2HD7A

Solution structure of c-teminal domain of twinfilin-1.
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
142
structure length
142
Chain Sequence
AQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELRDLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis and evolutionary origin of actin filament capping by twinfilin
pubmed doi rcsb
molecule tags Contractile protein
source organism Mus musculus
molecule keywords Twinfilin-1
total genus 38
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2006-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2hd7A00
1TMWA 5FAFA 5IVUA 2W0IA 1M2VB 1AK6A 5KYNA 1J72A 3EGDB 4KEEA 2VIKA 1V6FA 4PKGG 2NUTA 1WM4A 1F7SA 1T2LA 5L6WC 1T3XA 5A1MA 3EH1A 4KEFA 1PD1A 2FF3A 3L50A 5KYWB 2FH2A 2XF1A 1JHWA 1PCXA 3FFNA 1Q8XA 2QTVA 1CFYA 5KYXB 1M2VA 4CBUG 3TU5B 2VACA 1D0NA 3EGDA 4Z94G 2VILA 1NPHA 1YVNG 3CIPG 3FG6A 3FFKA 1AK7A 2NUPB 1C0GS 1PD0A 3DAWB 5KYYA 2LJ8A 1WNJA 5KYWA 1VFQA 1M2OA 3EG9B 1SVYA 2FF6G 4KEDA 1SVRA 1QPVA 5KYUB 3CI5G 2LXXA 1CNUA 4PKIG 1UDMA 5DD2A 1NMDG 1WFSA 3A5LS 5KYXA 1P8ZG 1SVQA 3FG7A 1EQYS 2HD7A 3A5OS 1C0FS 1H1VG 1COFA 1P8XA 4LIZA 2D8BA 4BEX1 1T44G 2FH4A 2NUPA 5HVKB 1ESVS 1Q8GA 3EGXB 4CBWG 2MOTA 2MV2A 3EH2A 1MDUA 3CJBG 2KVKA 3EFOB 3EG9A 5KYYB 2LLFA 3CJCG 1YAGG 1HQZ1 1NLVG 1TVJA 1T3YA 5KYUA 2MP4A 2FH3A 3A5NS 2FH1A 2FGHA 1KCQA 2I2QA 2NUTB 1DEJS 4CBXG 2XFAA 4JD2H 3Q2BA 3A5MS 5HVKD 5FAEA 1NM1G 1M4JA 1VKKA 1X67A 2L72A 3EGXA 4PKHB 4S10C 1D4XG 1RGIG 3EFOA 1AHQA
chains in the Genus database with same CATH superfamily
1TMWA 5FAFA 5IVUA 2W0IA 1M2VB 1AK6A 5KYNA 1J72A 3EGDB 4KEEA 2VIKA 1V6FA 4PKGG 2NUTA 1WM4A 1F7SA 1T2LA 5L6WC 1T3XA 5A1MA 3EH1A 4KEFA 1PD1A 2FF3A 3L50A 5KYWB 2FH2A 2XF1A 1JHWA 1PCXA 3FFNA 1Q8XA 2QTVA 1CFYA 5KYXB 1M2VA 4CBUG 3TU5B 2VACA 1D0NA 3EGDA 4Z94G 2VILA 1NPHA 1YVNG 3CIPG 3FG6A 3FFKA 1AK7A 2NUPB 1C0GS 1PD0A 3DAWB 5KYYA 2LJ8A 1WNJA 5KYWA 1VFQA 1M2OA 3EG9B 1SVYA 2FF6G 4KEDA 1SVRA 1QPVA 5KYUB 3CI5G 2LXXA 1CNUA 4PKIG 1UDMA 5DD2A 1NMDG 1WFSA 3A5LS 5KYXA 1P8ZG 1SVQA 3FG7A 1EQYS 2HD7A 3A5OS 1C0FS 1H1VG 1COFA 1P8XA 4LIZA 2D8BA 4BEX1 1T44G 2FH4A 2NUPA 5HVKB 1ESVS 1Q8GA 3EGXB 4CBWG 2MOTA 2MV2A 3EH2A 1MDUA 3CJBG 2KVKA 3EFOB 3EG9A 5KYYB 2LLFA 3CJCG 1YAGG 1HQZ1 1NLVG 1TVJA 1T3YA 5KYUA 2MP4A 2FH3A 3A5NS 2FH1A 2FGHA 1KCQA 2I2QA 2NUTB 1DEJS 3DA7A 4CBXG 2XFAA 4JD2H 3Q2BA 3A5MS 5HVKD 5FAEA 1NM1G 1M4JA 1VKKA 1X67A 2L72A 3EGXA 4PKHB 4S10C 1D4XG 1RGIG 3EFOA 1AHQA
chains in the Genus database with same CATH topology
1TMWA 5FAFA 5IVUA 2W0IA 1M2VB 1AK6A 5KYNA 1J72A 3EGDB 4KEEA 2VIKA 1V6FA 4PKGG 2NUTA 1WM4A 1F7SA 1T2LA 5L6WC 1T3XA 5A1MA 3EH1A 4KEFA 1PD1A 2FF3A 3L50A 5KYWB 2FH2A 2XF1A 1JHWA 1PCXA 3FFNA 1Q8XA 2QTVA 1CFYA 5KYXB 1M2VA 4CBUG 3TU5B 2VACA 1D0NA 3EGDA 4Z94G 2VILA 1NPHA 1YVNG 3CIPG 3FG6A 3FFKA 1AK7A 2NUPB 1C0GS 1PD0A 3DAWB 5KYYA 2LJ8A 1WNJA 5KYWA 1VFQA 1M2OA 3EG9B 1SVYA 2FF6G 4KEDA 1SVRA 1QPVA 5KYUB 3CI5G 2LXXA 1CNUA 4PKIG 1UDMA 5DD2A 1NMDG 1WFSA 3A5LS 5KYXA 1P8ZG 1SVQA 3FG7A 1EQYS 2HD7A 3A5OS 1C0FS 1H1VG 1COFA 1P8XA 4LIZA 2D8BA 4BEX1 1T44G 2FH4A 2NUPA 5HVKB 1ESVS 1Q8GA 3EGXB 4CBWG 2MOTA 2MV2A 3EH2A 1MDUA 3CJBG 2KVKA 3EFOB 3EG9A 5KYYB 2LLFA 3CJCG 1YAGG 1HQZ1 1NLVG 1TVJA 1T3YA 5KYUA 2MP4A 2FH3A 3A5NS 2FH1A 2FGHA 1KCQA 2I2QA 2NUTB 1DEJS 3DA7A 4CBXG 2XFAA 4JD2H 3Q2BA 3A5MS 5HVKD 5FAEA 1NM1G 1M4JA 1VKKA 1X67A 2L72A 3EGXA 4PKHB 4S10C 1D4XG 1RGIG 3EFOA 1AHQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TMW A;  5FAF A;  5IVU A;  2W0I A;  1M2V B;  1AK6 A;  5KYN A;  1J72 A;  3EGD B;  4KEE A;  2VIK A;  1V6F A;  4PKG G;  2NUT A;  1WM4 A;  1F7S A;  1T2L A;  5L6W C;  1T3X A;  5A1M A;  3EH1 A;  4KEF A;  1PD1 A;  2FF3 A;  3L50 A;  5KYW B;  2FH2 A;  2XF1 A;  1JHW A;  1PCX A;  3FFN A;  1Q8X A;  2QTV A;  1CFY A;  5KYX B;  1M2V A;  4CBU G;  3TU5 B;  2VAC A;  1D0N A;  3EGD A;  4Z94 G;  2VIL A;  1NPH A;  1YVN G;  3CIP G;  3FG6 A;  3FFK A;  1AK7 A;  2NUP B;  1C0G S;  1PD0 A;  3DAW B;  5KYY A;  2LJ8 A;  1WNJ A;  5KYW A;  1VFQ A;  1M2O A;  3EG9 B;  1SVY A;  2FF6 G;  4KED A;  1SVR A;  1QPV A;  5KYU B;  3CI5 G;  2LXX A;  1CNU A;  4PKI G;  1UDM A;  5DD2 A;  1NMD G;  1WFS A;  3A5L S;  5KYX A;  1P8Z G;  1SVQ A;  3FG7 A;  1EQY S;  2HD7 A;  3A5O S;  1C0F S;  1H1V G;  1COF A;  1P8X A;  4LIZ A;  2D8B A;  4BEX 1;  1T44 G;  2FH4 A;  2NUP A;  5HVK B;  1ESV S;  1Q8G A;  3EGX B;  4CBW G;  2MOT A;  2MV2 A;  3EH2 A;  1MDU A;  3CJB G;  2KVK A;  3EFO B;  3EG9 A;  5KYY B;  2LLF A;  3CJC G;  1YAG G;  1HQZ 1;  1NLV G;  1TVJ A;  1T3Y A;  5KYU A;  2MP4 A;  2FH3 A;  3A5N S;  2FH1 A;  2FGH A;  1KCQ A;  2I2Q A;  2NUT B;  1DEJ S;  4CBX G;  2XFA A;  4JD2 H;  3Q2B A;  3A5M S;  5HVK D;  5FAE A;  1NM1 G;  1M4J A;  1VKK A;  1X67 A;  2L72 A;  3EGX A;  4PKH B;  4S10 C;  1D4X G;  1RGI G;  3EFO A;  1AHQ A; 
#chains in the Genus database with same CATH topology
 1TMW A;  5FAF A;  5IVU A;  2W0I A;  1M2V B;  1AK6 A;  5KYN A;  1J72 A;  3EGD B;  4KEE A;  2VIK A;  1V6F A;  4PKG G;  2NUT A;  1WM4 A;  1F7S A;  1T2L A;  5L6W C;  1T3X A;  5A1M A;  3EH1 A;  4KEF A;  1PD1 A;  2FF3 A;  3L50 A;  5KYW B;  2FH2 A;  2XF1 A;  1JHW A;  1PCX A;  3FFN A;  1Q8X A;  2QTV A;  1CFY A;  5KYX B;  1M2V A;  4CBU G;  3TU5 B;  2VAC A;  1D0N A;  3EGD A;  4Z94 G;  2VIL A;  1NPH A;  1YVN G;  3CIP G;  3FG6 A;  3FFK A;  1AK7 A;  2NUP B;  1C0G S;  1PD0 A;  3DAW B;  5KYY A;  2LJ8 A;  1WNJ A;  5KYW A;  1VFQ A;  1M2O A;  3EG9 B;  1SVY A;  2FF6 G;  4KED A;  1SVR A;  1QPV A;  5KYU B;  3CI5 G;  2LXX A;  1CNU A;  4PKI G;  1UDM A;  5DD2 A;  1NMD G;  1WFS A;  3A5L S;  5KYX A;  1P8Z G;  1SVQ A;  3FG7 A;  1EQY S;  2HD7 A;  3A5O S;  1C0F S;  1H1V G;  1COF A;  1P8X A;  4LIZ A;  2D8B A;  4BEX 1;  1T44 G;  2FH4 A;  2NUP A;  5HVK B;  1ESV S;  1Q8G A;  3EGX B;  4CBW G;  2MOT A;  2MV2 A;  3EH2 A;  1MDU A;  3CJB G;  2KVK A;  3EFO B;  3EG9 A;  5KYY B;  2LLF A;  3CJC G;  1YAG G;  1HQZ 1;  1NLV G;  1TVJ A;  1T3Y A;  5KYU A;  2MP4 A;  2FH3 A;  3A5N S;  2FH1 A;  2FGH A;  1KCQ A;  2I2Q A;  2NUT B;  1DEJ S;  3DA7 A;  4CBX G;  2XFA A;  4JD2 H;  3Q2B A;  3A5M S;  5HVK D;  5FAE A;  1NM1 G;  1M4J A;  1VKK A;  1X67 A;  2L72 A;  3EGX A;  4PKH B;  4S10 C;  1D4X G;  1RGI G;  3EFO A;  1AHQ A; 
#chains in the Genus database with same CATH homology
 1TMW A;  5FAF A;  5IVU A;  2W0I A;  1M2V B;  1AK6 A;  5KYN A;  1J72 A;  3EGD B;  4KEE A;  2VIK A;  1V6F A;  4PKG G;  2NUT A;  1WM4 A;  1F7S A;  1T2L A;  5L6W C;  1T3X A;  5A1M A;  3EH1 A;  4KEF A;  1PD1 A;  2FF3 A;  3L50 A;  5KYW B;  2FH2 A;  2XF1 A;  1JHW A;  1PCX A;  3FFN A;  1Q8X A;  2QTV A;  1CFY A;  5KYX B;  1M2V A;  4CBU G;  3TU5 B;  2VAC A;  1D0N A;  3EGD A;  4Z94 G;  2VIL A;  1NPH A;  1YVN G;  3CIP G;  3FG6 A;  3FFK A;  1AK7 A;  2NUP B;  1C0G S;  1PD0 A;  3DAW B;  5KYY A;  2LJ8 A;  1WNJ A;  5KYW A;  1VFQ A;  1M2O A;  3EG9 B;  1SVY A;  2FF6 G;  4KED A;  1SVR A;  1QPV A;  5KYU B;  3CI5 G;  2LXX A;  1CNU A;  4PKI G;  1UDM A;  5DD2 A;  1NMD G;  1WFS A;  3A5L S;  5KYX A;  1P8Z G;  1SVQ A;  3FG7 A;  1EQY S;  2HD7 A;  3A5O S;  1C0F S;  1H1V G;  1COF A;  1P8X A;  4LIZ A;  2D8B A;  4BEX 1;  1T44 G;  2FH4 A;  2NUP A;  5HVK B;  1ESV S;  1Q8G A;  3EGX B;  4CBW G;  2MOT A;  2MV2 A;  3EH2 A;  1MDU A;  3CJB G;  2KVK A;  3EFO B;  3EG9 A;  5KYY B;  2LLF A;  3CJC G;  1YAG G;  1HQZ 1;  1NLV G;  1TVJ A;  1T3Y A;  5KYU A;  2MP4 A;  2FH3 A;  3A5N S;  2FH1 A;  2FGH A;  1KCQ A;  2I2Q A;  2NUT B;  1DEJ S;  3DA7 A;  4CBX G;  2XFA A;  4JD2 H;  3Q2B A;  3A5M S;  5HVK D;  5FAE A;  1NM1 G;  1M4J A;  1VKK A;  1X67 A;  2L72 A;  3EGX A;  4PKH B;  4S10 C;  1D4X G;  1RGI G;  3EFO A;  1AHQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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