2HD7A

Solution structure of c-teminal domain of twinfilin-1.
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
142
structure length
142
Chain Sequence
AQGVAFPISRDAFQALEKLSKKQLNYVQLEIDIKNETIILANTENTELRDLPKRIPKDSARYHFFLYKHSHEGDYLESVVFIYSMPGYTCSIRERMLYSSCKSPLLEIVERQLQMDVIRKIEIDNGDELTADFLYDEVHPKQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis and evolutionary origin of actin filament capping by twinfilin
pubmed doi rcsb
molecule tags Contractile protein
source organism Mus musculus
molecule keywords Twinfilin-1
total genus 38
structure length 142
sequence length 142
ec nomenclature
pdb deposition date 2006-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00241 Cofilin_ADF Cofilin/tropomyosin-type actin-binding protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.20.10 Alpha Beta 3-Layer(aba) Sandwich Severin Severin 2hd7A00
4BEX1 3EH2A 5HVKD 3EGXA 1V6FA 5IVUA 1ESVS 1CNUA 1YVNG 1VFQA 4KEDA 1PD1A 3FG7A 4PKIG 1NM1G 2L72A 2VILA 2MP4A 3EG9A 1WFSA 3Q2BA 4KEEA 5KYXB 1T3XA 1WNJA 3FFNA 2NUPB 5KYWB 2XF1A 3A5LS 2W0IA 2FH2A 1M2VA 1PCXA 1AHQA 1WM4A 3EFOB 1VKKA 1JHWA 3A5MS 2KVKA 3FG6A 3EH1A 3EGXB 1KCQA 1YAGG 1SVRA 3CIPG 1P8ZG 1D4XG 5A1MA 1AK7A 1MDUA 2MV2A 3L50A 1NPHA 1SVQA 3EG9B 2FH1A 5KYUB 5DD2A 3EGDA 2FF6G 1T2LA 4KEFA 2FH4A 4S10C 1EQYS 5FAFA 4JD2H 1M2VB 1Q8GA 2MOTA 4LIZA 1QPVA 1AK6A 1H1VG 4PKGG 1COFA 1UDMA 1RGIG 2NUTA 5KYYA 1F7SA 1Q8XA 1TMWA 1M4JA 2FH3A 2I2QA 3FFKA 4Z94G 1C0GS 1NLVG 4CBUG 5HVKB 2LXXA 5KYNA 2HD7A 2QTVA 3A5NS 5FAEA 1PD0A 1SVYA 5L6WC 3EGDB 1J72A 1HQZ1 2FF3A 1TVJA 3DAWB 1T3YA 1T44G 3CJBG 3A5OS 1DEJS 2VIKA 1C0FS 1NMDG 1D0NA 1X67A 4CBWG 2LJ8A 2VACA 2D8BA 2FGHA 3CJCG 5KYXA 2NUTB 3CI5G 5KYUA 5KYYB 2NUPA 5KYWA 4CBXG 1P8XA 3EFOA 1CFYA 2XFAA 3TU5B 4PKHB 1M2OA 2LLFA
chains in the Genus database with same CATH superfamily
4BEX1 3EH2A 5HVKD 3EGXA 1V6FA 5IVUA 1ESVS 1CNUA 1YVNG 1VFQA 4KEDA 1PD1A 3FG7A 4PKIG 1NM1G 2L72A 2VILA 2MP4A 3EG9A 1WFSA 3Q2BA 4KEEA 5KYXB 1T3XA 1WNJA 3FFNA 2NUPB 5KYWB 2XF1A 3A5LS 2W0IA 2FH2A 1M2VA 1PCXA 1AHQA 1WM4A 3EFOB 1VKKA 1JHWA 3A5MS 2KVKA 3FG6A 3EH1A 3EGXB 1KCQA 1YAGG 1SVRA 3CIPG 1P8ZG 1D4XG 5A1MA 1AK7A 1MDUA 2MV2A 3L50A 1NPHA 1SVQA 3EG9B 2FH1A 5KYUB 5DD2A 3EGDA 2FF6G 1T2LA 4KEFA 2FH4A 4S10C 1EQYS 5FAFA 4JD2H 1M2VB 1Q8GA 2MOTA 4LIZA 1QPVA 1AK6A 1H1VG 4PKGG 1COFA 1UDMA 1RGIG 2NUTA 5KYYA 1F7SA 1Q8XA 1TMWA 1M4JA 2FH3A 2I2QA 3FFKA 4Z94G 1C0GS 1NLVG 4CBUG 5HVKB 2LXXA 5KYNA 2HD7A 2QTVA 3A5NS 5FAEA 1PD0A 1SVYA 5L6WC 3EGDB 1J72A 1HQZ1 2FF3A 1TVJA 3DAWB 1T3YA 1T44G 3CJBG 3A5OS 1DEJS 2VIKA 1C0FS 1NMDG 1D0NA 1X67A 3DA7A 4CBWG 2LJ8A 2VACA 2D8BA 2FGHA 3CJCG 5KYXA 2NUTB 3CI5G 5KYUA 5KYYB 2NUPA 5KYWA 4CBXG 1P8XA 3EFOA 1CFYA 2XFAA 3TU5B 4PKHB 1M2OA 2LLFA
chains in the Genus database with same CATH topology
4BEX1 3EH2A 5HVKD 3EGXA 1V6FA 5IVUA 1ESVS 1CNUA 1YVNG 1VFQA 4KEDA 1PD1A 3FG7A 4PKIG 1NM1G 2L72A 2VILA 2MP4A 3EG9A 1WFSA 3Q2BA 4KEEA 5KYXB 1T3XA 1WNJA 3FFNA 2NUPB 5KYWB 2XF1A 3A5LS 2W0IA 2FH2A 1M2VA 1PCXA 1AHQA 1WM4A 3EFOB 1VKKA 1JHWA 3A5MS 2KVKA 3FG6A 3EH1A 3EGXB 1KCQA 1YAGG 1SVRA 3CIPG 1P8ZG 1D4XG 5A1MA 1AK7A 1MDUA 2MV2A 3L50A 1NPHA 1SVQA 3EG9B 2FH1A 5KYUB 5DD2A 3EGDA 2FF6G 1T2LA 4KEFA 2FH4A 4S10C 1EQYS 5FAFA 4JD2H 1M2VB 1Q8GA 2MOTA 4LIZA 1QPVA 1AK6A 1H1VG 4PKGG 1COFA 1UDMA 1RGIG 2NUTA 5KYYA 1F7SA 1Q8XA 1TMWA 1M4JA 2FH3A 2I2QA 3FFKA 4Z94G 1C0GS 1NLVG 4CBUG 5HVKB 2LXXA 5KYNA 2HD7A 2QTVA 3A5NS 5FAEA 1PD0A 1SVYA 5L6WC 3EGDB 1J72A 1HQZ1 2FF3A 1TVJA 3DAWB 1T3YA 1T44G 3CJBG 3A5OS 1DEJS 2VIKA 1C0FS 1NMDG 1D0NA 1X67A 3DA7A 4CBWG 2LJ8A 2VACA 2D8BA 2FGHA 3CJCG 5KYXA 2NUTB 3CI5G 5KYUA 5KYYB 2NUPA 5KYWA 4CBXG 1P8XA 3EFOA 1CFYA 2XFAA 3TU5B 4PKHB 1M2OA 2LLFA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BEX 1;  3EH2 A;  5HVK D;  3EGX A;  1V6F A;  5IVU A;  1ESV S;  1CNU A;  1YVN G;  1VFQ A;  4KED A;  1PD1 A;  3FG7 A;  4PKI G;  1NM1 G;  2L72 A;  2VIL A;  2MP4 A;  3EG9 A;  1WFS A;  3Q2B A;  4KEE A;  5KYX B;  1T3X A;  1WNJ A;  3FFN A;  2NUP B;  5KYW B;  2XF1 A;  3A5L S;  2W0I A;  2FH2 A;  1M2V A;  1PCX A;  1AHQ A;  1WM4 A;  3EFO B;  1VKK A;  1JHW A;  3A5M S;  2KVK A;  3FG6 A;  3EH1 A;  3EGX B;  1KCQ A;  1YAG G;  1SVR A;  3CIP G;  1P8Z G;  1D4X G;  5A1M A;  1AK7 A;  1MDU A;  2MV2 A;  3L50 A;  1NPH A;  1SVQ A;  3EG9 B;  2FH1 A;  5KYU B;  5DD2 A;  3EGD A;  2FF6 G;  1T2L A;  4KEF A;  2FH4 A;  4S10 C;  1EQY S;  5FAF A;  4JD2 H;  1M2V B;  1Q8G A;  2MOT A;  4LIZ A;  1QPV A;  1AK6 A;  1H1V G;  4PKG G;  1COF A;  1UDM A;  1RGI G;  2NUT A;  5KYY A;  1F7S A;  1Q8X A;  1TMW A;  1M4J A;  2FH3 A;  2I2Q A;  3FFK A;  4Z94 G;  1C0G S;  1NLV G;  4CBU G;  5HVK B;  2LXX A;  5KYN A;  2HD7 A;  2QTV A;  3A5N S;  5FAE A;  1PD0 A;  1SVY A;  5L6W C;  3EGD B;  1J72 A;  1HQZ 1;  2FF3 A;  1TVJ A;  3DAW B;  1T3Y A;  1T44 G;  3CJB G;  3A5O S;  1DEJ S;  2VIK A;  1C0F S;  1NMD G;  1D0N A;  1X67 A;  4CBW G;  2LJ8 A;  2VAC A;  2D8B A;  2FGH A;  3CJC G;  5KYX A;  2NUT B;  3CI5 G;  5KYU A;  5KYY B;  2NUP A;  5KYW A;  4CBX G;  1P8X A;  3EFO A;  1CFY A;  2XFA A;  3TU5 B;  4PKH B;  1M2O A;  2LLF A; 
#chains in the Genus database with same CATH topology
 4BEX 1;  3EH2 A;  5HVK D;  3EGX A;  1V6F A;  5IVU A;  1ESV S;  1CNU A;  1YVN G;  1VFQ A;  4KED A;  1PD1 A;  3FG7 A;  4PKI G;  1NM1 G;  2L72 A;  2VIL A;  2MP4 A;  3EG9 A;  1WFS A;  3Q2B A;  4KEE A;  5KYX B;  1T3X A;  1WNJ A;  3FFN A;  2NUP B;  5KYW B;  2XF1 A;  3A5L S;  2W0I A;  2FH2 A;  1M2V A;  1PCX A;  1AHQ A;  1WM4 A;  3EFO B;  1VKK A;  1JHW A;  3A5M S;  2KVK A;  3FG6 A;  3EH1 A;  3EGX B;  1KCQ A;  1YAG G;  1SVR A;  3CIP G;  1P8Z G;  1D4X G;  5A1M A;  1AK7 A;  1MDU A;  2MV2 A;  3L50 A;  1NPH A;  1SVQ A;  3EG9 B;  2FH1 A;  5KYU B;  5DD2 A;  3EGD A;  2FF6 G;  1T2L A;  4KEF A;  2FH4 A;  4S10 C;  1EQY S;  5FAF A;  4JD2 H;  1M2V B;  1Q8G A;  2MOT A;  4LIZ A;  1QPV A;  1AK6 A;  1H1V G;  4PKG G;  1COF A;  1UDM A;  1RGI G;  2NUT A;  5KYY A;  1F7S A;  1Q8X A;  1TMW A;  1M4J A;  2FH3 A;  2I2Q A;  3FFK A;  4Z94 G;  1C0G S;  1NLV G;  4CBU G;  5HVK B;  2LXX A;  5KYN A;  2HD7 A;  2QTV A;  3A5N S;  5FAE A;  1PD0 A;  1SVY A;  5L6W C;  3EGD B;  1J72 A;  1HQZ 1;  2FF3 A;  1TVJ A;  3DAW B;  1T3Y A;  1T44 G;  3CJB G;  3A5O S;  1DEJ S;  2VIK A;  1C0F S;  1NMD G;  1D0N A;  1X67 A;  3DA7 A;  4CBW G;  2LJ8 A;  2VAC A;  2D8B A;  2FGH A;  3CJC G;  5KYX A;  2NUT B;  3CI5 G;  5KYU A;  5KYY B;  2NUP A;  5KYW A;  4CBX G;  1P8X A;  3EFO A;  1CFY A;  2XFA A;  3TU5 B;  4PKH B;  1M2O A;  2LLF A; 
#chains in the Genus database with same CATH homology
 4BEX 1;  3EH2 A;  5HVK D;  3EGX A;  1V6F A;  5IVU A;  1ESV S;  1CNU A;  1YVN G;  1VFQ A;  4KED A;  1PD1 A;  3FG7 A;  4PKI G;  1NM1 G;  2L72 A;  2VIL A;  2MP4 A;  3EG9 A;  1WFS A;  3Q2B A;  4KEE A;  5KYX B;  1T3X A;  1WNJ A;  3FFN A;  2NUP B;  5KYW B;  2XF1 A;  3A5L S;  2W0I A;  2FH2 A;  1M2V A;  1PCX A;  1AHQ A;  1WM4 A;  3EFO B;  1VKK A;  1JHW A;  3A5M S;  2KVK A;  3FG6 A;  3EH1 A;  3EGX B;  1KCQ A;  1YAG G;  1SVR A;  3CIP G;  1P8Z G;  1D4X G;  5A1M A;  1AK7 A;  1MDU A;  2MV2 A;  3L50 A;  1NPH A;  1SVQ A;  3EG9 B;  2FH1 A;  5KYU B;  5DD2 A;  3EGD A;  2FF6 G;  1T2L A;  4KEF A;  2FH4 A;  4S10 C;  1EQY S;  5FAF A;  4JD2 H;  1M2V B;  1Q8G A;  2MOT A;  4LIZ A;  1QPV A;  1AK6 A;  1H1V G;  4PKG G;  1COF A;  1UDM A;  1RGI G;  2NUT A;  5KYY A;  1F7S A;  1Q8X A;  1TMW A;  1M4J A;  2FH3 A;  2I2Q A;  3FFK A;  4Z94 G;  1C0G S;  1NLV G;  4CBU G;  5HVK B;  2LXX A;  5KYN A;  2HD7 A;  2QTV A;  3A5N S;  5FAE A;  1PD0 A;  1SVY A;  5L6W C;  3EGD B;  1J72 A;  1HQZ 1;  2FF3 A;  1TVJ A;  3DAW B;  1T3Y A;  1T44 G;  3CJB G;  3A5O S;  1DEJ S;  2VIK A;  1C0F S;  1NMD G;  1D0N A;  1X67 A;  3DA7 A;  4CBW G;  2LJ8 A;  2VAC A;  2D8B A;  2FGH A;  3CJC G;  5KYX A;  2NUT B;  3CI5 G;  5KYU A;  5KYY B;  2NUP A;  5KYW A;  4CBX G;  1P8X A;  3EFO A;  1CFY A;  2XFA A;  3TU5 B;  4PKH B;  1M2O A;  2LLF A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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