NPHA 1T2LA 3CJBG 1ESVS 3CI5G 3L50A 1JHWA 5HVKB 2FH1A 1TMWA 1VKKA 1KCQA 1V6FA 1X67A 4CBUG 4KEFA 1RGIG 1T3XA 4PKHB 1F7SA 1YAGG 1M2OA 3EH2A 2LLFA 1T44G 3FFKA 2FF6G 2MOTA 2I2QA 2LJ8A 2XFAA 1M4JA 3DAWB 3EG9A 3FG7A 3EGXB 2D8BA 1MDUA 1YVNG 3EFOA 5KYWA 2KVKA 3EG9B 5KYNA 5KYUA 4PKIG 4Z94G 2NUTA 1T3YA 3A5MS 3FG6A 1DEJS 1WM4A 3EFOB 1AK7A 5KYWB 5IVUA 3EGXA 2MV2A 1VFQA 5KYUB 1EQYS 2W0IA 4KEEA 2NUTB 1TVJA 1PD1A 4BEX1 1H1VG 1SVRA 2MP4A 5L6WC 1SVQA 1Q8XA 1WNJA 4PKGG 3CJCG 2XF1A 2FF3A 3EGDA 2QTVA 1HQZ1 3FFNA 3Q2BA 1J72A 2VILA 3A5OS 1D4XG 1NLVG 5HVKD 3CIPG 4CBWG 3EGDB 1PCXA 5FAEA 2LXXA 1WFSA 1AK6A 5KYXA 1PD0A 1C0FS 5A1MA 1QPVA 2FH2A 5DD2A 3EH1A 1AHQA 1D0NA 3TU5B 5KYXB 1CNUA 2HD7A 2NUPA 1Q8GA 2FGHA 3A5NS 5KYYA 3A5LS 5FAFA 1COFA 4LIZA 1P8ZG 1M2VA 1CFYA 4JD2H 2NUPB 1C0GS 1P8XA 5KYYB 1UDMA 1NM1G 2FH3A 1NMDG 2FH4A 4CBXG 1SVYA 2VACA 2VIKA
chains in the Genus database with same CATH superfamily
1M2VB 2L72A 4S10C 4KEDA 1NPHA 1T2LA 3CJBG 1ESVS 3CI5G 3L50A 1JHWA 5HVKB 2FH1A 1TMWA 1VKKA 1KCQA 1V6FA 1X67A 4CBUG 4KEFA 1RGIG 1T3XA 4PKHB 1F7SA 1YAGG 1M2OA 3EH2A 2LLFA 1T44G 3FFKA 2FF6G 2MOTA 2I2QA 2LJ8A 2XFAA 1M4JA 3DAWB 3EG9A 3FG7A 3EGXB 2D8BA 1MDUA 1YVNG 3EFOA 5KYWA 2KVKA 3EG9B 5KYNA 3DA7A 5KYUA 4PKIG 4Z94G 2NUTA 1T3YA 3A5MS 3FG6A 1DEJS 1WM4A 3EFOB 1AK7A 5KYWB 5IVUA 3EGXA 2MV2A 1VFQA 5KYUB 1EQYS 2W0IA 4KEEA 2NUTB 1TVJA 1PD1A 4BEX1 1H1VG 1SVRA 2MP4A 5L6WC 1SVQA 1Q8XA 1WNJA 4PKGG 3CJCG 2XF1A 2FF3A 3EGDA 2QTVA 1HQZ1 3FFNA 3Q2BA 1J72A 2VILA 3A5OS 1D4XG 1NLVG 5HVKD 3CIPG 4CBWG 3EGDB 1PCXA 5FAEA 2LXXA 1WFSA 1AK6A 5KYXA 1PD0A 1C0FS 5A1MA 1QPVA 2FH2A 5DD2A 3EH1A 1AHQA 1D0NA 3TU5B 5KYXB 1CNUA 2HD7A 2NUPA 1Q8GA 2FGHA 3A5NS 5KYYA 3A5LS 5FAFA 1COFA 4LIZA 1P8ZG 1M2VA 1CFYA 4JD2H 2NUPB 1C0GS 1P8XA 5KYYB 1UDMA 1NM1G 2FH3A 1NMDG 2FH4A 4CBXG 1SVYA 2VACA 2VIKA
chains in the Genus database with same CATH topology
1M2VB 2L72A 4S10C 4KEDA 1NPHA 1T2LA 3CJBG 1ESVS 3CI5G 3L50A 1JHWA 5HVKB 2FH1A 1TMWA 1VKKA 1KCQA 1V6FA 1X67A 4CBUG 4KEFA 1RGIG 1T3XA 4PKHB 1F7SA 1YAGG 1M2OA 3EH2A 2LLFA 1T44G 3FFKA 2FF6G 2MOTA 2I2QA 2LJ8A 2XFAA 1M4JA 3DAWB 3EG9A 3FG7A 3EGXB 2D8BA 1MDUA 1YVNG 3EFOA 5KYWA 2KVKA 3EG9B 5KYNA 3DA7A 5KYUA 4PKIG 4Z94G 2NUTA 1T3YA 3A5MS 3FG6A 1DEJS 1WM4A 3EFOB 1AK7A 5KYWB 5IVUA 3EGXA 2MV2A 1VFQA 5KYUB 1EQYS 2W0IA 4KEEA 2NUTB 1TVJA 1PD1A 4BEX1 1H1VG 1SVRA 2MP4A 5L6WC 1SVQA 1Q8XA 1WNJA 4PKGG 3CJCG 2XF1A 2FF3A 3EGDA 2QTVA 1HQZ1 3FFNA 3Q2BA 1J72A 2VILA 3A5OS 1D4XG 1NLVG 5HVKD 3CIPG 4CBWG 3EGDB 1PCXA 5FAEA 2LXXA 1WFSA 1AK6A 5KYXA 1PD0A 1C0FS 5A1MA 1QPVA 2FH2A 5DD2A 3EH1A 1AHQA 1D0NA 3TU5B 5KYXB 1CNUA 2HD7A 2NUPA 1Q8GA 2FGHA 3A5NS 5KYYA 3A5LS 5FAFA 1COFA 4LIZA 1P8ZG 1M2VA 1CFYA 4JD2H 2NUPB 1C0GS 1P8XA 5KYYB 1UDMA 1NM1G 2FH3A 1NMDG 2FH4A 4CBXG 1SVYA 2VACA 2VIKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M2V B;  2L72 A;  4S10 C;  4KED A;  1NPH A;  1T2L A;  3CJB G;  1ESV S;  3CI5 G;  3L50 A;  1JHW A;  5HVK B;  2FH1 A;  1TMW A;  1VKK A;  1KCQ A;  1V6F A;  1X67 A;  4CBU G;  4KEF A;  1RGI G;  1T3X A;  4PKH B;  1F7S A;  1YAG G;  1M2O A;  3EH2 A;  2LLF A;  1T44 G;  3FFK A;  2FF6 G;  2MOT A;  2I2Q A;  2LJ8 A;  2XFA A;  1M4J A;  3DAW B;  3EG9 A;  3FG7 A;  3EGX B;  2D8B A;  1MDU A;  1YVN G;  3EFO A;  5KYW A;  2KVK A;  3EG9 B;  5KYN A;  5KYU A;  4PKI G;  4Z94 G;  2NUT A;  1T3Y A;  3A5M S;  3FG6 A;  1DEJ S;  1WM4 A;  3EFO B;  1AK7 A;  5KYW B;  5IVU A;  3EGX A;  2MV2 A;  1VFQ A;  5KYU B;  1EQY S;  2W0I A;  4KEE A;  2NUT B;  1TVJ A;  1PD1 A;  4BEX 1;  1H1V G;  1SVR A;  2MP4 A;  5L6W C;  1SVQ A;  1Q8X A;  1WNJ A;  4PKG G;  3CJC G;  2XF1 A;  2FF3 A;  3EGD A;  2QTV A;  1HQZ 1;  3FFN A;  3Q2B A;  1J72 A;  2VIL A;  3A5O S;  1D4X G;  1NLV G;  5HVK D;  3CIP G;  4CBW G;  3EGD B;  1PCX A;  5FAE A;  2LXX A;  1WFS A;  1AK6 A;  5KYX A;  1PD0 A;  1C0F S;  5A1M A;  1QPV A;  2FH2 A;  5DD2 A;  3EH1 A;  1AHQ A;  1D0N A;  3TU5 B;  5KYX B;  1CNU A;  2HD7 A;  2NUP A;  1Q8G A;  2FGH A;  3A5N S;  5KYY A;  3A5L S;  5FAF A;  1COF A;  4LIZ A;  1P8Z G;  1M2V A;  1CFY A;  4JD2 H;  2NUP B;  1C0G S;  1P8X A;  5KYY B;  1UDM A;  1NM1 G;  2FH3 A;  1NMD G;  2FH4 A;  4CBX G;  1SVY A;  2VAC A;  2VIK A; 
#chains in the Genus database with same CATH topology
 1M2V B;  2L72 A;  4S10 C;  4KED A;  1NPH A;  1T2L A;  3CJB G;  1ESV S;  3CI5 G;  3L50 A;  1JHW A;  5HVK B;  2FH1 A;  1TMW A;  1VKK A;  1KCQ A;  1V6F A;  1X67 A;  4CBU G;  4KEF A;  1RGI G;  1T3X A;  4PKH B;  1F7S A;  1YAG G;  1M2O A;  3EH2 A;  2LLF A;  1T44 G;  3FFK A;  2FF6 G;  2MOT A;  2I2Q A;  2LJ8 A;  2XFA A;  1M4J A;  3DAW B;  3EG9 A;  3FG7 A;  3EGX B;  2D8B A;  1MDU A;  1YVN G;  3EFO A;  5KYW A;  2KVK A;  3EG9 B;  5KYN A;  3DA7 A;  5KYU A;  4PKI G;  4Z94 G;  2NUT A;  1T3Y A;  3A5M S;  3FG6 A;  1DEJ S;  1WM4 A;  3EFO B;  1AK7 A;  5KYW B;  5IVU A;  3EGX A;  2MV2 A;  1VFQ A;  5KYU B;  1EQY S;  2W0I A;  4KEE A;  2NUT B;  1TVJ A;  1PD1 A;  4BEX 1;  1H1V G;  1SVR A;  2MP4 A;  5L6W C;  1SVQ A;  1Q8X A;  1WNJ A;  4PKG G;  3CJC G;  2XF1 A;  2FF3 A;  3EGD A;  2QTV A;  1HQZ 1;  3FFN A;  3Q2B A;  1J72 A;  2VIL A;  3A5O S;  1D4X G;  1NLV G;  5HVK D;  3CIP G;  4CBW G;  3EGD B;  1PCX A;  5FAE A;  2LXX A;  1WFS A;  1AK6 A;  5KYX A;  1PD0 A;  1C0F S;  5A1M A;  1QPV A;  2FH2 A;  5DD2 A;  3EH1 A;  1AHQ A;  1D0N A;  3TU5 B;  5KYX B;  1CNU A;  2HD7 A;  2NUP A;  1Q8G A;  2FGH A;  3A5N S;  5KYY A;  3A5L S;  5FAF A;  1COF A;  4LIZ A;  1P8Z G;  1M2V A;  1CFY A;  4JD2 H;  2NUP B;  1C0G S;  1P8X A;  5KYY B;  1UDM A;  1NM1 G;  2FH3 A;  1NMD G;  2FH4 A;  4CBX G;  1SVY A;  2VAC A;  2VIK A; 
#chains in the Genus database with same CATH homology
 1M2V B;  2L72 A;  4S10 C;  4KED A;  1NPH A;  1T2L A;  3CJB G;  1ESV S;  3CI5 G;  3L50 A;  1JHW A;  5HVK B;  2FH1 A;  1TMW A;  1VKK A;  1KCQ A;  1V6F A;  1X67 A;  4CBU G;  4KEF A;  1RGI G;  1T3X A;  4PKH B;  1F7S A;  1YAG G;  1M2O A;  3EH2 A;  2LLF A;  1T44 G;  3FFK A;  2FF6 G;  2MOT A;  2I2Q A;  2LJ8 A;  2XFA A;  1M4J A;  3DAW B;  3EG9 A;  3FG7 A;  3EGX B;  2D8B A;  1MDU A;  1YVN G;  3EFO A;  5KYW A;  2KVK A;  3EG9 B;  5KYN A;  3DA7 A;  5KYU A;  4PKI G;  4Z94 G;  2NUT A;  1T3Y A;  3A5M S;  3FG6 A;  1DEJ S;  1WM4 A;  3EFO B;  1AK7 A;  5KYW B;  5IVU A;  3EGX A;  2MV2 A;  1VFQ A;  5KYU B;  1EQY S;  2W0I A;  4KEE A;  2NUT B;  1TVJ A;  1PD1 A;  4BEX 1;  1H1V G;  1SVR A;  2MP4 A;  5L6W C;  1SVQ A;  1Q8X A;  1WNJ A;  4PKG G;  3CJC G;  2XF1 A;  2FF3 A;  3EGD A;  2QTV A;  1HQZ 1;  3FFN A;  3Q2B A;  1J72 A;  2VIL A;  3A5O S;  1D4X G;  1NLV G;  5HVK D;  3CIP G;  4CBW G;  3EGD B;  1PCX A;  5FAE A;  2LXX A;  1WFS A;  1AK6 A;  5KYX A;  1PD0 A;  1C0F S;  5A1M A;  1QPV A;  2FH2 A;  5DD2 A;  3EH1 A;  1AHQ A;  1D0N A;  3TU5 B;  5KYX B;  1CNU A;  2HD7 A;  2NUP A;  1Q8G A;  2FGH A;  3A5N S;  5KYY A;  3A5L S;  5FAF A;  1COF A;  4LIZ A;  1P8Z G;  1M2V A;  1CFY A;  4JD2 H;  2NUP B;  1C0G S;  1P8X A;  5KYY B;  1UDM A;  1NM1 G;  2FH3 A;  1NMD G;  2FH4 A;  4CBX G;  1SVY A;  2VAC A;  2VIK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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