2FH2A

C-terminal half of gelsolin soaked in egta at ph 4.5
Total Genus 94
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
94
sequence length
330
structure length
321
Chain Sequence
MDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYNYRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLFGGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTPSAAYLWVGTGASEAEKTGAQELLRVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLKDKKMHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEEEKTEALTSAKRYIETDTPITVVKQGFEPPSFVGWFLGWDDDYW
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Calcium ion exchange in crystalline gelsolin
pubmed doi rcsb
molecule tags Contractile protein
source organism Homo sapiens
molecule keywords Gelsolin
total genus 94
structure length 321
sequence length 330
chains with identical sequence B, C
ec nomenclature
pdb deposition date 2005-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00626 Gelsolin Gelsolin repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A01
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A03
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2fh2A02
3FFNA 1NM1G 5FAEA 1DEJS 1CNUA 4JD2H 2LXXA 1UDMA 1JHWA 5FAFA 3L50A 1D4XG 1V6FA 5KYXB 1SVRA 1J72A 1F7SA 2NUTA 1WNJA 1NLVG 1KCQA 3A5NS 1EQYS 1QPVA 3FG6A 1WFSA 2LLFA 1ESVS 5A1MA 2MOTA 1YVNG 1COFA 1PCXA 3FG7A 5KYXA 5HVKD 5KYWB 5KYUB 1WM4A 2XFAA 1H1VG 1MDUA 2HD7A 2FH2A 1M2OA 3CJCG 2MP4A 2KVKA 3EGDB 1C0FS 1D0NA 4KEEA 4BEX1 1TVJA 4KEFA 5KYWA 3EH1A 1T2LA 1T3YA 5KYUA 1Q8GA 3EGXB 2XF1A 4LIZA 2VIKA 4PKIG 1M4JA 1Q8XA 3A5MS 1P8ZG 1T3XA 1AK6A 3CIPG 3EGDA 3TU5B 4CBWG 2FF3A 1YAGG 1TMWA 1CFYA 1SVYA 3Q2BA 3EGXA 1NMDG 5DD2A 3FFKA 2MV2A 3A5OS 2FH3A 1P8XA 2FH4A 2QTVA 2LJ8A 3CJBG 2I2QA 1VKKA 5KYYB 4Z94G 1PD0A 1C0GS 1M2VB 1X67A 5IVUA 2VACA 3A5LS 2FGHA 1T44G 2FF6G 1NPHA 1VFQA 4S10C 4CBUG 2D8BA 2L72A 5KYNA 5KYYA 1AHQA 4KEDA 2NUPB 5HVKB 1M2VA 3EG9B 2W0IA 3EFOB 3EH2A 1PD1A 3DAWB 4PKHB 2FH1A 1RGIG 1HQZ1 1SVQA 3CI5G 2NUPA 4PKGG 2VILA 3EG9A 5L6WC 3EFOA 4CBXG 2NUTB 1AK7A
chains in the Genus database with same CATH superfamily
3FFNA 1NM1G 5FAEA 1DEJS 1CNUA 4JD2H 2LXXA 1UDMA 1JHWA 5FAFA 3L50A 1D4XG 1V6FA 5KYXB 1SVRA 1J72A 1F7SA 2NUTA 1WNJA 1NLVG 1KCQA 3A5NS 1EQYS 1QPVA 3FG6A 1WFSA 2LLFA 1ESVS 5A1MA 2MOTA 1YVNG 1COFA 1PCXA 3FG7A 5KYXA 5HVKD 5KYWB 5KYUB 1WM4A 2XFAA 1H1VG 1MDUA 2HD7A 2FH2A 1M2OA 3CJCG 3DA7A 2MP4A 2KVKA 3EGDB 1C0FS 1D0NA 4KEEA 4BEX1 1TVJA 4KEFA 5KYWA 3EH1A 1T2LA 1T3YA 5KYUA 1Q8GA 3EGXB 2XF1A 4LIZA 2VIKA 4PKIG 1M4JA 1Q8XA 3A5MS 1P8ZG 1T3XA 1AK6A 3CIPG 3EGDA 3TU5B 4CBWG 2FF3A 1YAGG 1TMWA 1CFYA 1SVYA 3Q2BA 3EGXA 1NMDG 5DD2A 3FFKA 2MV2A 3A5OS 2FH3A 1P8XA 2FH4A 2QTVA 2LJ8A 3CJBG 2I2QA 1VKKA 5KYYB 4Z94G 1PD0A 1C0GS 1M2VB 1X67A 5IVUA 2VACA 3A5LS 2FGHA 1T44G 2FF6G 1NPHA 1VFQA 4S10C 4CBUG 2D8BA 2L72A 5KYNA 5KYYA 1AHQA 4KEDA 2NUPB 5HVKB 1M2VA 3EG9B 2W0IA 3EFOB 3EH2A 1PD1A 3DAWB 4PKHB 2FH1A 1RGIG 1HQZ1 1SVQA 3CI5G 2NUPA 4PKGG 2VILA 3EG9A 5L6WC 3EFOA 4CBXG 2NUTB 1AK7A
chains in the Genus database with same CATH topology
3FFNA 1NM1G 5FAEA 1DEJS 1CNUA 4JD2H 2LXXA 1UDMA 1JHWA 5FAFA 3L50A 1D4XG 1V6FA 5KYXB 1SVRA 1J72A 1F7SA 2NUTA 1WNJA 1NLVG 1KCQA 3A5NS 1EQYS 1QPVA 3FG6A 1WFSA 2LLFA 1ESVS 5A1MA 2MOTA 1YVNG 1COFA 1PCXA 3FG7A 5KYXA 5HVKD 5KYWB 5KYUB 1WM4A 2XFAA 1H1VG 1MDUA 2HD7A 2FH2A 1M2OA 3CJCG 3DA7A 2MP4A 2KVKA 3EGDB 1C0FS 1D0NA 4KEEA 4BEX1 1TVJA 4KEFA 5KYWA 3EH1A 1T2LA 1T3YA 5KYUA 1Q8GA 3EGXB 2XF1A 4LIZA 2VIKA 4PKIG 1M4JA 1Q8XA 3A5MS 1P8ZG 1T3XA 1AK6A 3CIPG 3EGDA 3TU5B 4CBWG 2FF3A 1YAGG 1TMWA 1CFYA 1SVYA 3Q2BA 3EGXA 1NMDG 5DD2A 3FFKA 2MV2A 3A5OS 2FH3A 1P8XA 2FH4A 2QTVA 2LJ8A 3CJBG 2I2QA 1VKKA 5KYYB 4Z94G 1PD0A 1C0GS 1M2VB 1X67A 5IVUA 2VACA 3A5LS 2FGHA 1T44G 2FF6G 1NPHA 1VFQA 4S10C 4CBUG 2D8BA 2L72A 5KYNA 5KYYA 1AHQA 4KEDA 2NUPB 5HVKB 1M2VA 3EG9B 2W0IA 3EFOB 3EH2A 1PD1A 3DAWB 4PKHB 2FH1A 1RGIG 1HQZ1 1SVQA 3CI5G 2NUPA 4PKGG 2VILA 3EG9A 5L6WC 3EFOA 4CBXG 2NUTB 1AK7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3FFN A;  1NM1 G;  5FAE A;  1DEJ S;  1CNU A;  4JD2 H;  2LXX A;  1UDM A;  1JHW A;  5FAF A;  3L50 A;  1D4X G;  1V6F A;  5KYX B;  1SVR A;  1J72 A;  1F7S A;  2NUT A;  1WNJ A;  1NLV G;  1KCQ A;  3A5N S;  1EQY S;  1QPV A;  3FG6 A;  1WFS A;  2LLF A;  1ESV S;  5A1M A;  2MOT A;  1YVN G;  1COF A;  1PCX A;  3FG7 A;  5KYX A;  5HVK D;  5KYW B;  5KYU B;  1WM4 A;  2XFA A;  1H1V G;  1MDU A;  2HD7 A;  2FH2 A;  1M2O A;  3CJC G;  2MP4 A;  2KVK A;  3EGD B;  1C0F S;  1D0N A;  4KEE A;  4BEX 1;  1TVJ A;  4KEF A;  5KYW A;  3EH1 A;  1T2L A;  1T3Y A;  5KYU A;  1Q8G A;  3EGX B;  2XF1 A;  4LIZ A;  2VIK A;  4PKI G;  1M4J A;  1Q8X A;  3A5M S;  1P8Z G;  1T3X A;  1AK6 A;  3CIP G;  3EGD A;  3TU5 B;  4CBW G;  2FF3 A;  1YAG G;  1TMW A;  1CFY A;  1SVY A;  3Q2B A;  3EGX A;  1NMD G;  5DD2 A;  3FFK A;  2MV2 A;  3A5O S;  2FH3 A;  1P8X A;  2FH4 A;  2QTV A;  2LJ8 A;  3CJB G;  2I2Q A;  1VKK A;  5KYY B;  4Z94 G;  1PD0 A;  1C0G S;  1M2V B;  1X67 A;  5IVU A;  2VAC A;  3A5L S;  2FGH A;  1T44 G;  2FF6 G;  1NPH A;  1VFQ A;  4S10 C;  4CBU G;  2D8B A;  2L72 A;  5KYN A;  5KYY A;  1AHQ A;  4KED A;  2NUP B;  5HVK B;  1M2V A;  3EG9 B;  2W0I A;  3EFO B;  3EH2 A;  1PD1 A;  3DAW B;  4PKH B;  2FH1 A;  1RGI G;  1HQZ 1;  1SVQ A;  3CI5 G;  2NUP A;  4PKG G;  2VIL A;  3EG9 A;  5L6W C;  3EFO A;  4CBX G;  2NUT B;  1AK7 A; 
#chains in the Genus database with same CATH topology
 3FFN A;  1NM1 G;  5FAE A;  1DEJ S;  1CNU A;  4JD2 H;  2LXX A;  1UDM A;  1JHW A;  5FAF A;  3L50 A;  1D4X G;  1V6F A;  5KYX B;  1SVR A;  1J72 A;  1F7S A;  2NUT A;  1WNJ A;  1NLV G;  1KCQ A;  3A5N S;  1EQY S;  1QPV A;  3FG6 A;  1WFS A;  2LLF A;  1ESV S;  5A1M A;  2MOT A;  1YVN G;  1COF A;  1PCX A;  3FG7 A;  5KYX A;  5HVK D;  5KYW B;  5KYU B;  1WM4 A;  2XFA A;  1H1V G;  1MDU A;  2HD7 A;  2FH2 A;  1M2O A;  3CJC G;  3DA7 A;  2MP4 A;  2KVK A;  3EGD B;  1C0F S;  1D0N A;  4KEE A;  4BEX 1;  1TVJ A;  4KEF A;  5KYW A;  3EH1 A;  1T2L A;  1T3Y A;  5KYU A;  1Q8G A;  3EGX B;  2XF1 A;  4LIZ A;  2VIK A;  4PKI G;  1M4J A;  1Q8X A;  3A5M S;  1P8Z G;  1T3X A;  1AK6 A;  3CIP G;  3EGD A;  3TU5 B;  4CBW G;  2FF3 A;  1YAG G;  1TMW A;  1CFY A;  1SVY A;  3Q2B A;  3EGX A;  1NMD G;  5DD2 A;  3FFK A;  2MV2 A;  3A5O S;  2FH3 A;  1P8X A;  2FH4 A;  2QTV A;  2LJ8 A;  3CJB G;  2I2Q A;  1VKK A;  5KYY B;  4Z94 G;  1PD0 A;  1C0G S;  1M2V B;  1X67 A;  5IVU A;  2VAC A;  3A5L S;  2FGH A;  1T44 G;  2FF6 G;  1NPH A;  1VFQ A;  4S10 C;  4CBU G;  2D8B A;  2L72 A;  5KYN A;  5KYY A;  1AHQ A;  4KED A;  2NUP B;  5HVK B;  1M2V A;  3EG9 B;  2W0I A;  3EFO B;  3EH2 A;  1PD1 A;  3DAW B;  4PKH B;  2FH1 A;  1RGI G;  1HQZ 1;  1SVQ A;  3CI5 G;  2NUP A;  4PKG G;  2VIL A;  3EG9 A;  5L6W C;  3EFO A;  4CBX G;  2NUT B;  1AK7 A; 
#chains in the Genus database with same CATH homology
 3FFN A;  1NM1 G;  5FAE A;  1DEJ S;  1CNU A;  4JD2 H;  2LXX A;  1UDM A;  1JHW A;  5FAF A;  3L50 A;  1D4X G;  1V6F A;  5KYX B;  1SVR A;  1J72 A;  1F7S A;  2NUT A;  1WNJ A;  1NLV G;  1KCQ A;  3A5N S;  1EQY S;  1QPV A;  3FG6 A;  1WFS A;  2LLF A;  1ESV S;  5A1M A;  2MOT A;  1YVN G;  1COF A;  1PCX A;  3FG7 A;  5KYX A;  5HVK D;  5KYW B;  5KYU B;  1WM4 A;  2XFA A;  1H1V G;  1MDU A;  2HD7 A;  2FH2 A;  1M2O A;  3CJC G;  3DA7 A;  2MP4 A;  2KVK A;  3EGD B;  1C0F S;  1D0N A;  4KEE A;  4BEX 1;  1TVJ A;  4KEF A;  5KYW A;  3EH1 A;  1T2L A;  1T3Y A;  5KYU A;  1Q8G A;  3EGX B;  2XF1 A;  4LIZ A;  2VIK A;  4PKI G;  1M4J A;  1Q8X A;  3A5M S;  1P8Z G;  1T3X A;  1AK6 A;  3CIP G;  3EGD A;  3TU5 B;  4CBW G;  2FF3 A;  1YAG G;  1TMW A;  1CFY A;  1SVY A;  3Q2B A;  3EGX A;  1NMD G;  5DD2 A;  3FFK A;  2MV2 A;  3A5O S;  2FH3 A;  1P8X A;  2FH4 A;  2QTV A;  2LJ8 A;  3CJB G;  2I2Q A;  1VKK A;  5KYY B;  4Z94 G;  1PD0 A;  1C0G S;  1M2V B;  1X67 A;  5IVU A;  2VAC A;  3A5L S;  2FGH A;  1T44 G;  2FF6 G;  1NPH A;  1VFQ A;  4S10 C;  4CBU G;  2D8B A;  2L72 A;  5KYN A;  5KYY A;  1AHQ A;  4KED A;  2NUP B;  5HVK B;  1M2V A;  3EG9 B;  2W0I A;  3EFO B;  3EH2 A;  1PD1 A;  3DAW B;  4PKH B;  2FH1 A;  1RGI G;  1HQZ 1;  1SVQ A;  3CI5 G;  2NUP A;  4PKG G;  2VIL A;  3EG9 A;  5L6W C;  3EFO A;  4CBX G;  2NUT B;  1AK7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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